公开(公告)号：US20120302638A1

公开(公告)日：2012-11-29

申请号：US13569287

申请日：2012-08-08

Applicant: Michael Fitzpatrick Wempe ,  Liu Deng ,  Stephanie Kay Clendennen ,  Neil Warren Boaz

Inventor： Michael Fitzpatrick Wempe ,  Liu Deng ,  Stephanie Kay Clendennen ,  Neil Warren Boaz

IPC: A61K31/235 ,  A61P29/00 ,  A61P17/00 ,  C07C67/08 ,  C12P7/62

CPC classification number: A61K31/22 ,  A61K31/23 ,  C07C67/08 ,  C07C69/95 ,  C07C2601/16

Abstract: Esters of 4,5-disubstituted-oxy-2-methyl-3,6-dioxo-cyclohexa-1,4-dienyl alkyl acids were prepared chemically and/or enzymatically. Depending upon the ester, improved melanocyte cytotoxicity was achieved. Improved cytotoxicity characteristics are consistent with ester analogs being more physiologically compatible and less irritating to skin than their corresponding acids.

Abstract translation: 化学和/或酶促制备4,5-二取代 - 氧基-2-甲基-3,6-二氧代 - 环己-1,4-二烯基烷基酯的酯。 取决于酯，实现了改善的黑素细胞细胞毒性。 改进的细胞毒性特征与酯类似物与其相应的酸相比更具生理学相容性并且对皮肤刺激性较低。

公开(公告)号：US07927855B2

公开(公告)日：2011-04-19

申请号：US11890974

申请日：2007-08-08

Applicant: Stephanie Kay Clendennen ,  Neil Warren Boaz

Inventor： Stephanie Kay Clendennen ,  Neil Warren Boaz

IPC: C12N9/20 ,  C12N9/50 ,  C07C69/76 ,  A61F2/00

CPC classification number: C07C69/24 ,  C07C69/587 ,  C07C2601/16 ,  C12P7/62 ,  C12P7/6436

Abstract: Disclosed are esters and a process for the preparation of the esters represented by formula 1: The process includes reacting an alcohol with a long-chain acid R2COOH or long-chain ester R2COOR4 in the presence of an organic solvent and an enzyme with or without the removal of water.

Abstract translation: 公开了酯和制备由式1表示的酯的方法：该方法包括在有机溶剂和具有或不具有该官能团的酶的存在下，使醇与长链酸R2COOH或长链酯R2COOR4反应 去除水。

公开(公告)号：US20090033683A1

公开(公告)日：2009-02-05

申请号：US12157932

申请日：2008-06-13

Applicant: Jeremy Schiff ,  Dominic Antonelli ,  Frank Wang ,  Neil Warren ,  Heston Liebowitz ,  Jonathan Burgstone ,  Sharam Shirazi

Inventor： Jeremy Schiff ,  Dominic Antonelli ,  Frank Wang ,  Neil Warren ,  Heston Liebowitz ,  Jonathan Burgstone ,  Sharam Shirazi

IPC: G09G5/00

CPC classification number: G06T3/0012

Abstract: A new approach contemplating a variety of improved methods and systems to perform intelligent image resizing on an image is proposed. The approach enables a user to interactively mark or select portions of the image to preserve and/or remove. An energy function can then be used to calculate values of an energy metric, for a non-limiting example, entropy, on every pixel over the entire image. Such calculated values can then be used to determine the optimal regions where new pixels are to be inserted or existing pixels are to be removed in order to minimize the amount of energy lost (for shrinking) or added (for growing) in the image.

Abstract translation: 提出了一种考虑在图像上执行智能图像调整大小的各种改进方法和系统的新方法。 该方法使得用户能够交互地标记或选择图像的部分以保存和/或移除。 然后可以使用能量函数来计算整个图像上每个像素上的非限制性示例熵的能量度量的值。 然后可以使用这样的计算值来确定要插入新像素或现有像素将被去除的最佳区域，以便最小化在图像中损失（用于收缩）或添加（用于生长）的能量的量。

公开(公告)号：US20080306144A1

公开(公告)日：2008-12-11

申请号：US11811055

申请日：2007-06-08

Applicant: Stephanie Kay Clendennen ,  Neil Warren Boaz ,  Jeffrey M. Clauson

Inventor： Stephanie Kay Clendennen ,  Neil Warren Boaz ,  Jeffrey M. Clauson

IPC: A61K31/351 ,  A61K31/235 ,  A61P17/00 ,  C07C69/76 ,  C07D309/38

CPC classification number: C12P7/62 ,  A61K31/235 ,  A61K31/351 ,  C07D309/38 ,  C12P17/06

Abstract: Method for the preparation of ester compounds for use as skin brightening agents and compositions for brightening skin containing the ester compounds.

Abstract translation: 用于制备用作皮肤增亮剂的酯化合物的方法和用于增亮含有酯化合物的皮肤的组合物。

公开(公告)号：US07214803B2

公开(公告)日：2007-05-08

申请号：US11095988

申请日：2005-03-31

Applicant: Neil Warren Boaz ,  Sheryl Davis Debenham

Inventor： Neil Warren Boaz ,  Sheryl Davis Debenham

IPC: C07D207/08

CPC classification number: C07D203/04 ,  C07B2200/07 ,  C07C231/18 ,  C07C253/30 ,  C07C269/06 ,  C07C2601/02 ,  C07D205/08 ,  C07D207/27 ,  C07D211/76 ,  C07D223/10 ,  C07D225/02 ,  C07F9/5532 ,  C07F9/564 ,  C07F9/568 ,  C07F9/572 ,  C07F9/59 ,  Y02P20/52 ,  C07C233/47 ,  C07C233/83 ,  C07C233/84 ,  C07C255/60 ,  C07C271/22

Abstract: The present invention relates to highly enantiomerically pure lactam-substituted propanoic acid derivatives and methods of making and using therefor. The invention involves a multi-step synthesis to produce the lactam compounds. In one step of the reaction sequence, asymmetric hydrogenation of a lactam-enamide was performed to produce an intermediate that can ultimately be converted to a series of pharmaceutical compounds. The invention also contemplates the in situ synthesis of an intermediate of the multi-step synthesis, which provides economic advantages to the overall synthesis of the lactam compounds.

Abstract translation: 本发明涉及高度对映体纯的内酰胺取代的丙酸衍生物及其制备和使用方法。 本发明涉及多步合成来制备内酰胺化合物。 在反应顺序的一个步骤中，进行内酰胺 - 酰胺的不对称氢化以产生最终可以转化成一系列药物化合物的中间体。 本发明还考虑了多步合​​成中间体的原位合成，其为内酰胺化合物的总体合成提供经济优势。

公开(公告)号：US06906212B1

公开(公告)日：2005-06-14

申请号：US10876387

申请日：2004-06-25

Applicant: Neil Warren Boaz

Inventor： Neil Warren Boaz

IPC: B01J31/18 ,  B01J31/22 ,  C07C51/36 ,  C07C67/303 ,  C07F9/24 ,  C07F9/6571 ,  C07F17/00 ,  C07F17/02 ,  B01J31/00 ,  C07C5/03

CPC classification number: C07F17/02 ,  B01J31/187 ,  B01J31/2295 ,  B01J2231/645 ,  B01J2531/822 ,  C07B2200/07 ,  C07C51/36 ,  C07C67/303 ,  C07F9/2458 ,  C07F9/657154 ,  C07F17/00 ,  C07C55/02 ,  C07C69/34

Abstract: Disclosed are novel phosphine-phosphoramidite compounds which may be employed in combination with a catalytically-active metal to effect a wide variety of reactions such as asymmetric hydrogenations, asymmetric reductions, asymmetric hydroborations, asymmetric olefin isomerizations, asymmetric hydrosilations, asymmetric allylations, asymmetric conjugate additions, and asymmetric organometallic additions. Also disclosed are a process for the preparation of the phosphine-phosphoramidite compounds, metal complex compounds comprising at least one of the phosphine-phosphoramidite compounds and a catalytically-active metal and hydrogenation processes utilizing the metal complex compounds.

Abstract translation: 公开了可与催化活性金属组合使用的新型膦 - 亚磷酰胺化合物，以实现多种反应，例如不对称氢化，不对称还原，不对称氢化，不对称烯烃异构化，不对称氢化硅，不对称烯丙基化，不对称共轭加成 ，和不对称有机金属添加剂。 还公开了制备膦 - 亚磷酰胺化合物的方法，包含至少一种膦 - 亚磷酰胺化合物和催化活性金属的金属络合物，以及利用金属络合物的氢化方法。

公开(公告)号：US06686477B2

公开(公告)日：2004-02-03

申请号：US09957182

申请日：2001-09-20

Applicant: Neil Warren Boaz ,  Sheryl Davis Debenham

Inventor： Neil Warren Boaz ,  Sheryl Davis Debenham

IPC: C07F902

CPC classification number: C07D203/04 ,  C07B2200/07 ,  C07C231/18 ,  C07C253/30 ,  C07C269/06 ,  C07C2601/02 ,  C07D205/08 ,  C07D207/27 ,  C07D211/76 ,  C07D223/10 ,  C07D225/02 ,  C07F9/5532 ,  C07F9/564 ,  C07F9/568 ,  C07F9/572 ,  C07F9/59 ,  Y02P20/52 ,  C07C233/47 ,  C07C233/83 ,  C07C233/84 ,  C07C255/60 ,  C07C271/22

Abstract: The present invention relates to highly enantiomerically pure lactam-substituted propanoic acid derivatives and methods of making and using therefor. The invention involves a multi-step synthesis to produce the lactam compounds. In one step of the reaction sequence, asymmetric hydrogenation of a lactam-enamide was performed to produce an intermediate that can ultimately be converted to a series of pharmaceutical compounds. The invention also contemplates the in situ synthesis of an intermediate of the multi-step synthesis, which provides economic advantages to the overall synthesis of the lactam compounds.

公开(公告)号：US06620954B1

公开(公告)日：2003-09-16

申请号：US10105516

申请日：2002-03-25

Applicant: Neil Warren Boaz

Inventor： Neil Warren Boaz

IPC: C07F1700

CPC classification number: B01J31/2404 ,  B01J31/2226 ,  B01J31/2252 ,  B01J31/2295 ,  B01J2231/4205 ,  B01J2531/40 ,  B01J2531/50 ,  B01J2531/60 ,  B01J2531/70 ,  B01J2531/80 ,  B01J2531/821 ,  B01J2531/824 ,  B01J2531/825 ,  B01J2531/842 ,  C07F17/00 ,  C07F17/02

Abstract: Disclosed are novel phosphinometallocenylamides that are useful as ligands for asymmetric catalysis. The novel ligands, which are readily modifiable, contain both a phosphine and an amide functionality linked by a metallocene backbone. In addition, the novel compounds are phosphine-amides derived from a phosphine-amine, rather than a phosphine-carboxylic acid. Further, described herein are both processes to make the novel ligands as well as processes that employ such ligands in a catalytically active composition comprising one or more phosphinometallocenylamide compounds in complex association with one or more Group VIb or Group VIII metals to provide chiral products. Further, we describe exemplary catalyst complexes incorporating the novel ligands.

Abstract translation: 公开了可用作不对称催化配体的新型次膦基金属烯基酰胺。 容易修饰的新配体含有通过茂金属主链连接的膦和酰胺官能团。 此外，新化合物是衍生自膦 - 胺而不是膦 - 羧酸的膦酰胺。 此外，本文描述的是制备新型配体的方法以及在包含一种或多种次金属茂金属酰胺化合物的催化活性组合物中使用这种配体的方法，其与一种或多种VIb族或VIII族金属络合以提供手性产物。 此外，我们描述了掺入新配体的示例性催化剂配合物。

公开(公告)号：US20130273183A1

公开(公告)日：2013-10-17

申请号：US13446240

申请日：2012-04-13

Applicant: Stephanie Kay Clendennen ,  Liu Deng ,  Neil Warren Boaz

Inventor： Stephanie Kay Clendennen ,  Liu Deng ,  Neil Warren Boaz

IPC: A61K8/49 ,  A61K8/58 ,  A61Q19/02 ,  A61K8/97 ,  A61K8/92 ,  A61K8/67

CPC classification number: A61Q19/02 ,  A61K8/4926 ,  A61K2800/782

Abstract: 2-Pyrimidine thioesters and thiocarbonates are disclosed as effective skin brightening agents. These compounds may be formulated with dermatologically acceptable carriers to form skin brightening compositions. Methods for brightening skin and for inhibiting melanogenesis using these agents are also disclosed.

Abstract translation: 公开了2-嘧啶硫酯和硫代碳酸酯作为有效的皮肤增亮剂。 这些化合物可以与皮肤病学上可接受的载体配制以形成皮肤增亮组合物。 还公开了使用这些试剂增亮皮肤和抑制黑素生成的方法。

公开(公告)号：US08263094B2

公开(公告)日：2012-09-11

申请号：US12236171

申请日：2008-09-23

Applicant: Michael Fitzpatrick Wempe ,  Liu Deng ,  Stephanie Kay Clendennen ,  Neil Warren Boaz

Inventor： Michael Fitzpatrick Wempe ,  Liu Deng ,  Stephanie Kay Clendennen ,  Neil Warren Boaz

IPC: A61K8/02 ,  C12P33/20 ,  C07D487/00

CPC classification number: A61K31/22 ,  A61K31/23 ,  C07C67/08 ,  C07C69/95 ,  C07C2601/16

Abstract: Esters of 4,5-disubstituted-oxy-2-methyl-3,6-dioxo-cyclohexa-1,4-dienyl alkyl acids were prepared chemically and/or enzymatically. Depending upon the ester, improved melanocyte cytotoxicity was achieved. Improved cytotoxicity characteristics are consistent with ester analogs being more physiologically compatible and less irritating to skin than their corresponding acids.

Abstract translation: 化学和/或酶促制备4,5-二取代 - 氧基-2-甲基-3,6-二氧代 - 环己-1,4-二烯基烷基酯的酯。 取决于酯，实现了改善的黑素细胞细胞毒性。 改进的细胞毒性特征与酯类似物与其相应的酸相比更具生理学相容性并且对皮肤刺激性较低。