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1.发明授权Fermentative production of acetone from renewable resources by means of novel metabolic pathway 有权通过新型代谢途径从可再生资源中发酵生产丙酮公开(公告)号：US08986961B2
公开(公告)日：2015-03-24
申请号：US12679488
申请日：2008-10-01
申请人： Stefan Verseck , Steffen Schaffer , Werner Freitag , Friedrich-Georg Schmidt , Matthias Orschel , Gerda Grund , Wilfried Schmidt , Hubert Johannes Bahl , Ralf-Joerg Fischer , Antje May , Peter Duerre , Simone Lederle
发明人： Stefan Verseck , Steffen Schaffer , Werner Freitag , Friedrich-Georg Schmidt , Matthias Orschel , Gerda Grund , Wilfried Schmidt , Hubert Johannes Bahl , Ralf-Joerg Fischer , Antje May , Peter Duerre , Simone Lederle
CPC分类号： C12P7/28 , C12N9/16 , C12N9/93 , C12Y301/02 , C12Y301/02018
摘要： The invention describes a process for preparing acetone starting from acetyl-coenzyme A comprising process steps A. enzymatic conversion of acetyl-CoA into acetoacetyl-CoA B. enzymatic conversion of acetoacetyl-CoA into acetoacetate and CoA and C. decarboxylation of acetoacetate to acetone and CO2, which is characterized in that the coenzyme A is not transferred in process step B to an acceptor molecule. In addition, process step B is surprisingly catalyzed by enzymes of the classes of acyl-CoA thioesterase, acyl-CoA synthetase or acyl-CoA thiokinase.A completely novel metabolic pathway is concerned, because the enzymatic hydrolysis of acetoacetyl-CoA without simultaneous transfer of CoA to a receptor molecule has never previously been described for any microbial enzyme.
摘要翻译： 本发明描述了从乙酰辅酶A开始制备丙酮的方法，包括方法步骤A.将乙酰辅酶A酶促转化为乙酰乙酰辅酶A.将乙酰乙酰辅酶A酶促转化为乙酰乙酸酯，并将乙酰乙酸酯脱羧至丙酮， CO 2，其特征在于辅酶A在工艺步骤B中不转移到受体分子。 此外，方法步骤B令人惊奇地由酰基-CoA硫酯酶，酰基辅酶A合成酶或酰基辅酶A硫代激酶类的酶催化。 关注一个完全新颖的代谢途径，因为乙酰乙酰辅酶A的酶水解而不会同时转移CoA到受体分子，从未以前没有描述任何微生物酶。
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公开(公告)号：US08679799B2
公开(公告)日：2014-03-25
申请号：US13140398
申请日：2009-12-15
申请人： Wolfgang Wach , Karsten Harms , Michael Klingeberg , Peter Duerre , Niklas Nold , Bettina Schiel
发明人： Wolfgang Wach , Karsten Harms , Michael Klingeberg , Peter Duerre , Niklas Nold , Bettina Schiel
CPC分类号： C12P7/16 , C12N15/1137 , C12N2310/11 , C12N2310/14 , C12P7/40 , C12P7/52 , C12P7/54 , Y02E50/10
摘要： The invention relates to a method and means for the bioengineered fermentative production of solvents, in particular of butanol, acetone and ethanol, and of short-chained carboxylic acids such as acetic acid and butyric acid, in particular in host cells of the species Clostridium. The invention provides new methods and means for regulating the expression of the enzyme activities involved in acid production and or solvent production of the host cell.
摘要翻译： 本发明涉及用于生物工程化发酵生产溶剂，特别是丁醇，丙酮和乙醇以及短链羧酸如乙酸和丁酸的方法和装置，特别是在梭菌属的宿主细胞中。 本发明提供调节宿主细胞的酸生产和/或溶剂生产中涉及的酶活性表达的新方法和方法。
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公开(公告)号：US20110281313A1
公开(公告)日：2011-11-17
申请号：US13140398
申请日：2009-12-15
申请人： Wolfgang Wach , Karsten Harms , Michael Klingeberg , Peter Duerre , Niklas Nold , Bettina Schiel
发明人： Wolfgang Wach , Karsten Harms , Michael Klingeberg , Peter Duerre , Niklas Nold , Bettina Schiel
CPC分类号： C12P7/16 , C12N15/1137 , C12N2310/11 , C12N2310/14 , C12P7/40 , C12P7/52 , C12P7/54 , Y02E50/10
摘要： The invention relates to a method and means for the bioengineered fermentative production of solvents, in particular of butanol, acetone and ethanol, and of short-chained carboxylic acids such as acetic acid and butyric acid, in particular in host cells of the species Clostridium. The invention provides new methods and means for regulating the expression of the enzyme activities involved in acid production and or solvent production of the host cell.
摘要翻译： 本发明涉及用于生物工程化发酵生产溶剂，特别是丁醇，丙酮和乙醇以及短链羧酸如乙酸和丁酸的方法和装置，特别是在梭菌属的宿主细胞中。 本发明提供调节宿主细胞的酸生产和/或溶剂生产中涉及的酶活性表达的新方法和方法。
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公开(公告)号：US09453210B2
公开(公告)日：2016-09-27
申请号：US13260012
申请日：2010-02-23
申请人： Franz Ulrich Becker , Gerda Grund , Matthias Orschel , Kai Doderer , Gerd Loehden , Gerd Brand , Peter Duerre , Simone Thum , Hubert Johannes Bahl , Ralf-Joerg Fischer , Antje May
发明人： Franz Ulrich Becker , Gerda Grund , Matthias Orschel , Kai Doderer , Gerd Loehden , Gerd Brand , Peter Duerre , Simone Thum , Hubert Johannes Bahl , Ralf-Joerg Fischer , Antje May
CPC分类号： C12N9/13 , C12N9/1029 , C12N9/16 , C12N9/88 , C12P7/30 , C12Y203/01009 , Y02P20/52
摘要： The invention relates to cells and a method for producing acetone.
摘要翻译： 本发明涉及细胞和生产丙酮的方法。
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5.发明申请公开(公告)号：US20100261237A1
公开(公告)日：2010-10-14
申请号：US12679488
申请日：2008-10-01
申请人： Stefan Verseck , Steffen Schaffer , Werner Freitag , Friedrich-Georg Schmidt , Matthias Orschel , Gerda Grund , Wilfried Schmidt , Hubert Johannes Bahl , Ralf-Joerg Fischer , Antje May , Peter Duerre , Simone Lederle
发明人： Stefan Verseck , Steffen Schaffer , Werner Freitag , Friedrich-Georg Schmidt , Matthias Orschel , Gerda Grund , Wilfried Schmidt , Hubert Johannes Bahl , Ralf-Joerg Fischer , Antje May , Peter Duerre , Simone Lederle
CPC分类号： C12P7/28 , C12N9/16 , C12N9/93 , C12Y301/02 , C12Y301/02018
摘要： The invention describes a process for preparing acetone starting from acetyl-coenzyme A comprising process steps A. enzymatic conversion of acetyl-CoA into acetoacetyl-CoA B. enzymatic conversion of acetoacetyl-CoA into acetoacetate and CoA and C. decarboxylation of acetoacetate to acetone and CO2, which is characterized in that the coenzyme A is not transferred in process step B to an acceptor molecule. In addition, process step B is surprisingly catalysed by enzymes of the classes of acyl-CoA thioesterase, acyl-CoA synthetase or acyl-CoA thiokinase.A completely novel metabolic pathway is concerned, because the enzymatic hydrolysis of acetoacetyl-CoA without simultaneous transfer of CoA to a receptor molecule has never previously been described for any microbial enzyme.
摘要翻译： 本发明描述了从乙酰辅酶A开始制备丙酮的方法，包括方法步骤A.将乙酰辅酶A酶促转化为乙酰乙酰辅酶A.将乙酰乙酰辅酶A酶促转化为乙酰乙酸酯，并将乙酰乙酸酯脱羧至丙酮， CO 2，其特征在于辅酶A在工艺步骤B中不转移到受体分子。 此外，工艺步骤B由酰基-CoA硫酯酶，酰基辅酶A合成酶或酰基辅酶A硫代激酶类的催化剂惊人地催化。 关注一个完全新颖的代谢途径，因为乙酰乙酰辅酶A的酶水解而不会同时转移CoA到受体分子，从未以前没有描述任何微生物酶。
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