公开(公告)号：US20200306232A1

公开(公告)日：2020-10-01

申请号：US16308672

申请日：2017-06-08

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Carlos Antonio TRINDADE DA SILVA ,  Buce D. HAMMOCK ,  Fawaz G. HAJ ,  Ahmed BETTAIEB ,  Ahmet Bora INCEOGLU

IPC: A61K31/4468 ,  A61P19/08 ,  C12N15/113 ,  A61K9/00

Abstract: Provided are compositions and methods for preventing, mitigating, decreasing, inhibiting and/or reversing bone loss and/or increasing and/or promoting bone regeneration and remodeling and/or preventing, mitigating, decreasing, inhibiting and/or reversing periodontitis and/or periodontal disease in a subject by administering to the subject an effective amount of an inhibitor of soluble epoxide hydrolase (sEH).

公开(公告)号：US10777724B2

公开(公告)日：2020-09-15

申请号：US16049205

申请日：2018-07-30

Applicant: GAS TECHNOLOGY INSTITUTE ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, ON BEHALF OF ITS MERCED CAMPUS ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, ON BEHALF OF ITS BERKELEY CAMPUS

Inventor： David Cygan ,  Hamid Abbasi ,  Aleksandr Kozlov ,  Roland Winston ,  Eli Yablonovitch

IPC: H01L35/02 ,  H01L31/046 ,  H02S40/22 ,  H02S40/44 ,  F24S23/70

Abstract: A hybrid solar system including a hybrid solar collector using non-imaging optics and photovoltaic components and a heat transfer and storage system in thermal communication with the hybrid solar collector, the heat transfer and storage system using particle laden gas as thermal media to simultaneously generate and store electricity and high temperature dispatchable heat.

公开(公告)号：US20250167730A1

公开(公告)日：2025-05-22

申请号：US18961804

申请日：2024-11-27

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Filippo Capolino ,  Alireza Nikzamir

IPC: H03B5/02 ,  H03B5/12 ,  H03B5/18

Abstract: Some embodiments relate to systems and methods for electronic circuits configured to operate at or near an exceptional point of degeneracy (EPD). An electronic system includes an electronic circuit configured to operate approximately at an EPD. The electronic circuit includes an active component that, via an instability, brings the system to self-oscillations, wherein a second component of the circuit is perturbed leading to high sensitivity to such perturbation.

公开(公告)号：US20250163277A1

公开(公告)日：2025-05-22

申请号：US18841593

申请日：2023-03-06

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： David Kisailus ,  Devis Montroni

IPC: C09D5/18 ,  C09D7/63 ,  C09D129/04 ,  C09D179/08 ,  C09K5/16

Abstract: Systems. materials. and methods for heat management and protecting a manufactured article or surface from thermal damage. The protective materials have heat absorbing elements comprised of a metastable or a thermally stable material. The materials include particles with high thermal conductivity. thermally conductive protrusions or patterns. heat absorbing matrices or layers, or a combination thereof. The materials can be applied to an article to prevent or reduce thermal damage.

公开(公告)号：US20250161418A1

公开(公告)日：2025-05-22

申请号：US19028837

申请日：2025-01-17

Applicant: The Regents of the University of California

Inventor： Dena Dubal

IPC: A61K38/47 ,  A61K38/00 ,  A61P25/28 ,  C12N9/24

Abstract: Provided herein are klotho polypeptide compositions and methods for improving cognitive function in an individual comprising treatment of with klotho polypeptides.

公开(公告)号：US20250158667A1

公开(公告)日：2025-05-15

申请号：US18722883

申请日：2022-12-22

Applicant: The Regents of the University of California

Inventor： Agrim Gupta ,  Dinesh Bharadia

IPC: H04B7/0413 ,  H04B1/00 ,  H04B7/08

Abstract: In some embodiments, there may be provided systems, methods, and articles of manufacture for timeinterleaved multiple output. In some example embodiments, there may be provided an apparatus including a plurality of antennas; an analog spreader coupled the plurality of antennas; a radio frequency chain coupled to the analog spreader, wherein the radio frequency chain down converts and performs an analog-to-digital conversion to generate a stream; and a digital despreader, wherein the digital despreader receives the stream output by the radio frequency chain and digitally inverts analog spreading caused by the analog spreader to generate one or more user streams. Related systems, methods, and articles of manufacture are also disclosed.

公开(公告)号：US20250155371A1

公开(公告)日：2025-05-15

申请号：US19021025

申请日：2025-01-14

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Eric D. Diebold ,  Bahram Jalali ,  Brandon Buckley

IPC: G01N21/64 ,  G01N21/05 ,  G02B21/00 ,  G02B21/16 ,  G02B27/10 ,  G02F1/11

Abstract: Apparatus and methods for fluorescence imaging using radiofrequency multiplexed excitation. One apparatus splits an excitation laser beam into two arms of a Mach-Zehnder interferometer. The light in the first beam is frequency shifted by an acousto-optic deflector, which is driven by a phase-engineered radiofrequency comb designed to minimize peak-to-average power ratio. This RF comb generates multiple deflected optical beams possessing a range of output angles and frequency shifts. The second beam is shifted in frequency using an acousto-optic frequency shifter. After combining at a second beam splitter, the two beams are focused to a line on the sample using a conventional laser scanning microscope lens system. The acousto-optic deflectors frequency-encode the simultaneous excitation of an entire row of pixels, which enables detection and de-multiplexing of fluorescence images using a single photomultiplier tube and digital phase-coherent signal recovery techniques.

公开(公告)号：US20250154510A1

公开(公告)日：2025-05-15

申请号：US18949317

申请日：2024-11-15

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Thomas G. GRAEBER ,  Chia-Chin CHEN ,  Owen WITTE ,  Jung Wook PARK

IPC: C12N15/113 ,  A61K45/06 ,  A61N5/10

Abstract: The current disclosure is centered on the hypothesis that a better understanding of the neuroendocrine transdifferentiation (NEtD) process will provide therapeutic targets for inhibiting this transition and thus improving standard of care therapies. Accordingly, the current disclosure provides for a method for treating cancer in a subject, the method comprising administering an inhibitor of a gene, wherein the gene comprises one or more of tenascin C (TNC), advillin (AVIL), S100A7, PPARG, LOX lysyl oxidase, KLF5, APOBEC2, FOSL1, FOXM1, hedgehog, RELA, p65, IKK complex, JAK, STAT, TFAP4, geminin, OCA-1, OCA-2, Nf-kB, Nf-kB family and associated regulators, angiogenesis regulators such as BMX kinase, TEK kinase, periostin (POSTN), and VEGF family, stress genes, such as the JUN/FOS family, a gene from the S100 family, and cell state regulators such as ASCL1, POU2F3, NEUROD1, ASCL2, and YAP1.

公开(公告)号：US20250152728A1

公开(公告)日：2025-05-15

申请号：US19027601

申请日：2025-01-17

Applicant: MedImmune, LLC ,  The Regents Of The University Of California

Inventor： Ronald James Christie ,  Changshou Gao ,  Andre Henri St. Amant ,  Javier Read de Alaniz

IPC: A61K47/68 ,  A61K47/69 ,  C07C271/22 ,  C07D207/46

Abstract: The present invention provides a bioconjugation method and compounds for use therein. The bioconjugation method comprises the step of conjugating a biological molecule containing a first unsaturated functional group with a payload comprising a second unsaturated functional group, wherein the first and second unsaturated functional groups are complementary to each other such that conjugation is a reaction of said functional groups via a Diels-Alder reaction which forms a cyclohexene ring.

公开(公告)号：US20250152119A1

公开(公告)日：2025-05-15

申请号：US18834619

申请日：2023-02-02

Applicant: The Regents of the University of California

Inventor： Francisco Contijoch ,  Zhennong Chen ,  Elliot McVeigh

IPC: A61B6/00 ,  A61B6/03 ,  A61B6/46 ,  A61B6/50 ,  G06T7/00 ,  G06T7/246 ,  G06T15/08 ,  G16H10/60 ,  G16H30/40 ,  G16H50/20

Abstract: Systems and methods that pertain to a cardiac function abnormality detection via automated evaluation of volume rendering movies are disclosed. In some implementations, a system includes a view generator to create a plurality of volume rendered views of an organ of a patient, a motion detector coupled to the view generator to detect a regional motion of a section of the organ based on the plurality of volume rendered views of the organ, and a display coupled to the motion detector to show the plurality of volume rendered views or a detection of an abnormality of the section.