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公开(公告)号：US12297427B2
公开(公告)日：2025-05-13
申请号：US15780938
申请日：2016-12-02
Applicant: St. Jude Children's Research Hospital, Inc.
Inventor： Paul Thomas , Xizhi Guo , Pradyot Dash
IPC: C40B50/06 , C07K14/725 , C12N15/10 , C12N15/66
Abstract: The invention provides a method for rapid cloning of T-cell receptors (TCRs) (e.g., paired αβ and γδ TCR chains) and B-cell receptors (BCRs) (e.g. paired IgH or IgK or Igλ) from single cells by CDR3 substitution using single cell PCR products and Gibson Assembly techniques and a pre-generated TCR (or BCR) library in an expression vector.
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公开(公告)号：US20250122185A1
公开(公告)日：2025-04-17
申请号：US18712987
申请日：2022-11-23
Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.
Inventor： Jun J. YANG , Zoran RANKOVIC , Jianzhong HU , Jamie JARUSIEWICZ , Gisele A. NISHIGUCHI
IPC: C07D417/14 , A61K31/506 , A61K31/55 , A61K45/06 , C07D471/08 , C07D471/10 , C07D487/04 , C07D487/08 , C07D487/10
Abstract: In one aspect, the disclosure relates to proteolysis-targeting chimeric molecules (PROTACs) that induce degradation of LCK tyrosine kinase, i.e., the disclosed substituted N-(2-chloro-6-methylphenyl)-2-((6-(6-membered heterocycloalkyl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide analogues. The disclosed compounds are useful for modulating LCK tyrosine kinase activity through targeted degradation. In further aspects, the present disclosure relates to methods of making the disclosed compounds, pharmaceutical compositions comprising the disclosed compounds, and methods of treating various clinical conditions and disorders using same, e.g., a disorder of uncontrolled cellular proliferation, such as a cancer, which may be associated with a LCK tyrosine kinase dysfunction. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
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公开(公告)号：US20240287039A1
公开(公告)日：2024-08-29
申请号：US18390494
申请日：2023-12-20
Inventor： Richard E. LEE , Rajendra P. TANGALLAPALLY , Charles O. ROCK , Suzanne JACKOWSKI , Anne V. EDWARDS , Mi Kyung YUN , Chitra SUBRAMANIAN , Robert ZAMBONI , T. Jagadeeswar REDDY
IPC: C07D403/04 , A61K31/197
CPC classification number: C07D403/04 , A61K31/197
Abstract: The present disclosure relates to chemical compounds that modulate pantothenate kinase (PanK) activity for the treatment of metabolic disorders (such as diabetes mellitus type II), neurologic disorders (such as pantothenate kinase-associated neurodegeneration), pharmaceutical compositions containing such compounds, and their use in treatment. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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公开(公告)号：US20240216427A1
公开(公告)日：2024-07-04
申请号：US18270675
申请日：2021-12-29
Applicant: St. Jude Children's Research Hospital, Inc.
Inventor： Stephen GOTTSCHALK , Jessica WAGNER , Elizabeth WICKMAN , Timothy Isham SHAW , Jinghui ZHANG
IPC: A61K35/17 , A61K39/00 , A61P35/02 , C07K14/705 , C07K14/725 , C07K16/18
CPC classification number: A61K35/17 , A61K39/4611 , A61K39/4631 , A61P35/02 , C07K14/7051 , C07K14/70521 , C07K16/18 , A61K2239/13 , A61K2239/21 , C07K2317/565 , C07K2317/622 , C07K2319/02 , C07K2319/03
Abstract: The application provides chimeric antigen receptors (CARs) that target splice variants of the extracellular matrix proteins tenascin C (TNC) and procollagen 11A1 (Col11A1), and their uses in tumor immunotherapy. The application also provides polynucleotides and vectors that encode the chimeric antigen receptors, as well as host cells comprising the chimeric antigen receptors. The application also provides methods for preparing host cells comprising the chimeric antigen receptors and methods for treating patients using the modified host cells.
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5.发明公开公开(公告)号：US20240124465A1
公开(公告)日：2024-04-18
申请号：US18256857
申请日：2021-12-17
Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL
Inventor： Jaeki Min , Jamie Jarusiewicz , Marisa Actis , Yunchao Chang , Lisa Alcock , Charles Mulligan , Zoran Rankovic
IPC: C07D487/04 , C07D519/00
CPC classification number: C07D487/04 , C07D519/00
Abstract: The present disclosure relates to chemical compounds that modulate JAK-2 signaling, which are useful in the treatment of disorders associated with JAK-2 signaling dysfunction such as, for example, disorders of cellular proliferation (e.g., cancer) and autoimmune and inflammatory disorders, pharmaceutical compositions containing such compounds, and their use in treatment. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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Patent Agency Ranking
公开(公告)号：US20240018230A1
公开(公告)日：2024-01-18
申请号：US18245257
申请日：2021-09-21
Applicant: St. Jude Children's Research Hospital, Inc.
Inventor： Thirumala-Devi KANNEGANTI , Rajendra KARKI
CPC classification number: C07K16/241 , C07K16/249 , A61P37/06 , A61K2039/507
Abstract: Methods for treating or mitigating COVID-19, sepsis or hemophagocytic lymphohistiocystosis or cytokine storm-associated syndromes; and treating or preventing inflammatory cell death associated with an inflammatory condition or infection such as SARS-CoV-2, or inducing inflammatory cell death in the context of cancer are provided, which includes the modulation of TNF and/or IFN-γ activity.
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公开(公告)号：US20230340040A1
公开(公告)日：2023-10-26
申请号：US17918644
申请日：2021-04-14
Applicant: St. Jude Children's Research Hospital, Inc.
Inventor： Stephen GOTTSCHALK , Brooke PRINZING
CPC classification number: C07K14/4702 , A61P35/00 , C12N15/63 , C07K2319/03
Abstract: The present disclosure provides chimeric MyD88 receptors. Also provided are polynucleotides encoding the chimeric MyD88 receptors, vectors comprising the polynucleotides encoding the chimeric MyD88 receptors, and cell compositions comprising the chimeric MyD88 receptors, polynucleotides and/or vectors. Pharmaceutical compositions comprising the polypeptides, polynucleotides, vectors, or cells of the present disclosure, and their uses in treating a disease in a subject are also provided.
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公开(公告)号：US20230310575A1
公开(公告)日：2023-10-05
申请号：US18043442
申请日：2021-09-01
Applicant: St. Jude Children's Research Hospital, Inc.
Inventor： Natalie LEE , Sanja TRIFKOVIC , Rhodri HARFOOT
IPC: A61K39/145 , C07K14/005 , C12N15/86
CPC classification number: A61K39/145 , C07K14/005 , C12N15/86 , C12N2760/16122 , C12N2760/16134 , C12N2760/16152 , C12N2760/16162 , C12N2760/16171
Abstract: Mutation of adenosine methylation sites in nucleic acids encoding influenza virus hemagglutinin are provided that result in increases in vRNA, mRNA, and protein expression over time and increases in infectious titers when produced in mammalian cells.
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公开(公告)号：US20230220343A1
公开(公告)日：2023-07-13
申请号：US18067199
申请日：2022-12-16
Inventor： Dario Campana , David Shook , Masaru Imamura
IPC: C12N5/0783 , A61K38/20 , C07K14/54 , C07K14/705 , C12N5/00 , C12N15/62 , A61K35/17
CPC classification number: C12N5/0646 , A61K38/2086 , C07K14/5443 , A61K38/2013 , C07K14/70517 , C12N5/0006 , C12N15/62 , A61K35/17 , C12N2510/00 , C12N2501/2315 , C07K2319/03
Abstract: The present invention provides, in certain aspects, a natural killer (NK) cell that expresses all or a functional portion of interleukin-15 (IL-15), and methods for producing such cells. The invention further provides methods of using a natural killer (NK) cell that expresses all or a functional portion of interleukin-15 (IL-15) to treat cancer in a subject or to enhance expansion and/or survival of NK cells.
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公开(公告)号：US20230203535A1
公开(公告)日：2023-06-29
申请号：US17927038
申请日：2021-05-24
Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.
Inventor： Mark BRIMBLE , Andrew DAVIDOFF , Pei-Hsin CHENG , Christopher MORTON
IPC: C12N15/86
CPC classification number: C12N15/86 , C12N2710/20022 , C12N2750/14143
Abstract: A recombinant P5 promoter having an insertion of an exogenous spacer between the REP binding site and a transcription start site-localized Ying-Yang 1 (YY1) binding site is described, wherein said recombinant P5 promoter provides for a reduction in DNA contamination upstream of the P5 promoter without a concomitant reduction in viral titer.
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