公开(公告)号：US06387414B1

公开(公告)日：2002-05-14

申请号：US09368960

申请日：1999-08-05

Applicant: Mitsuru Akashi ,  Tetsushi Taguchi ,  Akio Kishida ,  Akio Hayashi

Inventor： Mitsuru Akashi ,  Tetsushi Taguchi ,  Akio Kishida ,  Akio Hayashi

IPC: A61K3342

CPC classification number: A61K9/0024 ,  A61L27/46

Abstract: A method for preparing a hydroxyapatite composite is disclosed. This method comprises alternately soaking a matrix which has been made hydrophilic at least on its surface, in a calcium ion aqueous solution containing calcium ions and substantially free of phosphate ions and in a phosphate ion aqueous solution containing phosphate ions and substantially free of calcium ions to securely form hydroxyapatite at least on the surface of the matrix. Also disclosed is a biocompatible material composed of the hydroxyapatite composite obtained by the method.

公开(公告)号：US09320622B2

公开(公告)日：2016-04-26

申请号：US13988870

申请日：2011-11-25

Applicant: Tetsushi Taguchi ,  Yasuyuki Katada ,  Ryozo Nagai ,  Ichiro Manabe ,  Katsuhito Fujiu

Inventor： Tetsushi Taguchi ,  Yasuyuki Katada ,  Ryozo Nagai ,  Ichiro Manabe ,  Katsuhito Fujiu

IPC: C22C38/22 ,  C22C38/02 ,  C22C38/04 ,  A61F2/82 ,  C22C38/00 ,  C22C38/26 ,  C22C38/28 ,  A61L31/02

CPC classification number: A61F2/82 ,  A61L31/022 ,  C22C38/001 ,  C22C38/002 ,  C22C38/02 ,  C22C38/04 ,  C22C38/06 ,  C22C38/22 ,  C22C38/26 ,  C22C38/28 ,  C22C38/32 ,  C22C38/44

Abstract: A nickel-free stainless steel stent using a stainless steel which does not substantially contain Ni in the stainless steel, has a metal allergy onset-preventing effect, and is excellent in terms of precision workability, strength, and ductility, is provided. The nickel-free stainless steel stent is characterized by using a stainless steel containing, as a chemical composition, from 15 to 30% by mass of Cr, from 0.97 to 2% by mass of Mo, and from 0.5 to 1% by mass of N, with the remainder being Fe, and optionally containing inevitable impurities.

Abstract translation: 使用不锈钢不含镍的不含镍的不锈钢支架，具有金属过敏起效防止效果，并且在精加工性，强度和延展性方面优异。 无镍不锈钢支架的特征在于，使用含有15〜30质量％的Cr，0.97〜2质量％的Mo和0.5〜1质量％的作为化学组成的不锈钢， N，其余为Fe，并且任选地含有不可避免的杂质。

公开(公告)号：US07348060B2

公开(公告)日：2008-03-25

申请号：US10568680

申请日：2004-03-25

Applicant: Junzo Tanaka ,  Toshiyuki Ikoma ,  Tetsushi Taguchi

Inventor： Junzo Tanaka ,  Toshiyuki Ikoma ,  Tetsushi Taguchi

IPC: B32B5/16

CPC classification number: B01J20/3204 ,  B01J20/048 ,  B01J20/28004 ,  B01J20/28019 ,  B01J20/282 ,  B01J20/286 ,  B01J20/3236 ,  B01J20/3272 ,  B01J20/3293 ,  C01B25/32 ,  Y10T428/2982 ,  Y10T428/2991

Abstract: A porous and spherical calcium phosphate particle which is substituted with a metal ion or has a metal ion carried on the surface thereof, and has a particle diameter of 0.1 to 100 μm. The calcium phosphate particle is a novel functional particle which is useful, for example, as a material for use in gas chromatography allowing the separation of a chemical substance of a trace amount with high accuracy.

Abstract translation: 一种由金属离子取代或在其表面承载有金属离子的多孔和球形磷酸钙颗粒，其粒径为0.1-100微米。 磷酸钙颗粒是新的功能性颗粒，其可用作例如用于气相色谱的材料，其允许以高精度分离微量的化学物质。

公开(公告)号：US20060128948A1

公开(公告)日：2006-06-15

申请号：US10527694

申请日：2003-09-11

Applicant: Tetsushi Taguchi ,  Hisatoshi Kobayashi ,  Junzo Tanaka ,  Hirofumi Saito

Inventor： Tetsushi Taguchi ,  Hisatoshi Kobayashi ,  Junzo Tanaka ,  Hirofumi Saito

IPC: C08B37/08 ,  C08B37/00

CPC classification number: C07D207/02 ,  C07D207/46

Abstract: The crosslinking agents and condensing agents that have been employed in biological adhesives and in treating medical devices such as cardiac valves are non-natural compounds synthesized artificially. Thus, they are not metabolized in vivo and exhibit toxicity to living bodies. These compounds are thus used only in a restricted amount and for limited purposes in the clinical sites. The present invention provides a biological low-molecular-weight derivative obtained by modifying carboxyl groups of a biological low-molecular-weight compound with N-hydroxysuccinimide, N-hydroxysulfosuccinimide, or a derivative thereof and a crosslinked high-molecular-weight product obtained by crosslinking various high-molecular-weight compounds with this derivative.

Abstract translation: 已经用于生物粘合剂和治疗医疗装置如心脏瓣膜的交联剂和缩合剂是人工合成的非天然化合物。 因此，它们不会在体内代谢并对活体表现出毒性。 因此，这些化合物仅在临床部位中仅限于有限的目的和用途。 本发明提供一种通过用N-羟基琥珀酰亚胺，N-羟基磺基琥珀酰亚胺或其衍生物修饰生物低分子量化合物的羧基得到的生物学低分子量衍生物和通过以下方法得到的交联的高分子量产物： 用该衍生物交联各种高分子量化合物。

公开(公告)号：US20130220174A1

公开(公告)日：2013-08-29

申请号：US13877880

申请日：2011-10-04

Applicant: Tetsushi Taguchi ,  Miyuki Matsuda

Inventor： Tetsushi Taguchi ,  Miyuki Matsuda

IPC: C09J189/00

CPC classification number: C09J189/00 ,  A61L24/104

Abstract: The present invention addresses the problem of providing: a two-component tissue adhesive having high adhesive strength and high biocompatibility; and a method for producing the two-component tissue adhesive. The present invention involves a two-component tissue adhesive comprising hydrophobically-modified gelatin as a first agent and a cross-linking reagent as a second agent. The hydrophobically-modified gelatin is provided with an amino group and a hydrophobic group on the side chain thereof, and the cross-linking reagent has two or more active ester groups or anhydrides within a single molecule.

Abstract translation: 本发明解决了提供：具有高粘合强度和高生物相容性的双组分组织粘合剂的问题; 以及双组分组织粘合剂的制造方法。 本发明涉及包含疏水改性明胶作为第一试剂的双组分组织粘合剂和作为第二试剂的交联剂。 疏水改性的明胶在其侧链上具有氨基和疏水性基团，交联剂在单分子内具有两个以上的活性酯基或酸酐。

公开(公告)号：US20130211048A1

公开(公告)日：2013-08-15

申请号：US13877865

申请日：2011-10-05

Applicant: Tetsushi Taguchi

Inventor： Tetsushi Taguchi

IPC: A61L24/10

CPC classification number: A61L24/104

Abstract: The present invention addresses the problem of providing: a tissue adhesive film having high adhesive strength and high biocompatibility; and a method for producing the tissue adhesive film. This problem can be solved by using a tissue adhesive film comprising an integration of gelatin and cross-linking reagents, wherein the gelatin is provided with an amino group on the side chain thereof and has a molecular weight of 50,000 or higher and 100,000 or lower, and the cross-linking reagents have two or more active ester groups or an anhydride.

Abstract translation: 本发明的目的在于提供：具有高粘合强度和高生物相容性的组织粘合膜的问题; 以及组织粘合膜的制造方法。 该问题可以通过使用包含明胶和交联剂整合的组织粘合剂膜来解决，其中明胶在其侧链上具有氨基，分子量为50,000以上且100,000以下， 交联剂具有两个以上的活性酯基或酸酐。

公开(公告)号：US20110251281A1

公开(公告)日：2011-10-13

申请号：US13060532

申请日：2009-09-08

Applicant: Tetsushi Taguchi ,  Mariko Takayanagi

Inventor： Tetsushi Taguchi ,  Mariko Takayanagi

IPC: A61K31/196 ,  A61P7/02

CPC classification number: A61L31/042 ,  C08K5/0008 ,  C08K5/09 ,  C08L5/00 ,  C08L5/08 ,  C08L5/10 ,  C08L89/00 ,  C08L89/04 ,  C08L89/06

Abstract: Previously reported composite materials comprising a hydrophilic high-molecular-weight matrix and a low-molecular-weight organic compound involve a problem in that: it is difficult to compound a high load of the low-molecular-weight organic compound in the high-molecular-weight matrix; and thus produced composite material yields a high-molecular-weight matrix component that can form a thrombus when contacting with blood. Now, it becomes possible to produce a composite material having an antithrombogenic activity and a high content of a low-molecular-weight organic compound by the present invention comprising the steps of: crosslinking a polymer with an organic acid derivative which is used as a crosslinker in an organic solvent while at the same time embedding the low-molecular-weight organic compound therein; and substituting the organic solvent by water after the production of the high-molecular-weight matrix to effect precipitation and compounding of the low-molecular-weight organic compound in the high-molecular-weight matrix.

Abstract translation: 以前报道的包含亲水性高分子量基质和低分子量有机化合物的复合材料存在以下问题：难以将高分子量有机化合物在高分子量 重量矩阵; 从而产生复合材料产生当与血液接触时可形成血栓的高分子量基质组分。 现在，可以通过本发明制备具有抗血栓形成活性和高含量的低分子量有机化合物的复合材料，包括以下步骤：用用作交联剂的有机酸衍生物交联聚合物 在有机溶剂中同时在其中包埋低分子量有机化合物; 在生成高分子量基质后用水代替有机溶剂，使高分子量基质中的低分子量有机化合物发生沉淀和配混。

公开(公告)号：US20060257658A1

公开(公告)日：2006-11-16

申请号：US10568680

申请日：2004-03-25

Applicant: Junzo Tanaka ,  Toshiyuki Ikoma ,  Tetsushi Taguchi

Inventor： Junzo Tanaka ,  Toshiyuki Ikoma ,  Tetsushi Taguchi

IPC: B32B1/00 ,  B32B18/00

CPC classification number: B01J20/3204 ,  B01J20/048 ,  B01J20/28004 ,  B01J20/28019 ,  B01J20/282 ,  B01J20/286 ,  B01J20/3236 ,  B01J20/3272 ,  B01J20/3293 ,  C01B25/32 ,  Y10T428/2982 ,  Y10T428/2991

Abstract: A porous and spherical calcium phosphate particle which is substituted with a metal ion or has a metal ion carried on the surface thereof, and has a particle diameter of 0.1 to 100 μm. The calcium phosphate particle is a novel functional particle which is useful, for example, as a material for use in gas chromatography allowing the separation of a chemical substance of a trace amount with high accuracy.

Abstract translation: 一种由金属离子取代或在其表面承载有金属离子的多孔和球形磷酸钙颗粒，其粒径为0.1-100微米。 磷酸钙颗粒是新的功能性颗粒，其可用作例如用于气相色谱的材料，其允许以高精度分离微量的化学物质。

公开(公告)号：US09499728B2

公开(公告)日：2016-11-22

申请号：US13877880

申请日：2011-10-04

Applicant: Tetsushi Taguchi ,  Miyuki Matsuda

Inventor： Tetsushi Taguchi ,  Miyuki Matsuda

IPC: C09J189/00 ,  C09H7/00 ,  A61L24/10 ,  A61K38/00

CPC classification number: C09J189/00 ,  A61L24/104

Abstract: The present invention addresses the problem of providing: a two-component tissue adhesive having high adhesive strength and high biocompatibility; and a method for producing the two-component tissue adhesive. The present invention involves a two-component tissue adhesive comprising hydrophobically-modified gelatin as a first agent and a cross-linking reagent as a second agent. The hydrophobically-modified gelatin is provided with an amino group and a hydrophobic group on the side chain thereof, and the cross-linking reagent has two or more active ester groups or anhydrides within a single molecule.

Abstract translation: 本发明解决了提供：具有高粘合强度和高生物相容性的双组分组织粘合剂的问题; 以及双组分组织粘合剂的制造方法。 本发明涉及包含疏水改性明胶作为第一试剂的双组分组织粘合剂和作为第二试剂的交联剂。 疏水改性的明胶在其侧链上具有氨基和疏水性基团，交联剂在单分子内具有两个以上的活性酯基或酸酐。

公开(公告)号：US20130304184A1

公开(公告)日：2013-11-14

申请号：US13988870

申请日：2011-11-25

Applicant: Tetsushi Taguchi ,  Yasuyuki Katada ,  Ryozo Nagai ,  Ichiro Manabe ,  Katsuhito Fujiu

Inventor： Tetsushi Taguchi ,  Yasuyuki Katada ,  Ryozo Nagai ,  Ichiro Manabe ,  Katsuhito Fujiu

IPC: A61F2/82

CPC classification number: A61F2/82 ,  A61L31/022 ,  C22C38/001 ,  C22C38/002 ,  C22C38/02 ,  C22C38/04 ,  C22C38/06 ,  C22C38/22 ,  C22C38/26 ,  C22C38/28 ,  C22C38/32 ,  C22C38/44

Abstract: A nickel-free stainless steel stent using a stainless steel which does not substantially contain Ni in the stainless steel, has a metal allergy onset-preventing effect, and is excellent in terms of precision workability, strength, and ductility, is provided. The nickel-free stainless steel stent is characterized by using a stainless steel containing, as a chemical composition, from 15 to 30% by mass of Cr, from 0.97 to 2% by mass of Mo, and from 0.5 to 1% by mass of N, with the remainder being Fe, and optionally containing inevitable impurities.

Abstract translation: 使用不锈钢不含镍的不含镍的不锈钢支架，具有金属过敏起效防止效果，并且在精加工性，强度和延展性方面优异。 无镍不锈钢支架的特征在于，使用含有15〜30质量％的Cr，0.97〜2质量％的Mo和0.5〜1质量％的作为化学组成的不锈钢， N，其余为Fe，并且任选地含有不可避免的杂质。