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    Biopsy instrument for enriching sample material
    2.
    发明授权
    Biopsy instrument for enriching sample material 有权

    公开(公告)号：US09943292B2

    公开(公告)日：2018-04-17

    申请号：US13058735

    申请日：2009-09-08

    申请人： Ulrich Pison

    发明人： Ulrich Pison

    IPC分类号： A61B10/02 ,  A61B10/00 ,  A61B10/04

    CPC分类号： A61B10/02 ,  A61B10/0045 ,  A61B10/0064 ,  A61B10/04 ,  A61B2010/0077

    摘要： The present invention relates to a biopsy instrument, comprising the following components: i. a guide element (1) comprising a spring-elastic distal (2) region and a proximal (3) region; ii. a biofunctionalized element (4) arranged between the distal and the proximal region of the guide element and whose surface has detection molecules, and iii. a stabilizing element (5) connected to the proximal region of the guide element. The invention further relates to the use of said biopsy instrument for enriching specific sample material from the body as well as to a biopsy kit and the use of the same for enriching specific sample material.

    PREPARATION OF 6-OXA-8ALPHA-STEROID ESTROGEN ANALOGUES - A NEW GROUP OF UNNATURAL ESTROGENS AND THEIR USE IN MEDICINE
    10.
    发明申请
    PREPARATION OF 6-OXA-8ALPHA-STEROID ESTROGEN ANALOGUES - A NEW GROUP OF UNNATURAL ESTROGENS AND THEIR USE IN MEDICINE 审中-公开
    6-OXA-8ALPHA-STEROID雌激素类似物的制备 - 新一代的雌激素及其在医学中的应用

    公开(公告)号：US20110160296A1

    公开(公告)日：2011-06-30

    申请号：US12741696

    申请日：2008-11-10

    申请人： Ulrich Pison ,  Alexander Grigorievich Shawa ,  Svetlana Nikolaevna Morozkina

    发明人： Ulrich Pison ,  Alexander Grigorievich Shawa ,  Svetlana Nikolaevna Morozkina

    IPC分类号： A61K31/352 ,  C07J73/00 ,  C07D311/78 ,  A61P15/00 ,  A61P29/00 ,  A61P19/10 ,  A61P9/00 ,  A61P35/00 ,  A61P19/04 ,  A61P25/00 ,  A61P25/28 ,  A61P3/06 ,  A61P3/00

    CPC分类号： C07J73/003

    摘要： The invention is related to the area of new 6-Oxa-8α-steroid estrogen analogues and the synthesis of these new biological active steroid estrogen analogues, namely, to the preparation of 6-oxa-8α-steroid estrogens and their use as estrogen receptor modulators. These new estrogen analogues are ligands for estrogen receptors and as such may be useful for the treatment and prevention of a variety of conditions related to estrogen functioning. These conditions include bone and cartilage disorders, increased levels of LDL cholesterol, cardiovascular diseases, impairment of cognitive function, cerebral degeneration disorders, endometriosis and other types of inflammation, the metabolic syndrome, and cancer, in particular of the breast, uterus and prostate.

    摘要翻译： 本发明涉及新的6-Oxa-8α-类固醇雌激素类似物的面积和这些新的生物活性类固醇雌激素类似物的合成，即6-氧杂-8α类固醇雌激素的制备及其作为雌激素受体的用途 调制器 这些新的雌激素类似物是雌激素受体的配体，因此可用于治疗和预防与雌激素功能相关的各种病症。 这些病症包括骨和软骨障碍，LDL胆固醇水平升高，心血管疾病，认知功能障碍，脑变性障碍，子宫内膜异位症和其他类型的炎症，代谢综合征和癌症，特别是乳腺，子宫和前列腺。