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公开(公告)号:US20050170440A1
公开(公告)日:2005-08-04
申请号:US11056562
申请日:2005-02-11
申请人: Venita DeAlmeida , Timothy Stewart
发明人: Venita DeAlmeida , Timothy Stewart
IPC分类号: G01N33/53 , A61B20060101 , A61K20060101 , A61K31/175 , A61K31/64 , A61K38/00 , A61K38/17 , A61K38/18 , A61K38/22 , A61K38/28 , A61K45/00 , A61P20060101 , A61P3/04 , A61P3/10 , C07K14/435 , C07K14/47 , C07K16/18 , C07K16/46 , C12N20060101 , C12N5/10 , C12N5/12 , C12N15/09 , C12P21/08 , C12Q1/25 , G01N20060101 , G01N33/537 , G01N33/543 , G01N33/567 , G01N33/577 , G01N33/68
CPC分类号: A61K31/175 , A61K31/64 , A61K38/1709 , C07K14/4703 , G01N33/6893 , G01N2800/042 , G01N2800/044
摘要: Dickkopf-5 (Dkk-5) protein is administered in effective amounts to treat disorders involving insulin resistance, such as non-insulin-dependent diabetes mellitus (NIDDM) or obesity. Also provided is a method of diagnosing insulin resistance and related disorders using Dkk-5 as a measure, and kits for diagnosis and treatment, as well as hybridomas producing antibodies to Dkk-5 and preparations comprising Dkk-5.
摘要翻译: 以有效量施用Dickkopf-5(Dkk-5)蛋白,以治疗涉及胰岛素抵抗的疾病,例如非胰岛素依赖型糖尿病(NIDDM)或肥胖症。 还提供了使用Dkk-5作为测量来诊断胰岛素抵抗和相关疾病的方法,以及用于诊断和治疗的试剂盒,以及产生Dkk-5抗体的杂交瘤和包含Dkk-5的制剂。
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公开(公告)号:US20110256127A1
公开(公告)日:2011-10-20
申请号:US13069582
申请日:2011-03-23
申请人: Eric Bourhis , Tim Cao , Rick Carano , Andrea Cochran , Mike Costa , Venita DeAlmeida , James Ernst , Yan Gong , Rami Hannoush , Paul Polakis , Bonnee Rubinfeld , Mark Solloway , Yan Wu
发明人: Eric Bourhis , Tim Cao , Rick Carano , Andrea Cochran , Mike Costa , Venita DeAlmeida , James Ernst , Yan Gong , Rami Hannoush , Paul Polakis , Bonnee Rubinfeld , Mark Solloway , Yan Wu
CPC分类号: C07K16/28 , A61K39/3955 , A61K2039/505 , A61K2039/507 , C07K16/2863 , C07K2317/21 , C07K2317/31 , C07K2317/34 , C07K2317/526 , C07K2317/55 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2319/00
摘要: The invention provides anti-LRP6 antibodies and methods of using the same. A particular aspect of the invention provides for bispecific anti-LRP6 antibodies that inhibit signaling by multiple Wnt isoforms.
摘要翻译: 本发明提供抗LRP6抗体及其使用方法。 本发明的一个特定方面提供了抑制多种Wnt同种型的信号通路的双特异性抗LRP6抗体。
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公开(公告)号:US20060293239A1
公开(公告)日:2006-12-28
申请号:US11465956
申请日:2006-08-21
申请人: Venita DeAlmeida , Timothy Stewart
发明人: Venita DeAlmeida , Timothy Stewart
CPC分类号: A61K31/175 , A61K31/64 , A61K38/1709 , C07K14/4703 , G01N33/6893 , G01N2800/042 , G01N2800/044
摘要: Dickkopf-5 (Dkk-5) protein is administered in effective amounts to treat disorders involving insulin resistance, such as non-insulin-dependent diabetes mellitus (NIDDM) or obesity. Also provided is a method of diagnosing insulin resistance and related disorders using Dkk-5 as a measure, and kits for diagnosis and treatment, as well as hybridomas producing antibodies to Dkk-5 and preparations comprising Dkk-5.
摘要翻译: 以有效量施用Dickkopf-5(Dkk-5)蛋白,以治疗涉及胰岛素抵抗的疾病,例如非胰岛素依赖型糖尿病(NIDDM)或肥胖症。 还提供了使用Dkk-5作为测量来诊断胰岛素抵抗和相关疾病的方法,以及用于诊断和治疗的试剂盒,以及产生Dkk-5抗体的杂交瘤和包含Dkk-5的制剂。
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公开(公告)号:US08846041B2
公开(公告)日:2014-09-30
申请号:US13069582
申请日:2011-03-23
申请人: Eric Bourhis , Tim Cao , Rick Carano , Andrea Cochran , Mike Costa , Venita DeAlmeida , James Ernst , Yan Gong , Rami Hannoush , Paul Polakis , Bonnee Rubinfeld , Mark Solloway , Yan Wu
发明人: Eric Bourhis , Tim Cao , Rick Carano , Andrea Cochran , Mike Costa , Venita DeAlmeida , James Ernst , Yan Gong , Rami Hannoush , Paul Polakis , Bonnee Rubinfeld , Mark Solloway , Yan Wu
IPC分类号: A61K39/395 , C07K16/28 , C12P21/08 , A61K39/00
CPC分类号: C07K16/28 , A61K39/3955 , A61K2039/505 , A61K2039/507 , C07K16/2863 , C07K2317/21 , C07K2317/31 , C07K2317/34 , C07K2317/526 , C07K2317/55 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2319/00
摘要: The invention provides anti-LRP6 antibodies and methods of using the same. A particular aspect of the invention provides for bispecific anti-LRP6 antibodies that inhibit signaling by multiple Wnt isoforms.
摘要翻译: 本发明提供抗LRP6抗体及其使用方法。 本发明的一个特定方面提供了抑制多种Wnt同种型的信号通路的双特异性抗LRP6抗体。
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