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公开(公告)号：US20130041031A1
公开(公告)日：2013-02-14
申请号：US13551602
申请日：2012-07-17
申请人： Virginia Ursin , Byron Froman , Jennifer Simmons , Thomas J. LaRosa , Fenggao Dong , Steven Screen
发明人： Virginia Ursin , Byron Froman , Jennifer Simmons , Thomas J. LaRosa , Fenggao Dong , Steven Screen
IPC分类号： C07C57/03 , A23D9/00 , A61K31/202
CPC分类号： C12N9/0004 , C12N15/8247 , C12P7/6427
摘要： The invention relates generally to methods and compositions concerning desaturase enzymes that modulate the number and location of double bonds in long chain poly-unsaturated fatty acids (LC-PUFA's). In particular, the invention relates to methods and compositions for improving omega-3 fatty acid profiles in plant products and parts using desaturase enzymes and nucleic acids encoding for such enzymes. In particular embodiments, the desaturase enzymes are Primula Δ6-desaturases. Also provided are improved soybean oil compositions having SDA and a beneficial overall content of omega-3 fatty acids relative to omega-6 fatty acids.
摘要翻译： 本发明一般涉及调节长链多不饱和脂肪酸（LC-PUFA）中双键数目和位置的去饱和酶的方法和组合物。 特别地，本发明涉及用于使用去饱和酶和编码这些酶的核酸改善植物产品和部分中的ω-3脂肪酸谱的方法和组合物。 在具体实施方案中，去饱和酶是Primula＆Dgr; 6-去饱和酶。 还提供了具有SDA的改进的大豆油组合物和相对于ω-6脂肪酸的ω-3脂肪酸的有益总体含量。
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公开(公告)号：US08329994B2
公开(公告)日：2012-12-11
申请号：US12578880
申请日：2009-10-14
申请人： Virginia Ursin , Byron Froman , Steven Screen , Lori Lehman
发明人： Virginia Ursin , Byron Froman , Steven Screen , Lori Lehman
CPC分类号： C07K14/44 , C07K14/405 , C12N15/8247
摘要： The invention relates to methods and compositions concerning desaturase enzymes that modulate the number and location of double bonds in long chain poly-unsaturated fatty acids (LC-PUFA's). In particular, the invention relates to methods and compositions for improving omega-3 fatty acid profiles in plant products and parts using exogenous desaturase enzymes and nucleic acids encoding for such enzymes. In particular embodiments, the exogenous desaturase enzymes utilized are Hemiselmis spp. delta 5 desaturases. Also provided are improved soybean oil compositions having EPA derived from plants carrying the genes of interest.
摘要翻译： 本发明涉及关于调节长链多不饱和脂肪酸（LC-PUFA）中双键数目和位置的去饱和酶的方法和组合物。 特别地，本发明涉及用于使用外源性去饱和酶和编码这种酶的核酸改善植物产品和部分中的ω-3脂肪酸谱的方法和组合物。 在具体实施方案中，所使用的外源性去饱和酶是Hemiselmis spp。 δ5去饱和酶。 还提供了具有衍生自携带感兴趣的基因的植物的EPA的改进的大豆油组合物。
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公开(公告)号：US20080201801A1
公开(公告)日：2008-08-21
申请号：US12033178
申请日：2008-02-19
申请人： Edwards Allen , William P. Donovan , Gregory R. Heck , James K. Roberts , Virginia Ursin , Yuanji Zhang
发明人： Edwards Allen , William P. Donovan , Gregory R. Heck , James K. Roberts , Virginia Ursin , Yuanji Zhang
CPC分类号： C12N15/8286 , A01N63/02 , C12N15/113 , C12N15/8285 , C12N2310/14 , C12N2310/141 , C12N2310/531 , Y02A40/162 , Y02A40/164
摘要： This invention provides plants having resistance to invertebrate pests. More specifically, this invention discloses a non-natural transgenic plant cell expressing at least one invertebrate miRNA in planta for suppression of a target gene of an invertebrate pest or of a symbiont associated with the invertebrate pest. Also provided are recombinant DNA constructs for expression of at least one invertebrate miRNA in planta, a non-natural transgenic plant containing the non-natural transgenic plant cell of this invention, a non-natural transgenic plant grown from the non-natural transgenic plant cell of this invention, and non-natural transgenic seed produced by the non-natural transgenic plants, as well as commodity products produced from a non-natural transgenic plant cell, plant, or seed of this invention. This invention further provides a method of suppressing at least one target gene of an invertebrate pest of a plant or of a symbiont associated with the invertebrate, including providing a plant including the non-natural transgenic plant cell of this invention, wherein the invertebrate is the invertebrate pest, the recombinant DNA is transcribed in the non-natural transgenic plant cell to the recombinant miRNA precursor, and when the invertebrate pest ingests the recombinant miRNA precursor, the at least one target gene is suppressed.
摘要翻译： 本发明提供具有抗无脊椎害虫的植物。 更具体地，本发明公开了一种非天然转基因植物细胞，其在植物中表达至少一种无脊椎动物miRNA，用于抑制无脊椎害虫或与无脊椎害虫相关的共生体的靶基因。 还提供了用于在植物中表达至少一种无脊椎动物miRNA的重组DNA构建体，包含本发明的非天然转基因植物细胞的非天然转基因植物，从非天然转基因植物细胞生长的非天然转基因植物 以及由非天然转基因植物产生的非天然转基因种子，以及由本发明的非天然转基因植物细胞，植物或种子产生的商品。 本发明还提供一种抑制植物无脊椎动物害虫或与无脊椎动物相关共生体的至少一种靶基因的方法，包括提供包含本发明非天然转基因植物细胞的植物，其中无脊椎动物是 无脊椎动物害虫，重组DNA在非天然转基因植物细胞中转录至重组miRNA前体，当无脊椎害虫摄入重组miRNA前体时，抑制至少一种靶基因。
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公开(公告)号：US07163960B2
公开(公告)日：2007-01-16
申请号：US10384369
申请日：2003-03-07
申请人： Virginia Ursin , Michael J. James
发明人： Virginia Ursin , Michael J. James
IPC分类号： A61K31/20
CPC分类号： A23K50/45 , A23D7/0056 , A23D9/007 , A23K20/158 , A23L33/12 , A61K31/185 , A61K31/202
摘要： The invention relates to methods of treating and preventing disorders associated with elevated TNF-α and/or IL-1β by administering therapeutic amounts of stearidonic acid. Further provided are methods for down-regulating TNF-α and/or IL-1β and assays for determining the presence, absence, or quantity of TNF-α and/or IL-1β in a subject in conjunction with a regimen of stearidonic acid administration.
摘要翻译： 本发明涉及通过施用治疗量的十八碳四烯酸治疗和预防与升高的TNF-α和/或IL-1β相关的疾病的方法。 还提供了用于下调TNF-α和/或IL-1β的方法和用于测定受试者中的TNF-α和/或IL-1β的存在，不存在或数量的测定以及十八碳四烯酸给药方案 。
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公开(公告)号：US08410334B2
公开(公告)日：2013-04-02
申请号：US12033178
申请日：2008-02-19
申请人： Edwards Allen , William P. Donovan , Gregory R. Heck , James K. Roberts , Virginia Ursin , Yuanji Zhang
发明人： Edwards Allen , William P. Donovan , Gregory R. Heck , James K. Roberts , Virginia Ursin , Yuanji Zhang
CPC分类号： C12N15/8286 , A01N63/02 , C12N15/113 , C12N15/8285 , C12N2310/14 , C12N2310/141 , C12N2310/531 , Y02A40/162 , Y02A40/164
摘要： This invention provides a non-natural transgenic plant cell expressing at least one invertebrate miRNA in planta for suppression of a target gene of an invertebrate pest or of a symbiont associated with the invertebrate pest, recombinant DNA constructs for expression of at least one invertebrate miRNA in planta and methods of use thereof, a non-natural transgenic plant containing the non-natural transgenic plant cell of this invention, a non-natural transgenic plant grown from the non-natural transgenic plant cell of this invention, and non-natural transgenic seed produced by the non-natural transgenic plants, as well as commodity products produced from a non-natural transgenic plant cell, plant, or seed of this invention.
摘要翻译： 本发明提供了一种非天然转基因植物细胞，其在植物中表达至少一种无脊椎动物miRNA，用于抑制无脊椎害虫或与无脊椎害虫有关的共生体的靶基因，用于将至少一种无脊椎动物miRNA表达的重组DNA构建体 植物及其使用方法，含有本发明的非天然转基因植物细胞的非天然转基因植物，从本发明的非天然转基因植物细胞生长的非天然转基因植物和非天然转基因种子 由非天然转基因植物产生，以及由本发明的非天然转基因植物细胞，植物或种子产生的商品。
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公开(公告)号：US08173870B2
公开(公告)日：2012-05-08
申请号：US10569387
申请日：2004-08-20
申请人： Virginia Ursin , Byron Froman , Jennifer Gonzales , Steven E. Screen , Fenggao Dong , Thomas J. Larosa
发明人： Virginia Ursin , Byron Froman , Jennifer Gonzales , Steven E. Screen , Fenggao Dong , Thomas J. Larosa
CPC分类号： C12N9/0004 , C12N15/8247 , C12P7/6427
摘要： The invention relates generally to methods and compositions concerning desaturase enzymes that modulate the number and location of double bonds in long chain poly-unsaturated fatty acids (LC-PUFA's). In particular, the invention relates to methods and compositions for improving omega-3 fatty acid profiles in plant products and parts using desaturase enzymes and nucleic acids encoding for such enzymes. In particular embodiments, the desaturase enzymes are Primula Δ6-desaturases. Also provided are improved soybean oil compositions having SDA and a beneficial overall content of omega-3 fatty acids relative to omega-6 fatty acids.
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公开(公告)号：US20100092640A1
公开(公告)日：2010-04-15
申请号：US12578880
申请日：2009-10-14
申请人： Virginia Ursin , Byron Froman , Steven Screen , Lori Lehman
发明人： Virginia Ursin , Byron Froman , Steven Screen , Lori Lehman
IPC分类号： A23K1/00 , C07H21/00 , C12N5/04 , C12N1/21 , C12N1/15 , A01H5/10 , A01H5/00 , C07K14/00 , C11B1/00 , A23D9/00 , A23L1/10 , A23L1/0522 , A23J1/00
CPC分类号： C07K14/44 , C07K14/405 , C12N15/8247
摘要： The invention relates to methods and compositions concerning desaturase enzymes that modulate the number and location of double bonds in long chain poly-unsaturated fatty acids (LC-PUFA's). In particular, the invention relates to methods and compositions for improving omega-3 fatty acid profiles in plant products and parts using exogenous desaturase enzymes and nucleic acids encoding for such enzymes. In particular embodiments, the exogenous desaturase enzymes utilized are Hemiselmis spp. delta 5 desaturases. Also provided are improved soybean oil compositions having EPA derived from plants carrying the genes of interest.
摘要翻译： 本发明涉及关于调节长链多不饱和脂肪酸（LC-PUFA）中双键数目和位置的去饱和酶的方法和组合物。 特别地，本发明涉及用于使用外源性去饱和酶和编码这种酶的核酸改善植物产品和部分中的ω-3脂肪酸谱的方法和组合物。 在具体实施方案中，所使用的外源性去饱和酶是Hemiselmis spp。 δ5去饱和酶。 还提供了具有衍生自携带感兴趣的基因的植物的EPA的改进的大豆油组合物。
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公开(公告)号：US20080260929A1
公开(公告)日：2008-10-23
申请号：US11578447
申请日：2005-04-15
申请人： Virginia Ursin , Byron Froman , A.J. Nava , Jennifer Gonzales
发明人： Virginia Ursin , Byron Froman , A.J. Nava , Jennifer Gonzales
CPC分类号： C12P7/6427 , C12N9/0083 , C12N15/8247
摘要： The invention relates generally to the expression of desaturase enzymes in transgenic corn plants and compositions derived therefrom. In particular, the invention relates to the production of oils with improved omega-3 fatty acid profiles in corn plants and the seed oils produced thereby. Such oils may contain stearidonic acid, which is not naturally found in corn plants and has been shown to have beneficial effects on health.
摘要翻译： 本发明一般涉及转基因玉米植物中去饱和酶的表达及其衍生物。 特别地，本发明涉及在玉米植物中生产具有改进的ω-3脂肪酸谱的油以及由此生产的种子油。 这样的油可以含有十八碳四烯酸，其在玉米植物中不是天然存在的，并且已经显示出对健康有益的效果。
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公开(公告)号：US20130276161A1
公开(公告)日：2013-10-17
申请号：US13566369
申请日：2012-08-03
申请人： Mark Abad , Erin Bell , R. Eric Cerny , Jaishree M. Chittoor-Vijayanath , Molian Deng , Michael D. Edgerton , Karen K. Gabbert , Barry S. Goldman , Brian Hauge , Steve He , Jacqueline E. Heard , Ping Li , Linda Lutfiyya , Bradley McDill , Robert J. Meister , Peter Morrell , Anil Neelam , Marie Petracek , John Pitkin , M. S. Rajani , Maria F. Rodriguez , Thomas Ruff , T. V. Venkatesh , Xiaoyun Wu , Jianmin Zhao , Albert Iandolino , Monica Ravanello , Kraig Brustad , Paul Chomet , Julie Davis , Virginia Ursin , T. Ambika , Shobha Char , Savitha Madappa , Dhanalakshmi Ramachandra , S. Sangeetha , K. R. Vidya , K. Vijayalakshmi , Todd Dezwaan
发明人： Mark Abad , Erin Bell , R. Eric Cerny , Jaishree M. Chittoor-Vijayanath , Molian Deng , Michael D. Edgerton , Karen K. Gabbert , Barry S. Goldman , Brian Hauge , Steve He , Jacqueline E. Heard , Ping Li , Linda Lutfiyya , Bradley McDill , Robert J. Meister , Peter Morrell , Anil Neelam , Marie Petracek , John Pitkin , M. S. Rajani , Maria F. Rodriguez , Thomas Ruff , T. V. Venkatesh , Xiaoyun Wu , Jianmin Zhao , Albert Iandolino , Monica Ravanello , Kraig Brustad , Paul Chomet , Julie Davis , Virginia Ursin , T. Ambika , Shobha Char , Savitha Madappa , Dhanalakshmi Ramachandra , S. Sangeetha , K. R. Vidya , K. Vijayalakshmi , Todd Dezwaan
IPC分类号： C12N15/82
CPC分类号： C12N15/8273 , C07K14/415 , C12N15/8247 , C12N15/8251 , C12N15/8261 , C12N15/8271 , C12N15/8274 , C12N15/8275 , C12Q1/6895 , C12Q2600/13 , G01N33/68 , G01N2333/415 , Y02A40/146
摘要： This invention provides transgenic plant cells with recombinant DNA for expression of proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants. This invention also provides transgenic plants and progeny seed comprising the transgenic plant cells where the plants are selected for having an enhanced trait selected from the group of traits consisting of enhanced water use efficiency, enhanced cold tolerance, increased yield, enhanced nitrogen use efficiency, enhanced seed protein and enhanced seed oil. Also disclosed are methods for manufacturing transgenic seed and plants with enhanced traits.
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公开(公告)号：US08221819B2
公开(公告)日：2012-07-17
申请号：US11891426
申请日：2008-06-12
申请人： Virginia Ursin , Byron Froman , Jennifer Simmons , Thomas J. LaRosa , Fenggao Dong , Steven Screen
发明人： Virginia Ursin , Byron Froman , Jennifer Simmons , Thomas J. LaRosa , Fenggao Dong , Steven Screen
CPC分类号： C12N9/0004 , C12N15/8247 , C12P7/6427
摘要： The invention relates generally to methods and compositions concerning desaturase enzymes that modulate the number and location of double bonds in long chain poly-unsaturated fatty acids (LC-PUFA's). In particular, the invention relates to methods and compositions for improving omega-3 fatty acid profiles in plant products and parts using desaturase enzymes and nucleic acids encoding for such enzymes. In particular embodiments, the desaturase enzymes are Primula Δ6-desaturases. Also provided are improved soybean oil compositions having SDA and a beneficial overall content of omega-3 fatty acids relative to omega-6 fatty acids.
摘要翻译： 本发明一般涉及调节长链多不饱和脂肪酸（LC-PUFA）中双键数目和位置的去饱和酶的方法和组合物。 特别地，本发明涉及用于使用去饱和酶和编码这些酶的核酸改善植物产品和部分中的ω-3脂肪酸谱的方法和组合物。 在具体实施方案中，去饱和酶是Primula＆Dgr; 6-去饱和酶。 还提供了具有SDA的改进的大豆油组合物和相对于ω-6脂肪酸的ω-3脂肪酸的有益总体含量。
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