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公开(公告)号：US09214325B2
公开(公告)日：2015-12-15
申请号：US14213447
申请日：2014-03-14
Applicant: 1ST DETECT CORPORATION
Inventor： David Rafferty , Michael Spencer
CPC classification number: H01J49/06 , H01J49/0013 , H01J49/0031 , H01J49/0481 , H01J49/424
Abstract: Apparatuses and methods for performing mass analysis are disclosed. One such apparatus may include an ion trap device. The ion trap device may comprise a first end cap having a first aperture and a second end cap having a second aperture, wherein the first aperture and the second aperture may define an ejection axis. The ion trap device may also comprise a ring electrode substantially coaxially aligned between the first and second end caps. The ring electrode may include an opening extending along a radial direction of the ring electrode, wherein the radial direction is substantially perpendicular to the ejection axis. One such method may include ionizing a sample in an ion trap through an opening separating at least part of first and second ring sections of the ion trap and detecting ions ejected though an aperture on an end cap of the ion trap.
Abstract translation: 公开了用于进行质量分析的装置和方法。 一种这样的装置可以包括离子阱装置。 离子阱装置可以包括具有第一孔的第一端盖和具有第二孔的第二端盖，其中第一孔和第二孔可以限定喷射轴线。 离子阱装置还可以包括在第一和第二端盖之间大致同轴对准的环形电极。 环形电极可以包括沿着环形电极的径向方向延伸的开口，其中径向基本上垂直于喷射轴线。 一种这样的方法可以包括通过分离离子阱的第一和第二环部分的至少一部分并检测通过离子阱的端盖上的孔喷射的离子的开口离子化离子阱中的样品。
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公开(公告)号：US08969794B2
公开(公告)日：2015-03-03
申请号：US14206524
申请日：2014-03-12
Applicant: 1st Detect Corporation
Inventor： James Wylde , David Rafferty , Michael Spencer
CPC classification number: H01J49/067 , H01J49/06 , H01J49/26 , H01J49/4265
Abstract: Systems and methods for automatic gain control in mass spectrometers are disclosed. An exemplary system may include a mass spectrometer, comprising a lens configured to receive a supply of ions, and a mass analyzer. The mass analyzer may include an ion trap for trapping the supplied ions. The mass analyzer may also include an ion detector for detecting ions that exit the ion trap. The lens may focus the ions non-uniformly based on mass of the ions to compensate for space charge effects reflected in a measurement output of the mass spectrometer. An exemplary method may include focusing an ion beam into a mass analyzer. The method may also include obtaining a mass spectrum and identifying a space charge characteristic based on the mass spectrum. The method may further include defocusing the lens based on the identified space charge characteristic, wherein defocusing the lens is configured to divert lighter ions away from the entrance aperture. The method may include obtaining a mass spectrum of a defocused ion beam generated from the sample.
Abstract translation: 公开了用于质谱仪中自动增益控制的系统和方法。 示例性系统可以包括质谱仪，其包括被配置为接收离子供应的透镜和质量分析器。 质量分析器可以包括用于捕获所提供的离子的离子阱。 质量分析器还可以包括用于检测离子离子的离子的离子检测器。 透镜可以基于离子质量不均匀地聚焦离子，以补偿在质谱仪的测量输出中反映的空间电荷效应。 示例性方法可以包括将离子束聚焦到质量分析器中。 该方法还可以包括获得质谱并基于质谱识别空间电荷特性。 该方法还可以包括基于所识别的空间电荷特性使透镜散焦，其中散焦透镜被配置为将较轻离子转移离开入口孔。 该方法可以包括获得从样品产生的散焦离子束的质谱。
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公开(公告)号：US20140299760A1
公开(公告)日：2014-10-09
申请号：US14206524
申请日：2014-03-12
Applicant: 1ST DETECT CORPORATION
Inventor： James Wylde , David Rafferty , Michael Spencer
CPC classification number: H01J49/067 , H01J49/06 , H01J49/26 , H01J49/4265
Abstract: Systems and methods for automatic gain control in mass spectrometers are disclosed. An exemplary system may include a mass spectrometer, comprising a lens configured to receive a supply of ions, and a mass analyzer. The mass analyzer may include an ion trap for trapping the supplied ions. The mass analyzer may also include an ion detector for detecting ions that exit the ion trap. The lens may focus the ions non-uniformly based on mass of the ions to compensate for space charge effects reflected in a measurement output of the mass spectrometer. An exemplary method may include focusing an ion beam into a mass analyzer. The method may also include obtaining a mass spectrum and identifying a space charge characteristic based on the mass spectrum. The method may further include defocusing the lens based on the identified space charge characteristic, wherein defocusing the lens is configured to divert lighter ions away from the entrance aperture. The method may include obtaining a mass spectrum of a defocused ion beam generated from the sample.
Abstract translation: 公开了用于质谱仪中自动增益控制的系统和方法。 示例性系统可以包括质谱仪，其包括被配置为接收离子供应的透镜和质量分析器。 质量分析器可以包括用于捕获所提供的离子的离子阱。 质量分析器还可以包括用于检测离子离子的离子的离子检测器。 透镜可以基于离子质量不均匀地聚焦离子，以补偿在质谱仪的测量输出中反映的空间电荷效应。 示例性方法可以包括将离子束聚焦到质量分析器中。 该方法还可以包括获得质谱并基于质谱识别空间电荷特性。 该方法还可以包括基于所识别的空间电荷特性使透镜散焦，其中散焦透镜被配置为将较轻离子转移离开入口孔。 该方法可以包括获得从样品产生的散焦离子束的质谱。
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公开(公告)号：US20140264013A1
公开(公告)日：2014-09-18
申请号：US14211827
申请日：2014-03-14
Applicant: 1st Detect Corporation
Inventor： David Rafferty , Michael Spencer
CPC classification number: H01J49/147 , H01J49/0013 , H01J49/025 , H01J49/424
Abstract: A mass spectrometer system is disclosed. The mass spectrometer includes a vacuum chamber defining an enclosed evacuated space and an ion trap disposed in the enclosed space. The ion trap is configured to trap an ionized sample. The mass spectrometer further includes an ion detector coupled to the chamber at a location external to the chamber such that sample ions may exit the evacuated space and into the externally-coupled detector without loss of vacuum pressure.
Abstract translation: 公开了一种质谱仪系统。 质谱仪包括限定封闭空间的真空室和设置在封闭空间中的离子阱。 离子阱被配置成捕获电离样品。 质谱仪还包括离子检测器，该离子检测器在室外部的位置处耦合到室，使得样品离子可以离开真空空间并进入外部耦合的检测器而不损失真空压力。
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公开(公告)号：US20140252224A1
公开(公告)日：2014-09-11
申请号：US14082555
申请日：2013-11-18
Applicant: 1st DETECT CORPORATION
Inventor： David Rafferty , Michael Spencer
IPC: H01J49/02
CPC classification number: H01J49/02 , H01J49/424 , H01J49/4255
Abstract: An ion trap for a mass spectrometer is disclosed. The ion trap includes a ring electrode and first and second electrodes which are arranged on opposite sides of the ring electrode. The ring electrode and the first and second electrodes are configured to generate an electric field based on the received RF signal. The first electrode defines a first aperture and the second electrode defines a second aperture, the first aperture and the second aperture being asymmetric relative to each other and configured to generate a hexapole field.
Abstract translation: 公开了用于质谱仪的离子阱。 离子阱包括环形电极和布置在环形电极的相对侧上的第一和第二电极。 环形电极和第一和第二电极被配置为基于所接收的RF信号产生电场。 第一电极限定第一孔，并且第二电极限定第二孔，第一孔和第二孔相对于彼此是不对称的并且被配置成产生六极场。
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Patent Agency Ranking
公开(公告)号：US08754361B1
公开(公告)日：2014-06-17
申请号：US13794751
申请日：2013-03-11
Applicant: 1st Detect Corporation
Inventor： David Rafferty , Brian Oliver , Darron Black
CPC classification number: H01J49/0009 , H01J49/424
Abstract: A mass spectrometer comprises an ion trap configured to trap ions and to eject ions. The ion trap comprises an electrode. The mass spectrometer further comprises a detector configured to detect ions ejected from the ion trap, a radio frequency (RF) generator electrically coupled to the electrode and configured to generate an RF signal, a sampling circuit electrically coupled to electrode and configured to measure a voltage of the RF signal at the electrode, and a signal processor electrically coupled to the sampling circuit and the detector. The signal processor is configured to receive outputs from the detector and the sampling circuit and to correct the output from the detector based on the output from the sampling circuit.
Abstract translation: 质谱仪包括被配置成捕获离子并排出离子的离子阱。 离子阱包括电极。 所述质谱仪还包括检测器，其被配置为检测从所述离子阱排出的离子;射频（RF）发生器，其电耦合到所述电极并被配置为产生RF信号;采样电路，电耦合到电极并且被配置为测量电压 的电极上的RF信号，以及电耦合到采样电路和检测器的信号处理器。 信号处理器被配置为从检测器和采样电路接收输出，并且基于采样电路的输出来校正来自检测器的输出。
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公开(公告)号：US09599547B2
公开(公告)日：2017-03-21
申请号：US14270322
申请日：2014-05-05
Applicant: 1st Detect Corporation
Inventor： David Rafferty , Michael Spencer , James Wylde , Pedro Ojeda , Thomas Bowden
CPC classification number: G01N1/405 , G01N1/2214 , G01N7/04 , G01N30/08 , G01N30/6069 , G01N2030/085
Abstract: A chemical pre-concentrator includes a conduit defining a flow path between two ends and having a heating element disposed within the conduit, such that the heating element has at least one sorbent material deposited directly on at least a portion of a conductive surface of the heating element. Some such heating elements are in the form of electrically conductive strips defining both a plurality of apertures through the strip and a series of undulations spaced along the flow path.
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8.发明授权公开(公告)号：US09570282B2
公开(公告)日：2017-02-14
申请号：US14205905
申请日：2014-03-12
Applicant: 1ST DETECT CORPORATION
Inventor： Abrar Riaz , David Rafferty , James Wylde
CPC classification number: H01J49/107 , H01J49/147 , H01J49/162 , H01J49/42 , H01J49/4215
Abstract: A mass spectrometer is disclosed. The mass spectrometer may include an ion trap configured to trap and analyze an ionized sample. A first aperture may be provided having a first diameter, and a second aperture may be provided having a second diameter. The first aperture may be configured to receive electrons for the purpose of ionizing sample ions within the ion trap. The second aperture may be configured to receive photons for the purpose of ionizing sample ions within the ion trap.
Abstract translation: 公开了一种质谱仪。 质谱仪可以包括被配置为捕获和分析电离样品的离子阱。 可以提供具有第一直径的第一孔，并且可以设置具有第二直径的第二孔。 第一孔可以被配置为接收电子以便离子阱内的样品离子离子化。 第二孔可以被配置为接收光子以便离子阱内的样品离子离子化。
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公开(公告)号：US09035244B2
公开(公告)日：2015-05-19
申请号：US14202531
申请日：2014-03-10
Applicant: 1st Detect Corporation
Inventor： David Rafferty , Michael Spencer , James Wylde , David Lorenz Gardner , Warren Mino
CPC classification number: H01J49/147 , H01J49/0013 , H01J49/0031 , H01J49/067 , H01J49/424 , H01J49/4265
Abstract: A method and apparatus for performing mass spectrometry using an electron source, an ion trap, and a voltage-controlled lens located between the electron source and the ion trap. A controller applies a voltage to the lens. Features of the resulting output spectrum can be analyzed to determine whether to adjust the lens voltage.
Abstract translation: 使用位于电子源和离子阱之间的电子源，离子阱和电压控制透镜进行质谱分析的方法和装置。 控制器向镜头施加电压。 可以分析产生的输出光谱的特征，以确定是否调整透镜电压。
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公开(公告)号：US08946624B2
公开(公告)日：2015-02-03
申请号：US14211827
申请日：2014-03-14
Applicant: 1st Detect Corporation
Inventor： David Rafferty , Michael Spencer
CPC classification number: H01J49/147 , H01J49/0013 , H01J49/025 , H01J49/424
Abstract: A mass spectrometer system is disclosed. The mass spectrometer includes a vacuum chamber defining an enclosed evacuated space and an ion trap disposed in the enclosed space. The ion trap is configured to trap an ionized sample. The mass spectrometer further includes an ion detector coupled to the chamber at a location external to the chamber such that sample ions may exit the evacuated space and into the externally-coupled detector without loss of vacuum pressure.
Abstract translation: 公开了一种质谱仪系统。 质谱仪包括限定封闭空间的真空室和设置在封闭空间中的离子阱。 离子阱被配置成捕获电离样品。 质谱仪还包括离子检测器，该离子检测器在室外部的位置处耦合到室，使得样品离子可以离开真空空间并进入外部耦合的检测器而不损失真空压力。
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