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公开(公告)号：US20180325707A1
公开(公告)日：2018-11-15
申请号：US15590817
申请日：2017-05-09
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Jana Buccola , Joel Harrington , Syed Hossainy , Mary Beth Kossuth , Annie Liu , James Oberhauser , Fuh-Wei Tang
Abstract: A method of accelerated aging of bioresorbable polymer scaffolds including exposing the scaffold to water is disclosed. The scaffold is exposed to water at a controlled temperature for a selected aging time. The functional outputs, such as radial strength, expandability, and % recoil obtained from aged scaffolds predict those of real-time aging of the scaffold. The accelerated aging factor, which is the required shelf life divided by the aging time, is significantly higher for poly(L-lactide) scaffolds tested than thermal aging.
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公开(公告)号：US09681972B2
公开(公告)日：2017-06-20
申请号：US14918318
申请日：2015-10-20
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Yunbing Wang , Rommel Lumauig , James Oberhauser
CPC classification number: A61F2/958 , A61F2/915 , A61F2002/9522 , B23P11/005 , B23P11/025 , B29C53/02 , B29C2793/0009 , B29K2067/046 , B29K2995/006 , B29L2031/7534 , Y10T29/49865 , Y10T29/49913
Abstract: A medical device-includes a scaffold crimped to a catheter having an expansion balloon. The scaffold is crimped to the balloon by a process that includes one or more balloon pressurization steps. The balloon pressurization steps are selected to enhance scaffold retention to the balloon and maintain a relatively uniform arrangement of balloon folds about the inner surface of the crimped scaffold so that the scaffold expands in a uniform manner when the balloon is inflated.
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3.发明授权Method to minimize molecular weight drop of poly(L-lactide) stent during processing 有权减少加工过程中聚（L-丙交酯）支架分子量下降的方法公开(公告)号：US09278470B2
公开(公告)日：2016-03-08
申请号：US14530151
申请日：2014-10-31
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Byron Lambert , Yunbing Wang , James Oberhauser
IPC: A61L31/06 , B29C47/00 , A61L31/04 , A61L31/14 , C08J3/28 , A61F2/82 , B29D23/20 , B29L23/20 , B29L31/00
CPC classification number: B29C47/0076 , A61F2/82 , A61L31/041 , A61L31/06 , A61L31/143 , A61L31/148 , B29D23/20 , B29K2005/00 , B29L2023/20 , B29L2031/753 , C08J3/28 , C08J2367/04 , C08L67/04
Abstract: A method to reduce or minimize the reduction in molecular weight of a stent during processing is disclosed. The stent has a scaffolding including a polymer formulation comprising PLLA and polymandelide. The polymandelide reduces the molecular weight drop during processing, particularly during sterilization. The stent scaffolding can further include one or more additional stabilizing agents that additionally reduce the molecular weight drop during processing.
Abstract translation: 公开了减少或最小化处理期间支架分子量降低的方法。 支架具有包括PLLA和聚扁桃酸酯的聚合物制剂的脚手架。 聚对苯二甲酸丁二醇酯降低加工过程中的分子量下降，特别是在灭菌过程中。 支架支架还可包括一种或多种附加的稳定剂，其另外降低加工过程中的分子量下降。
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公开(公告)号：US20140277398A1
公开(公告)日：2014-09-18
申请号：US13802098
申请日：2013-03-13
Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.
Inventor： Yunbing Wang , James Oberhauser , Manish Gada
IPC: A61F2/06
CPC classification number: A61F2/06 , A61L31/041 , A61L31/129 , A61L31/148 , A61L31/16 , A61L2300/422 , C08L67/04
Abstract: A medical device implantable within a peripheral vessel of the body composed of a bioresorbable polymer is disclosed. The device has a high resistance to fracture, is very flexible, and has a high crush recovery when subjected to crushing, axial, or torsional forces.
Abstract translation: 公开了一种可植入在由生物可再吸收的聚合物组成的身体的外周血管内的医疗装置。 该装置具有高抗断裂性，非常柔软，并且当受到破碎，轴向或扭转力时具有高的压碎恢复性。
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公开(公告)号：US20140128959A1
公开(公告)日：2014-05-08
申请号：US13998195
申请日：2013-10-09
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： David C. Gale , Bin Huang , Timothy A. Limon , Vincent J. Gueriguian , Anthony J. Abbate , Klaus Kleine , Stephen Schaible , Jonathan P. Durcan , Thierry Glauser , Bethany Steichen , James Oberhauser , Manish Gada , Lothar Kleiner , Mary Beth Kossuth , Yunbing Wang , Daniel Castro , David Wrolstad
IPC: A61F2/82
CPC classification number: A61F2/915 , A61F2002/91533 , A61F2002/91566 , A61F2210/0004 , A61F2240/001 , A61F2250/0067 , A61L31/06 , A61L31/14 , A61L31/148 , B29C35/045 , B29C49/0005 , B29C49/04 , B29C49/14 , B29C49/4823 , B29C55/24 , B29C2049/0089 , B29C2793/0009 , B29K2067/00 , B29K2067/046 , B29K2105/258 , B29K2995/006 , B29L2031/7534 , C08L67/04
Abstract: Stents and methods of manufacturing a stents with enhanced fracture toughness are disclosed.
Abstract translation: 公开了制造具有增强的断裂韧性的支架的支架和方法。
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Patent Agency Ranking
6.发明申请STENTS INCLUDING POLY(L-LACTIDE) FORMULATIONS THAT MINIMIZE MOLECULAR WEIGHT DROP DURING PROCESSING 有权包括在加工过程中最小化分子量降低的聚（L-柠檬酸）配方的方法公开(公告)号：US20140012365A1
公开(公告)日：2014-01-09
申请号：US14022098
申请日：2013-09-09
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Byron Lambert , Yunbing Wang , James Oberhauser
CPC classification number: B29C47/0076 , A61F2/82 , A61L31/041 , A61L31/06 , A61L31/143 , A61L31/148 , B29D23/20 , B29K2005/00 , B29L2023/20 , B29L2031/753 , C08J3/28 , C08J2367/04 , C08L67/04
Abstract: A stent scaffolding including a polymer formulation comprising PLLA and polymandelide is disclosed. The polymandelide reduces the molecular weight drop during processing, particularly during sterilization. The stent scaffolding can further include one or more additional stabilizing agents that additionally reduce the molecular weight drop during processing.
Abstract translation: 公开了一种包括含有PLLA和聚扁桃酸酯的聚合物制剂的支架支架。 聚对苯二甲酸丁二醇酯降低加工过程中的分子量下降，特别是在灭菌过程中。 支架支架还可包括一种或多种附加的稳定剂，其另外降低加工过程中的分子量下降。
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7.发明授权Bioabsorbable scaffold with particles providing delayed acceleration of degradation 有权具有提供延迟加速降解的颗粒的生物可吸收支架公开(公告)号：US09283097B2
公开(公告)日：2016-03-15
申请号：US14223908
申请日：2014-03-24
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Yunbing Wang , James Oberhauser
CPC classification number: A61F2/82 , A61F2210/0004 , A61F2250/003 , A61L31/10 , A61L31/14 , A61L31/148 , A61L31/16
Abstract: Methods of controlling the degradation profile of a biodegradable stent scaffolding are disclosed. A bioabsorbable scaffold having a plurality of particles incorporated into the scaffolding that accelerate the absorption of the scaffolding after an induction time during degradation is disclosed.
Abstract translation: 公开了控制可生物降解的支架支架的降解特征的方法。 公开了一种生物吸收性支架，其具有并入到脚手架中的多个颗粒，其在降解过程中的诱导时间之后加速脚手架的吸收。
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公开(公告)号：US20150073536A1
公开(公告)日：2015-03-12
申请号：US14121435
申请日：2014-09-04
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Richard Rapoza , Susan Veldhof , James Oberhauser , Syed F.A. Hossainy
CPC classification number: A61F2/86 , A61F2/915 , A61F2002/91558 , A61F2002/91566 , A61F2210/0004 , A61F2250/0067 , A61L31/06 , A61L31/148 , A61L31/16 , A61L2300/422 , C08L67/04
Abstract: A method of treating vascular disease in a patient is disclosed that comprises deploying a bioabsorbable polymer scaffold composed of a plurality of struts at a stenotic segment of an artery of a patient, wherein after the scaffold supports the segment at an increased diameter for a period of time the polymer degrades and is progressively replaced by de novo formation of malleable provisional matrix comprising proteoglycan, wherein as the scaffold becomes more malleable and becomes disconnected as it degrades, wherein following coverage of the struts by a neointima layer and loss of mechanical support provided by the scaffold, the scaffold is pulled outward by positive remodeling of the vessel wall of the scaffolded segment.
Abstract translation: 公开了一种治疗患者血管疾病的方法，其包括在患者的动脉的狭窄部分部署由多个支柱构成的生物可吸收聚合物支架，其中在所述支架之后以增加的直径支撑所述片段一段时间 聚合物降解的时间逐渐被包含蛋白多糖的可延展的临时基质的从头形成所替代，其中当支架变得更有韧性并且随着其降解而变得断裂，其中由新内膜层覆盖支柱并且由 通过骨架段的血管壁的正重构，支架被向外拉。
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9.发明授权Method of improving fracture toughness of implantable medical devices through annealing 有权通过退火提高可植入医疗器械的断裂韧性的方法公开(公告)号：US08961862B2
公开(公告)日：2015-02-24
申请号：US13794537
申请日：2013-03-11
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Yunbing Wang , James Oberhauser
CPC classification number: B29C51/002 , A61L31/06 , A61L31/14 , Y10T29/49 , C08L67/04
Abstract: Methods of fabricating a polymeric implantable device with improved fracture toughness through annealing are disclosed herein. A polymeric construct is annealed with no or substantially no crystal growth to increase nucleation density. After the annealing, crystallites are grown around the formed nuclei. An implantable medical device, such as a stent, can be fabricated from the polymer construct after the crystallite growth.
Abstract translation: 本文公开了通过退火制造具有改善的断裂韧性的聚合物可植入装置的方法。 将聚合物构件退火，没有或基本上没有晶体生长以增加成核密度。 退火后，在形成的核周围生长微晶。 在微晶生长之后，可由聚合物构造体制造诸如支架的可植入医疗装置。
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10.发明申请SYSTEM FOR MANUFACTURING A POLYMER ENDOPROSTHESIS BY INJECTION MOLDING AND BLOW MOLDING 审中-公开通过注塑成型和吹塑制造聚合物内部结构的系统公开(公告)号：US20140239558A1
公开(公告)日：2014-08-28
申请号：US14268396
申请日：2014-05-02
Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.
Inventor： Yunbing Wang , James Oberhauser
IPC: B29C49/06
CPC classification number: B29C49/06 , A61F2/91 , B29K2067/043 , B29K2067/046 , B29L2031/7532
Abstract: A polymer endoprosthesis is fabricated by a combination of injection molding and blow molding which form a tubular substrate of polymer material, followed by laser cutting, crimping and sterilization. After the injection and blow molding processes, a subtractive process is performed on the tubular substrate to transform it into a stent having a network of stent struts. The tubular substrate can be made in an injection mold and blow mold which are attached to each other. The transition from injection molding and blow molding can be performed while the injection molded substrate remains at a temperature at or above Tg of the polymer material.
Abstract translation: 通过注射成型和吹塑成型的组合制造聚合物内用假体，其形成聚合物材料的管状基材，随后进行激光切割，卷曲和灭菌。 在注射和吹塑成型工艺之后，对管状基材进行减色处理以将其转变成具有支架支架网络的支架。 管状基板可以制造成彼此附接的注射模具和吹塑模具。 注射成型和吹塑成型的过渡可以在注塑基材保持在聚合物材料的Tg以上的温度下进行。
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