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公开(公告)号：US20150128527A1
公开(公告)日：2015-05-14
申请号：US14597119
申请日：2015-01-14
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Yunbing Wang , Derek Mortisen , Xiao Ma , Fuh-Wei Tang , Byron Lambert
IPC: B65B55/16
CPC classification number: A61F2/82 , A61F2/0095 , A61F2240/001 , A61L2/081 , A61L2/082 , A61L2/087 , B29C71/009 , B29C71/04 , B29C2035/0877 , B65B55/16
Abstract: Methods of stabilizing the molecular weight of polymer stents scaffolds after E-beam sterilization are disclosed. The molecular weight of the polymer of the irradiated scaffolds is stabilized through exposure to gas containing oxygen.
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2.发明申请MEDICAL DEVICE FABRICATION PROCESS INCLUDING STRAIN INDUCED CRYSTALLIZATION WITH ENHANCED CRYSTALLIZATION 审中-公开医疗装置制造工艺，包括具有增强结晶的应变诱导结晶公开(公告)号：US20140252675A1
公开(公告)日：2014-09-11
申请号：US14279215
申请日：2014-05-15
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Lothar W. Kleiner , Fuh-Wei Tang
CPC classification number: B29C35/16 , B29C45/0055 , B29C47/0038 , B29C71/02 , B29L2031/7534
Abstract: Methods of fabricating a polymeric implantable device, such as a stent, with improved fracture toughness through annealing a polymer construct below the glass transition temperature of the polymer of the construct prior to a deformation step are disclosed herein. The deformation of the construct induces crystallization in the polymer construct through strain-induced crystallization. The annealing of the polymer construct accelerates the crystallization induced during the deformation and results in an increase in crystallite density with smaller crystallites as compared to deformation of a tube that has not been annealed. A stent scaffolding is then made from the deformed tube.
Abstract translation: 本文公开了通过在变形步骤之前将构建体的聚合物的玻璃化转变温度退火到低于聚合物的玻璃化转变温度来制备具有改进的断裂韧性的聚合物可植入装置（例如支架）的方法。 构建体的变形通过应变诱导结晶在聚合物构造体中诱导结晶。 聚合物构件的退火加速了在变形期间引起的结晶，并且与没有退火的管的变形相比，结晶晶体密度随着较小晶粒的增加而增加。 然后从变形管制成支架式支架。
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公开(公告)号：US20140234164A1
公开(公告)日：2014-08-21
申请号：US14266717
申请日：2014-04-30
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Lothar Kleiner , Fuh-Wei Tang
IPC: A61L2/08
CPC classification number: A61L2/08 , A61L2/087 , A61L31/06 , A61L2202/24 , A61L2400/18 , C08L67/04
Abstract: Methods are disclosed for chemically stabilizing a polymer stent after sterilization. The stent is exposed to a temperature above ambient for a period of time after radiation sterilization. The exposure reduces the concentration of free radicals generated by the radiation.
Abstract translation: 公开了灭菌后化学稳定聚合物支架的方法。 在辐射灭菌后，将支架暴露于高于环境温度的时间内。 暴露降低了由辐射产生的自由基的浓度。
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公开(公告)号：US10709589B2
公开(公告)日：2020-07-14
申请号：US15590817
申请日：2017-05-09
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Jana Buccola , Joel Harrington , Syed Hossainy , Mary Beth Kossuth , Annie Liu , James Oberhauser , Fuh-Wei Tang
Abstract: A method of accelerated aging of bioresorbable polymer scaffolds including exposing the scaffold to water is disclosed. The scaffold is exposed to water at a controlled temperature for a selected aging time. The functional outputs, such as radial strength, expandability, and % recoil obtained from aged scaffolds predict those of real-time aging of the scaffold. The accelerated aging factor, which is the required shelf life divided by the aging time, is significantly higher for poly(L-lactide) scaffolds tested than thermal aging.
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公开(公告)号：US09669137B2
公开(公告)日：2017-06-06
申请号：US14613304
申请日：2015-02-03
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Stephen Pacetti , Fuh-Wei Tang , Xiao Ma , Ni Ding , Derek Mortisen
IPC: A61F2/82 , A61K47/48 , A61L31/06 , A61L31/10 , A61L31/14 , C08G63/91 , A61L2/08 , B29C71/04 , C08G63/08 , B29B13/08 , B29C35/08 , A61F2/91
CPC classification number: A61L31/06 , A61F2/82 , A61F2/91 , A61F2210/0004 , A61F2240/001 , A61F2250/0067 , A61K47/593 , A61L2/087 , A61L31/10 , A61L31/148 , A61L2300/606 , B29B13/08 , B29C71/04 , B29C2035/0827 , B29C2035/085 , B29C2035/0877 , C08G63/08 , C08G63/912
Abstract: It is provided herein modified polylactide (PLA) polymers comprising biocompatibile functional group(s) on the polymers and methods of making and using the modified PLA polymers.
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Patent Agency Ranking
公开(公告)号：US09566723B2
公开(公告)日：2017-02-14
申请号：US14139740
申请日：2013-12-23
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Yunbing Wang , Xiao Ma , Fuh-Wei Tang , Ni Ding
CPC classification number: B29C71/02 , A61F2/82 , A61F2/915 , A61F2002/91558 , A61F2002/91583 , A61F2210/0004 , A61F2240/001 , A61L2/007 , A61L2/08 , A61L2/087 , A61L31/06 , A61L31/148 , A61L2202/21 , A61L2202/24 , A61L2400/18 , B29C35/02 , B29C2035/0877 , B29C2071/022 , B29L2031/753 , C08J7/08 , C08J7/123 , C08J2367/04 , C08L67/04
Abstract: Methods are disclosed for conditioning a polymeric stent after sterilization, and/or after crimping and before packaging, such that the properties of the polymeric stent fall within a narrower range of values. The stent is exposed to a controlled temperature at or above ambient for a period of time after radiation sterilization and/or after crimping and before sterilization. As a result, the polymeric stent properties, particularly radial strength and number-average molecular weight of the polymer of the polymeric stent, fall within a narrower range.
Abstract translation: 公开了用于在灭菌后和/或在卷曲之后和包装之前调节聚合物支架的方法，使得聚合物支架的性质落在较窄的值范围内。 在辐射灭菌后和/或在压接之后和灭菌之前将支架暴露于等于或高于环境的受控温度一段时间。 结果，聚合物支架的聚合物支架性质，特别是聚合物支架的聚合物的径向强度和数均分子量落在更窄的范围内。
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公开(公告)号：US20170113424A1
公开(公告)日：2017-04-27
申请号：US15397574
申请日：2017-01-03
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Yunbing Wang , Xiao Ma , Fuh-Wei Tang , Ni Ding
CPC classification number: B29C71/02 , A61F2/82 , A61F2/915 , A61F2002/91558 , A61F2002/91583 , A61F2210/0004 , A61F2240/001 , A61L2/007 , A61L2/08 , A61L2/087 , A61L31/06 , A61L31/148 , A61L2202/21 , A61L2202/24 , A61L2400/18 , B29C35/02 , B29C2035/0877 , B29C2071/022 , B29L2031/753 , C08J7/08 , C08J7/123 , C08J2367/04 , C08L67/04
Abstract: Methods are disclosed for conditioning a polymeric stent after sterilization, and/or after crimping and before packaging, such that the properties of the polymeric stent fall within a narrower range of values. The stent is exposed to a controlled temperature at or above ambient for a period of time after radiation sterilization and/or after crimping and before sterilization. As a result, the polymeric stent properties, particularly radial strength and number-average molecular weight of the polymer of the polymeric stent, fall within a narrower range.
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8.发明授权公开(公告)号：US09205575B2
公开(公告)日：2015-12-08
申请号：US14279215
申请日：2014-05-15
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Lothar W. Kleiner , Fuh-Wei Tang
CPC classification number: B29C35/16 , B29C45/0055 , B29C47/0038 , B29C71/02 , B29L2031/7534
Abstract: Methods of fabricating a polymeric implantable device, such as a stent, with improved fracture toughness through annealing a polymer construct below the glass transition temperature of the polymer of the construct prior to a deformation step are disclosed herein. The deformation of the construct induces crystallization in the polymer construct through strain-induced crystallization. The annealing of the polymer construct accelerates the crystallization induced during the deformation and results in an increase in crystallite density with smaller crystallites as compared to deformation of a tube that has not been annealed. A stent scaffolding is then made from the deformed tube.
Abstract translation: 本文公开了通过在变形步骤之前将构建体的聚合物的玻璃化转变温度退火到低于聚合物的玻璃化转变温度来制备具有改进的断裂韧性的聚合物可植入装置（例如支架）的方法。 构建体的变形通过应变诱导结晶在聚合物构造体中诱导结晶。 聚合物构件的退火加速了在变形期间引起的结晶，并且与没有退火的管的变形相比，结晶晶体密度随着较小晶粒的增加而增加。 然后从变形管制成支架式支架。
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公开(公告)号：US20150217028A1
公开(公告)日：2015-08-06
申请号：US14613304
申请日：2015-02-03
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Stephen Pacetti , Fuh-Wei Tang , Xiao Ma , Ni Ding , Derek Mortisen
CPC classification number: A61L31/06 , A61F2/82 , A61F2/91 , A61F2210/0004 , A61F2240/001 , A61F2250/0067 , A61K47/593 , A61L2/087 , A61L31/10 , A61L31/148 , A61L2300/606 , B29B13/08 , B29C71/04 , B29C2035/0827 , B29C2035/085 , B29C2035/0877 , C08G63/08 , C08G63/912
Abstract: It is provided herein modified polylactide (PLA) polymers comprising biocompatibile functional group(s) on the polymers and methods of making and using the modified PLA polymers.
Abstract translation: 提供了在聚合物上包含生物相容性官能团的改性聚丙交酯（PLA）聚合物以及制备和使用改性PLA聚合物的方法。
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公开(公告)号：US20140110885A1
公开(公告)日：2014-04-24
申请号：US14139740
申请日：2013-12-23
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Yunbing Wang , Xiao Ma , Fuh-Wei Tang , Ni Ding
IPC: B29C35/02
CPC classification number: B29C71/02 , A61F2/82 , A61F2/915 , A61F2002/91558 , A61F2002/91583 , A61F2210/0004 , A61F2240/001 , A61L2/007 , A61L2/08 , A61L2/087 , A61L31/06 , A61L31/148 , A61L2202/21 , A61L2202/24 , A61L2400/18 , B29C35/02 , B29C2035/0877 , B29C2071/022 , B29L2031/753 , C08J7/08 , C08J7/123 , C08J2367/04 , C08L67/04
Abstract: Methods are disclosed for conditioning a polymeric stent after sterilization, and/or after crimping and before packaging, such that the properties of the polymeric stent fall within a narrower range of values. The stent is exposed to a controlled temperature at or above ambient for a period of time after radiation sterilization and/or after crimping and before sterilization. As a result, the polymeric stent properties, particularly radial strength and number-average molecular weight of the polymer of the polymeric stent, fall within a narrower range.
Abstract translation: 公开了用于在灭菌后和/或在卷曲之后和包装之前调节聚合物支架的方法，使得聚合物支架的性质落在较窄的值范围内。 在辐射灭菌后和/或在压接之后和灭菌之前将支架暴露于等于或高于环境的受控温度一段时间。 结果，聚合物支架的聚合物支架性质，特别是聚合物支架的聚合物的径向强度和数均分子量落在更窄的范围内。
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