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    POLYESTERAMIDE PLATFORM FOR SITE SPECIFIC DRUG DELIVERY
    7.
    发明申请
    POLYESTERAMIDE PLATFORM FOR SITE SPECIFIC DRUG DELIVERY 审中-公开
    用于特定药物递送的聚酰胺平台

    公开(公告)号：US20150290336A1

    公开(公告)日：2015-10-15

    申请号：US14750732

    申请日：2015-06-25

    Applicant: Abbott Cardiovascular Systems Inc.

    Inventor： Lothar W. Kleiner ,  Syed Hossainy ,  Stephen Pacetti ,  Jessica DesNoyer

    IPC: A61K47/48 ,  A61K47/34 ,  A61K31/727

    CPC classification number: A61K47/48207 ,  A61K9/0024 ,  A61K9/08 ,  A61K9/10 ,  A61K31/337 ,  A61K31/4745 ,  A61K31/727 ,  A61K47/34 ,  A61K47/593 ,  A61K47/595 ,  A61K47/60 ,  C08L77/12 ,  C08L2205/02 ,  C08L2666/20

    Abstract: A therapeutic agent delivery system formed of a specific type of poly(ester amide) (PEA), a therapeutic agent, and a water miscible solvent is described herein. A method of delivering the therapeutic agent delivery system by delivering the therapeutic agent delivery system formed of a PEA polymer, a therapeutic agent, and a water miscible solvent to a physiological environment and separating the phase of the therapeutic agent delivery system to form a membrane from the polymer to contain the therapeutic agent within the physiological environment is also described. Additionally disclosed is a kit including a syringe and a therapeutic agent delivery system within the syringe.

    Abstract translation: 本文描述了由特定类型的聚（酯酰胺）（PEA），治疗剂和水混溶性溶剂形成的治疗剂递送系统。 通过将由PEA聚合物，治疗剂和水混溶性溶剂形成的治疗剂递送系统递送到生理环境来递送治疗剂递送系统的方法，并分离治疗剂递送系统的相以形成膜 还描述了在生理环境中含有治疗剂的聚合物。 另外公开了一种试剂盒，其包括注射器内的注射器和治疗剂递送系统。

    Reducing Recoil in Peripherally-Implanted Scaffolds
    8.
    发明申请
    Reducing Recoil in Peripherally-Implanted Scaffolds 审中-公开
    减少外周植入脚手架的回收

    公开(公告)号：US20140277331A1

    公开(公告)日：2014-09-18

    申请号：US13801691

    申请日：2013-03-13

    Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.

    Inventor： Michael Huy Ngo ,  Benjamyn Serna ,  Mikael Trollsas ,  Syed Hossainy

    IPC: A61F2/958

    CPC classification number: A61F2/958 ,  A61F2/0095 ,  A61F2250/0085 ,  A61F2250/0097

    Abstract: A peripherally implanted polymer scaffold having a high degree of recoil is worked to reduce recoil in the scaffold when initially deployed at a target lesion in the body. The scaffold is plastically deformed from a crimped state to an expanded state by a balloon catheter. The scaffold is contained within a sheath to prevent recoil up until the point of use. Before the scaffold is introduced to the body, the restraining sheath is removed from the scaffold.

    Abstract translation: 当最初部署在体内的目标损伤时，加工具有高度后坐力的外周植入聚合物支架以减少支架中的反冲。 支架通过气囊导管从卷曲状态塑性变形到膨胀状态。 支架被包含在护套内以防止反冲直到使用点。 在将脚手架引入身体之前，将约束护套从支架上移除。

    Methods and compositions for treating tissue using silk proteins
    9.
    发明授权
    Methods and compositions for treating tissue using silk proteins 有权
    使用丝蛋白处理组织的方法和组合物

    公开(公告)号：US08828436B2

    公开(公告)日：2014-09-09

    申请号：US13888143

    申请日：2013-05-06

    Applicant: Abbott Cardiovascular Systems Inc.

    Inventor： Syed Hossainy ,  Michael Ngo ,  Mikael Trollsas ,  John Stankus ,  Gene Michal

    IPC: A61K35/28 ,  C07K17/08 ,  A61F2/00 ,  A61K47/48 ,  C08L89/00 ,  A61K47/42 ,  A61L27/38 ,  A61K9/00 ,  A61L27/52 ,  A61K47/34 ,  A61L27/48

    CPC classification number: A61K47/42 ,  A61K9/0024 ,  A61K47/34 ,  A61L27/3804 ,  A61L27/3839 ,  A61L27/3895 ,  A61L27/48 ,  A61L27/52 ,  Y10S530/812 ,  Y10S530/815 ,  C08L89/00 ,  C08L71/02

    Abstract: Compositions for forming a self-reinforcing composite biomatrix, methods of manufacture and use therefore are herein disclosed. Kits including delivery devices suitable for delivering the compositions are also disclosed. In some embodiments, the composition can include at least three components. In one embodiment, a first component can include a first functionalized polymer, a second component can include a second functionalized polymer and a third component can include silk protein or constituents thereof. In some embodiments, the composition can include at least one cell type and/or at least one growth factor. In some embodiments, the composition can include a biologic encapsulated, suspended, disposed within or loaded into a biodegradable carrier. In some embodiments, the composition(s) of the present invention can be delivered by a dual lumen injection device to a treatment area in situ, in vivo, as well as ex vivo applications.

    Abstract translation: 本文公开了用于形成自增强复合生物基质的组合物，因此制造和使用方法。 还公开了包括适合递送组合物的递送装置的试剂盒。 在一些实施方案中，组合物可以包括至少三种组分。 在一个实施方案中，第一组分可以包括第一官能化聚合物，第二组分可以包括第二官能化聚合物，第三组分可以包括丝蛋白或其组分。 在一些实施方案中，组合物可以包括至少一种细胞类型和/或至少一种生长因子。 在一些实施方案中，组合物可以包括生物封装的，悬浮的，置于生物降解载体内或加载到可生物降解的载体中。 在一些实施方案中，本发明的组合物可以通过双腔注射装置原位，体内和离体应用递送至治疗区域。

    METHODS AND COMPOSITIONS FOR TREATING TISSUE USING SILK PROTEINS
    10.
    发明申请
    METHODS AND COMPOSITIONS FOR TREATING TISSUE USING SILK PROTEINS 有权
    用丝素蛋白处理组织的方法和组合物

    公开(公告)号：US20130251764A1

    公开(公告)日：2013-09-26

    申请号：US13888143

    申请日：2013-05-06

    Applicant: Abbott Cardiovascular Systems Inc.

    Inventor： Syed Hossainy ,  Michael Ngo ,  Mikael Trollsas ,  John Stankus ,  Gene Michal

    IPC: A61K47/42 ,  A61K47/34

    CPC classification number: A61K47/42 ,  A61K9/0024 ,  A61K47/34 ,  A61L27/3804 ,  A61L27/3839 ,  A61L27/3895 ,  A61L27/48 ,  A61L27/52 ,  Y10S530/812 ,  Y10S530/815 ,  C08L89/00 ,  C08L71/02

    Abstract: Compositions for forming a self-reinforcing composite biomatrix, methods of manufacture and use therefore are herein disclosed. Kits including delivery devices suitable for delivering the compositions are also disclosed. In some embodiments, the composition can include at least three components. In one embodiment, a first component can include a first functionalized polymer, a second component can include a second functionalized polymer and a third component can include silk protein or constituents thereof. In some embodiments, the composition can include at least one cell type and/or at least one growth factor. In some embodiments, the composition can include a biologic encapsulated, suspended, disposed within or loaded into a biodegradable carrier. In some embodiments, the composition(s) of the present invention can be delivered by a dual lumen injection device to a treatment area in situ, in vivo, as well as ex vivo applications.

    Abstract translation: 本文公开了用于形成自增强复合生物基质的组合物，因此制造和使用方法。 还公开了包括适合递送组合物的递送装置的试剂盒。 在一些实施方案中，组合物可以包括至少三种组分。 在一个实施方案中，第一组分可以包括第一官能化聚合物，第二组分可以包括第二官能化聚合物，第三组分可以包括丝蛋白或其组分。 在一些实施方案中，组合物可以包括至少一种细胞类型和/或至少一种生长因子。 在一些实施方案中，组合物可以包括生物封装的，悬浮的，置于生物降解载体内或加载到可生物降解的载体中。 在一些实施方案中，本发明的组合物可以通过双腔注射装置原位，体内和离体应用递送至治疗区域。

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