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公开(公告)号：US20220024915A1
公开(公告)日：2022-01-27
申请号：US17279422
申请日：2019-09-27
Applicant: ACUCELA INC.
Inventor： Mark W. ORME , Edison S. ZUNIGA , Vladimir A. KUKSA , Russell Stuart CRAFT , Eduardo Moreno SAVEEDRA , Johannes Wilhelm Georg MEISSNER , Jacobus Antonius Joseph den HARTOG , Albert Cornelis DROS
IPC: C07D471/04 , C07D487/04
Abstract: Provided herein are compounds and methods of use thereof for the modulation of VAP-1 activity.
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Patent Agency Ranking
公开(公告)号：US20210387975A1
公开(公告)日：2021-12-16
申请号：US17279382
申请日：2019-09-27
Applicant: ACUCELA INC.
Inventor： Mark W. ORME , Edison S. ZUNIGA , Vladimir A. KUKSA , Russell Stuart CRAFT , Eduardo Moreno SAVEEDRA , Johannes Wilhelm Georg MEISSNER , Jacobus Antonius Joseph den HARTOG , Albert Cornelis DROS
IPC: C07D413/12 , C07D263/56 , C07D277/64 , C07D263/58 , C07D277/82 , C07D261/20 , C07D235/08 , C07D413/04 , C07D491/107 , C07D249/18
Abstract: Provided herein are compounds and methods of use thereof for the modulation of VAP-1 activity.
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公开(公告)号：US20230218549A1
公开(公告)日：2023-07-13
申请号：US17817927
申请日：2022-08-05
Applicant: Acucela Inc.
Inventor： Ian L. SCOTT , Vladimir A. KUKSA , Mark W. ORME , Thomas L. LITTLE, JR. , Anna GALL , Feng HONG
IPC: A61K31/137 , C07C217/60 , C07C217/62 , C07C217/64 , C07C217/72 , C07C225/16 , C07C229/38 , C07C233/18 , C07C235/08 , C07C251/86 , C07C279/08 , C07C317/28 , C07C323/25 , C07D277/24 , C07D309/06 , C07C217/20 , C07C215/20 , C07C309/06 , C07C217/84 , C07C323/33 , A61K31/165 , A61K31/222
CPC classification number: A61K31/137 , A61K31/165 , A61K31/222 , C07C215/20 , C07C217/20 , C07C217/60 , C07C217/62 , C07C217/64 , C07C217/72 , C07C217/84 , C07C225/16 , C07C229/38 , C07C233/18 , C07C235/08 , C07C251/86 , C07C279/08 , C07C309/06 , C07C317/28 , C07C323/25 , C07C323/33 , C07D277/24 , C07D309/06 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/42
Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt’s Disease.
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公开(公告)号：US20210077427A1
公开(公告)日：2021-03-18
申请号：US16865195
申请日：2020-05-01
Applicant: Acucela Inc.
Inventor： Ian L. SCOTT , Vladimir A. KUKSA , Mark W. ORME , Thomas L. LITTLE, Jr. , Anna GALL , Feng HONG
IPC: A61K31/137 , C07C217/60 , C07C217/62 , C07C217/64 , C07C217/72 , C07C225/16 , C07C229/38 , C07C233/18 , C07C235/08 , C07C251/86 , C07C279/08 , C07C317/28 , C07C323/25 , C07D277/24 , C07D309/06 , C07C217/20 , C07C215/20 , C07C309/06 , C07C217/84 , C07C323/33 , A61K31/165 , A61K31/222
Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
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公开(公告)号：US20230295140A1
公开(公告)日：2023-09-21
申请号：US18201715
申请日：2023-05-24
Applicant: Acucela Inc.
Inventor： Mark W. ORME , Edison S. ZUNIGA , Vladimir A. KUKSA , Russell Stuart CRAFT , Eduardo Moreno SAVEEDRA , Johannes Wilhelm Georg MEISSNER , Jacobus Antonius Joseph den HARTOG , Albert Cornelis DROS
IPC: C07D413/12 , C07D235/08 , C07D249/18 , C07D261/20 , C07D263/56 , C07D263/58 , C07D277/64 , C07D277/82 , C07D413/04 , C07D491/107
CPC classification number: C07D413/12 , C07D235/08 , C07D249/18 , C07D261/20 , C07D263/56 , C07D263/58 , C07D277/64 , C07D277/82 , C07D413/04 , C07D491/107
Abstract: Provided herein are compounds and methods of use thereof for the modulation of VAP-1 activity.
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公开(公告)号：US20190183816A1
公开(公告)日：2019-06-20
申请号：US16043019
申请日：2018-07-23
Applicant: Acucela Inc.
Inventor： Ian L. SCOTT , Vladimir A. KUKSA , Mark W. ORME , Thomas L. LITTLE, JR. , Anna GALL , Feng HONG
IPC: A61K31/137 , C07C317/28 , C07C217/84 , C07C217/20 , C07C217/60 , C07C217/62 , C07C217/64 , A61K31/222 , A61K31/165 , C07C323/33 , C07C215/20 , C07D309/06 , C07D277/24 , C07C323/25 , C07C309/06 , C07C279/08 , C07C251/86 , C07C235/08 , C07C233/18 , C07C229/38 , C07C225/16 , C07C217/72
CPC classification number: A61K31/137 , A61K31/165 , A61K31/222 , C07C215/20 , C07C217/20 , C07C217/60 , C07C217/62 , C07C217/64 , C07C217/72 , C07C217/84 , C07C225/16 , C07C229/38 , C07C233/18 , C07C235/08 , C07C251/86 , C07C279/08 , C07C309/06 , C07C317/28 , C07C323/25 , C07C323/33 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07D277/24 , C07D309/06
Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
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