公开(公告)号：US10117946B2

公开(公告)日：2018-11-06

申请号：US14655223

申请日：2013-12-24

Applicant: Agency for Science, Technology and Research

Inventor： Michael R. Reithofer ,  Charlotte A. E. Hauser ,  Kiat Hwa Chan ,  Archana Mishra

IPC: A01N55/02 ,  A61K31/28 ,  A61K47/48 ,  A61K31/282 ,  A61K38/08 ,  A61K31/555

Abstract: The present invention relates to hydrogels comprising a first peptide with a covalently linked bioactive agent and optionally a second peptide. The present invention further relates to uses of the hydrogel for delivery of the bioactive agent or as an implant. The present invention further relates to drug delivery devices, implant, pharmaceutical or cosmetic compositions comprising the hydrogel. The present invention further relates to methods of local treatment of diseases and to methods for preparing the first peptide and the hydrogels.

公开(公告)号：US20180016304A1

公开(公告)日：2018-01-18

申请号：US15549874

申请日：2016-03-03

Applicant: Agency for Science, Technology and Research

Inventor： Charlotte A. E. Hauser ,  Michael R. Reithofer ,  Yihua Loo

IPC: C07K11/00 ,  A61K47/34 ,  A61L27/52 ,  A61L27/54 ,  A61L27/22

CPC classification number: C07K11/00 ,  A61K47/34 ,  A61L27/227 ,  A61L27/52 ,  A61L27/54 ,  A61L2400/06 ,  A61L2430/34 ,  G01N2800/7095

Abstract: The present invention relates to ultrashort depsipeptides which are capable of self-assembling into hydrogels. One preferred embodiment is of Ac-ILVaGK-NH2, where a represents lactic acid. The invention also relates to the use of these depsipeptides in formulating hydrogels, co-gels or co-hydrogels, and pharmaceutical compositions or biomedical device or surgical implants or kits comprising these depsipeptides for various therapeutic applications such as regenerative medicine, tissue regeneration and tissue re-placement.

公开(公告)号：US20180030093A1

公开(公告)日：2018-02-01

申请号：US15551116

申请日：2016-03-31

Applicant: Agency for Science, Technology and Research

Inventor： Charlotte A. E. Hauser ,  Michael R. Reithofer

IPC: C07K7/64 ,  A61K8/64 ,  A61K9/00 ,  A61K9/06 ,  A61K8/04 ,  A61K47/42 ,  A61Q19/00

CPC classification number: C07K7/64 ,  A61K8/042 ,  A61K8/64 ,  A61K9/0019 ,  A61K9/06 ,  A61K47/42 ,  A61K2800/10 ,  A61K2800/91 ,  A61L27/227 ,  A61L27/52 ,  A61L27/54 ,  A61Q19/00 ,  C07K5/123 ,  C07K5/126

Abstract: The invention relates to cyclic peptides of 3-9 amino acids comprising 2-7 aliphatic and 0-2 polar amino acids that are capable of self-assembling, wherein said aliphatic amino acids are arranged in decreasing hydrophobicity from N- to C-terminus and at least a portion of the cyclic peptide has to have its amino acids in alternating D- and L-configuration, as well as their use in hydrogels as well as co-gels or co-hydrogels. The hydrogels of the invention may be used in nanomedicine or drug delivery, cell culture or alternatively in electronic devices.

公开(公告)号：US20150352220A1

公开(公告)日：2015-12-10

申请号：US14655223

申请日：2013-12-24

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Michael R. Reithofer ,  Charlotte A.E. Hauser ,  Kiat Hwa CHAN ,  Archana Mishra

IPC: A61K47/48 ,  A61K31/282

CPC classification number: A61K47/48246 ,  A61K31/282 ,  A61K31/555 ,  A61K38/08 ,  A61K47/64

Abstract: The present invention relates to hydrogels comprising a first peptide with a covalently linked bioactive agent and optionally a second peptide. The present invention further relates to uses of the hydrogel for delivery of the bioactive agent or as an implant. The present invention further relates to drug delivery devices, implant, pharmaceutical or cosmetic compositions comprising the hydrogel. The present invention further relates to methods of local treatment of diseases and to methods for preparing the first peptide and the hydrogels.

Abstract translation: 本发明涉及包含具有共价连接的生物活性剂和任选的第二肽的第一肽的水凝胶。 本发明还涉及水凝胶用于递送生物活性剂或作为植入物的用途。 本发明还涉及包含该水凝胶的药物递送装置，植入物，药物或化妆品组合物。 本发明还涉及疾病的局部治疗方法以及制备第一种肽和水凝胶的方法。