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    ANTIFUNGAL COMPOUND
    2.
    发明申请
    ANTIFUNGAL COMPOUND 有权
    抗菌化合物

    公开(公告)号：US20170037013A1

    公开(公告)日：2017-02-09

    申请号：US15297906

    申请日：2016-10-19

    Applicant: Agency for Science, Technology and Research

    Inventor： Yugen Zhang ,  Jackie Y. Ying ,  Lihong Liu ,  Hong Wu

    IPC: C07D233/61

    CPC classification number: C07D233/61 ,  A01N43/50 ,  A61K31/787

    Abstract: There is provided compound for use in therapy, the compound comprising repeating units of hydrophilic heterocyclic amine monomers that are coupled by hydrophobic linkers selected to confer a therapeutic effect. There is also provided the use of the above compound in the manufacture of a medicament for the treatment of a fungal infection and a method of treating a fungal infection using the above compound.

    Abstract translation: 提供用于治疗的化合物，所述化合物包含亲水性杂环胺单体的重复单元，所述亲水性杂环胺单体通过被选择赋予治疗效果的疏水性接头偶联。 还提供了上述化合物在制备用于治疗真菌感染的药物中的用途以及使用上述化合物治疗真菌感染的方法。

    PROCESS FOR PRODUCING AN AMINOPROPYNE OR ENAMINONE
    3.
    发明申请
    PROCESS FOR PRODUCING AN AMINOPROPYNE OR ENAMINONE 审中-公开
    生产氨基丙烯或诺曼酮的方法

    公开(公告)号：US20160052863A1

    公开(公告)日：2016-02-25

    申请号：US14932724

    申请日：2015-11-04

    Applicant: Agency for Science, Technology and Research

    Inventor： Yugen Zhang ,  Dingyi Yu ,  Zhewang Lin

    IPC: C07C209/66 ,  C07D207/04 ,  C07D295/03

    CPC classification number: C07C209/66 ,  C07B37/02 ,  C07C209/78 ,  C07C213/08 ,  C07C253/30 ,  C07D207/04 ,  C07D249/04 ,  C07D249/06 ,  C07D295/023 ,  C07D295/03 ,  C07C211/27 ,  C07C211/29 ,  C07C211/35 ,  C07C255/58 ,  C07C217/58

    Abstract: There is provided a process for producing an aminopropyne or an enaminone comprising the step of reacting a metal acetylide, an amine and a carbonyl-containing compound in the presence of a transition metal catalyst. There is also provided a process for producing an aminopropyne comprising the step of reacting a metal acetylide, an amine and a halide-containing compound in the presence of a transition metal catalyst at a reaction temperature of 50° C. to 150° C. There are also provided processes to further synthesize the aminopropyne produced to obtain a butyneamine, another aminopropyne or a triazol.

    Abstract translation: 提供了一种制备氨基丙炔或烯胺的方法，包括在过渡金属催化剂存在下使金属乙炔，胺和含羰基化合物反应的步骤。 还提供了一种制备氨基丙炔的方法，包括在过渡金属催化剂存在下，在50℃至150℃的反应温度下使金属乙炔化物，胺和含卤化合物反应的步骤。 还提供了进一步合成产生的氨基丙炔以获得丁炔胺，另一种氨基丙炔或三唑的方法。

    METHOD OF PRODUCING 5-HYDROXYMETHYLFURFURAL FROM CARBOHYDRATES
    4.
    发明申请
    METHOD OF PRODUCING 5-HYDROXYMETHYLFURFURAL FROM CARBOHYDRATES 审中-公开
    从碳水化合物生产5-羟基甲基纤维素的方法

    公开(公告)号：US20140357878A1

    公开(公告)日：2014-12-04

    申请号：US14346678

    申请日：2012-09-24

    Applicant: AGENCY FOR SCIENCE , TECHNOLOGY AND RESEARCH

    Inventor： Yugen Zhang ,  Linke Lai

    IPC: C07D307/48

    CPC classification number: C07D307/48 ,  C07D307/46

    Abstract: Disclosed herein is a process for preparing 5-hydroxymethylfurfural comprising the step of contacting a carbohydrate and a Brønsted acid in an alcoholic solvent comprising an alcohol selected from the group consisting of secondary alcohols, tertiary alcohols, aryl alcohols and combinations thereof under conditions to dehydrate the carbohydrate thereby forming a reaction product containing 5-hydroxymethylfurfural.

    Abstract translation: 本文公开了一种制备5-羟甲基糠醛的方法，其包括使碳水化合物和布朗斯台德酸在醇溶剂中接触的步骤，该醇溶剂包含选自仲醇，叔醇，芳基醇及其组合的醇， 从而形成含有5-羟甲基糠醛的反应产物。

    Antimicrobial coatings
    7.
    发明授权
    Antimicrobial coatings 有权

    公开(公告)号：US10519323B2

    公开(公告)日：2019-12-31

    申请号：US15769709

    申请日：2016-10-19

    Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

    Inventor： Yugen Zhang ,  Yuan Yuan

    IPC: C09D5/14 ,  A01N25/34 ,  A01N43/50 ,  A61K31/4164 ,  A61K47/02 ,  C07F3/06 ,  C07D233/58 ,  B82Y30/00 ,  C01B39/32

    Abstract: A coating comprising a metal-organic framework, wherein the metal-organic framework having a zeolitic structure comprising at least one multivalent metal species and at least one organic ligand (such as zeolitic imidazolate framework (ZIF)). Said coating has a topography comprising an array of projections, and each projection having at least one tapered distal end. There is also provided a method of coating substrates with the disclosed coating and use of said coating as a disinfectant, an antiseptic, or an antibiotic. Such use is possible because the tapered distal end of the disclosed zeolitic structure exerting higher pressure on any microbial cell that comes into contact with the disclosed coating, thereby piercing through the cell membrane more easily, causing cell deformation and lysis.

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