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公开(公告)号：US20220402866A1
公开(公告)日：2022-12-22
申请号：US17545940
申请日：2021-12-08
申请人： Allergan, Inc.
发明人： Christopher D. Hein , Tien T. Duong , Santosh Sinha , Ling Li , Jeremiah H. Nguyen , David W. Old , Robert Burk , Veena Viswanath , Sandhya Rao , John E. Donello
IPC分类号： C07C311/39 , A61P17/06 , C07C237/44 , A61P27/02 , C07C211/52 , C07D307/36 , C07D307/79 , C07D215/42 , C07B59/00 , C07D333/54 , C07C311/43 , A61P29/00
摘要： Described herein are compounds, or pharmaceutically acceptable salts thereof, of the following formula: The compounds are useful for treating inflammatory and autoimmune diseases.
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公开(公告)号：US20210008085A1
公开(公告)日：2021-01-14
申请号：US17028440
申请日：2020-09-22
申请人： Allergan, Inc.
IPC分类号： A61K31/683 , C07F9/40 , C07C235/82 , C07C275/42 , C07D217/24 , C07D223/10 , C07D233/80 , C07D235/02 , C07D257/04 , C07D261/12 , C07D401/06 , C07D405/06 , C07D405/14 , C07D409/06 , A61P17/12 , A61P17/02 , A61P35/00 , A61P17/18 , A61P17/10 , A61P17/04 , A61P17/14 , A61P17/06 , A61P17/16 , A61K31/17 , A61K31/196 , A61K31/4166 , A61K31/42 , A61K31/662 , A61P17/08 , A61K9/00 , A61K31/167 , A61K31/192 , A61K31/4045 , A61K31/41 , A61K31/4174 , A61K31/4178 , A61K31/4184 , A61K31/472 , A61K31/4725 , A61K31/55
摘要： The present invention relates to a method for treating dermal inflammation and dermal diseases by local or systemic delivery, in a subject in need of such treatment, which comprises administering a pharmaceutical composition comprising a therapeutically effective amount of at least one agonist of Formyl peptide receptor 2 (FPR2).
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公开(公告)号：US09850264B2
公开(公告)日：2017-12-26
申请号：US14196047
申请日：2014-03-04
申请人： Allergan, Inc.
IPC分类号： A61K31/66 , A61K31/554 , A61K31/47 , A61K31/42 , A61K31/41 , A61K31/415 , C07F9/40 , C07C235/82 , C07C275/42 , C07D217/24 , C07D223/10 , C07D233/02 , C07D235/02 , C07D257/04 , C07D261/12 , C07D401/06 , C07D401/14 , C07D403/14 , C07D405/06 , C07D409/06 , A61K9/00 , A61K31/17 , A61K31/196 , A61K31/4166 , A61K31/662
CPC分类号： C07F9/40 , A61K9/0019 , A61K9/0048 , A61K31/17 , A61K31/196 , A61K31/4166 , A61K31/42 , A61K31/662 , C07C235/82 , C07C275/42 , C07D217/24 , C07D223/10 , C07D233/02 , C07D235/02 , C07D257/04 , C07D261/12 , C07D401/06 , C07D401/14 , C07D403/14 , C07D405/06 , C07D409/06
摘要： The present invention relates to a method for treating ocular inflammatory diseases in a subject in need of such treatment, which comprises administering a pharmaceutical composition comprising a therapeutically effective amount of at least one agonist of Formyl peptide receptor 2.
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4.发明申请公开(公告)号：US20170172957A1
公开(公告)日：2017-06-22
申请号：US15223985
申请日：2016-07-29
申请人： Allergan, Inc.
发明人： Alan C. Foster , Yong-Xin Li , Ursula Staubli , Veena Viswanath , Lauren Luhrs
IPC分类号： A61K31/197 , A61K31/401
CPC分类号： A61K31/197 , A61K31/196 , A61K31/198 , A61K31/216 , A61K31/401 , A61K31/405 , A61K45/06 , A61K2300/00
摘要： The present invention relates to pharmaceutical compositions comprising D-serine transporter inhibitors and therapeutic methods using such pharmaceutical compositions in methods for the treatment of central nervous system disorders.
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公开(公告)号：US08877804B2
公开(公告)日：2014-11-04
申请号：US13872845
申请日：2013-04-29
申请人： Allergan, Inc.
发明人： Haiqing Yuan , Richard L. Beard , Michael E. Garst , John E. Donello , Xiaoxia Liu , Veena Viswanath
IPC分类号： A61K31/343 , C07D307/82 , A61P27/02 , A61P31/00 , C07C323/49 , C07D413/12 , C07D307/64 , C07D233/64 , C07C317/34 , C07D417/12 , C07D405/12
CPC分类号： C07C311/21 , C07C317/34 , C07C317/36 , C07C317/42 , C07C317/44 , C07C317/50 , C07C321/30 , C07C323/49 , C07C323/52 , C07C323/56 , C07C323/60 , C07C323/67 , C07C2601/08 , C07D207/09 , C07D207/46 , C07D213/32 , C07D213/52 , C07D233/64 , C07D277/40 , C07D295/13 , C07D295/185 , C07D295/24 , C07D307/64 , C07D307/82 , C07D333/34 , C07D405/12 , C07D413/12 , C07D417/12 , C07F9/304 , C07F9/3229 , C07F9/4021 , C07F9/5325 , C07F9/59 , C07F9/6533
摘要： The present invention relates to novel sulfur derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of chemokine receptors.
摘要翻译： 本发明涉及新的硫衍生物，其制备方法，含有它们的药物组合物及其作为药物作为趋化因子受体调节剂的用途。
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6.发明申请PYRIDINYL AND PYRIMIDINYL SULFONAMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS 有权吡啶并吡啶酰胺衍生物作为化学受体调节剂公开(公告)号：US20140275132A1
公开(公告)日：2014-09-18
申请号：US14206491
申请日：2014-03-12
申请人： Allergan, Inc.
发明人： Richard L. Beard , John E. Donello , Veena Viswanath , Michael E. Garst , Haiqing Yuan , Xiaoxia Liu
IPC分类号： C07D409/12 , C07D213/76 , C07D405/12
CPC分类号： C07D409/12 , C07D213/75 , C07D213/76 , C07D405/12 , C07D413/10
摘要： The present invention relates to novel pyridine or pyrimidine derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of chemokine receptors. The invention relates specifically to the use of these compounds and their pharmaceutical compositions to treat disorders associated with chemokine receptor modulation.
摘要翻译： 本发明涉及新颖的吡啶或嘧啶衍生物，其制备方法，含有它们的药物组合物及其作为药物作为趋化因子受体调节剂的用途。 本发明具体涉及这些化合物及其药物组合物用于治疗与趋化因子受体调节相关的病症的用途。
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7.发明申请USE OF AGONISTS OF FORMYL PEPTIDE RECEPTOR 2 FOR TREATING OCULAR INFLAMMATORY DISEASES 有权甲状腺受体2激动剂治疗眼部炎症性疾病的应用公开(公告)号：US20140256684A1
公开(公告)日：2014-09-11
申请号：US14196047
申请日：2014-03-04
申请人： Allergan, Inc.
IPC分类号： C07F9/40 , C07C275/42 , C07D223/10 , C07C235/82 , C07D401/06 , C07D261/12 , C07D403/14 , C07D401/14 , C07D235/02 , C07D405/06 , C07D409/06 , C07D257/04 , C07D233/02 , C07D217/24
CPC分类号： C07F9/40 , A61K9/0019 , A61K9/0048 , A61K31/17 , A61K31/196 , A61K31/4166 , A61K31/42 , A61K31/662 , C07C235/82 , C07C275/42 , C07D217/24 , C07D223/10 , C07D233/02 , C07D235/02 , C07D257/04 , C07D261/12 , C07D401/06 , C07D401/14 , C07D403/14 , C07D405/06 , C07D409/06
摘要： The present invention relates to a method for treating ocular inflammatory diseases in a subject in need of such treatment, which comprises administering a pharmaceutical composition comprising a therapeutically effective amount of at least one agonist of Formyl peptide receptor 2.
摘要翻译： 本发明涉及在需要这种治疗的受试者中治疗眼部炎性疾病的方法，其包括给予包含治疗有效量的至少一种甲酰基肽受体2激动剂的药物组合物。
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8.发明授权Benzofuran-2-sulfonamides pyridine derivatives as chemokine receptor modulators 有权苯并呋喃-2-磺酰胺吡啶衍生物作为趋化因子受体调节剂公开(公告)号：US08815915B2
公开(公告)日：2014-08-26
申请号：US13782174
申请日：2013-03-01
申请人： Allergan, Inc.
发明人： Haiqing Yuan , Richard L. Beard , Xiaoxia Liu , John E. Donello , Veena Viswanath , Michael E. Garst
IPC分类号： A61K31/44 , A01N43/40 , C07D405/14 , C07D307/82 , C07D405/12
CPC分类号： C07D307/78 , A61P29/00 , C07D307/82 , C07D405/12 , C07D405/14
摘要： The present invention relates to novel benzofuran-2-sulfonamide pyridine derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of chemokine receptors.
摘要翻译： 本发明涉及新型苯并呋喃-2-磺酰胺吡啶衍生物，其制备方法，含有它们的药物组合物及其作为药物作为趋化因子受体调节剂的用途。
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9.发明申请AMIDE DERIVATIVES OF N-UREA SUBSTITUTED AMINO ACIDS AS FORMYL PEPTIDE RECEPTOR LIKE-1 (FPRL-1) RECEPTOR MODULATORS 有权作为甲基肽受体LIKE-1（FPRL-1）受体调节剂的N-尿素替代氨基酸的酰胺衍生物公开(公告)号：US20140094614A1
公开(公告)日：2014-04-03
申请号：US14102145
申请日：2013-12-10
申请人： Allergan, Inc.
IPC分类号： C07C275/30 , C07C323/44 , C07D233/64 , C07C317/50
CPC分类号： A61K31/417 , A61K31/17 , A61K31/197 , A61K31/198 , A61K31/216 , A61K31/4045 , C07C275/30 , C07C317/42 , C07C317/50 , C07C323/44 , C07C323/60 , C07D209/20 , C07D233/64 , C07K5/06017 , C07K5/06034 , C07K5/06052 , C07K5/0606 , C07K5/06113 , C07K5/06147 , C07K5/06156 , Y02A50/401
摘要： The present invention relates to novel amide derivatives of N-urea substituted amino acids, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of the N-formyl peptide receptor like-1 (FPRL-1) receptor.
摘要翻译： 本发明涉及N-脲取代氨基酸的新型酰胺衍生物，其制备方法，含有它们的药物组合物及其作为N-甲酰基肽受体1（FPRL-1）受体调节剂的药物的用途。
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公开(公告)号：US20140051682A1
公开(公告)日：2014-02-20
申请号：US14034945
申请日：2013-09-24
申请人： ALLERGAN, INC.
发明人： Haiqing Yuan , Richard L. Beard , Michael E. Garst , Xiaoxia Liu , John E. Donello , Veena Viswanath
IPC分类号： C07D333/34 , C07D409/12 , C07D417/12 , C07D413/12 , C07D405/12 , C07D513/04
CPC分类号： A61K31/381 , A61K31/343 , A61K31/37 , A61K31/404 , A61K31/4155 , A61K31/4196 , A61K31/422 , A61K31/423 , A61K31/4245 , A61K31/427 , A61K31/428 , A61K31/429 , A61K31/4436 , A61K31/4709 , A61K31/4725 , A61K31/497 , A61K31/498 , A61K31/506 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/55 , A61K31/635 , C07C311/21 , C07C311/44 , C07D231/18 , C07D307/82 , C07D333/34 , C07D405/12 , C07D407/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D498/04 , C07D513/04
摘要： The present invention relates to novel bis-sulfonamide derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of chemokine receptors.
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