公开(公告)号：US11919964B2

公开(公告)日：2024-03-05

申请号：US17005202

申请日：2020-08-27

Applicant: AMGEN INC.

Inventor： Gunasekaran Kannan ,  Ling Liu ,  Edward J. Belouski ,  Cen Xu

IPC: C07K16/28 ,  C07K16/18

CPC classification number: C07K16/2869 ,  C07K16/18 ,  C07K16/28 ,  C07K2317/31 ,  C07K2317/35 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/52 ,  C07K2317/522 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/53 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/70 ,  C07K2317/76 ,  C07K2317/92

Abstract: The present invention relates to bispecific antigen binding proteins that are capable of binding to both the human CGRP receptor and the human PAC1 receptor. Pharmaceutical compositions comprising the bispecific antigen binding proteins as well as methods for producing them are also disclosed. Methods of using the bispecific antigen binding proteins to ameliorate or treat conditions associated with the two receptors, such as chronic pain, migraine, and cluster headache, are also described.

公开(公告)号：US11466078B2

公开(公告)日：2022-10-11

申请号：US16267758

申请日：2019-02-05

Applicant: Amgen Inc.

Inventor： Gunasekaran Kannan ,  Monica Florio ,  Zhi Liu ,  Wei Yan

IPC: C07K16/46 ,  C07K16/22 ,  C07K16/18 ,  C07K16/28 ,  C07K16/32 ,  A61K39/00

Abstract: The present application is directed to heterodimeric antibodies and methods of use.

公开(公告)号：US10934362B2

公开(公告)日：2021-03-02

申请号：US15511176

申请日：2015-09-15

Applicant: AMGEN INC.

Inventor： Gunasekaran Kannan ,  Ling Liu ,  Edward J. Belouski ,  Cen Xu

IPC: C07K16/28 ,  C07K16/18

Abstract: The present invention relates to bispecific antigen binding proteins that are capable of binding to both the human CGRP receptor and the human PAC1 receptor. Pharmaceutical compositions comprising the bispecific antigen binding proteins as well as methods for producing them are also disclosed. Methods of using the bispecific antigen binding proteins to ameliorate or treat conditions associated with the two receptors, such as chronic pain, migraine, and cluster headache, are also described.

公开(公告)号：US20190270817A1

公开(公告)日：2019-09-05

申请号：US16245733

申请日：2019-01-11

Applicant: AMGEN INC.

Inventor： Khaled M.K.Z. Ali ,  Neeraj Jagdish Agrawal ,  Gunasekaran Kannan ,  Ian Foltz ,  Zhulun Wang ,  Daren Bates ,  Marissa Mock ,  Shunsuke Takenaka

IPC: C07K16/28 ,  C07K16/06 ,  A61P35/00 ,  C12N15/85

Abstract: Provided herein are PD-1 antigen-binding proteins and related nucleic acids, vectors, host cells, kits and pharmaceutical compositions. Methods of making PD-1 antigen-binding proteins and methods of treating a subject are further provided.

公开(公告)号：US10421824B2

公开(公告)日：2019-09-24

申请号：US15258750

申请日：2016-09-07

Applicant: Amgen Inc.

Inventor： Hailing Hsu ,  Ming Zhang ,  Gunasekaran Kannan ,  Frederick Jacobsen ,  Wayne Tsuji

IPC: C07K16/28 ,  A61K39/395 ,  C07K16/46 ,  A61K45/06 ,  A61K39/00

Abstract: Described herein are bispecific proteins specific for BAFF and B7RP1, nucleic acids encoding such proteins, methods of making such proteins, and uses for such proteins.

公开(公告)号：US10421823B2

公开(公告)日：2019-09-24

申请号：US14776399

申请日：2014-03-12

Applicant: AMGEN INC.

Inventor： Hailing Hsu ,  Ming Zhang ,  Gunasekaran Kannan ,  Frederick W. Jacobsen ,  Wayne Tsuji

IPC: C07K16/28 ,  C07K16/46 ,  A61K39/395 ,  A61P37/06 ,  C07K16/18 ,  C07K16/24 ,  A61P29/02 ,  A61P19/02 ,  A61K39/00

Abstract: Described herein are bispecific proteins specific for BAFF and B7RP1, nucleic acids encoding such proteins, methods of making such proteins, and uses for such proteins.

公开(公告)号：US10220090B2

公开(公告)日：2019-03-05

申请号：US14967167

申请日：2015-12-11

Applicant: Amgen Inc.

Inventor： Richard J. Armitage ,  Michelle Blake ,  William C. Fanslow, III ,  Jason Charles O'Neill ,  Gunasekaran Kannan ,  Jiangchun Xu ,  Mark Edward Tometsko

IPC: C07K16/18 ,  A61K45/06 ,  A61K39/00 ,  C07K16/28 ,  A61K39/395 ,  A61K31/395 ,  A61K47/68

Abstract: The present invention relates to BCMA (B-Cell Maturation Antigen) antigen binding proteins, such as antibodies, polynucleotide sequences encoding said antigen binding proteins, and compositions and methods for diagnosing and treating diseases. The present invention also relates to BCMA antibody drug conjugates.

公开(公告)号：US09932380B2

公开(公告)日：2018-04-03

申请号：US15408281

申请日：2017-01-17

Applicant: Amgen Inc.

Inventor： Marc A. Gavin ,  Gunasekaran Kannan ,  Li Li ,  Joshua T. Pearson ,  Margaret Karow

IPC: A61K38/20 ,  C07K14/55 ,  C07K16/00 ,  A61K38/00

CPC classification number: C07K14/55 ,  A61K38/00 ,  C07K16/00 ,  C07K2317/41 ,  C07K2317/52 ,  C07K2317/524 ,  C07K2317/71 ,  C07K2317/94 ,  C07K2319/21 ,  C07K2319/30 ,  C07K2319/43

Abstract: Provided herein are IL-2 muteins and IL-2 mutein Fc-fusion molecules that preferentially expand and activate T regulatory cells and are amenable to large scale production. Also provided herein are variant human IgG1 Fc molecules lacking or with highly reduced effector function and high stability despite lacking glycosylation at N297. Also, provided herein are linker peptides that are glycosylated when expressed in mammalian cells.

公开(公告)号：US09822173B2

公开(公告)日：2017-11-21

申请号：US14443107

申请日：2013-11-21

Applicant: AMGEN INC.

Inventor： Gunasekaran Kannan ,  Monica Florio ,  Zhi Liu ,  Wei Yan

IPC: A61K39/00 ,  A61K39/395 ,  C07K16/22 ,  C07K16/18 ,  C07K16/28 ,  C07K16/32 ,  C07K16/46

CPC classification number: C07K16/22 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/2863 ,  C07K16/32 ,  C07K16/468 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/52 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/72 ,  C07K2317/732 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2319/00

Abstract: The present application is directed to heterodimeric antibodies and methods of use.

公开(公告)号：US09714276B2

公开(公告)日：2017-07-25

申请号：US14374885

申请日：2013-01-28

Applicant: AMGEN INC

Inventor： Yumei Xiong ,  Yi Zhang ,  Jackie Zeqi Sheng ,  Agnes Eva Hamburger ,  Murielle Veniant-Ellison ,  Grant Shimamoto ,  Xiaoshan Min ,  Zhulun Wang ,  Jie Tang ,  Gunasekaran Kannan ,  Kenneth W. Walker ,  Bryan Lemon

IPC: C07K14/00 ,  C07K14/475 ,  A61K39/00 ,  C12N15/62

CPC classification number: C07K14/475 ,  A61K39/0005 ,  A61K2039/6056 ,  C07K2319/30

Abstract: GDF15 polypeptides, constructs comprising GDF15, and mutants thereof are provided. In various embodiments the GDF15 polypeptides, constructs comprising GDF15, and mutants thereof, can be of use in the treatment or ameliorating a metabolic disorder. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy.