公开(公告)号：US20180179146A1

公开(公告)日：2018-06-28

申请号：US15736406

申请日：2016-06-03

Applicant: AMOREPACIFIC CORPORATION

Inventor： Yung Hyup JOO ,  Heung Soo BAEK ,  Yong Jin KIM ,  Hong-Ju SHIN ,  John Hwan LEE

IPC: C07C231/02

Abstract: The present invention relates to a method for preparing a benzoic acid amide compound in a high yield by presenting a novel method for preparing a benzyl amine compound to be used as a reactant and delimiting the reaction condition of each step by using the same, and the method is economically advantageous since mass production is possible.

公开(公告)号：US20170312230A1

公开(公告)日：2017-11-02

申请号：US15518428

申请日：2015-10-21

Applicant: Amorepacific Corporation

Inventor： Heung Soo BAEK ,  Byeong Yung WOO ,  Se Jin YOO ,  Yung Hyup JOO ,  Song Seok SHIN ,  Mi Hyun OH ,  John Hwan LEE ,  Seo Young KIM

IPC: A61K31/047 ,  A61Q19/10 ,  A61K8/34

CPC classification number: A61K31/047 ,  A61K8/30 ,  A61K8/34 ,  A61Q19/10

Abstract: The present invention relates to a composition which can effectively control bacteria by containing meso-2,3-butanediol, which is an isomer of 2,3-butane diol, and has excellent antiseptic power even without containing a chemical antiseptic agent.

公开(公告)号：US20180116933A1

公开(公告)日：2018-05-03

申请号：US15561428

申请日：2016-03-29

Applicant: Amorepacific Corporation

Inventor： Yung Hyup JOO ,  Heung Soo BAEK ,  Jeong Ah HWANG ,  Hae Kwang LEE ,  Yongjin KIM ,  Hong-Ju SHIN ,  Jon Hwan LEE

IPC: A61K8/42 ,  A61Q19/08 ,  A61K31/166 ,  A23L33/00 ,  A23L33/15 ,  A23L33/155 ,  A23L33/16 ,  A23L2/52

CPC classification number: A61K8/42 ,  A23L2/52 ,  A23L33/15 ,  A23L33/155 ,  A23L33/16 ,  A23L33/30 ,  A23V2002/00 ,  A61K8/30 ,  A61K8/34 ,  A61K31/166 ,  A61Q19/08

Abstract: 5-Adamantan-1-yl-N-(2,4-dihydroxybenzyl)-2,4-dimethoxybenzamide disclosed in the present specification can exhibit excellent anti-oxidative and anti-aging effects while having no toxicity. For example, the compound exhibits excellent anti-oxidative and anti-aging effects by scavenging free radicals or inhibiting MMP-1 expression.

公开(公告)号：US20180267022A1

公开(公告)日：2018-09-20

申请号：US15542263

申请日：2016-02-26

Applicant: AMOREPACIFIC CORPORATION

Inventor： Chang Seok LEE ,  Heung Soo BAEK ,  Yung Hyup JOO ,  Jeong Hwan KIM ,  Hong-Ju SHIN ,  Mi Young PARK ,  Song Seok SHIN

IPC: G01N33/50

CPC classification number: G01N33/5044 ,  G01N33/5014

Abstract: In one aspect of the present specification, provided is a method for predicting a side effect of a whitening ingredient, the method comprising measuring at least one of i) the increase in toxicity according to long-term use of a whitening ingredient, ii) the difference between a concentration having whitening effect and a concentration having cell toxicity, and iii) the increase in sensitivity to the whitening ingredient according to ultraviolet pretreatment. In addition, the method has an effect of effectively predicting whether a side effect will occur if the whitening ingredient is used for a long time.

公开(公告)号：US20180065922A1

公开(公告)日：2018-03-08

申请号：US15561585

申请日：2016-03-30

Applicant: AMOREPACIFIC CORPORATION

Inventor： Yung Hyup JOO ,  Soo Jeong CHOI ,  Heung Soo BAEK ,  Chang Seok LEE ,  Jeong Hwan KIM ,  Yongjin KIM ,  Hong-Ju SHIN ,  Ho Sik RHO ,  Song Seok SHIN ,  Jon Hwan LEE

IPC: C07C233/70 ,  A61K8/42 ,  A61K31/166 ,  A61Q19/02

CPC classification number: C07C233/70 ,  A23L29/00 ,  A61K8/42 ,  A61K31/166 ,  A61Q19/02 ,  C07C231/12 ,  C07C235/48

Abstract: Disclosed are a novel benzoic acid amide derivative compound, an isomer thereof, a pharmaceutically acceptable salt thereof, a prodrug thereof, a hydrate thereof, or a solvate thereof. The novel compound and the like inhibit melanin production, prevent tyrosinase activity, and have an excellent skin whitening effect.

公开(公告)号：US20170283347A1

公开(公告)日：2017-10-05

申请号：US15506972

申请日：2015-08-24

Applicant: AMOREPACIFIC CORPORATION

Inventor： Yung Hyup JOO ,  Song Seok SHIN ,  Byoung Young WOO ,  Heung Soo BAEK ,  Yong Deog HONG ,  Hong-Ju SHIN ,  Yeon Su JEONG ,  Jon Hwan LEE

IPC: C07C13/615 ,  C07C233/57 ,  C07C15/04

Abstract: Disclosed is a novel adamantine derivative compound, an isomer thereof, pharmaceutically acceptable salt thereof, prodrug thereof, hydrate thereof or a solvate thereof. Also disclosed is a method for preparing a novel adamantine derivative compound, an isomer thereof, pharmaceutically acceptable salt thereof, prodrug thereof, hydrate thereof or a solvate thereof. The novel adamantane derivative compound or the like has an excellent anti-androgenic effect.

公开(公告)号：US20160324824A1

公开(公告)日：2016-11-10

申请号：US15107955

申请日：2015-01-20

Applicant: AMOREPACIFIC CORPORATION

Inventor： Ho Sik RHO ,  Heung Soo BAEK ,  Yu Jung KIM ,  Song Seok SHIN ,  John Hwan LEE

IPC: A61K31/357 ,  A61K8/49 ,  A61Q19/00 ,  A61K31/36

CPC classification number: A61K31/357 ,  A61K8/498 ,  A61K31/36 ,  A61K2800/74 ,  A61K2800/91 ,  A61K2800/92 ,  A61Q19/00 ,  A61Q19/08

Abstract: The present invention relates to a cosmetic composition containing a hydroxypyranone derivative compound as an active ingredient for promoting the differentiation of adipocytes. The composition according to the present invention has an effect of promoting the differentiation of adipocytes, and thus allows the differentiation of adipocyte in a skin layer, thereby increasing the skin volume or elasticity. Therefore, the composition of the present invention can be variously used as a cosmetic composition or a pharmaceutical composition in the field, such as skin damage.

Abstract translation: 本发明涉及含有羟基吡喃酮衍生物化合物作为促进脂肪细胞分化的活性成分的化妆品组合物。 根据本发明的组合物具有促进脂肪细胞分化的作用，从而允许脂肪细胞在皮肤层中分化，从而增加皮肤体积或弹性。 因此，本发明的组合物可以各种用作本领域的化妆品组合物或药物组合物，例如皮肤损伤。