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    SYSTEMS AND METHODS FOR ASSESSING DATA COLLECTED FROM AN ELECTRICALLY ACTIVE CELL CULTURE
    3.
    发明申请
    SYSTEMS AND METHODS FOR ASSESSING DATA COLLECTED FROM AN ELECTRICALLY ACTIVE CELL CULTURE 审中-公开

    公开(公告)号：US20180292389A1

    公开(公告)日：2018-10-11

    申请号：US15964139

    申请日：2018-04-27

    Applicant: Axion BioSystems, Inc.

    Inventor： Stacie Ann Chvatal ,  Daniel Christopher Millard ,  James David Ross

    IPC: G01N33/50 ,  H04L29/08 ,  A61B5/04 ,  A61B5/0464

    Abstract: Disclosed herein are systems and methods for assessing electrically active cell cultures. Optionally, the data can be collected using a microelectrode array (MEA). For example, electrically active cells, such as cardiomyocytes, are cultured such that they are in electrical communication with at least a portion of the electrodes of a well of the MEA. The assessments derived from the disclosed methods may be used to reduce the effects of confounding variables in data obtained from an electrically active cell culture. The methods may also be used to determine a quantitative measure of arrhythmia burden. The methods may also be used to decide if a particular culture or set of data is suitable for inclusion in scientific and characterization studies. Also disclosed is a method of finding the global conduction velocity of an electrically active cell culture.

    Device and system for creating and maintaining a localized environment for a cell culture plate
    7.
    发明授权
    Device and system for creating and maintaining a localized environment for a cell culture plate 有权

    公开(公告)号：US10351812B2

    公开(公告)日：2019-07-16

    申请号：US14838575

    申请日：2015-08-28

    Applicant: Axion BioSystems, Inc.

    Inventor： Robert Dixon Grier, Jr. ,  David Ernest Irvine ,  James David Ross

    IPC: C12M1/00 ,  C12M1/12 ,  C12M1/32 ,  C12M1/34 ,  C12M3/00

    Abstract: Systems and methods for creating a localized environment for a cell culture plate are described herein. An example system can include a dock shaped to receive the cell culture plate, and a gas distribution device positioned on the dock. The gas distribution device can include a frame including a plurality of sides connected to form an opening, an internal channel within the frame for directing a gas mixture within the gas distribution device, an inlet port in fluid communication with the internal channel for receiving the gas mixture, and a plurality of apertures in fluid communication with the internal channel. The plurality of apertures can be spaced apart from one another along the frame and configured to direct the gas mixture toward the opening.

    SYSTEMS AND METHODS FOR ASSESSING DATA COLLECTED FROM AN ELECTRICALLY ACTIVE CELL CULTURE
    8.
    发明申请
    SYSTEMS AND METHODS FOR ASSESSING DATA COLLECTED FROM AN ELECTRICALLY ACTIVE CELL CULTURE 有权
    用于评估从电动活性细胞培养物收集的数据的系统和方法

    公开(公告)号：US20160274088A1

    公开(公告)日：2016-09-22

    申请号：US15076223

    申请日：2016-03-21

    Applicant: Axion BioSystems, Inc.

    Inventor： Stacie Ann Chvatal ,  Daniel Christopher Millard ,  James David Ross

    IPC: G01N33/50 ,  H04L29/08

    CPC classification number: G01N33/5044 ,  A61B5/04 ,  A61B5/0464 ,  G01N33/5058 ,  G01N33/5061 ,  G01N33/5091 ,  G01N2800/326 ,  H04L67/12

    Abstract: Disclosed herein are systems and methods for assessing electrically active cell cultures. Optionally, the data can be collected using a microelectrode array (MEA). For example, electrically active cells, such as cardiomyocytes, are cultured such that they are in electrical communication with at least a portion of the electrodes of a well of the MEA. The assessments derived from the disclosed methods may be used to reduce the effects of confounding variables in data obtained from an electrically active cell culture. The methods may also be used to determine a quantitative measure of arrhythmia burden. The methods may also be used to decide if a particular culture or set of data is suitable for inclusion in scientific and characterization studies. Also disclosed is a method of finding the global conduction velocity of an electrically active cell culture.

    Abstract translation: 本文公开了用于评估电活性细胞培养物的系统和方法。 任选地，可以使用微电极阵列（MEA）收集数据。 例如，培养电活性细胞，例如心肌细胞，使得它们与MEA的孔的至少一部分电极电连通。 从公开的方法得到的评估可用于减少混合变量对从电活性细胞培养物获得的数据的影响。 方法也可用于确定心律失常负荷的定量测量。 这些方法也可用于确定特定文化或数据集是否适合纳入科学和表征研究。 还公开了一种找到电活性细胞培养物的全局传导速度的方法。

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