公开(公告)号：US20200345782A1

公开(公告)日：2020-11-05

申请号：US16875486

申请日：2020-05-15

Applicant: Agency for Science, Technology and Research

Inventor： Lawrence Stanton ,  Padmapriya Sathiyanathan ,  Simon Cool ,  Victor Nurcombe ,  Rebekah M. Samsonraj

IPC: A61K35/28 ,  C12Q1/6881 ,  A61K35/545 ,  C12N5/0775

Abstract: A method for providing a sub-population of stem cell or plurality of stem cells by determining or modulating GSTT1 expression level or genotype is disclosed together with uses of the stem cells.

公开(公告)号：US10596296B2

公开(公告)日：2020-03-24

申请号：US15307407

申请日：2015-04-30

Applicant: Agency for Science, Technology and Research

Inventor： Simon Cool ,  Victor Nurcombe ,  Jonathan Lee

IPC: A61L27/20 ,  A61L27/38 ,  A61L27/52 ,  A61L27/54 ,  A61K31/727 ,  C08B37/00 ,  C07K14/495 ,  A61L15/44 ,  A61L15/60 ,  A01N1/02 ,  A61K8/73 ,  A61L27/34 ,  C12N5/0775

Abstract: A heparan sulphate that binds TGPβ1 is disclosed.

公开(公告)号：US10266612B2

公开(公告)日：2019-04-23

申请号：US14891564

申请日：2013-05-16

Applicant: Agency for Science, Technology and Research

Inventor： Victor Nurcombe ,  Simon Cool

IPC: C08B37/10 ,  C08B37/00 ,  C12N5/0775 ,  A61K9/00 ,  A61K31/737 ,  A61K35/28 ,  A61K38/18 ,  A61L27/20

Abstract: A novel class of structurally and functionally related isolated Heparan sulphate is disclosed. The novel class of Heparan sulphates has been found to bind FGF2 and enhance the proliferation of stem cells while maintaining their pluripotency/multipotency.

公开(公告)号：US10220054B2

公开(公告)日：2019-03-05

申请号：US15336407

申请日：2016-10-27

Applicant: Agency for Science, Technology and Research

Inventor： Simon McKenzie Cool ,  Victor Nurcombe ,  Christian Dombrowski

IPC: A61K31/727 ,  A61K31/726 ,  A61K38/18 ,  C08B37/00 ,  A61L27/20 ,  A61L27/54 ,  A61K9/00 ,  A61K35/28

Abstract: Heparan sulphate HS/BMP2 is disclosed, together with the use of HS/BMP2 in the repair and regeneration of bone tissue.

公开(公告)号：US20180258193A1

公开(公告)日：2018-09-13

申请号：US15542123

申请日：2016-01-08

Applicant: Agency for Science, Technology and Research

Inventor： Simon Cool ,  Victor Nurcombe

IPC: C08B37/00 ,  A61K31/727 ,  A61K38/18 ,  A61L33/00

CPC classification number: C08B37/0075 ,  A61K31/727 ,  A61K38/1858 ,  A61K45/06 ,  A61L33/0011 ,  A61L2300/42 ,  A61L2400/18 ,  A61P17/02 ,  C08B37/0078 ,  C08B37/0081 ,  A61K2300/00

Abstract: Affinity purification of platelet-derived growth factor-binding heparan sulphate from porcine mucosa (HS6) is disclosed. Also disclosed is the use of HS6 in repair and regeneration of the skin for treating wounds, burns, ulcers and other skin injuries.

公开(公告)号：US20160375099A1

公开(公告)日：2016-12-29

申请号：US15262895

申请日：2016-09-12

Applicant: Agency for Science, Technology and Research

Inventor： Simon McKenzie Cool ,  Victor Nurcombe ,  Christian Dombrowski

IPC: A61K38/18 ,  A61L27/38 ,  A61L27/54 ,  A61L27/26 ,  A61K31/737 ,  A61K35/28

CPC classification number: A61K38/1875 ,  A61K31/727 ,  A61K31/737 ,  A61K35/28 ,  A61K2035/124 ,  A61L27/26 ,  A61L27/365 ,  A61L27/3834 ,  A61L27/3847 ,  A61L27/54 ,  A61L2300/236 ,  A61L2300/252 ,  A61L2300/414 ,  A61L2430/02 ,  B01D15/3823 ,  C07K14/51 ,  C08B37/0003 ,  C08B37/0075 ,  C12N5/0663 ,  C12N2501/155 ,  C12N2501/90

Abstract: Heparan sulphate HS/BMP2 is disclosed, together with the use of HS/BMP2 in the repair and regeneration of bone tissue.

公开(公告)号：US20150328251A1

公开(公告)日：2015-11-19

申请号：US14814680

申请日：2015-07-31

Applicant: Agency for Science, Technology and Research

Inventor： Simon Cool ,  Victor Nurcombe

IPC: A61K31/727 ,  A61K38/18

CPC classification number: A61K31/727 ,  A61K31/737 ,  A61K38/1866 ,  A61L27/34 ,  A61L27/54 ,  A61L2300/412 ,  A61P9/10 ,  C08B37/0078 ,  C08L5/00

Abstract: Heparan sulphate HS7 is disclosed, together with the use of HS7 in the growth and/or development and/or regeneration of tissue.

Abstract translation: 公开了硫酸肝素HS7以及在组织的生长和/或发育和/或再生中使用HS7。

公开(公告)号：US11331337B2

公开(公告)日：2022-05-17

申请号：US16770721

申请日：2018-12-11

Applicant: Agency for Science, Technology and Research

Inventor： Raymond Alexander Alfred Smith ,  Simon McKenzie Cool ,  Victor Nurcombe ,  Sadasivam Murali

IPC: A61K31/727

Abstract: Isolated heparin or heparan sulphate oligosaccharide fragments having a chain length of at least 10 saccharides and no more than 50 saccharides, which are capable of binding BMP2, are disclosed. Also disclosed is the use of the same heparin or heparan sulphate oligosaccharide fragments in kits and pharmaceutical compositions, and the use of the same heparan sulphate oligosaccharide fragments in the repair and/or regeneration of connective tissue and bones, and the treatment of wounds.

公开(公告)号：US10245301B2

公开(公告)日：2019-04-02

申请号：US15262895

申请日：2016-09-12

Applicant: Agency for Science, Technology and Research

Inventor： Simon McKenzie Cool ,  Victor Nurcombe ,  Christian Dombrowski

IPC: A61K31/727 ,  A61L27/54 ,  A61L27/26 ,  C08B37/00 ,  A61K38/18 ,  A61L27/36 ,  B01D15/38 ,  C07K14/51 ,  C12N5/0775 ,  A61K31/737 ,  A61K35/28 ,  A61L27/38 ,  A61K35/12

Abstract: Heparan sulphate HS/BMP2 is disclosed, together with the use of HS/BMP2 in the repair and regeneration of bone tissue.

公开(公告)号：US20170143766A1

公开(公告)日：2017-05-25

申请号：US15318909

申请日：2015-06-26

Applicant: Agency for Science, Technology and Research

Inventor： Lawrence Stanton ,  Padmapriya Sathiyanathan ,  Simon Cool ,  Victor Nurcombe ,  Rebekah M. Samsonraj

IPC: A61K35/28 ,  C12N5/0775 ,  C12Q1/68

CPC classification number: A61K35/28 ,  A61K35/545 ,  C12N5/0662 ,  C12N5/0663 ,  C12Q1/6881 ,  C12Q2600/158 ,  C12Y205/01018

Abstract: A method for providing a sub-population of stem cell or plurality of stem cells by determining or modulating GSTT1 expression level or genotype is disclosed together with uses of the stem cells.