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公开(公告)号：US20230164299A1
公开(公告)日：2023-05-25
申请号：US17981228
申请日：2022-11-04
Applicant: Alentic Microscience Inc.
Inventor： Alan Marc Fine , Hershel Macaulay , Laurent Kreplak
CPC classification number: H04N7/18 , G02B21/0008
Abstract: An imaging device includes light sensitive locations that are separately sensitive to light received at a surface with respect to a portion of a sample associated with the surface, the light sensitive locations having a resolution of 5 microns or smaller. There is a device to associate the portion of the sample with the surface. The imaging device and a distance of the portion of the sample to the light sensitive locations are such that usable useful image of the portion of the sample can be acquired directly by operation of the imaging device.
An imaging device includes light sensitive sources that are separately able to deliver light with respect to a portion of a sample associated with the surface. The light source locations having a resolution of 5 microns or smaller. There is a device to associate the portion of the sample with the surface. The imaging device and a distance of the portion of the sample to the light source locations are such that a useful image of the portion of the sample can be acquired directly by operation of the imaging device.
An imaging device can include both the light source locations and the light source locations and the light sensitive locations.-
公开(公告)号：US11635447B2
公开(公告)日：2023-04-25
申请号：US17103246
申请日：2020-11-24
Applicant: Alentic Microscience Inc.
Inventor： Alan Marc Fine
IPC: G01Q60/20 , G01N21/64 , G02B21/00 , G02B21/36 , H01L27/146
Abstract: Among other things, an imaging device has a photosensitive array of pixels, and a surface associated with the array is configured to receive a specimen with at least a part of the specimen at a distance from the surface equivalent to less than about half of an average width of the pixels.
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公开(公告)号：US20220404600A1
公开(公告)日：2022-12-22
申请号：US17712959
申请日：2022-04-04
Applicant: Alentic Microscience Inc.
Inventor： Alan Marc Fine , Peter Hodges Gregson
IPC: G02B21/00
Abstract: Among other things, an imaging device has a photosensitive array of pixels, and a surface associated with the array is configured to receive a specimen with at least a part of the specimen at a distance from the surface equivalent to less than about half of an average width of the pixels.
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公开(公告)号：US11442261B2
公开(公告)日：2022-09-13
申请号：US17193680
申请日：2021-03-05
Applicant: Alentic Microscience Inc.
Inventor： Alan Marc Fine , Joel Ironstone , Christopher Gillespie
Abstract: A base assembly includes an imaging sensor having a sensor surface to receive a sample, and a platform connected to the base assembly. The base assembly includes (a) an aperture configured to receive a lid surface of a lid in a position to define an imaging space between the sensor surface and the lid surface and (b) a movement portion movable toward and away from the base assembly. The platform and the base assembly are configured to limit contact between the sample and the base assembly other than at the sensor surface.
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公开(公告)号：US11061031B2
公开(公告)日：2021-07-13
申请号：US16839752
申请日：2020-04-03
Applicant: Alentic Microscience Inc.
Inventor： Alan Marc Fine
IPC: G01N33/80 , G01N33/569 , G06K9/00 , G02B21/36 , G02B21/00 , G01N15/14 , G01T1/02 , G01B9/02 , G06T7/00 , G03H1/04 , G01N11/00 , G03H1/00 , G01N15/10 , G01N15/00 , C12M1/34
Abstract: Among other things, a method comprises imaging a sample displaced between a sensor surface and a surface of a microscopy sample chamber to produce an image of at least a part of the sample. The image is produced using lensless optical microscopy, and the sample contains at least blood from a subject. The method also comprises automatically differentiating cells of different types in the image, generating a count of one or more cell types based on the automatic differentiation, and deriving a radiation dose the subject has absorbed based on the count.
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Patent Agency Ranking
公开(公告)号：US20200379234A1
公开(公告)日：2020-12-03
申请号：US16995271
申请日：2020-08-17
Applicant: Alentic Microscience Inc.
Inventor： Alan Marc Fine , Hershel Macaulay , Noah Hymes-Vandermeulen
Abstract: Among other things, a first surface is configured to receive a sample and is to be used in a microscopy device. There is a second surface to be moved into a predefined position relative to the first surface to form a sample space that is between the first surface and the second surface and contains at least part of the sample. There is a mechanism configured to move the second surface from an initial position into the predefined position to form the sample space. When the sample is in place on the first surface, the motion of the second surface includes a trajectory that is not solely a linear motion of the second surface towards the first surface.
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公开(公告)号：US20200292801A1
公开(公告)日：2020-09-17
申请号：US16839752
申请日：2020-04-03
Applicant: Alentic Microscience Inc.
Inventor： Alan Marc Fine
Abstract: Among other things, a method comprises imaging a sample displaced between a sensor surface and a surface of a microscopy sample chamber to produce an image of at least a part of the sample. The image is produced using lensless optical microscopy, and the sample contains at least blood from a subject. The method also comprises automatically differentiating cells of different types in the image, generating a count of one or more cell types based on the automatic differentiation, and deriving a radiation dose the subject has absorbed based on the count.
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公开(公告)号：US20190242794A1
公开(公告)日：2019-08-08
申请号：US16367791
申请日：2019-03-28
Applicant: Alentic Microscience Inc.
Inventor： Alan Marc Fine , Hershel Macaulay
Abstract: Among other things, a diluted sample is generated based on mixing a small sample of blood with a one or more diluents. A thin film of the diluted sample is formed on the surface of a contact optical microscopy sensor. Red blood cells within a portion of the thin film of the diluted sample are illuminated using light of a predetermined wavelength. One or more images of the diluted sample are acquired based on illuminating the red blood cells within the portion of the thin film of the diluted sample. The acquired one or more images of the diluted sample are then processed. The mean corpuscular hemoglobin in the red blood cells within the portion of the thin film of the diluted sample is determined based on processing the acquired images of the diluted sample.
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公开(公告)号：US10317662B2
公开(公告)日：2019-06-11
申请号：US15482215
申请日：2017-04-07
Applicant: Alentic Microscience Inc.
Inventor： Alan Marc Fine
IPC: G02B21/36 , G01N33/49 , G01N1/38 , G01N21/31 , G01N1/28 , B01L3/00 , G01N15/06 , G01N15/00 , B01L3/02 , G01N1/40 , G01N15/14 , G01N35/10
Abstract: In some instances, an apparatus can include a light sensitive imaging sensor having a surface to receive a fluid sample, a body to be moved relative to the light sensitive imaging sensor and having a surface to touch a portion of the fluid sample, and a carrier to move the body toward the surface of the light sensitive imaging sensor to cause the surface of the body to touch the portion of the fluid sample, so that as the surface of the body touches the portion of the fluid, the surface of the body (i) is parallel to the surface of the light sensitive imaging sensor, and (ii) settles on top of the fluid sample independently of motion of the carrier.
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公开(公告)号：US10153317B1
公开(公告)日：2018-12-11
申请号：US15963894
申请日：2018-04-26
Applicant: Alentic Microscience Inc.
Inventor： Alan Marc Fine , Madhuranga Srinath Rankaduwa
IPC: H01L27/146 , G01N21/27 , G01N33/49
Abstract: Among other things, an integral image sensor includes a sensor surface having a surface area at which light-sensitive pixels are arranged in rows and columns. The surface area includes two or more light-sensitive subareas each of the subareas having been configured to have been diced from a wafer along two orthogonal dimensions to form a discrete image sensor. The two or more light-sensitive subareas are arranged along one of the two orthogonal dimensions. The sensor surface of the integral image sensor is flat and continuous across the two or more subareas.
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