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公开(公告)号：US4083951A
公开(公告)日：1978-04-11
申请号：US792118
申请日：1977-04-29
CPC分类号： A61K31/60 , A61K33/26 , A61K9/0007
摘要： Pharmaceutical compositions containing acetyl salicylic acid or a salt thereof and a ferrous salt having 1 to 7 equivalents of acetyl salicylic acid per equivalent of ferrous ion and characterized by reduced gastric irritation without major reduction of the usual properties of the acetyl salicylic acid. The compositions are orally administrable and may be formulated in one part or in multi-parts with the parts physically separated to prevent premature reaction particularly when the composition is effervescent.
摘要翻译： 含有乙酰水杨酸或其盐的药物组合物和每当量亚铁离子具有1至7当量乙酰水杨酸的亚铁盐，其特征在于减少胃刺激而不会大幅降低乙酰水杨酸的通常性质。 组合物可口服施用，并且可以配制成一部分或多部分，其中物理分离的部分防止过早反应，特别是当组合物是泡腾时。
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公开(公告)号：US4062978A
公开(公告)日：1977-12-13
申请号：US588638
申请日：1975-06-20
IPC分类号： A61K31/12 , A61K31/13 , C07C29/143 , C07C45/45 , C07C45/46 , C07C45/62 , C07C45/64 , C07C45/71 , C07C49/213 , C07C49/215 , C07C49/217 , C07C49/223 , C07C49/225 , C07C49/235 , C07C49/245 , C07C49/248 , C07C49/255 , C07C49/76 , C07C49/782 , C07C49/792 , C07C49/794 , C07C49/813 , C07C49/83 , C07C49/84 , A01N9/24
CPC分类号： C07C49/84 , C07C205/45 , C07C29/143 , C07C45/45 , C07C45/46 , C07C45/62 , C07C45/64 , C07C45/71 , C07C49/213 , C07C49/215 , C07C49/217 , C07C49/223 , C07C49/225 , C07C49/235 , C07C49/245 , C07C49/248 , C07C49/255 , C07C49/76 , C07C49/782 , C07C49/792 , C07C49/794 , C07C49/813 , C07C49/83
摘要： Anti-inflammatory compositions are prepared which comprise a therapeutically effective amount of a compound of the formula ##STR1## wherein X is CO or CHOH; Y is CO, an oxygen atom or a direct bond; the dotted line represents a double bond which is optionally present when Y is an oxygen atom or a direct bond; R.sub.1 is hydrogen or methyl; R.sub.2 is hydrogen, fluorine, chlorine, bromine, methyl, trifluoromethyl, methoxyl, hydroxyl, acetoxyl, nitro or amino; R.sub.3 is alkyl of 3-8 carbon atoms, cycloalkyl of 3-8 carbon atoms, alkenyl of 3-8 carbon atoms, cycloalkenyl of 5-8 carbon atoms, phenyl or phenyl substituted by 1 or 2 substituents selected from the group consisting of fluorine, chlorine, bromine, methyl, ethyl, methoxyl, ethoxyl, benzyloxyl, hydroxyl, acetoxyl, trifluoromethyl, nitro, amino, acetyl, methylthiol, methylsulphonyl, methylamino and dimethylamino.Compounds of the above formula are novel except that R.sub.1 must be methyl: when R.sub.3 -- Y is a 4-phenyl group, R.sub.2 is hydrogen and X is CO; when R.sub.3 -- Y is a 4-benzyl group and R.sub.2 is hydrogen; and also when R.sub.3 -- Y is a 3-benzoyl group, R.sub.2 is hydrogen and X is CO.
摘要翻译： 制备抗炎组合物，其包含治疗有效量的式（I）化合物，其中X为CO或CHOH; Y是CO，氧原子或直接键; 虚线表示当Y是氧原子或直接键时任选存在的双键; R1是氢或甲基; R2是氢，氟，氯，溴，甲基，三氟甲基，甲氧基，羟基，乙酰氧基，硝基或氨基; R3是3-8个碳原子的烷基，3-8个碳原子的环烷基，3-8个碳原子的烯基，5-8个碳原子的环烯基，苯基或被1或2个选自氟的取代基取代的苯基 氯，溴，甲基，乙基，甲氧基，乙氧基，苄氧基，羟基，乙酰氧基，三氟甲基，硝基，氨基，乙酰基，甲基硫醇，甲基磺酰基，甲基氨基和二甲基氨基。
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公开(公告)号：US3963750A
公开(公告)日：1976-06-15
申请号：US491060
申请日：1974-07-23
IPC分类号： C07D333/38 , C07D333/24
CPC分类号： C07D333/38
摘要： Compounds of the formula: ##SPC1##Wherein R.sub.1 is NHR.sub.5 or OR.sub.5 where R.sub.5 is a hydrogen atom or alkyl group of 1-6 carbon atoms; R.sub.2 is a hydrogen atom or a CO.R.sub.6 group where R.sub.6 is an alkyl group of 1-6 carbon atoms; R.sub.3 is a phenyl group substituted by 1 or 2 halogen atoms or methyl, trifluoromethyl or methoxyl groups; and R.sub.4 is a hydrogen atom or an alkyl group of 1-6 carbon atoms or a phenyl group optionally substituted by 1 or 2 halogen atoms or methyl, trifluoromethyl or methoxyl groups; and salts thereof; have been found to possess valuable anti-inflammatory properties. The preparation and use of such compounds is described.
摘要翻译： 下式的化合物：
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