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公开(公告)号：US06417247B1
公开(公告)日：2002-07-09
申请号：US09079884
申请日：1998-05-15
IPC分类号： A61F202
CPC分类号： A61L27/46 , A61L24/0084 , Y10S524/916 , C08L5/00
摘要： The present invention provides a composition which comprises a polymer or polymer solution that forms a gel under controlled parameters and a ceramic matrix, the composition being fluid under non-physiological conditions and non fluid under physiological conditions. Polymers may be resorbable or non-resorbable, natural or synthetic and the solution aqueous or non-aqueous. Preferred polymers are poly saccharides, polyamides or polyamino acids, however any polymer or polymer solution that is biologically compatible and that is fluid under nonphysiological conditions and increases in viscosity under physiological conditions is suitable.
摘要翻译： 本发明提供一种组合物，其包含在受控参数下形成凝胶的聚合物或聚合物溶液和陶瓷基质，所述组合物在非生理条件下为流体，在生理条件下为非流体。 聚合物可以是可再吸收的或不可再吸收的，天然的或合成的，并且水溶液或非水溶液。 优选的聚合物是多糖，聚酰胺或聚氨基酸，然而任何生物相容的聚合物或聚合物溶液，并且在非生理条件下是流体，并且在生理条件下粘度增加是合适的。
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公开(公告)号：US5958430A
公开(公告)日：1999-09-28
申请号：US26748
申请日：1998-02-20
申请人： Allison A. Campbell , Lin Song
发明人： Allison A. Campbell , Lin Song
CPC分类号： A61K9/7007
摘要： The invention provides a thin-film composition comprising an underlying substrate of a first material including a plurality of attachment sites; a plurality of functional groups chemically attached to the attachment sites of the underlying substrate; and a thin film of a second material deposited onto the attachment sites of the underlying substrate, and a biologically active substance deposited with the thin-film. Preferably the functional groups are attached to a self assembling monolayer attached to the underlying substrate. Preferred functional groups attached to the underlying substrate are chosen from the group consisting of carboxylates, sulfonates, phosphates, optionally substituted, linear or cyclo, alkyl, alkene, alkyne, aryl, alkylaryl, amine, hydroxyl, thiol, silyl, phosphoryl, cyano, metallocenyl, carbonyl, and polyphosphate. Preferred materials for the underlying substrate are selected from the group consisting of a metal, a metal alloy, a plastic, a polymer, a proteic film, a membrane, a glass or a ceramic. The second material is selected from the group consisting of inorganic crystalline structures, inorganic amorphus structures, organic crystalline structures, and organic amorphus structures. Preferred second materials are phosphates, especially calcium phosphates and most particularly calcium apatite. The biologically active molecule is a protein, peptide, DNA segment, RNA segment, nucleotide, polynucleotide, nucleoside, antibiotic, antimicrobal, radioisotope, chelated radioisotope, chelated metal, metal salt, anti-inflamatory, steriod, nonsteriod anti-inflammatory, analgesic, antihistamine, receptor binding agent, or chemotherapeutic agent, or other biologically active material. Preferably the biologically active molecule is an osteogenic factor the compositions listed above.
摘要翻译： 本发明提供一种薄膜组合物，其包含包含多个附着位点的第一材料的下面的基底; 化学连接到下面的基底的附着位点上的多个官能团; 以及沉积在下面的基底的附着位置上的第二材料的薄膜和沉积有薄膜的生物活性物质。 优选地，官能团连接到连接到下面的基底上的自组装单层。 连接到下面的底物的优选的官能团选自羧酸盐，磺酸盐，磷酸盐，任选取代的，直链或环烷基，烯烃，炔烃，芳基，烷基芳基，胺，羟基，硫醇，甲硅烷基，磷酰基，氰基， 金属茂基，羰基和多磷酸盐。 用于下层基材的优选材料选自金属，金属合金，塑料，聚合物，蛋白质膜，膜，玻璃或陶瓷。 第二种材料选自无机结晶结构，无机非晶体结构，有机晶体结构和有机非晶体结构。 优选的第二种材料是磷酸盐，特别是磷酸钙，最特别是磷酸钙。 生物活性分子是蛋白质，肽，DNA片段，RNA片段，核苷酸，多核苷酸，核苷，抗生素，抗微生物，放射性同位素，螯合放射性同位素，螯合金属，金属盐，抗炎，异位，非甾体抗炎，镇痛， 抗组胺剂，受体结合剂或化学治疗剂，或其他生物活性物质。 优选地，生物活性分子是上面列出的组合物的成骨因子。
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公开(公告)号：US08705709B2
公开(公告)日：2014-04-22
申请号：US13228488
申请日：2011-09-09
申请人： Jack Jianxiu Hao , Dahai Ren , Wei Xia , Lin Song
发明人： Jack Jianxiu Hao , Dahai Ren , Wei Xia , Lin Song
IPC分类号： H04M1/64
CPC分类号： H04L67/02 , H04M3/53333 , H04M3/5335 , H04M3/537 , H04M7/0024 , H04M2203/252 , H04M2203/4536 , H04W4/00
摘要： One or more devices in a visual voicemail system voicemail notification messages indicating voicemails are available for a user of the visual voicemail system and distribute the voicemail notification messages to a network device. The one or more devices receive an indication of a backlog processing requests for the visual voicemail system and stop, based on the indication, distributing the voicemail notification messages to the network device. After the stopping, the one or more devices receive another indication that the backlog processing requests for the visual voicemail system no longer exists and resume, based on the other indication, distributing the voicemail notification messages to the network device.
摘要翻译： 可视语音邮件系统中的一个或多个设备指示语音邮件的语音邮件通知消息可用于可视语音邮件系统的用户，并将语音邮件通知消息分发到网络设备。 所述一个或多个设备接收对可视语音邮件系统的积压处理请求的指示，并基于指示将语音邮件通知消息分发到网络设备停止。 在停止之后，一个或多个设备基于将语音邮件通知消息分发到网络设备的其他指示，接收另一个指示，即指示对待可视语音邮件系统的积压处理请求不再存在并恢复。
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公开(公告)号：US20100166822A1
公开(公告)日：2010-07-01
申请号：US12319129
申请日：2008-12-31
申请人： Lin Song
发明人： Lin Song
CPC分类号： A61F2/30756 , A61F2/3094 , A61F2002/30762 , A61L27/227 , A61L27/34 , A61L27/3817 , A61L27/3852 , A61L27/3895 , A61L2430/06
摘要： A method of producing a cartilage implant which may include coating a substrate with a thermo-sensitive polymer, seeding the polymer with a cell suspension comprising cells that may differentiate into chrondocyte-like cells, wherein the seeding may be conducted at a first temperature, culturing the cell suspension at an increased temperature, whereby cells in the suspension may adhere to the polymer and differentiate into chrondrocyte-like cells, which may form a cartilagenous implant, and decreasing the temperature of the polymer which may allow detachment of the implant from the polymer. The present invention may also include an implant based on this method. The invention may further include a cartilage implant for use in a patient in need thereof, which may include a random three-dimensional configuration of differentiated cells, which may have a natural adhesion surface on at least a portion of the outer surface of the three-dimensional configuration.
摘要翻译： 一种生产软骨植入体的方法，其可以包括用热敏聚合物涂覆底物，将聚合物与包含可分化成类细胞细胞的细胞的细胞悬浮液接种，其中接种可以在第一温度下进行，培养 细胞悬浮液在升高的温度下，由此悬浮液中的细胞可能粘附到聚合物上并分化成软骨细胞样细胞，其可以形成软骨植入物，并降低聚合物的温度，这可允许植入物从聚合物中分离 。 本发明还可以包括基于该方法的植入物。 本发明还可以包括用于有需要的患者的软骨植入物，其可以包括分化细胞的随机三维构型，其可以在三维细胞的外表面的至少一部分上具有天然粘合表面， 尺寸配置。
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5.发明授权公开(公告)号：US08709401B2
公开(公告)日：2014-04-29
申请号：US13406035
申请日：2012-02-27
IPC分类号： A01N63/00
CPC分类号： A61K35/28 , A61K35/50 , A61K35/545 , C12N5/0663
摘要： Disclosed are methods of treating inflammation within a synovial joint, comprising administering to the joint a composition comprising primed stem or progenitor cells in an amount effective to enhance recovery, and a pharmaceutically acceptable carrier.
摘要翻译： 公开了治疗滑膜关节内的炎症的方法，其包括以有效提高恢复的量给予关节包含引发干细胞或祖细胞的组合物和药学上可接受的载体。
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公开(公告)号：US20110289049A1
公开(公告)日：2011-11-24
申请号：US12782730
申请日：2010-05-19
申请人： Nanshan Zeng , Meng Ye , Honghua Feng , Junwei Xu , Yu-chao Cao , Yingjun Yu , Lin Song
发明人： Nanshan Zeng , Meng Ye , Honghua Feng , Junwei Xu , Yu-chao Cao , Yingjun Yu , Lin Song
IPC分类号： G06F17/30
CPC分类号： G06F17/30312 , G06F11/2041 , G06F11/2097 , G06F17/30997
摘要： Metadata may be stored in, and retrieved from, a scalable, fault-tolerant metadata service. In one example, metadata is divided into partitions, and each partition is served by one or more nodes. For each partition, a first one of the nodes may handle read and write requests, and the other nodes may handle read requests in the event that the first node is down or is experiencing high load. When a request is made with respect to metadata, a metadata server may identify a node, in the partition to which the metadata is assigned, to which the request is to be made. The entity that is making the request then contacts that node, and requests the read or write on the metadata. In a partition, metadata may be replicated between the first node and the other nodes using a log-based replication protocol.
摘要翻译： 元数据可以存储在可扩展的容错元数据服务中并从其检索。 在一个示例中，元数据被划分成分区，并且每个分区由一个或多个节点服务。 对于每个分区，第一个节点可以处理读取和写入请求，并且其他节点可以在第一个节点关闭或正在经历高负载的情况下处理读取请求。 当针对元数据提出请求时，元数据服务器可以识别要向其分配请求的分配中的元数据分配的节点。 然后，发出请求的实体联系该节点，并请求读取或写入元数据。 在分区中，可以使用基于日志的复制协议在第一节点和其他节点之间复制元数据。
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7.发明申请PRIMED STEM CELLS AND USES THEREOF TO TREAT INFLAMMATORY CONDITIONS IN JOINTS 有权原始干细胞及其在接合中治疗炎症病症的用途公开(公告)号：US20120328578A1
公开(公告)日：2012-12-27
申请号：US13406035
申请日：2012-02-27
CPC分类号： A61K35/28 , A61K35/50 , A61K35/545 , C12N5/0663
摘要： Disclosed are methods of treating inflammation within a synovial joint, comprising administering to the joint a composition comprising primed stem or progenitor cells in an amount effective to enhance recovery, and a pharmaceutically acceptable carrier.
摘要翻译： 公开了治疗滑膜关节内的炎症的方法，其包括以有效提高恢复的量给予关节包含引发干细胞或祖细胞的组合物和药学上可接受的载体。
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公开(公告)号：US20120258086A1
公开(公告)日：2012-10-11
申请号：US13508882
申请日：2010-11-11
CPC分类号： A61K38/1875 , A61K35/19 , A61K35/545 , A61K2300/00
摘要： The invention is directed to a method of accelerating healing in a joint comprising administering a platelet composition to the joint.
摘要翻译： 本发明涉及一种加速关节愈合的方法，其包括将血小板组合物施用于关节。
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9.发明授权Administration of stem or progenitor cells to a joint to enhance recovery from joint surgery 有权将茎或祖细胞施用于关节以增强关节手术的恢复公开(公告)号：US08343480B2
公开(公告)日：2013-01-01
申请号：US12617042
申请日：2009-11-12
IPC分类号： A01N63/00
CPC分类号： A61K35/545 , A61K35/28 , A61K35/50 , A61K38/1875 , A61L27/3834 , A61L27/3852 , A61L2400/06 , A61L2430/24 , A61K2300/00
摘要： Disclosed are methods of enhancing recovery from joint surgery, comprising administering to the joint during surgery a composition comprising stem or progenitor cells in an amount effective to enhance recovery, and a pharmaceutically acceptable carrier.
摘要翻译： 公开了增强关节手术的恢复的方法，包括在手术期间给予关节以包含有效增强恢复的量的干细胞或祖细胞的组合物和药学上可接受的载体。
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公开(公告)号：US20120230967A1
公开(公告)日：2012-09-13
申请号：US13042842
申请日：2011-03-08
CPC分类号： A61K35/19
摘要： The present invention includes a method for activating platelets in a platelet solution, the method may include passing the platelet solution through an activator at least once to activate at least one of the platelets in the platelet solution to produce an activated platelet solution. The activator may further include a flow disruption element. The method may further induce administering the activated platelet solution to the repair site of a patient. The present invention may also be a system for treating a medical condition at a repair site within a patient in need thereof, which may include a platelet solution container for housing a platelet solution; an activator to activate at least one platelet; and an introducer to direct the at least one activated platelet to the repair site.
摘要翻译： 本发明包括用于激活血小板溶液中的血小板的方法，所述方法可以包括使血小板溶液通过活化剂至少一次以活化血小板溶液中的至少一种血小板以产生活化的血小板溶液。 活化剂可以进一步包括流动破坏元件。 该方法还可以诱导将活化的血小板溶液施用于患者的修复部位。 本发明还可以是用于治疗有需要的患者内的修复部位的医疗状况的系统，其可以包括用于容纳血小板溶液的血小板溶液容器; 活化剂以激活至少一种血小板; 以及导引器，用于将所述至少一个活化的血小板引导至所述修复部位。
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