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    IN VITRO METHOD FOR DIAGNOSING TUMOR DISEASES
    3.
    发明申请
    IN VITRO METHOD FOR DIAGNOSING TUMOR DISEASES 审中-公开
    用于诊断肿瘤疾病的体外方法

    公开(公告)号：US20100247438A1

    公开(公告)日：2010-09-30

    申请号：US12731499

    申请日：2010-03-25

    申请人： Arne Hengerer ,  Andreas Kappel ,  Luis Lasalvia ,  Andrea Lichte ,  Thomas Mertelmeier ,  Sven Meyburg ,  Christoph Petry ,  Marcus Pfister ,  Martin Requardt

    发明人： Arne Hengerer ,  Andreas Kappel ,  Luis Lasalvia ,  Andrea Lichte ,  Thomas Mertelmeier ,  Sven Meyburg ,  Christoph Petry ,  Marcus Pfister ,  Martin Requardt

    IPC分类号： A61K49/00 ,  G01N33/53 ,  G01N33/573 ,  G01N33/48 ,  A61B1/00

    CPC分类号： G01N33/57488 ,  G01N33/57407 ,  G01N33/57419 ,  G01N33/57473 ,  G01N2333/585 ,  G01N2333/70503 ,  G01N2333/96486

    摘要： An in vitro method is for diagnosing a tumor disease in a patient. In at least one embodiment, the method includes: (i) determining an IVD marker or an IVD marker panel in at least one biological sample of a patient, wherein the IVD marker has a high sensitivity to the tumor disease, (ii) determining the proportion of patients tested positive due to an adapted reference range of the IVD marker/IVD marker panel, wherein the reference range was adapted such that the number of individuals with false negative tests, the number of individuals with false positive tests and the number of individuals ultimately needing to be subjected to imaging diagnostics to clarify false negative and false positive results are balanced in respect of one another such that tumor screening can be carried out, possibly: (iii) deciding to carry out an imaging method specific to the respective tumor disease for clarifying possible false negative and/or false positive IVD results, or (iv) repeating stages (i) and (ii) after a defined time interval, or (v) carrying out an imaging method for imaging the tumor.

    摘要翻译： 体外方法是用于诊断患者的肿瘤疾病。 在至少一个实施方案中，该方法包括：（i）确定患者的至少一个生物样品中的IVD标记或IVD标记物组，其中IVD标记对肿瘤疾病具有高度敏感性，（ii）确定 由于IVD标记/ IVD标记物组的适应参考范围，患者的比例为阳性，其中参考范围被改编为使得具有假阴性测试的个体数量，具有假阳性测试的个体数量和个体数量 最终需要进行成像诊断以澄清假阴性和假阳性结果在彼此之间相互平衡，使得可以进行肿瘤筛选，可能：（iii）决定执行特定于各自肿瘤疾病的成像方法 用于澄清可能的假阴性和/或假阳性IVD结果，或（iv）在限定的时间间隔后重复阶段（i）和（ii），或（v）进行成像 肿瘤成像方法。

    Optical diagnosis system for small animal imaging
    4.
    发明授权
    Optical diagnosis system for small animal imaging 失效
    小动物成像光学诊断系统

    公开(公告)号：US06833915B2

    公开(公告)日：2004-12-21

    申请号：US10188745

    申请日：2002-07-05

    申请人： Jürgen Beuthan ,  Arne Hengerer ,  Tobias Jochum ,  Thomas Mertelmeier

    发明人： Jürgen Beuthan ,  Arne Hengerer ,  Tobias Jochum ,  Thomas Mertelmeier

    IPC分类号： G01N2164

    CPC分类号： A61B5/0059 ,  A61B6/508 ,  A61B2503/40

    摘要： Optical diagnosis system for small animal imaging, in which the animal which has been arranged on a bearing plate and treated with an activatable optical contrast medium is irradiated by an excitation source and the resulting fluorescent radiation that is radiated back is detected by a detector system, in which case the bearing plate is designed as a radiation-transparent window (13) for a reference radiation—generated by a second marker of the contrast medium—for the detection of the initial concentration of the inert contrast medium.

    摘要翻译： 用于小动物成像的光学诊断系统，其中已经布置在支承板上并用可激活的光学造影剂处理的动物被激发源照射，并且所产生的被辐射回的荧光辐射由检测器系统检测， 在这种情况下，承载板被设计为用于由造影剂的第二标记物产生的参考辐射的辐射透明窗口（13），用于检测惰性造影剂的初始浓度。

    X-Ray Diagnostic Device for Mammography
    5.
    发明申请
    X-Ray Diagnostic Device for Mammography 审中-公开
    用于乳房X光检查的X射线诊断装置

    公开(公告)号：US20070249925A1

    公开(公告)日：2007-10-25

    申请号：US11661889

    申请日：2005-08-29

    申请人： Martin Hoheisel ,  Thomas Mertelmeier ,  Marcus Pfister

    发明人： Martin Hoheisel ,  Thomas Mertelmeier ,  Marcus Pfister

    IPC分类号： A61B5/05

    CPC分类号： A61B5/0537 ,  A61B6/0414 ,  A61B6/502 ,  A61B6/544

    摘要： An X-ray diagnostic device is provided. The X-ray diagnostic device includes a control device that is operable to optimally adjust a radiation of an X-ray emitter for a particular patient, and a measuring device. The measuring device is coupled to the control device. The measuring device is operable to determine a tissue composition of a body part to be examined. The control device is operable to optimally adjust the radiation of the X-ray emitter for the particular patient on the basis of the measured tissue composition.

    摘要翻译： 提供X射线诊断装置。 X射线诊断装置包括可操作以最佳地调整特定患者的X射线发射器的辐射的控制装置和测量装置。 测量装置连接到控制装置。 测量装置可操作以确定待检查的身体部位的组织组成。 控制装置可操作以基于所测量的组织组成来最佳地调整特定患者的X射线发射器的辐射。

    Method to show a concentration of a contrast agent in a predetermined volume segment by means of tomosynthesis, and corresponding tomosynthesis apparatus
    6.
    发明授权
    Method to show a concentration of a contrast agent in a predetermined volume segment by means of tomosynthesis, and corresponding tomosynthesis apparatus 有权
    通过断层合成法显示预定体积段中的造影剂浓度的方法，以及对应的层析合成装置

    公开(公告)号：US08594274B2

    公开(公告)日：2013-11-26

    申请号：US13252334

    申请日：2011-10-04

    申请人： Mathias Hoernig ,  Thomas Mertelmeier

    发明人： Mathias Hoernig ,  Thomas Mertelmeier

    IPC分类号： A61B6/00 ,  H05G1/64 ,  G06K9/00

    CPC分类号： A61B6/025 ,  A61B6/481 ,  A61B6/482 ,  A61B6/486 ,  A61B6/502

    摘要： In an imaging method and a tomosynthesis apparatus, a two-dimensional low-energy image of the predetermined volume segment is obtained after administration of a contrast agent, followed by a two-dimensional high-energy image and then a high-energy tomosynthesis of the predetermined volume segment is obtained with a high total radiation dose that is significantly higher than the low radiation dose. The two-dimensional low-energy image is subtracted from the two-dimensional high-energy image to generate a result with which the concentration of the contrast agent is visible. Additionally, in a time interval in which an enrichment or a washing-out of the contrast agent occurs within the predetermined volume segment, a tomosynthesis of the predetermined volume segment is automatically implemented to show the concentration of the contrast agent in the predetermined volume segment.

    摘要翻译： 在成像方法和断层融合装置中，在施用造影剂之后获得预定体积段的二维低能量图像，随后是二维高能量图像，然后进行高能量的能量合成 获得具有明显高于低辐射剂量的高总辐射剂量的预定体积段。 从二维高能量图像中减去二维低能量图像，以产生造影剂的浓度可见的结果。 此外，在预定体积段内产生浓缩物或洗出造影剂的时间间隔内，自动实施预定体积段的断层合成，以显示造影剂在预定体积段中的浓度。

    METHOD TO SHOW A CONCENTRATION OF A CONTRAST AGENT IN A PREDETERMINED VOLUME SEGMENT BY MEANS OF TOMOSYNTHESIS, AND CORRESPONDING TOMOSYNTHESIS APPARATUS
    7.
    发明申请
    METHOD TO SHOW A CONCENTRATION OF A CONTRAST AGENT IN A PREDETERMINED VOLUME SEGMENT BY MEANS OF TOMOSYNTHESIS, AND CORRESPONDING TOMOSYNTHESIS APPARATUS 有权
    通过骨髓增生症和对照药物装置显示对照剂在预测体积分数中的浓度的方法

    公开(公告)号：US20120134464A1

    公开(公告)日：2012-05-31

    申请号：US13252334

    申请日：2011-10-04

    申请人： Mathias Hoernig ,  Thomas Mertelmeier

    发明人： Mathias Hoernig ,  Thomas Mertelmeier

    IPC分类号： A61B6/03 ,  H05G1/64

    CPC分类号： A61B6/025 ,  A61B6/481 ,  A61B6/482 ,  A61B6/486 ,  A61B6/502

    摘要： In an imaging method and a tomosynthesis apparatus, a two-dimensional low-energy image of the predetermined volume segment is obtained after administration of a contrast agent, followed by a two-dimensional high-energy image and then a high-energy tomosynthesis of the predetermined volume segment is obtained with a high total radiation dose that is significantly higher than the low radiation dose. The two-dimensional low-energy image is subtracted from the two-dimensional high-energy image to generate a result with which the concentration of the contrast agent is visible. Additionally, in a time interval in which an enrichment or a washing-out of the contrast agent occurs within the predetermined volume segment, a tomosynthesis of the predetermined volume segment is automatically implemented to show the concentration of the contrast agent in the predetermined volume segment.

    摘要翻译： 在成像方法和断层融合装置中，在施用造影剂之后获得预定体积段的二维低能量图像，随后是二维高能量图像，然后进行高能量的能量合成 获得具有明显高于低辐射剂量的高总辐射剂量的预定体积段。 从二维高能量图像中减去二维低能量图像，以产生造影剂的浓度可见的结果。 此外，在预定体积段内产生浓缩物或洗出造影剂的时间间隔内，自动实施预定体积段的断层合成，以显示造影剂在预定体积段中的浓度。

    DIAGNOSTIC UNIT HAVING A PROTECTIVE DEVICE
    8.
    发明申请
    DIAGNOSTIC UNIT HAVING A PROTECTIVE DEVICE 审中-公开
    具有保护装置的诊断装置

    公开(公告)号：US20100183119A1

    公开(公告)日：2010-07-22

    申请号：US12664942

    申请日：2008-09-02

    申请人： Jasmina Ludwig ,  Thomas Mertelmeier

    发明人： Jasmina Ludwig ,  Thomas Mertelmeier

    IPC分类号： A61B6/10

    CPC分类号： A61B6/107 ,  A61B6/025 ,  A61B6/502

    摘要： A radiography diagnostic apparatus has a radiation source that emits an x-ray beam, and a protection that is mounted to prevent unwanted body portions of a patient, or operating personnel, from interacting with the x-ray beam.

    摘要翻译： 射线照相诊断装置具有发射X射线束的辐射源，以及安装以防止患者或操作人员的不必要身体部分与X射线束相互作用的保护。

    Mammography tomosynthesis apparatus with a compression plate having a recess therein
    9.
    发明授权
    Mammography tomosynthesis apparatus with a compression plate having a recess therein 有权
    具有压缩板的乳房X光照相断层合成装置，其中具有凹部

    公开(公告)号：US07742558B2

    公开(公告)日：2010-06-22

    申请号：US12437957

    申请日：2009-05-08

    申请人： Thomas Mertelmeier ,  Wei Zhao

    发明人： Thomas Mertelmeier ,  Wei Zhao

    IPC分类号： A61B6/00

    CPC分类号： A61B6/04 ,  A61B6/025 ,  A61B6/0414 ,  A61B6/4028 ,  A61B6/466 ,  A61B6/502

    摘要： A tomosynthesis apparatus for mammography has an x-ray source for emission of x-ray beams from different directions directed toward a detector, and a compression plate and a support plate arranged in the beam path between the x-ray source and the detector. A breast to be examined is positioned and compressed between the compression plate and the support plate. The compression plate exhibits a concave recess open in the direction of the support plate on the side of the compression plate facing toward the support plate.

    摘要翻译： 用于乳房X线照相术的断层合成装置具有用于从指向检测器的不同方向发射X射线束的X射线源，以及布置在x射线源和检测器之间的束路径中的压缩板和支撑板。 被检查的乳房被定位并压缩在压缩板和支撑板之间。 压缩板在压板的面向支撑板的一侧在支撑板的方向上露出凹形凹部。

    Measurement system for examining a section of tissue on a patient and the use of a measurement system of this type
    10.
    发明授权
    Measurement system for examining a section of tissue on a patient and the use of a measurement system of this type 失效
    用于检查患者部分组织的测量系统以及这种测量系统的使用

    公开(公告)号：US07729756B2

    公开(公告)日：2010-06-01

    申请号：US10181402

    申请日：2001-01-18

    申请人： Thomas Mertelmeier ,  Bernhard Scholz

    发明人： Thomas Mertelmeier ,  Bernhard Scholz

    IPC分类号： A61B5/05

    CPC分类号： A61B5/0536 ,  A61B5/0091 ,  A61B2562/0209 ,  A61B2562/046

    摘要： A measurement system for examining a section of tissue on a patient in which electric current and/or voltages are applied to a patient in at least one location and are measured on the section of tissue to be examined by at least one electrode of a contact surface of the measurement system. As a result, conclusions can be drawn about the interior of the section of tissue to be examined. The electrode is at least partially surrounded by a conductor element for contacting with a potential which deviates from that of the conductor element.

    摘要翻译： 一种用于检查患者的组织部分的测量系统，其中在至少一个位置向患者施加电流和/或电压，并且通过接触表面的至少一个电极在要检查的组织的部分上测量 的测量系统。 因此，可以得出关于要检查的组织部分的内部的结论。 电极至少部分地被导体元件包围，以与与导体元件的电位相偏离的电位接触。