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公开(公告)号：US20210206723A1
公开(公告)日：2021-07-08
申请号：US16754171
申请日：2018-10-08
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： James Aaron BALOG , Emily Charlotte CHERNEY , Weifang SHAN , David K. WILLIAMS , Liping ZHANG
IPC: C07D215/46 , C07D215/14 , C07D401/12 , C07D401/04 , C07D401/06 , C07K16/28
Abstract: The present invention provides compounds of formula (I), formula (II) or formula (III), wherein all of the variables are as defined herein. These compounds are inhibitors of indoleamine 2,3-dioxygenase (IDO), which may be used as medicaments for the treatment of proliferative disorders, such as cancer, viral infections and/or autoimmune diseases.
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公开(公告)号：US20200095231A1
公开(公告)日：2020-03-26
申请号：US16612076
申请日：2018-05-10
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： James Aaron BALOG , Emily Charlotte CHERNEY , Liping ZHANG , Audris HUANG , Weifang SHAN , David K. WILLIAMS , Xiao ZHU , Weiwei GUO
IPC: C07D403/12 , C07D213/85 , C07D401/12 , C07D471/04
Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.
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公开(公告)号：US20190135758A1
公开(公告)日：2019-05-09
申请号：US16098288
申请日：2017-05-04
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Emily Charlotte CHERNEY , Weifang SHAN , Liping ZHANG , David K. WILLIAMS , Weiwei GUO , Audris HUANG , James Aaron BALOG
IPC: C07D215/18 , C07D401/04 , A61K31/4709 , A61P35/00 , A61K47/42
Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.
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公开(公告)号：US20190144416A1
公开(公告)日：2019-05-16
申请号：US16098239
申请日：2017-05-04
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： David K. WILLIAMS , Weifang SHAN , James Aaron BALOG
IPC: C07D401/04 , C07C275/30 , C07D215/18 , A61P35/00 , A61K31/4709 , C07C275/36 , C07C275/34 , C07C275/28 , C07C275/42 , C07C275/26 , A61K31/47 , A61K31/277 , A61K31/17
Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.
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Patent Agency Ranking
公开(公告)号：US20210070698A1
公开(公告)日：2021-03-11
申请号：US16959487
申请日：2019-01-03
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： James Aaron BALOG , Steven P. SEITZ , David K. WILLIAMS , Murugaiah ANDAPPAN MURUGAIAH SUBBAIAH
IPC: C07C275/42
Abstract: The present invention provides a compound of formula (II): an inhibitor of indoleamine 2,3-dioxygenase (IDO), which may be used as medicaments for the treatment of proliferative disorders, such as cancer, viral infections and/or autoimmune diseases. Its prodrugs are disclosed.
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公开(公告)号：US20190144417A1
公开(公告)日：2019-05-16
申请号：US16098245
申请日：2017-05-04
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： David K. WILLIAMS , Weifanq SHAN , Liping ZHANG , Emily Charlotte CHERNEY , James Aaron BALOG
IPC: C07D401/04 , A61P35/00 , C07D215/18 , A61K31/4709 , A61K31/47 , A61K31/496 , C07D401/06 , A61K31/444
Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.
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公开(公告)号：US20210355113A1
公开(公告)日：2021-11-18
申请号：US17261968
申请日：2019-07-20
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： James Aaron BALOG , Steven P. SEITZ , Jay A. MARKWALDER , David K. WILLIAMS , Weifang SHAN , Susheel Jethanand NARA , Saumya ROY , Srinivas CHERUKU , Nagalakshmi PULICHARLA
IPC: C07D405/14 , C07D405/10 , C07D413/14 , C07D313/08 , C07D413/10 , C07D417/14 , C07D307/79 , C07K16/28
Abstract: The present invention provides compounds of formula (I) wherein all of the variables are as defined herein. These compounds are inhibitors of indoleamine 2,3-dioxygenase (IDO), which may be used as medicaments for the treatment of proliferative disorders, such as cancer, viral infections and/or autoimmune diseases.
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公开(公告)号：US20210299126A1
公开(公告)日：2021-09-30
申请号：US17261954
申请日：2019-07-22
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： James Aaron BALOG , Jay A. MARKWALDER , Weifang SHAN , David K. WILLIAMS , Susheel Jethanand NARA , Saumya ROY , Soodamani THANGAVEL , Srinivas CHERUKU , Ramesh Kumar SISTLA
IPC: A61K31/506 , A61K39/395 , C07D403/10 , C07D403/14 , C07D413/10 , C07D417/10 , C07D213/75 , C07D401/14 , A61K31/4439 , A61K31/4418 , A61K31/496 , A61K31/501 , A61K31/519 , C07D405/14 , C07D487/04 , C07D417/14 , A61K31/5377 , A61K31/4725 , C07D413/14 , C07D213/74
Abstract: The present invention provides compounds of formula (I): wherein all of the variables are as defined herein. These compounds are inhibitors of indoleamine 2,3-dioxygenase (IDO), which may be used as medicaments for the treatment of proliferative disorders, such as cancer, viral infections and/or autoimmune diseases.
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公开(公告)号：US20190119216A1
公开(公告)日：2019-04-25
申请号：US16098260
申请日：2017-05-04
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Emily Charlotte CHERNEY , Liping ZHANG , David K. WILLIAMS , James Aaron BALOG
IPC: C07D215/18 , C07D401/04 , C07D215/233 , A61K31/4709 , A61K31/47 , A61K45/06 , A61P35/00
Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.
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