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公开(公告)号：US11370785B2
公开(公告)日：2022-06-28
申请号：US16759782
申请日：2018-10-31
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Joseph E. Carpenter , Jianxin Feng , Ji Jiang , Soong-Hoon Kim , Ying Wang , Gang Wu
IPC: C07D417/14 , C07D401/14 , C07D413/06 , C07D413/14 , C07D471/04 , C07D471/08 , C07D487/04 , C07D513/04
Abstract: The present invention provides compounds of Formula (I), or stereoisomers, tautomers, or pharmaceutically acceptable salts or solvates thereof, wherein all the variables are as defined herein. These compounds modulate the activity of farnesoid X receptor (FXR), for example, as agonists. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating a disease, disorder, or condition associated with FXR dysregulation, such as pathological fibrosis, transplant rejection, cancer, osteoporosis, and inflammatory disorders, by using the compounds and pharmaceutical compositions.
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2.发明授权Amide, urea or sulfone amide linked benzothiazole inhibitors of endothelial lipase 有权酰胺，尿素或砜酰胺连接苯并噻唑抑制剂的内皮脂肪酶公开(公告)号：US08987314B2
公开(公告)日：2015-03-24
申请号：US13944921
申请日：2013-07-18
Applicant: Bristol-Myers Squibb Company
Inventor： Heather Finlay , Ji Jiang , Soong-Hoon Kim , Brandon Parkhurst , Jennifer X. Qiao , Tammy C. Wang , Zulan Pi , George O. Tora , John Lloyd , James A. Johnson
IPC: C07D277/64 , C07D417/04 , C07D417/10 , C07D417/12 , C07D417/14 , A61K31/428 , A61P9/10
CPC classification number: C07D277/64 , C07D417/04 , C07D417/10 , C07D417/12 , C07D417/14
Abstract: The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments.
Abstract translation: 本发明提供式（I）化合物：如说明书中所定义和包含任何这些新化合物的组合物。 这些化合物是可用作药物的内皮脂肪酶抑制剂。
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3.发明申请公开(公告)号：US20140221357A1
公开(公告)日：2014-08-07
申请号：US14346745
申请日：2012-09-25
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Lynn Abell , Leonard Adam , Cullen L. Cavallaro , Heather Finlay , Todd J. Friends , Jon J. Hangeland , Ji Jiang , R. Michael Lawrence , John Lloyd , Zulan Pi , George O. Tora , Jennifer X. Qiao , Carol Hui Hu , Tammy C. Wang
IPC: C07D207/38 , C07D417/12 , C07D471/04 , C07D417/04 , C07D401/12 , C07D403/12 , C07D403/04 , C07D487/04 , C07D403/06
CPC classification number: C07D471/04 , C07D207/28 , C07D207/38 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D413/06 , C07D417/04 , C07D417/06 , C07D417/12 , C07D487/04
Abstract: The present invention provides compounds of Formula (I) or Formula (III): [INSERT CHEMICAL STRUCTURE HERE] (I) [INSERT CHEMICAL STRUCTURE HERE] (III) as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments.
Abstract translation: 本发明提供式（I）或式（III）的化合物：[INSERT CHEMICAL Structure这里]（I）如本说明书中定义的[INSERT CHEMICAL STRUCTURE HERE]（III）和包含任何这些新化合物的组合物。 这些化合物是可用作药物的内皮脂肪酶抑制剂。
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公开(公告)号：US20190330186A1
公开(公告)日：2019-10-31
申请号：US16309168
申请日：2017-06-14
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Ji Jiang , Heather Finlay , Soong-Hoon Kim , Wei Meng , George O. Tora
IPC: C07D401/12 , C07D221/00 , C07D401/14 , C07D471/04 , C07D413/14
Abstract: The present invention provides compounds of Formula (I) wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.
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公开(公告)号：US10392347B2
公开(公告)日：2019-08-27
申请号：US15767364
申请日：2016-10-13
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Soong-Hoon Kim , Hannguang J. Chao , Heather Finlay , Ji Jiang , James A. Johnson , R. Michael Lawrence , Michael C. Myers , Monique Phillips , George O. Tora , Wei Meng
IPC: C07D213/82 , C07D401/06 , C07D401/14 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D491/107 , C07D498/10 , C07D401/12 , C07D471/10
Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.
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Patent Agency Ranking
公开(公告)号：US20180273518A1
公开(公告)日：2018-09-27
申请号：US15990855
申请日：2018-05-29
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： James A. Johnson , Soong-Hoon Kim , R. Michael Lawrence , Michael C. Myers , Hannguang J. Chao , Monique Phillips , Ji Jiang
IPC: C07D413/04 , C07D417/14 , C07D498/04 , C07D401/04 , C07D413/14
CPC classification number: C07D413/04 , C07D401/04 , C07D413/14 , C07D417/14 , C07D498/04
Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.
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公开(公告)号：US10011594B2
公开(公告)日：2018-07-03
申请号：US15171276
申请日：2016-06-02
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： James A. Johnson , Soong-Hoon Kim , R. Michael Lawrence , Michael C. Myers , Hannguang J. Chao , Monique Phillips , Ji Jiang
IPC: C07D413/04 , C07D413/14 , C07D401/04 , C07D417/14 , C07D498/04
CPC classification number: C07D413/04 , C07D401/04 , C07D413/14 , C07D417/14 , C07D498/04
Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.
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公开(公告)号：US20190263791A1
公开(公告)日：2019-08-29
申请号：US16411221
申请日：2019-05-14
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： James A. Johnson , Soong-Hoon Kim , R. Michael Lawrence , Michael C. Myers , Hannguang J. Chao , Monique Phillips , Ji Jiang
IPC: C07D413/04 , C07D417/14 , C07D498/04 , C07D413/14 , C07D401/04
Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.
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公开(公告)号：US09458114B2
公开(公告)日：2016-10-04
申请号：US14038814
申请日：2013-09-27
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： James A. Johnson , John Lloyd , Heather Finlay , Ji Jiang , James Neels , Naveen Kumar Dhondi , Prashantha Gunaga , Abhisek Banerjee , Ashokkumar Adisechan
IPC: C07D239/94 , C07D239/95 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D407/12 , C07D413/14 , C07D417/12 , C07D417/14 , A61K31/517 , A61K31/5377 , A61K31/549 , A61K45/06 , C07D405/12 , C07D471/04 , C07D513/04
CPC classification number: C07D401/14 , A61K31/517 , A61K31/5377 , A61K31/549 , A61K45/06 , C07D239/94 , C07D239/95 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D407/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D513/04
Abstract: A compound of formula I wherein A, X, Y, Z, R1 and R24 are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment and prevention of arrhythmia, IKur-associated disorders, and other disorders mediated by ion channel function.
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公开(公告)号：US09199946B2
公开(公告)日：2015-12-01
申请号：US14390172
申请日：2013-03-29
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Jennifer X. Qiao , Carol Hui Hu , Tammy C. Wang , Ji Jiang
IPC: C07D403/12 , C07D239/545 , A61K31/505 , C07D239/557 , A61K31/4709 , C07D401/14 , C07D405/14 , C07D401/12 , C07D403/14 , C07D405/12 , C07D409/12 , C07D239/60 , C07D413/12 , C07D417/12 , C07D487/04 , C07D495/04
CPC classification number: C07D239/557 , A61K31/4709 , A61K31/505 , C07D239/60 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D487/04 , C07D495/04
Abstract: The present invention provides compounds of Formula (I), as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments.
Abstract translation: 本发明提供了如说明书中所定义的式（I）化合物和包含任何这些新化合物的组合物。 这些化合物是可用作药物的内皮脂肪酶抑制剂。
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