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公开(公告)号：US20190382412A1
公开(公告)日：2019-12-19
申请号：US16357109
申请日：2019-03-18
发明人： Kyriacos C. Nicolaou , Min LU , Debashis MANDAL , Sanjeev GANGWAR , Naidu S. CHOWDARI , Yam B. POUDEL
IPC分类号： C07D491/08 , A61K47/68
摘要： In one aspect, the present disclosure provides new analogs of uncialamycin. The present disclosure also provides novel synthetic pathways to obtaining uncialamycin and analogs thereof. Additionally, the present disclosure also describes methods of use of uncialamycin and analogs thereof. In another aspect, the present disclosure provides antibody-drug conjugates which may be used to treat cancer or another disease or disorder.
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2.发明申请公开(公告)号：US20180037581A1
公开(公告)日：2018-02-08
申请号：US15785608
申请日：2017-10-17
发明人： Ivar M. MCDONALD , Naidu S. CHOWDARI , Walter Lewis JOHNSON , Yong ZHANG , Robert M. BORZILLERI , Sanjeev GANGWAR
IPC分类号： C07D471/04 , C07D487/04 , C07D519/00 , A61K47/68 , C07K5/062
CPC分类号： C07D471/04 , A61K47/6803 , A61K47/6851 , A61K47/6889 , C07D487/04 , C07D519/00 , C07K5/06052
摘要： Benzodiazepine dimers having a structure represented by wherein X comprises a heteroaromatic moiety and is as further defined in the application; R1 is and the other variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).
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公开(公告)号：US20180065976A1
公开(公告)日：2018-03-08
申请号：US15677959
申请日：2017-08-15
发明人： Kyriacos C. NICOLAOU , Min LU , Debashis MANDAL , Sanjeev GANGWAR , Naidu S. CHOWDARI , Yam B. POUDEL
IPC分类号： C07D491/08 , A61K47/68
CPC分类号： C07D491/08 , A61K47/6803 , A61K47/6851
摘要： In one aspect, the present disclosure provides new analogs of uncialamycin. The present disclosure also provides novel synthetic pathways to obtaining uncialamycin and analogs thereof. Additionally, the present disclosure also describes methods of use of uncialamycin and analogs thereof. In another aspect, the present disclosure provides antibody-drug conjugates which may be used to treat cancer or another disease or disorder.
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公开(公告)号：US20170233436A1
公开(公告)日：2017-08-17
申请号：US15587715
申请日：2017-05-05
发明人： Yong ZHANG , Ivar M. MCDONALD , Naidu S. CHOWDARI , Tram N. HUYNH , Robert M. BORZILLERI , Sanjeev GANGWAR
IPC分类号： C07K5/062
CPC分类号： C07K5/06052 , A61K47/6843 , A61K47/6849 , C07D487/04 , C07D519/00 , C07K16/18 , C07K16/28 , C07K16/30 , C07K2317/76
摘要： Benzodiazepine dimers having a structure represented by wherein R1 is wherein the variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).
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5.发明申请DERIVATIVES OF UNCIALAMYCIN, METHODS OF SYNTHESIS AND THEIR USE AS ANTITUMOR AGENTS 有权UNCIALAMYCIN的衍生物，合成方法及其作为抗肿瘤剂的用途公开(公告)号：US20160185791A1
公开(公告)日：2016-06-30
申请号：US14911881
申请日：2014-08-14
发明人： Kyriacos C. NICOLAOU , Min LU , Debashis MANDAL , Sanjeev GANGWAR , Naidu S. CHOWDARI , Yam B. POUDEL
IPC分类号： C07D491/08 , A61K47/48
CPC分类号： C07D491/08 , A61K47/6803 , A61K47/6851
摘要： In one aspect, the present disclosure provides new analogs of uncialamycin of formulae (I) and (II). The present disclosure also provides novel synthetic pathways to obtaining uncialamycin and analogs thereof. Additionally, the present disclosure also describes methods of use of uncialamycin and analogs thereof. In another aspect, the present disclosure provides antibody-drug conjugates comprising the compounds of formulae (I) and (II).
摘要翻译： 一方面，本公开提供式（I）和（II）的新型类似物。 本公开还提供了获得非丝氨酸霉素及其类似物的新型合成途径。 另外，本公开还描述了使用非丝氨酸霉素及其类似物的方法。 另一方面，本公开提供包含式（I）和（II）化合物的抗体 - 药物偶联物。
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公开(公告)号：US20180079781A1
公开(公告)日：2018-03-22
申请号：US15785675
申请日：2017-10-17
发明人： Yong ZHANG , Ivar M. MCDONALD , Naidu S. CHOWDARI , Tram N. HUYNH , Robert M. BORZILLERI , Sanjeev GANGWAR
IPC分类号： C07K5/062
CPC分类号： C07K5/06052 , A61K47/6843 , A61K47/6849 , C07D487/04 , C07D519/00 , C07K16/18 , C07K16/28 , C07K16/30 , C07K2317/76
摘要： Benzodiazepine dimers having a structure represented by wherein R1 is wherein the variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).
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7.发明申请公开(公告)号：US20170073357A1
公开(公告)日：2017-03-16
申请号：US15351843
申请日：2016-11-15
发明人： Yong ZHANG , Ivar M. MCDONALD , Naidu S. CHOWDARI , Tram N. HUYNH , Robert M. BORZILLERI , Sanjeev GANGWAR
IPC分类号： C07D519/00
CPC分类号： C07K5/06052 , A61K47/6843 , A61K47/6849 , C07D487/04 , C07D519/00 , C07K16/18 , C07K16/28 , C07K16/30 , C07K2317/76
摘要： Benzodiazepine dimers having a structure represented by wherein R1 is wherein the variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).
摘要翻译： 其中式（I），（Ia）和（Ib）中的变量如本申请中所定义。 这种二聚体可用作抗癌剂，特别是当用于抗体 - 药物偶联物（ADC）时。
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8.发明申请公开(公告)号：US20130209494A1
公开(公告)日：2013-08-15
申请号：US13764226
申请日：2013-02-11
发明人： Naidu S. CHOWDARI , Sanjeev Gangwar , Bilal Sufi
IPC分类号： C07K16/18 , C07D491/08
CPC分类号： C07D491/08 , A61K31/439 , A61K47/48384 , A61K47/6803 , C07K16/18
摘要： Enediyne compounds having a structure according to formula (I), where R0, R2, R3, R4, R5, R6, and R7 are defined herein, can be used in chemotherapeutic drugs, especially in conjugates, for the treatment of diseases such as cancer.
摘要翻译： 具有式（I）结构的烯二烯化合物，其中R 0，R 2，R 3，R 4，R 5，R 6和R 7在本文中定义，可用于化疗药物，特别是缀合物用于治疗疾病如癌症 。
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![1H-PYRAZOLO[4,3-d]PYRIMIDINE COMPOUNDS AS TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS](/abs-image/US/2023/04/27/US20230131192A1/abs.jpg.150x150.jpg)
公开(公告)号：US20230131192A1
公开(公告)日：2023-04-27
申请号：US17793155
申请日：2021-01-26
发明人： Christine M. TARBY , Matthias BROEKEMA , Ashvinikumar V. GAVAI , Sanjeev GANGWAR , Naidu S. CHOWDARI , Walter L JOHNSON , Murugaiah ANDAPPAN MURUGAIAH SUBBAIAH
IPC分类号： C07D487/04 , A61K45/06
摘要： Compounds according to formula I are useful as agonists of Toll-like receptor 7 (TLR7). (I) Such compounds can be used in cancer treatment, especially in combination with an anti-cancer immunotherapy agent, or as a vaccine adjuvant.
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公开(公告)号：US20210053979A1
公开(公告)日：2021-02-25
申请号：US17043886
申请日：2019-04-23
发明人： Ashok V. PURANDARE , Honghe WAN , Liqi HE , Sanjeev GANGWAR , Shoshana L. POSY , Yam B. POUDEL , Prasanna SIVAPRAKASAM , Naidu S. CHOWDARI
IPC分类号： C07D487/16 , A61K47/60
摘要： Compounds having a structure according to formula are modulators of TLR7 activity and can be used to treat conditions amenable to treatment by the modulation of TLR7 activity.
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