公开(公告)号：US11254679B2

公开(公告)日：2022-02-22

申请号：US16631915

申请日：2018-07-19

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Burcu Selin Aytar ,  Alina Borovika ,  Collin Chan ,  Joerg Deerberg ,  Nathan R. Domagalski ,  Martin D. Eastgate ,  Yu Fan ,  Michael David Bengt Fenster ,  Robert V. Forest ,  Francisco Gonzalez-Bobes ,  Rebecca A. Green ,  Matthew R. Hickey ,  Nathaniel David Kopp ,  Thomas E. La Cruz ,  Kathleen Lauser ,  Hong Geun Lee ,  David K. Leahy ,  Helen Y. Luo ,  Thomas M. Razler ,  Scott A. Savage ,  Chris Sfouggatakis ,  Maxime C. D. Soumeillant ,  Serge Zaretsky ,  Bin Zheng ,  Ye Zhu

IPC: C07D487/04

Abstract: The invention generally relates to an improved process for the preparation of N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrrolidin-1-yl)cyclohexyl)acetamide, as well as novel intermediates employed in the process, which may be useful for the treatment of cancer.

公开(公告)号：US20220177482A1

公开(公告)日：2022-06-09

申请号：US17677312

申请日：2022-02-22

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Burcu Selin Aytar ,  Alina Borovika ,  Collin Chan ,  Joerg Deerberg ,  Nathan R. Domagalski ,  Martin D. Eastgate ,  Yu Fan ,  Michael David Bengt Fenster ,  Robert V. Forest ,  Francisco Gonzalez-Bobes ,  Rebecca A. Green ,  Matthew R. Hickey ,  Nathaniel David Kopp ,  Thomas E. La Cruz ,  Kathleen Lauser ,  Hong Geun Lee ,  David K. Leahy ,  Helen Y. Luo ,  Thomas M. Razler ,  Scott A. Savage ,  Chris Sfouggatakis ,  Maxime C.D. Soumeillant ,  Serge Zaretsky ,  Bin Zheng ,  Ye Zhu

IPC: C07D487/04

Abstract: The invention generally relates to an improved process for the preparation of N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrrolidin-1-yl)cyclohexyl)acetamide, as well as novel intermediates employed in the process, which may be useful for the treatment of cancer.

公开(公告)号：US20210395200A1

公开(公告)日：2021-12-23

申请号：US17292123

申请日：2019-11-15

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Adrian Ortiz ,  Alina Borovika ,  Sergei Kolotuchin ,  Michael R. Luzung ,  Jeffrey A. Nye ,  Yichen Tan ,  Serge Zaretsky ,  Jason J. Zhu ,  Martin D. Eastgate

IPC: C07D207/273

Abstract: Highly efficient processes are provided for preparing key intermediates in the synthesis of compounds (I). The process are broadly applicable and can provide selected components having a variety of substituents. Some intermediates are claimed.

公开(公告)号：US20200223852A1

公开(公告)日：2020-07-16

申请号：US16631915

申请日：2018-07-19

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Burcu Selin Aytar ,  Alina Borovika ,  Collin Chan ,  Joerg Deerberg ,  Nathan R. Domagalski ,  Martin D. Eastgate ,  Yu Fan ,  Michael David Bengt Fenster ,  Robert V. Forest ,  Francisco Gonzalez-Bobes ,  Rebecca A. Green ,  Matthew R. Hickey ,  Nathaniel David Kopp ,  Thomas E. La Cruz ,  Kathleen Lauser ,  Hong Geun Lee ,  David K. Leahy ,  Helen Y. Luo ,  Thomas M. Razler ,  Scott A. Savage ,  Chris Sfouggatakis ,  Maxime C.D. Soumeillant ,  Serge Zaretsky ,  Bin Zheng ,  Ye Zhu

IPC: C07D487/04

Abstract: The invention generally relates to an improved process for the preparation of N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrrolodin-1-yl)cyclohexyl)acetamide, as well as novel intermediates employed in the process, which may be useful for the treatment of cancer.