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公开(公告)号：US06168950A
公开(公告)日：2001-01-02
申请号：US09359756
申请日：1999-07-23
申请人： Brett P. Monia , William Gaarde , Donna T. Ward , Lex M. Cowsert
发明人： Brett P. Monia , William Gaarde , Donna T. Ward , Lex M. Cowsert
IPC分类号： C07T2104
CPC分类号： C12N15/1137 , A61K38/00 , A61K48/00 , C12N2310/315 , C12N2310/321 , C12N2310/334 , C12N2310/3341 , Y02P20/582
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of MEKK1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding MEKK1. Methods of using these compounds for modulation of MEKK1 expression and for treatment of diseases associated with expression of MEKK1 are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节MEKK1的表达。 组合物包含靶向编码MEKK1的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节MEKK1表达和治疗与MEKK1表达相关的疾病的方法。
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公开(公告)号：US6080546A
公开(公告)日：2000-06-27
申请号：US359757
申请日：1999-07-23
申请人： Brett P. Monia , William Gaarde , Lex M. Cowsert
发明人： Brett P. Monia , William Gaarde , Lex M. Cowsert
IPC分类号： C12N15/09 , A61K31/711 , A61K31/7115 , A61K31/712 , A61K31/7125 , A61K38/00 , A61K48/00 , A61P17/02 , A61P29/00 , A61P35/00 , C12N15/113 , C12Q1/68 , C07H21/04 , C12N15/85 , C12P19/34
CPC分类号： C12N15/1137 , C12Y207/01037 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/334 , C12N2310/341 , C12N2310/346 , Y02P20/582
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of MEKK5. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding MEKK5. Methods of using these compounds for modulation of MEKK5 expression and for treatment of diseases associated with expression of MEKK5 are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节MEKK5的表达。 组合物包含靶向编码MEKK5的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节MEKK5表达和治疗与MEKK5表达相关的疾病的方法。
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公开(公告)号：US06287860B1
公开(公告)日：2001-09-11
申请号：US09488744
申请日：2000-01-20
IPC分类号： A61K317115
CPC分类号： C12N15/1137 , A61K31/7088 , A61K31/7115 , A61K31/712 , A61K31/7125 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/345 , C12N2310/346 , C12Y207/11025 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of MEKK2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding MEKK2. Methods of using these compounds for modulation of MEKK2 expression and for treatment of diseases associated with expression of MEKK2 are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节MEKK2的表达。 组合物包含针对编码MEKK2的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节MEKK2表达和治疗与MEKK2表达相关的疾病的方法。
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公开(公告)号：US07709630B2
公开(公告)日：2010-05-04
申请号：US12011761
申请日：2008-01-28
申请人： William Gaarde , Andrew T Watt , Brett P Monia , Mausumee Guha
发明人： William Gaarde , Andrew T Watt , Brett P Monia , Mausumee Guha
CPC分类号： C12N15/1136 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of connective tissue growth factor. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding connective tissue growth factor. Methods of using these compounds for modulation of connective tissue growth factor expression and for treatment of diseases associated with expression of connective tissue growth factor are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节结缔组织生长因子的表达。 组合物包含靶向编码结缔组织生长因子的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节结缔组织生长因子表达和治疗与结缔组织生长因子表达相关的疾病的方法。
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公开(公告)号：US20100035964A1
公开(公告)日：2010-02-11
申请号：US12011761
申请日：2008-01-28
申请人： William Gaarde , Andrew T. Watt , Brett P. Monia , Mausumee Guha
发明人： William Gaarde , Andrew T. Watt , Brett P. Monia , Mausumee Guha
IPC分类号： A61K31/7088 , C07H21/04
CPC分类号： C12N15/1136 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of connective tissue growth factor. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding connective tissue growth factor. Methods of using these compounds for modulation of connective tissue growth factor expression and for treatment of diseases associated with expression of connective tissue growth factor are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节结缔组织生长因子的表达。 组合物包含靶向编码结缔组织生长因子的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节结缔组织生长因子表达和治疗与结缔组织生长因子表达相关的疾病的方法。
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公开(公告)号：US20050059629A1
公开(公告)日：2005-03-17
申请号：US10946914
申请日：2004-09-21
申请人： William Gaarde , Andrew Watt , Brett Monia , Mausumee Guha
发明人： William Gaarde , Andrew Watt , Brett Monia , Mausumee Guha
IPC分类号： A61K38/00 , C12N15/113 , A61K48/00 , C12N15/85
CPC分类号： C12N15/1136 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of connective tissue growth factor. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding connective tissue growth factor. Methods of using these compounds for modulation of connective tissue growth factor expression and for treatment of diseases associated with expression of connective tissue growth factor are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节结缔组织生长因子的表达。 组合物包含靶向编码结缔组织生长因子的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节结缔组织生长因子表达和治疗与结缔组织生长因子表达相关的疾病的方法。
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公开(公告)号：US20070161593A1
公开(公告)日：2007-07-12
申请号：US11548650
申请日：2006-10-11
申请人： James Karras , Susan Gregory , Susan Freier , William Gaarde , Mausumee Guha
发明人： James Karras , Susan Gregory , Susan Freier , William Gaarde , Mausumee Guha
IPC分类号： A61K48/00 , C07H21/02 , C07F9/6533
CPC分类号： C12N15/1138 , A61K38/00 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/345 , C12N2310/3525
摘要： Disclosed herein are compounds, compositions and methods for modulating the expression of IL-4R alpha in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders related to expression of IL 4R-α, airway hyperresponsiveness, and/or pulmonary inflammation.
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公开(公告)号：US20050267063A1
公开(公告)日：2005-12-01
申请号：US11117013
申请日：2005-04-27
申请人： C. Bennett , Brett Monia , Susan Freier , Brenda Baker , William Gaarde , Erich Koller , Susan Murray , Andrew Watt , Jacqueline Wyatt , Pamela Nero , Mark Roach , Lex Cowsert , Kenneth Dobie
发明人： C. Bennett , Brett Monia , Susan Freier , Brenda Baker , William Gaarde , Erich Koller , Susan Murray , Andrew Watt , Jacqueline Wyatt , Pamela Nero , Mark Roach , Lex Cowsert , Kenneth Dobie
CPC分类号： C12N15/1137 , A61K38/00 , B23Q2011/0808 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of p70 S6 kinase. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding p70 S6 kinase. Methods of using these compounds for modulation of p70 S6 kinase expression and for treatment of diseases associated with expression of p70 S6 kinase are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节p70 S6激酶的表达。 组合物包含靶向编码p70 S6激酶的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节p70 S6激酶表达和治疗与p70 S6激酶表达相关的疾病的方法。
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公开(公告)号：US20060160758A1
公开(公告)日：2006-07-20
申请号：US11039632
申请日：2005-01-20
申请人： C. Bennett , Susan Freier , Brenda Baker , Brett Monia , Nicholas Dean , Hong Zhang , Susan Murray , Lex Cowsert , Madeline Butler , Robert McKay , Donna Ward , William Gaarde , Ian Popoff , Jacqueline Wyatt , Andrew Watt
发明人： C. Bennett , Susan Freier , Brenda Baker , Brett Monia , Nicholas Dean , Hong Zhang , Susan Murray , Lex Cowsert , Madeline Butler , Robert McKay , Donna Ward , William Gaarde , Ian Popoff , Jacqueline Wyatt , Andrew Watt
CPC分类号： C12N15/1138 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of CD40 ligand. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding CD40 ligand. Methods of using these compounds for modulation of CD40 ligand expression and for treatment of diseases associated with expression of CD40 ligand are provided.
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公开(公告)号：US06965025B2
公开(公告)日：2005-11-15
申请号：US10006191
申请日：2001-12-10
申请人： William Gaarde , Andrew T. Watt
发明人： William Gaarde , Andrew T. Watt
IPC分类号： A61K38/00 , C12N15/113 , C07H21/04 , A61K48/00 , C12N15/00
CPC分类号： C12N15/1136 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of connective tissue growth factor. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding connective tissue growth factor. Methods of using these compounds for modulation of connective tissue growth factor expression and for treatment of diseases associated with expression of connective tissue growth factor are provided.
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