公开(公告)号：US20170320909A1

公开(公告)日：2017-11-09

申请号：US15654876

申请日：2017-07-20

Applicant: EMD Millipore Corporation

Inventor： Alex Xenopoulos ,  Michael Phillips ,  Wilson Moya ,  Jad Jaber ,  Mikhail Kozlov ,  Ajish Potty ,  Matthew T. Stone ,  William Cataldo ,  Christopher Gillespie

IPC: C07K1/36 ,  C12M1/00 ,  B01D15/18 ,  B01D15/36 ,  B01D15/12 ,  C12N7/00 ,  C07K16/00 ,  B01D15/38

CPC classification number: C07K1/36 ,  B01D15/125 ,  B01D15/1871 ,  B01D15/362 ,  B01D15/363 ,  B01D15/3809 ,  B01D15/3847 ,  C07K16/00 ,  C07K2317/14 ,  C12M29/04 ,  C12M43/00 ,  C12M47/12 ,  C12N7/00

Abstract: The present invention relates to improved processes and systems for purification of biological molecules, where the processes can be performed in a continuous manner.

公开(公告)号：US20150133636A1

公开(公告)日：2015-05-14

申请号：US14400389

申请日：2013-06-21

Applicant: EMD Millipore Corporation

Inventor： Alex Xenopoulos ,  Michael Phillips ,  Wilson Moya ,  Jad Jaber ,  Mikhail Kozlov ,  Ajish Potty ,  Matthew T. Stone ,  William Cataldo ,  Christopher Gillespie

IPC: C07K1/36 ,  B01D15/18 ,  C12M1/00 ,  C07K16/00 ,  C12N7/00

CPC classification number: C07K1/36 ,  B01D15/125 ,  B01D15/1871 ,  B01D15/362 ,  B01D15/363 ,  B01D15/3809 ,  B01D15/3847 ,  C07K16/00 ,  C07K2317/14 ,  C12M29/04 ,  C12M43/00 ,  C12M47/12 ,  C12N7/00

Abstract: The present invention relates to improved processes and systems for purification of biological molecules, where the processes can be performed in a continuous manner.

Abstract translation: 本发明涉及用于纯化生物分子的改进方法和系统，其中所述方法可以以连续的方式进行。

公开(公告)号：US20250092089A1

公开(公告)日：2025-03-20

申请号：US18890289

申请日：2024-09-19

Applicant: North Carolina State University ,  Merck Sharp and Dohme LLC ,  EMD Millipore Corporation ,  Rensselaer Polytechnic Institute

Inventor： Stefano Menegatti ,  Ruben G. Carbonell ,  Jacob P. LeBarre ,  Cristiana Boi ,  Steven Cramer ,  Michael Phillips ,  David Roush

IPC: C07K1/16 ,  B01D15/34 ,  B01D15/36

Abstract: The present disclosure provides methods related to the purification of a biologic. In particular, the present disclosure methods for purifying a biologic using a multifunctional chromatography medium comprising porous beads or particles having a defined pore diameter distribution and one or more ligands conjugated to the surface of the pores capable of removing process-related impurities and product-related impurities from a target biologic.