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    Purification of proteins
    2.
    发明授权
    Purification of proteins 有权

    公开(公告)号：US10233211B2

    公开(公告)日：2019-03-19

    申请号：US13955024

    申请日：2013-07-31

    Applicant: EMD Millipore Corporation

    Inventor： Wilson Moya ,  Jad Jaber

    IPC: C07K1/32 ,  C07K1/30

    CPC classification number: C07K1/32 ,  C07K1/30

    Abstract: The present invention relates to a selectively soluble polymer capable of binding to a desired molecules in an unclarified mixture containing various biological materials and the methods of using such a polymer to purify a molecule from such a mixture. The polymer is soluble in the mixture under a certain set of process conditions such as pH or temperature and/or salt concentration and is rendered insoluble and precipitates out of solution upon a change in the process conditions. The polymer is capable of binding to the desired molecule (protein, polypeptide, etc) and remains capable of binding to that molecule even after the polymer is precipitated out of solution. The precipitate can then be filtered out from the remainder of the stream and the desired biomolecule is recovered such as by elution and further processed.

    Purification of Proteins
    4.
    发明申请
    Purification of Proteins 有权
    蛋白质的纯化

    公开(公告)号：US20130317204A1

    公开(公告)日：2013-11-28

    申请号：US13955024

    申请日：2013-07-31

    Applicant: EMD Millipore Corporation

    Inventor： Wilson Moya ,  Jad Jaber

    IPC: C07K1/32

    CPC classification number: C07K1/32 ,  C07K1/30

    Abstract: The present invention relates to a selectively soluble polymer capable of binding to a desired molecules in an unclarified mixture containing various biological materials and the methods of using such a polymer to purify a molecule from such a mixture. The polymer is soluble in the mixture under a certain set of process conditions such as pH or temperature and/or salt concentration and is rendered insoluble and precipitates out of solution upon a change in the process conditions. The polymer is capable of binding to the desired molecule (protein, polypeptide, etc) and remains capable of binding to that molecule even after the polymer is precipitated out of solution. The precipitate can then be filtered out from the remainder of the stream and the desired biomolecule is recovered such as by elution and further processed.

    Abstract translation: 本发明涉及能够在含有各种生物材料的未澄清混合物中结合所需分子的选择性可溶性聚合物以及使用这种聚合物从这种混合物中纯化分子的方法。 聚合物在一定的工艺条件例如pH或温度和/或盐浓度下可溶于混合物中，并且在工艺条件改变时变得不溶解并沉淀出溶液。 聚合物能够结合到所需的分子（蛋白质，多肽等），并且即使在聚合物从溶液中沉淀出来之后仍然能够结合该分子。 然后可以从流的其余部分过滤出沉淀物，并回收所需的生物分子，例如通过洗脱和进一步处理。

    Purification of proteins
    7.
    发明授权
    Purification of proteins 有权

    公开(公告)号：US09376464B2

    公开(公告)日：2016-06-28

    申请号：US13747495

    申请日：2013-01-23

    Applicant: EMD Millipore Corporation

    Inventor： Wilson Moya ,  Jad Jaber

    IPC: C07K1/30 ,  C07K1/32

    CPC classification number: C07K1/32 ,  C07K1/30

    Abstract: The present invention relates to a selectively soluble polymer capable of binding to a desired biomolecules in a mixture containing various biological materials and the methods of using such a polymer to purify a biomolecule from such a mixture. The polymer is soluble in the mixture under a certain set of process conditions such as pH or temperature and/or salt concentration and is rendered insoluble and precipitates out of solution upon a change in the process conditions. The polymer is capable of binding to the desired biomolecule (protein, polypeptide, etc) and remains capable of binding to that biomolecule even after the polymer is precipitated out of solution. The precipitate can then be filtered out from the remainder of the stream and the desired biomolecule is recovered such as by elution and further processed.

    Purification of proteins
    10.
    发明授权
    Purification of proteins 有权

    公开(公告)号：US09227994B2

    公开(公告)日：2016-01-05

    申请号：US13955024

    申请日：2013-07-31

    Applicant: EMD Millipore Corporation

    Inventor： Wilson Moya ,  Jad Jaber

    IPC: A23J1/00 ,  C07K1/00 ,  C07K1/32 ,  C07K1/30

    CPC classification number: C07K1/32 ,  C07K1/30

    Abstract: The present invention relates to a selectively soluble polymer capable of binding to a desired molecules in an unclarified mixture containing various biological materials and the methods of using such a polymer to purify a molecule from such a mixture. The polymer is soluble in the mixture under a certain set of process conditions such as pH or temperature and/or salt concentration and is rendered insoluble and precipitates out of solution upon a change in the process conditions. The polymer is capable of binding to the desired molecule (protein, polypeptide, etc) and remains capable of binding to that molecule even after the polymer is precipitated out of solution. The precipitate can then be filtered out from the remainder of the stream and the desired biomolecule is recovered such as by elution and further processed.

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