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公开(公告)号:US20240287560A1
公开(公告)日:2024-08-29
申请号:US17757752
申请日:2020-12-22
Applicant: FIRMENICH SA
Inventor: Laurent DAVIET , Yang HUANG , Vincent HARRACA , Michel SCHALK , Monica BANDERA
IPC: C12P15/00 , A01N65/08 , A01P7/04 , A61K31/045 , A61K31/11 , A61K36/185 , C11B9/00 , C11B9/02 , C12N9/02 , C12N9/88 , C12P5/00 , C12P7/02
CPC classification number: C12P15/00 , A01N65/08 , A01P7/04 , A61K31/045 , A61K31/11 , A61K36/185 , C11B9/0003 , C11B9/02 , C12N9/0042 , C12N9/0071 , C12N9/88 , C12P5/007 , C12P7/02 , C12Y106/02004 , C12Y402/03082
Abstract: Described herein is a biochemically produced sandalwood oil including at least 85% santalol and bergamotol and 1% or less cis-lanceol, where the oil has one or more of the following features: i) 5% or less alpha-santalal; ii) 5% or less farnesol; and iii) 0.5% or less spirosantalol. Also described herein are a perfuming composition including the sandalwood oil and a perfuming consumer product including the sandalwood oil. Also described herein are a method of using the biochemically produced sandalwood oil as an anti-microbial and anti-inflammatory agent, and an arthropod control composition including the sandalwood oil.
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公开(公告)号:US20180208948A1
公开(公告)日:2018-07-26
申请号:US15330813
申请日:2015-05-06
Applicant: Firmenich SA
Inventor: Laurent DAVIET , Olivier HAEFLIGER , Xiu-Feng HE , Jian LI , Yu-Hua ZHANG
CPC classification number: C12P7/02 , C12N9/88 , C12Y402/03
Abstract: The present invention relates to a method of producing drimenol and/or drimenol derivatives by contacting at least one polypeptide with farnesyl diphosphate. The method may be performed in vitro or in vivo. The present invention also provides amino acid sequences of polypeptides useful in the method of the invention and nucleic acid encoding the polypeptides of the invention. The method further provides host cells or organisms genetically modified to express the polypeptides of the invention and useful to produce drimenol and/or drimenol derivatives.
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公开(公告)号:US20210310031A1
公开(公告)日:2021-10-07
申请号:US17271474
申请日:2019-10-14
Applicant: FIRMENICH SA
Inventor: Daniel SOLIS ESCALANTE , Christian GÖRNER , Laurent DAVIET , Qi WANG
Abstract: Described herein are novel methods for the acetyl transferase-catalyzed production of drimanyl-acetate compounds by the acetylation of the respective drimanyl alcohol sources performed in vitro or in vivo. Also described herein is the identification of enzymes having corresponding acetyl transferase activity from different microbial and plant sources. Also described herein is the provision of enzyme mutants derived from the newly identified enzymes. Further described herein is the provision of corresponding coding sequences of such enzymes and mutants, recombinant vectors, and recombinant host cells suitable for the production of such acetyl transferases and mutants and for performing the novel production methods of drimanyl acetate compounds. Still further described herein is a method of using such drimanyl acetates as intermediates for the production of odorant, flavor or fragrance or insect/pest control ingredients.
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公开(公告)号:US20180208946A1
公开(公告)日:2018-07-26
申请号:US15877183
申请日:2018-01-22
Applicant: FIRMENICH SA
Inventor: Laurent DAVIET , Letizia ROCCI , Michel SCHALK
CPC classification number: C12P5/007 , C12N9/0071 , C12N9/0079 , C12P7/02 , C12Y114/13 , C12Y114/14001
Abstract: This invention relates generally to methods and compositions for producing a sesquiterpene alcohol comprising contacting a sesquiterpene with a P450 polypeptide with monooxygenase activity.
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公开(公告)号:US20160215301A1
公开(公告)日:2016-07-28
申请号:US15023640
申请日:2014-09-19
Applicant: FIRMENICH SA
Inventor: Laurent DAVIET , Letizia ROCCI , Michel SCHALK
CPC classification number: C12P5/007 , C12N9/0071 , C12N9/0079 , C12P7/02 , C12Y114/13 , C12Y114/14001
Abstract: Methods and compositions for producing a sesquiterpene alcohol comprising contacting a sesquiterpene with a p450 polypeptide with monooxygenase activity.
Abstract translation: 包括用于制备倍半萜醇的方法和组合物,包括使倍半萜烯与单加氧酶活性的p450多肽接触。
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