DRIMENOL SYNTHASES I
    2.
    发明申请

    公开(公告)号:US20180208948A1

    公开(公告)日:2018-07-26

    申请号:US15330813

    申请日:2015-05-06

    Applicant: Firmenich SA

    CPC classification number: C12P7/02 C12N9/88 C12Y402/03

    Abstract: The present invention relates to a method of producing drimenol and/or drimenol derivatives by contacting at least one polypeptide with farnesyl diphosphate. The method may be performed in vitro or in vivo. The present invention also provides amino acid sequences of polypeptides useful in the method of the invention and nucleic acid encoding the polypeptides of the invention. The method further provides host cells or organisms genetically modified to express the polypeptides of the invention and useful to produce drimenol and/or drimenol derivatives.

    METHOD FOR PRODUCING DRIMANYL ACETATE COMPOUNDS

    公开(公告)号:US20210310031A1

    公开(公告)日:2021-10-07

    申请号:US17271474

    申请日:2019-10-14

    Applicant: FIRMENICH SA

    Abstract: Described herein are novel methods for the acetyl transferase-catalyzed production of drimanyl-acetate compounds by the acetylation of the respective drimanyl alcohol sources performed in vitro or in vivo. Also described herein is the identification of enzymes having corresponding acetyl transferase activity from different microbial and plant sources. Also described herein is the provision of enzyme mutants derived from the newly identified enzymes. Further described herein is the provision of corresponding coding sequences of such enzymes and mutants, recombinant vectors, and recombinant host cells suitable for the production of such acetyl transferases and mutants and for performing the novel production methods of drimanyl acetate compounds. Still further described herein is a method of using such drimanyl acetates as intermediates for the production of odorant, flavor or fragrance or insect/pest control ingredients.

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