公开(公告)号：US20250146030A1

公开(公告)日：2025-05-08

申请号：US19006763

申请日：2024-12-31

Applicant: Firmenich SA

Inventor： Daniel SOLIS ESCALANTE ,  Christian GÖRNER ,  Laurent DAVIET ,  Qi WANG

IPC: C12P7/62 ,  C12P7/02

Abstract: Described herein are methods for the acetyl transferase-catalyzed production of drimanyl-acetate compounds by the acetylation of the respective drimanyl alcohol sources performed in vitro or in vivo. Also described herein is the identification of enzymes having corresponding acetyl transferase activity from different microbial and plant sources. Also described herein is the provision of enzyme mutants derived from the newly identified enzymes. Further described herein is the provision of corresponding coding sequences of such enzymes and mutants, recombinant vectors, and recombinant host cells suitable for the production of such acetyl transferases and mutants and for performing the novel production methods of drimanyl acetate compounds. Still further described herein is a method of using such drimanyl acetates as intermediates for the production of odorant, flavor or fragrance or insect/pest control ingredients.

公开(公告)号：US20180094281A1

公开(公告)日：2018-04-05

申请号：US15564671

申请日：2016-04-11

Applicant: Firmenich SA

Inventor： Michel SCHALK ,  Fabienne DEGUERRY ,  Pan LI ,  Xiufeng HE ,  Qi WANG

IPC: C12P5/00 ,  C12N9/88

CPC classification number: C12P5/007 ,  C12N9/88 ,  C12Y402/03039 ,  C12Y402/03079

Abstract: Provided herein is an isolated polypeptide from Juniperus virginiana, Platycladus orientalis ‘Beverleyensis’ or Platycladus orientalis comprising a (+)-cedrol or a (−)-thujopsene synthase. Further provided herein is an isolated nucleic acid molecule from Juniperus virginiana, Platycladus orientalis ‘Beverleyensis’ or Platycladus orientalis encoding a (+)-cedrol or (−)-thujopsene synthase. Further provided herein are methods of producing (+)-cedrol or (−)-thujopsene.

公开(公告)号：US20210310031A1

公开(公告)日：2021-10-07

申请号：US17271474

申请日：2019-10-14

Applicant: FIRMENICH SA

Inventor： Daniel SOLIS ESCALANTE ,  Christian GÖRNER ,  Laurent DAVIET ,  Qi WANG

IPC: C12P7/62 ,  C12P7/02

Abstract: Described herein are novel methods for the acetyl transferase-catalyzed production of drimanyl-acetate compounds by the acetylation of the respective drimanyl alcohol sources performed in vitro or in vivo. Also described herein is the identification of enzymes having corresponding acetyl transferase activity from different microbial and plant sources. Also described herein is the provision of enzyme mutants derived from the newly identified enzymes. Further described herein is the provision of corresponding coding sequences of such enzymes and mutants, recombinant vectors, and recombinant host cells suitable for the production of such acetyl transferases and mutants and for performing the novel production methods of drimanyl acetate compounds. Still further described herein is a method of using such drimanyl acetates as intermediates for the production of odorant, flavor or fragrance or insect/pest control ingredients.

公开(公告)号：US20240376502A1

公开(公告)日：2024-11-14

申请号：US17760705

申请日：2020-11-25

Applicant: FIRMENICH SA

Inventor： Qi WANG ,  Michel SCHALK

IPC: C12P7/22 ,  C12N9/14 ,  C12P5/00

Abstract: Described herein are plant-derived haloacid dehalogenase-like (HAD-like) polypeptides having cyclic terpene synthase (TPS) activity, in particular suitable for use in biochemical methods of producing drimane-type sesquiterpenes, encompassing drimenol and/or albicanol and related compounds, like phosphorylated drimane-type sesquiterpene alcohols, in particular phosphorylated drimenol and/or albicanol compounds and derivatives. Also described herein are the coding nucleotide sequences of the TPS activity, corresponding expression constructs, recombinant hosts, and methods of preparing such polypeptides and mutants and variants thereof. Also described herein is a method of using such polypeptides, the method including using the polypeptides in the production of odorants, flavours and fragrance ingredients.

公开(公告)号：US20240374666A1

公开(公告)日：2024-11-14

申请号：US18685391

申请日：2022-10-05

Applicant: Firmenich SA

Inventor： Qi WANG ,  Dong-Fang CHEN ,  Yong Ming YUAN ,  Yongtao WU ,  Frederic ZUCCA

IPC: A61K36/15 ,  A61K36/03 ,  A61K36/185 ,  A61K36/537 ,  A61K36/61 ,  A61K36/67 ,  A61K36/82 ,  A61K36/9066 ,  A61K45/06 ,  A61P31/14 ,  G01N33/50

Abstract: Described herein is a composition for use in the prevention or treatment of a viral infection, where the composition includes an extract, wherein the extract: (i) is a botanical extract; (ii) reduces viral infection into a host cell, with an IC50 of 10 ppm or less; and (iii) has a zeta potential of 10 mV or less. Also described herein are consumer goods and methods of using the composition.