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公开(公告)号：US09643972B2
公开(公告)日：2017-05-09
申请号：US14933863
申请日：2015-11-05
发明人： Hilary Plake Beck , Juan Carlos Jaen , Maksim Osipov , Jay Patrick Powers , Maureen Kay Reilly , Hunter Paul Shunatona , James Ross Walker , Mikhail Zibinsky , James Aaron Balog , David K. Williams , Jay A. Markwalder , Emily Charlotte Cherney , Weifang Shan , Audris Huang
IPC分类号： A61K31/4709 , C07D487/04 , C07D215/06 , A61K31/47 , C07D231/56 , A61K31/416 , C07D215/233 , C07D471/04 , A61K31/437 , C07D239/74 , A61K31/517 , A61K31/4375 , C07D217/04 , C07D405/08 , C07D417/08 , C07D401/12 , C07D401/14 , A61K31/506 , A61K31/496 , A61K31/519 , A61K45/06
CPC分类号： C07D487/04 , A61K31/416 , A61K31/437 , A61K31/4375 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/517 , A61K31/519 , A61K45/06 , C07D215/06 , C07D215/14 , C07D215/233 , C07D217/04 , C07D231/56 , C07D239/74 , C07D401/12 , C07D401/14 , C07D405/08 , C07D405/12 , C07D417/08 , C07D417/12 , C07D471/04
摘要： Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.
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公开(公告)号：US10533014B2
公开(公告)日：2020-01-14
申请号：US16123912
申请日：2018-09-06
发明人： Hilary Plake Beck , Juan Carlos Jaen , Maksim Osipov , Jay Patrick Powers , Maureen Kay Reilly , Hunter Paul Shunatona , James Ross Walker , Mikhail Zibinsky , James Aaron Balog , David K. Williams , Jay A. Markwalder , Emily Charlotte Cherney , Weifang Shan , Audris Huang
IPC分类号： C07D487/04 , A61K31/47 , C07D215/06 , C07D231/56 , A61K31/416 , C07D215/233 , C07D471/04 , A61K31/437 , C07D239/74 , A61K31/517 , A61K31/4375 , C07D217/04 , C07D405/08 , A61K31/4709 , C07D417/08 , C07D401/12 , C07D401/14 , A61K31/506 , A61K31/496 , A61K31/519 , A61K45/06 , C07D215/14 , C07D405/12 , C07D417/12 , A61P35/02 , C07D215/12 , C07D217/12 , C07D217/24 , A61K39/395
摘要： Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.
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公开(公告)号：US09598422B2
公开(公告)日：2017-03-21
申请号：US14933879
申请日：2015-11-05
发明人： Hilary Plake Beck , Juan Carlos Jaen , Maksim Osipov , Jay Patrick Powers , Maureen Kay Reilly , Hunter Paul Shunatona , James Ross Walker , Mikhail Zibinsky , James Aaron Balog , David K. Williams , Jay A. Markwalder , Steven P. Seitz , Emily Charlotte Cherney , Liping Zhang , Weifang Shan , Weiwei Guo , Audris Huang
IPC分类号： C07C255/50 , A61K31/277 , C07C233/65 , C07D487/04 , A61K31/166 , C07D211/08 , A61K31/445 , C07C211/45 , A61K31/136 , C07D215/04 , A61K31/47 , A61K31/4709 , C07D215/233 , C07D213/68 , A61K31/4412 , A61K31/496 , A61K31/519 , A61K31/5377 , A61K45/06 , A61K31/00
CPC分类号： A61K31/166 , A61K31/00 , A61K31/136 , A61K31/277 , A61K31/4412 , A61K31/445 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K45/06 , C07C211/45 , C07C217/80 , C07C233/10 , C07C233/59 , C07C233/60 , C07C233/65 , C07C233/74 , C07C255/50 , C07C255/58 , C07C275/30 , C07C2601/14 , C07D211/08 , C07D213/68 , C07D215/04 , C07D215/233 , C07D487/04
摘要： Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.
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公开(公告)号：US11932601B2
公开(公告)日：2024-03-19
申请号：US17552517
申请日：2021-12-16
发明人： Hilary Plake Beck , Juan Carlos Jaen , Maksim Osipov , Jay Patrick Powers , Maureen Kay Reilly , Hunter Paul Shunatona , James Ross Walker , Mikhail Zibinsky , James Aaron Balog , David K. Williams , Weiwei Guo
IPC分类号： C07D213/75 , A61K31/167 , A61K31/195 , A61K31/277 , A61K31/343 , A61K31/426 , A61K31/44 , A61K31/505 , A61K31/5375 , A61K39/39 , A61K45/06 , A61P35/00 , A61P37/06 , C07C233/11 , C07C233/15 , C07C233/28 , C07C233/29 , C07C233/66 , C07C235/26 , C07C235/36 , C07C235/38 , C07C237/20 , C07C237/22 , C07C255/57 , C07C255/60 , C07C317/40 , C07C317/44 , C07C321/28 , C07C323/41 , C07D207/27 , C07D213/56 , C07D231/12 , C07D239/42 , C07D277/30 , C07D295/15 , C07D295/155 , C07D309/04 , C07D309/06 , C07D317/46 , C07D317/66 , A61K39/00
CPC分类号： C07D213/75 , A61K31/167 , A61K31/195 , A61K31/277 , A61K31/343 , A61K31/426 , A61K31/44 , A61K31/505 , A61K31/5375 , A61K39/39 , A61K45/06 , A61P35/00 , A61P37/06 , C07C233/11 , C07C233/15 , C07C233/28 , C07C233/29 , C07C233/66 , C07C235/26 , C07C235/36 , C07C235/38 , C07C237/20 , C07C237/22 , C07C255/57 , C07C255/60 , C07C317/40 , C07C317/44 , C07C321/28 , C07C323/41 , C07D207/27 , C07D213/56 , C07D231/12 , C07D239/42 , C07D277/30 , C07D295/15 , C07D295/155 , C07D309/04 , C07D309/06 , C07D317/46 , C07D317/66 , A61K2039/55511 , C07C2601/02 , C07C2601/08 , C07C2601/14 , Y02A50/30 , A61K31/167 , A61K2300/00 , A61K31/195 , A61K2300/00 , A61K31/426 , A61K2300/00
摘要： Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.
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公开(公告)号：US11242319B2
公开(公告)日：2022-02-08
申请号：US15524113
申请日：2015-11-05
发明人： Hilary Plake Beck , Juan Carlos Jaen , Maksim Osipov , Jay Patrick Powers , Maureen Kay Reilly , Hunter Paul Shunatona , James Ross Walker , Mikhail Zibinsky , James Aaron Balog , David K. Williams , Weiwei Guo
IPC分类号： C07D213/75 , A61K45/06 , A61K31/167 , C07C255/60 , C07C317/40 , C07D239/42 , C07C233/15 , C07D295/155 , C07C233/29 , C07C237/22 , C07C233/66 , C07D213/56 , C07C321/28 , C07D295/15 , C07C235/26 , A61K31/195 , C07C255/57 , C07C235/38 , C07D207/27 , C07D231/12 , C07C317/44 , C07C237/20 , C07D309/06 , C07D309/04 , C07C235/36 , C07D317/46 , C07D277/30 , A61K31/426 , A61K39/39 , A61P35/00 , A61P37/06 , A61K31/277 , A61K31/343 , A61K31/44 , A61K31/505 , A61K31/5375 , C07C233/11 , C07C233/28 , C07C323/41 , C07D317/66 , A61K39/00
摘要： Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.
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公开(公告)号：US10106546B2
公开(公告)日：2018-10-23
申请号：US15469707
申请日：2017-03-27
发明人： Hilary Plake Beck , Juan Carlos Jaen , Maksim Osipov , Jay Patrick Powers , Maureen Kay Reilly , Hunter Paul Shunatona , James Ross Walker , Mikhail Zibinsky , James Aaron Balog , David K. Williams , Jay A. Markwalder , Emily Charlotte Cherney , Weifang Shan , Audris Huang
IPC分类号： A61K31/47 , C07D487/04 , C07D215/06 , C07D231/56 , A61K31/416 , C07D215/233 , C07D471/04 , A61K31/437 , C07D239/74 , A61K31/517 , A61K31/4375 , C07D217/04 , C07D405/08 , A61K31/4709 , C07D417/08 , C07D401/12 , C07D401/14 , A61K31/506 , A61K31/496 , A61K31/519 , A61K45/06 , C07D215/14 , C07D405/12 , C07D417/12
摘要： Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.
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公开(公告)号：US20170197973A1
公开(公告)日：2017-07-13
申请号：US15469707
申请日：2017-03-27
发明人： Hilary Plake Beck , Juan Carlos Jaen , Maksim Osipov , Jay Patrick Powers , Maureen Kay Reilly , Hunter Paul Shunatona , James Ross Walker , Mikhail Zibinsky , James Aaron Balog , David K. Williams , Jay A. Markwalder , Emily Charlotte Cherney , Weifang Shan , Audris Huang
IPC分类号： C07D487/04 , C07D215/14 , A61K31/416 , C07D231/56 , A61K45/06 , C07D215/233 , C07D471/04 , A61K31/437 , A61K31/517 , C07D239/74 , A61K31/4375 , A61K31/4709 , C07D405/12 , C07D401/12 , C07D417/12 , A61K31/496 , C07D401/14 , A61K31/519 , A61K31/506 , A61K31/47
CPC分类号： C07D215/12 , A61K31/416 , A61K31/437 , A61K31/4375 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/517 , A61K31/519 , A61K39/39558 , A61K45/06 , A61K2300/00 , A61P35/02 , C07D215/06 , C07D215/14 , C07D215/233 , C07D217/04 , C07D217/12 , C07D217/24 , C07D231/56 , C07D239/74 , C07D401/12 , C07D401/14 , C07D405/08 , C07D405/12 , C07D417/08 , C07D417/12 , C07D471/04 , C07D487/04
摘要： Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.
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公开(公告)号：US10206893B2
公开(公告)日：2019-02-19
申请号：US15422118
申请日：2017-02-01
发明人： Hilary Plake Beck , Juan Carlos Jaen , Maksim Osipov , Jay Patrick Powers , Maureen Kay Reilly , Hunter Paul Shunatona , James Ross Walker , Mikhail Zibinsky , James Aaron Balog , David K. Williams , Jay A. Markwalder , Steven P. Seitz , Emily Charlotte Cherney , Liping Zhang , Weifang Shan , Weiwei Guo , Audris Huang
IPC分类号： A61K31/166 , A61K31/5377 , A61K31/497 , A61K31/506 , A61K45/06 , A61K31/4709 , C07D487/04 , C07C255/50 , A61K31/277 , C07C233/65 , C07D211/08 , A61K31/445 , C07C211/45 , A61K31/136 , C07D215/04 , A61K31/47 , C07D215/233 , C07D213/68 , A61K31/4412 , A61K31/496 , A61K31/519 , A61K31/00 , C07C255/58 , C07C275/30 , C07C217/80 , C07C233/10 , C07C233/59 , C07C233/60 , C07C233/74
摘要： Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.
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公开(公告)号：US20190002472A1
公开(公告)日：2019-01-03
申请号：US16123912
申请日：2018-09-06
发明人： Hilary Plake Beck , Juan Carlos Jaen , Maksim Osipov , Jay Patrick Powers , Maureen Kay Reilly , Hunter Paul Shunatona , James Ross Walker , Mikhail Zibinsky , James Aaron Balog , David K. Williams , Jay A. Markwalder , Emily Charlotte Cherney , Weifang Shan , Audris Huang
IPC分类号： C07D487/04 , A61K45/06 , C07D405/12 , A61K31/496 , A61K31/506 , C07D401/14 , C07D401/12 , C07D417/08 , A61K31/4709 , C07D405/08 , C07D217/04 , A61K31/4375 , A61K31/517 , C07D239/74 , A61K31/437 , C07D471/04 , C07D215/233 , A61K31/416 , C07D231/56 , A61K31/47 , C07D215/06 , C07D417/12 , C07D215/14 , A61K31/519
摘要： Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.
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公开(公告)号：US20180325889A1
公开(公告)日：2018-11-15
申请号：US15524092
申请日：2015-11-05
发明人： Hilary Plake BECK , Juan Carlos JAEN , Maksim OSIPOV , Jay Patrick POWERS , Maureen Kay REILLY , Hunter Paul SHUNATONA , James Ross WALKER , Mikhail ZIBINSKY , James Aaron BALOG , David K. Williams , Jay A. MARKWALDER , Steven P. SEITZ , Emily Charlotte CHERNEY , Liping ZHANG , Weifang SHAN , Weiwei GUO , Audris HUANG
IPC分类号： A61K31/47 , A61P35/00 , A61K31/381
CPC分类号： A61K31/47 , A61K31/00 , A61K31/136 , A61K31/166 , A61K31/277 , A61K31/381 , A61K31/4412 , A61K31/445 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K45/06 , A61K2300/00 , A61P35/00 , C07C211/45 , C07C217/80 , C07C233/10 , C07C233/59 , C07C233/60 , C07C233/65 , C07C233/74 , C07C255/50 , C07C255/58 , C07C275/30 , C07C2601/14 , C07D211/08 , C07D213/68 , C07D215/04 , C07D215/233 , C07D487/04 , C07K16/18
摘要： Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.
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