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公开(公告)号：US20220274926A1
公开(公告)日：2022-09-01
申请号：US17552517
申请日：2021-12-16
发明人： Hilary Plake BECK , Juan Carlos JAEN , Maksim OSIPOV , Jay Patrick POWERS , Maureen Kay REILLY , Hunter Paul SHUNATONA , James Ross WALKER , Mikhail ZIBINSKY , James Aaron BALOG , David K. WILLIAMS , Weiwei GUO
IPC分类号： C07D213/75 , A61K45/06 , A61K31/167 , C07C255/60 , C07C317/40 , C07D239/42 , C07C233/15 , C07D295/155 , C07C233/29 , C07C237/22 , C07C233/66 , C07D213/56 , C07C321/28 , C07D295/15 , C07C235/26 , A61K31/195 , C07C255/57 , C07C235/38 , C07D207/27 , C07D231/12 , C07C317/44 , C07C237/20 , C07D309/06 , C07D309/04 , C07C235/36 , C07D317/46 , C07D277/30 , A61K31/426 , A61K39/39 , A61P35/00 , A61P37/06 , A61K31/277 , A61K31/343 , A61K31/44 , A61K31/505 , A61K31/5375 , C07C233/11 , C07C233/28 , C07C323/41 , C07D317/66
摘要： Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.
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公开(公告)号：US09540353B2
公开(公告)日：2017-01-10
申请号：US14759622
申请日：2014-01-07
发明人： Lloyd F. Mackenzie , Thomas B. Macrury , Curtis Harwig , David Bogucki , Jeffery R. Raymond , Jeremy D. Pettigrew , Vladimir Khlebnikov , Rudong Shan
IPC分类号： C07D213/82 , C07C49/83 , C07C43/205 , A61K31/44 , A61K31/05 , C07D405/12 , C07C49/835 , C07C43/215 , C07C62/34 , C07D241/24 , C07D213/81 , C07D249/08 , C07D295/112 , C07D213/75 , C07D295/215 , C07D211/66 , C07C311/18 , C07D213/89 , C07D233/64 , C07D401/12 , C07C233/76 , C07D213/38 , C07C39/17 , C07C43/21 , C07C43/23 , C07C49/84 , C07C62/32 , C07C255/47 , C07C275/26 , C07C275/64 , C07C279/16 , C07C311/07 , C07C311/17 , C07C317/22 , C07C217/84 , C07C323/20 , C07C225/20 , C07C233/26 , C07C233/28 , C07C233/31 , C07C233/32 , C07C233/60 , C07C235/82 , C07C237/08
CPC分类号： A61K31/4965 , A61K31/05 , A61K31/085 , A61K31/09 , A61K31/095 , A61K31/10 , A61K31/12 , A61K31/122 , A61K31/135 , A61K31/155 , A61K31/165 , A61K31/166 , A61K31/167 , A61K31/192 , A61K31/277 , A61K31/4164 , A61K31/4196 , A61K31/4402 , A61K31/4406 , A61K31/443 , A61K31/4439 , A61K31/444 , A61K31/4465 , A61K31/495 , A61K31/496 , C07B2200/07 , C07C39/17 , C07C43/21 , C07C43/215 , C07C43/23 , C07C49/83 , C07C49/835 , C07C49/84 , C07C62/32 , C07C62/34 , C07C217/84 , C07C225/20 , C07C233/26 , C07C233/28 , C07C233/31 , C07C233/32 , C07C233/60 , C07C233/76 , C07C235/82 , C07C237/08 , C07C255/47 , C07C275/26 , C07C275/64 , C07C279/16 , C07C311/07 , C07C311/17 , C07C311/18 , C07C317/22 , C07C323/20 , C07C2602/28 , C07D211/66 , C07D213/38 , C07D213/75 , C07D213/81 , C07D213/82 , C07D213/89 , C07D233/64 , C07D241/24 , C07D249/08 , C07D295/112 , C07D295/215 , C07D401/12 , C07D405/12
摘要： Compounds of formula (I): where, n, R1, R4a, R4b, R5, R7 and R8 are defined herein, or pharmaceutically acceptable salts thereof, are described herein. The disclosed compounds have activity as SHIP1 modulators, and thus may be used to treat any of a variety of diseases, disorders or conditions that would benefit from SHIP1 modulation. Compositions comprising a compound of formula (I) in combination with a pharmaceutically acceptable carrier or diluent are also disclosed, as are methods of SHIP1 modulation by administration of such compounds to an animal in need thereof.
摘要翻译： 本文描述式（I）的化合物：其中，n，R1，R4a，R4b，R5，R7和R8如本文所定义，或其药学上可接受的盐。 所公开的化合物具有作为SHIP1调节剂的活性，因此可用于治疗将受益于SHIP1调节的各种疾病，障碍或病症中的任何一种。 还公开了包含式（I）化合物与药学上可接受的载体或稀释剂的组合物，以及通过将这些化合物施用于有此需要的动物的SHIP1调节方法。
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3.发明申请Analgesics, anaesthetics, antifoulants, aversants, irritants, incapacitants and compositions containing the same 失效止痛药，麻醉剂，防污剂，厌食者，刺激物，丧失能力和含有它们的组合物公开(公告)号：US20070225515A1
公开(公告)日：2007-09-27
申请号：US11387277
申请日：2006-03-23
申请人： Mel Blum
发明人： Mel Blum
IPC分类号： C07C233/28
CPC分类号： C07C237/04 , A01N37/44 , C07C233/18 , C07C233/20 , C07C2601/14 , C07C2602/42 , A01N55/02 , A01N2300/00
摘要： Compounds and compositions the same. Method of making the compounds. The compounds and/or compositions used as an analgesic, anaesthetic, antifoulant, aversant, irritant, sternutator, neurodegenerator, counter irritant (delayed), rubifaciant, stomachic, fungicide, insecticide, preservative, circulatory stimulant, cardio-protective agent, immune booster, decongestant, anti-inflammatory agent, incapacitant, biocide, mildewcide, pharmaceutical, repellent, flavorant, carminative, antismoking agent, and/or antithrombotic agent. One of the compounds being lidocaine nonivamide. The compositions comprising one or more of: the compounds, one or more of an antioxidant, a UV absorber, and one or more biocides such as, for example, OBPA.
摘要翻译： 化合物和组成相同。 制备化合物的方法。 用作止痛剂，麻醉剂，防污剂，反应剂，刺激物，骨化剂，神经变性反应物，抗刺激剂（延迟剂），罗红糖，胃酸，杀真菌剂，杀虫剂，防腐剂，循环兴奋剂，心脏保护剂，免疫增强剂， 减充血剂，消炎剂，丧失能力，杀生物剂，防霉剂，药物，驱避剂，调味剂，助剂，抗静电剂和/或抗血栓形成剂。 其中一种化合物是利多卡因非维生素。 所述组合物包含以下物质中的一种或多种：所述化合物，抗氧化剂，UV吸收剂和一种或多种杀生物剂中的一种或多种，例如OBPA。
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公开(公告)号：US4666943A
公开(公告)日：1987-05-19
申请号：US514799
申请日：1983-07-19
申请人： Hiroshi Noguchi , Toshiro Kato , Junya Takahashi , Yukio Ishiguri , Shigeo Yamamoto , Naonori Hirata
发明人： Hiroshi Noguchi , Toshiro Kato , Junya Takahashi , Yukio Ishiguri , Shigeo Yamamoto , Naonori Hirata
IPC分类号： A01N37/18 , A01N37/08 , A01N37/22 , A01N37/24 , A01N37/32 , A01N37/34 , A01N37/36 , A01N37/40 , A01N37/46 , A01N39/02 , A01N39/04 , A01N43/24 , A01N47/34 , A01N53/00 , A01N53/04 , A01N53/12 , A01N57/30 , C07C67/00 , C07C231/00 , C07C231/02 , C07C233/02 , C07C233/07 , C07C233/08 , C07C233/09 , C07C233/11 , C07C233/12 , C07C233/15 , C07C233/25 , C07C233/27 , C07C233/28 , C07C233/29 , C07C233/43 , C07C233/46 , C07C233/55 , C07C233/58 , C07C233/65 , C07C235/24 , C07C235/56 , C07C237/06 , C07C239/00 , C07C251/48 , C07C253/00 , C07C255/27 , C07C255/44 , C07C255/60
摘要： Use of an anilide of the formula: ##STR1## as a fungicidal agent against phytophatogenic fungi, particularly their strains resistant to benzimidazole thiophanate fungicides and/or cyclic imide fungicides.
摘要翻译： 使用下式的酰苯胺：作为杀真菌剂的植物致病真菌，特别是其对苯并咪唑硫氮菌素杀真菌剂和/或环状酰亚胺杀真菌剂有抗性的菌株。
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公开(公告)号：US11932601B2
公开(公告)日：2024-03-19
申请号：US17552517
申请日：2021-12-16
发明人： Hilary Plake Beck , Juan Carlos Jaen , Maksim Osipov , Jay Patrick Powers , Maureen Kay Reilly , Hunter Paul Shunatona , James Ross Walker , Mikhail Zibinsky , James Aaron Balog , David K. Williams , Weiwei Guo
IPC分类号： C07D213/75 , A61K31/167 , A61K31/195 , A61K31/277 , A61K31/343 , A61K31/426 , A61K31/44 , A61K31/505 , A61K31/5375 , A61K39/39 , A61K45/06 , A61P35/00 , A61P37/06 , C07C233/11 , C07C233/15 , C07C233/28 , C07C233/29 , C07C233/66 , C07C235/26 , C07C235/36 , C07C235/38 , C07C237/20 , C07C237/22 , C07C255/57 , C07C255/60 , C07C317/40 , C07C317/44 , C07C321/28 , C07C323/41 , C07D207/27 , C07D213/56 , C07D231/12 , C07D239/42 , C07D277/30 , C07D295/15 , C07D295/155 , C07D309/04 , C07D309/06 , C07D317/46 , C07D317/66 , A61K39/00
CPC分类号： C07D213/75 , A61K31/167 , A61K31/195 , A61K31/277 , A61K31/343 , A61K31/426 , A61K31/44 , A61K31/505 , A61K31/5375 , A61K39/39 , A61K45/06 , A61P35/00 , A61P37/06 , C07C233/11 , C07C233/15 , C07C233/28 , C07C233/29 , C07C233/66 , C07C235/26 , C07C235/36 , C07C235/38 , C07C237/20 , C07C237/22 , C07C255/57 , C07C255/60 , C07C317/40 , C07C317/44 , C07C321/28 , C07C323/41 , C07D207/27 , C07D213/56 , C07D231/12 , C07D239/42 , C07D277/30 , C07D295/15 , C07D295/155 , C07D309/04 , C07D309/06 , C07D317/46 , C07D317/66 , A61K2039/55511 , C07C2601/02 , C07C2601/08 , C07C2601/14 , Y02A50/30 , A61K31/167 , A61K2300/00 , A61K31/195 , A61K2300/00 , A61K31/426 , A61K2300/00
摘要： Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.
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公开(公告)号：US11242319B2
公开(公告)日：2022-02-08
申请号：US15524113
申请日：2015-11-05
发明人： Hilary Plake Beck , Juan Carlos Jaen , Maksim Osipov , Jay Patrick Powers , Maureen Kay Reilly , Hunter Paul Shunatona , James Ross Walker , Mikhail Zibinsky , James Aaron Balog , David K. Williams , Weiwei Guo
IPC分类号： C07D213/75 , A61K45/06 , A61K31/167 , C07C255/60 , C07C317/40 , C07D239/42 , C07C233/15 , C07D295/155 , C07C233/29 , C07C237/22 , C07C233/66 , C07D213/56 , C07C321/28 , C07D295/15 , C07C235/26 , A61K31/195 , C07C255/57 , C07C235/38 , C07D207/27 , C07D231/12 , C07C317/44 , C07C237/20 , C07D309/06 , C07D309/04 , C07C235/36 , C07D317/46 , C07D277/30 , A61K31/426 , A61K39/39 , A61P35/00 , A61P37/06 , A61K31/277 , A61K31/343 , A61K31/44 , A61K31/505 , A61K31/5375 , C07C233/11 , C07C233/28 , C07C323/41 , C07D317/66 , A61K39/00
摘要： Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.
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公开(公告)号：US10272081B2
公开(公告)日：2019-04-30
申请号：US15884044
申请日：2018-01-30
发明人： Lloyd F. Mackenzie , Thomas B. MacRury , Curtis Harwig , David Bogucki , Jeffery R. Raymond , Jeremy D. Pettigrew , Vladimir Khlebnikov , Rudong Shan
IPC分类号： A61K31/05 , A61K31/09 , A61K31/10 , A61K31/12 , C07C39/17 , C07C43/21 , C07C43/23 , C07C49/83 , C07C49/84 , C07C62/32 , C07C62/34 , A61K31/085 , A61K31/095 , A61K31/122 , A61K31/135 , A61K31/155 , A61K31/165 , A61K31/166 , A61K31/167 , A61K31/192 , A61K31/4965 , C07D405/12 , C07C49/835 , C07C43/215 , C07D241/24 , C07D213/81 , C07D249/08 , C07D295/112 , C07D213/75 , C07D295/215 , C07D211/66 , C07C311/18 , C07D213/82 , C07D213/89 , C07D233/64 , C07D401/12 , C07C233/76 , C07D213/38 , C07C255/47 , C07C275/26 , C07C275/64 , C07C279/16 , C07C311/07 , C07C311/17 , C07C317/22 , C07C217/84 , C07C323/20 , C07C225/20 , C07C233/26 , C07C233/28 , C07C233/31 , C07C233/32 , C07C233/60 , C07C235/82 , C07C237/08 , A61K31/277 , A61K31/4164 , A61K31/4196 , A61K31/4402 , A61K31/4406 , A61K31/443 , A61K31/4439 , A61K31/444 , A61K31/4465 , A61K31/495 , A61K31/496
摘要： Compounds of formula (I): where n, R1, R4a, R4b, R5, R7 and R8 are defined herein, or pharmaceutically acceptable salts thereof, are described herein. The disclosed compounds have activity as SHIP1 modulators, and thus may be used to treat any of a variety of diseases, disorders or conditions that would benefit from SHIP1 modulation. Compositions comprising a compound of formula (I) in combination with a pharmaceutically acceptable carrier or diluent are also disclosed, as are methods of SHIP1 modulation by administration of such compounds to an animal in need thereof.
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8.发明授权Compositions and method comprising aminoalcohol derivatives as membrane penetration enhancers for physiological active agents 失效包含氨基醇衍生物作为生理活性剂的膜渗透增强剂的组合物和方法
公开(公告)号：US5482965A
公开(公告)日：1996-01-09
申请号：US115772
申请日：1993-09-03
IPC分类号： A61K47/16 , A61K8/41 , A61K8/44 , A61K8/49 , A61K9/00 , A61K31/23 , A61K31/335 , A61K47/18 , A61K47/22 , A61Q7/00 , A61Q17/02 , A61Q19/00 , C07C233/18 , C07C233/28 , C07D319/06 , A61K31/27 , A61K31/16 , A61K31/22 , A61K31/225
CPC分类号： A61K9/0014 , A61K47/18 , A61K47/22 , A61K8/41 , A61K8/44 , A61K8/4953 , A61K8/498 , A61Q19/00 , C07C233/18 , C07C233/28 , C07D319/06 , A61Q17/02 , A61Q17/04 , A61Q7/00 , A61Q9/04 , Y10S514/946 , Y10S514/947
摘要： A method and compositions for enhancing absorption of topically administered physiologically active agents through the skin and mucous membranes of humans and animals in a transdermal device or formulation for local or systemic use, comprising a therapeutically effective amount of a pharmaceutically active agent and a non-toxic, effective amount of penetration enhancing agent of the formula I or a physiologically acceptable salt thereof: ##STR1## wherein: R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as defined herein.
摘要翻译： 一种用于增强局部或全身用途的透皮装置或制剂中通过人和动物的皮肤和粘膜吸收局部施用的生理活性剂的方法和组合物，其包含治疗有效量的药物活性剂和无毒的 ，有效量的式I的渗透增强剂或其生理上可接受的盐：其中：R1，R2，R3和R4如本文所定义。
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公开(公告)号：US20190092729A1
公开(公告)日：2019-03-28
申请号：US15524113
申请日：2015-11-05
发明人： Hilary Plake BECK , Juan Carlos JAEN , Maksim OSIPOV , Jay Patrick POWERS , Maureen Kay REILLY , Hunter Paul SHUNATONA , James Ross WALKER , Mikhail ZIBINSKY , James Aaron BALOG , David K. WILLIAMS , Weiwei GUO
IPC分类号： C07D213/75 , A61K31/44 , C07D239/42 , A61K31/505 , C07C233/28 , A61K31/167 , C07C233/15 , C07C233/11 , C07C255/60 , A61K31/277 , C07D317/66 , A61K31/343 , C07C323/41 , C07C317/40 , A61K45/06 , C07D295/155 , A61K31/5375 , A61P37/06
摘要： Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.
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10.发明授权Ink, ink cartridge, ink jet recording device, ink jet ink printed matter, compound, and composition 有权油墨，墨盒，喷墨记录装置，喷墨油墨印刷品，化合物和组合物公开(公告)号：US09593248B2
公开(公告)日：2017-03-14
申请号：US14287789
申请日：2014-05-27
申请人： RICOH COMPANY, LTD.
发明人： Mitsunobu Morita , Soh Noguchi , Okitoshi Kimura
IPC分类号： C07C233/20 , C07C233/28 , C07C233/38 , C07C233/49 , C07D211/22 , C07D211/46 , C07D295/195 , C07D295/215 , C08F22/38 , C08F26/06 , C08F120/56 , C08F120/58 , C08F120/60 , C08F220/56 , C08F220/60 , C08F220/58 , C08K3/04 , C09D11/30 , C09D11/101
CPC分类号： C09D11/101 , C07C233/20 , C07C233/49 , C07D211/22 , C07D211/46 , C07D295/195 , C07D295/215 , C08F22/38 , C08F26/06 , C08F120/56 , C08F120/58 , C08F120/60 , C08F220/56 , C08F220/58 , C08F220/60 , C08F2220/585 , C08F2220/606 , C08K3/04 , C09D11/107 , C09D11/30 , C09D11/324 , C09D11/38 , Y10T428/24802
摘要： Ink contains at least one of a compound represented by the following chemical formula 1, a compound represented by chemical formula 2, a compound represented by chemical formula 3, or a compound represented by chemical formula 4.
摘要翻译： 油墨含有以下化学式1表示的化合物，化学式2表示的化合物，化学式3表示的化合物或化学式4表示的化合物中的至少一种。
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