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    Arthroscopic impedance probe to detect cartilage degeneration
    8.
    发明授权
    Arthroscopic impedance probe to detect cartilage degeneration 失效
    关节镜阻抗探针检测软骨退化

    公开(公告)号：US06735468B2

    公开(公告)日：2004-05-11

    申请号：US09776254

    申请日：2001-02-02

    申请人： Steven Treppo ,  Alan J. Grodzinsky ,  Emerson Quan ,  Eliot Frank ,  David Bombard ,  David Breslau

    发明人： Steven Treppo ,  Alan J. Grodzinsky ,  Emerson Quan ,  Eliot Frank ,  David Bombard ,  David Breslau

    IPC分类号： A61B505

    CPC分类号： A61B5/4514 ,  A61B5/05 ,  A61B5/053 ,  A61B5/103 ,  A61B5/4528 ,  A61B5/6847 ,  A61B2562/0209 ,  A61B2562/0261

    摘要： The change in tissue impedance due to the change in the extracellular matrix that results from the degradation of cartilage is utilized to detect degradation of articular cartilage. A probe applies a current to the articular cartilage which results in a current distribution and electric field within the cartilage, along with an associated voltage drop across the electrodes. The amplitude of this voltage drop is then measured and divided by the current applied to determine the tissue impedance. By measuring the impedance of patient tissue and comparing the detected patient impedance to a normal value for the tissue from clinically normal tissue, a determination of whether the patient tissue is degraded and the extent of degradation is possible. Preferably, the impedance is measured using a probe with interdigitated electrodes. By changing which electrodes are utilized, the wavelength of the current distribution changes, allowing the probe to image depth dependent focal lesions.

    摘要翻译： 利用由软骨降解导致的细胞外基质变化引起的组织阻抗变化来检测关节软骨的降解。 探针将电流施加到关节软骨上，导致软骨内的电流分布和电场以及电极两端的相关电压降。 然后测量该电压降的幅度并除以施加的电流以确定组织阻抗。 通过测量患者组织的阻抗并将检测到的患者阻抗与来自临床正常组织的组织的正常值进行比较，确定患者组织是否劣化并且降解程度是可能的。 优选地，使用具有交错电极的探针来测量阻抗。 通过改变使用哪些电极，电流分布的波长发生变化，允许探针成像深度相关的局灶性病变。

    Arthroscopic impedance probe to detect cartilage degeneration
    9.
    发明授权
    Arthroscopic impedance probe to detect cartilage degeneration 失效
    关节镜阻抗探针检测软骨退化

    公开(公告)号：US06882880B2

    公开(公告)日：2005-04-19

    申请号：US10324717

    申请日：2002-12-19

    申请人： Steven Treppo ,  Alan J. Grodzinsky ,  Emerson Quan ,  Eliot Frank ,  David Bombard ,  David Breslau

    发明人： Steven Treppo ,  Alan J. Grodzinsky ,  Emerson Quan ,  Eliot Frank ,  David Bombard ,  David Breslau

    IPC分类号： A61B5/05 ,  A61B5/053 ,  A61B5/103

    CPC分类号： A61B5/4514 ,  A61B5/05 ,  A61B5/053 ,  A61B5/103 ,  A61B5/4528 ,  A61B5/6847 ,  A61B2562/0209 ,  A61B2562/0261

    摘要： The change in tissue impedance due to the change in the extracellular matrix that results from the degradation of cartilage is utilized to detect degradation of articular cartilage. A probe includes electrodes that apply a current to the articular cartilage which results in a current distribution and electric field within the cartilage, along with an associated voltage drop across the electrodes. The amplitude of this voltage drop is then measured and divided by the current applied to determine the tissue impedance. By measuring the impedance of patient tissue and comparing the detected patient impedance to a normal value for the tissue from clinically normal tissue, a determination of whether the patient tissue is degraded, and a determination of the extent of degradation is possible. Preferably, the impedance is measured using a probe with interdigitated electrodes. By changing which electrodes are utilized, the wavelength of the current distribution changes, allowing the probe to image depth dependent focal lesions.

    摘要翻译： 利用由软骨降解导致的细胞外基质变化引起的组织阻抗变化来检测关节软骨的降解。 探针包括向关节软骨施加电流的电极，其导致软骨内的电流分布和电场，以及电极两端的相关电压降。 然后测量该电压降的幅度并除以施加的电流以确定组织阻抗。 通过测量患者组织的阻抗并将检测到的患者阻抗与来自临床正常组织的组织的正常值进行比较，确定患者组织是否退化，并确定降解程度是可能的。 优选地，使用具有交错电极的探针来测量阻抗。 通过改变使用哪些电极，电流分布的波长发生变化，允许探针成像深度相关的局灶性病变。

    Arthroscopic impedance probe to detect cartilage degeneration
    10.
    发明授权
    Arthroscopic impedance probe to detect cartilage degeneration 失效
    关节镜阻抗探针检测软骨退化

    公开(公告)号：US06856834B2

    公开(公告)日：2005-02-15

    申请号：US10600918

    申请日：2003-06-20

    申请人： Steven Treppo ,  Alan J. Grodzinsky ,  Emerson Quan ,  Eliot Frank ,  David Bombard ,  David Breslau

    发明人： Steven Treppo ,  Alan J. Grodzinsky ,  Emerson Quan ,  Eliot Frank ,  David Bombard ,  David Breslau

    IPC分类号： A61B5/05 ,  A61B5/053 ,  A61B5/103

    CPC分类号： A61B5/4514 ,  A61B5/05 ,  A61B5/053 ,  A61B5/103 ,  A61B5/4528 ,  A61B5/6847 ,  A61B2562/0209 ,  A61B2562/0261

    摘要： The change in tissue impedance due to the change in the extracellular matrix that results from the degradation of cartilage is utilized to detect degradation of articular cartilage. A probe comprising electrodes is applies a current to the articular cartilage which results in a current distribution and electric field within the cartilage, along with an associated voltage drop across the electrodes. The amplitude of this voltage drop is then measured and divided by the current applied to determine the tissue impedance. By measuring the impedance of patient tissue and comparing the detected patient impedance to a normal value for the tissue from clinically normal tissue, a determination of whether the patient tissue is degraded and the extent of degradation is possible. Preferably, the impedance is measured using a probe with interdigitated electrodes. By changing which electrodes are utilized, the wavelength of the current distribution changes, allowing the probe to image depth dependent focal lesions.

    摘要翻译： 利用由软骨降解导致的细胞外基质变化引起的组织阻抗变化来检测关节软骨的降解。 包括电极的探针向关节软骨施加电流，其导致软骨内的电流分布和电场以及电极两端的相关电压降。 然后测量该电压降的幅度并除以施加的电流以确定组织阻抗。 通过测量患者组织的阻抗并将检测到的患者阻抗与来自临床正常组织的组织的正常值进行比较，确定患者组织是否劣化并且降解程度是可能的。 优选地，使用具有交错电极的探针来测量阻抗。 通过改变使用哪些电极，电流分布的波长发生变化，允许探针成像深度相关的局灶性病变。