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Patent Agency Ranking
公开(公告)号：US10041050B2
公开(公告)日：2018-08-07
申请号：US15355675
申请日：2016-11-18
Applicant: GE Healthcare BioProcess R&D AB
Inventor： Patrik Adielsson , Tobias E. Soderman , Anna Akerblom
Abstract: The present invention relates to a method for endotoxin removal from a sample comprising the following steps: combining the sample comprising one or more target molecule(s) with a chromatography media comprising beads having an inner porous core functionalized with ligands capable of binding endotoxin and an outer porous layer without functional groups and a pore size small enough to exclude the target molecule from the inner core; and collecting the sample from the media, wherein the sample comprises an endotoxin level which is at least 75% less, preferably 90% less, than before the removal and the yield of the target molecule is at least 75%.
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公开(公告)号：US20170067031A1
公开(公告)日：2017-03-09
申请号：US15355675
申请日：2016-11-18
Applicant: GE Healthcare BioProcess R&D AB
Inventor： Patrik Adielsson , Tobias E. Soderman , Anna Akerblom
CPC classification number: C12N7/00 , B01D15/3847 , C12N2760/16151
Abstract: The present invention relates to a method for endotoxin removal from a sample comprising the following steps: combining the sample comprising one or more target molecule(s) with a chromatography media comprising beads having an inner porous core functionalized with ligands capable of binding endotoxin and an outer porous layer without functional groups and a pore size small enough to exclude the target molecule from the inner core; and collecting the sample from the media, wherein the sample comprises an endotoxin level which is at least 75% less, preferably 90% less, than before the removal and the yield of the target molecule is at least 75%.
Abstract translation: 本发明涉及一种从样品中去除内毒素的方法，包括以下步骤：将包含一种或多种靶分子的样品与包含珠的色谱介质组合，所述珠粒具有由能够结合内毒素的配体功能化的内部多孔核心和 没有官能团的外部多孔层和足够小以从靶芯排出靶分子的孔径; 并从培养基中收集样品，其中样品包含与去除前相比至少75％以上，优选90％以下的内毒素水平，并且目标分子的产率为至少75％。
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公开(公告)号：US20160243526A1
公开(公告)日：2016-08-25
申请号：US15027146
申请日：2014-10-09
Applicant: GE HEALTHCARE BIOPROCESS R&D AB
Inventor： Tobias E. Soderman
IPC: B01J20/32 , C08F290/10 , B01D15/32 , B01J20/287
Abstract: The present invention relates to a method for production of a chromatography material. More closely, the invention relates to a method for production of a reverse phase chromatography (RPC) material comprising the following steps: introduction of unsaturated groups onto porous carbohydrate particles and grafting of styrenic monomers on said particles comprising an unsaturated group.
Abstract translation: 本发明涉及色谱材料的制造方法。 更详细地说，本发明涉及一种生产反相色谱（RPC）材料的方法，包括以下步骤：将不饱和基团引入到多孔碳水化合物颗粒上，并将苯乙烯单体接枝到包含不饱和基团的所述颗粒上。
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公开(公告)号：US20170120232A1
公开(公告)日：2017-05-04
申请号：US15407240
申请日：2017-01-16
Applicant: GE Healthcare BioProcess R&D AB
Inventor： Jesper Hansson , Gustav Rodrigo , Tobias E. Soderman
CPC classification number: B01J39/26 , B01D15/1864 , B01D15/34 , B01D15/361 , B01D15/362 , B01D15/3809 , B01J20/24 , B01J20/261 , B01J20/265 , B01J20/267 , B01J20/28014 , B01J20/28033 , B01J20/286 , B01J20/289 , B01J20/3085 , B01J20/3212 , B01J20/3278 , B01J20/3282 , B01J2220/80 , C07H1/08 , C07K1/22 , G01N2030/8827 , Y02P20/582
Abstract: The invention discloses a method of separating a biomolecule from at least one other component in a liquid, comprising a step of contacting said liquid with a separation matrix comprising a solid support and polymer chains bound to said solid support. The polymer chains comprise units derived from a first monomer of structure CH2═CH-L-X, where L is a covalent bond or an alkyl ether or hydroxysubstituted alkyl ether chain comprising 2-6 carbon atoms, and X is a sulfonate or phosphonate group.
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公开(公告)号：US09580692B2
公开(公告)日：2017-02-28
申请号：US14380477
申请日：2013-02-27
Applicant: GE Healthcare BioProcess R&D AB
Inventor： Patrik Adielsson , Tobias E. Soderman , Anna Akerblom
IPC: C12N7/02 , B01D15/36 , C12N7/00 , C07K1/20 , B01D15/38 , B01J20/24 , B01J20/285 , B01J20/286
CPC classification number: C12N7/00 , B01D15/363 , B01D15/3847 , B01J20/24 , B01J20/285 , B01J20/286 , C07K1/20 , C12N2760/16151
Abstract: The present invention relates to a method for endotoxin removal from a sample comprising the following steps: combining the sample comprising one or more target molecule(s) with a chromatography media comprising beads having an inner porous core functionalized with ligands capable of binding endotoxin and an outer porous layer without functional groups and a pore size small enough to exclude the target molecule from the inner core; and collecting the sample from the media, wherein the sample comprises an endotoxin level which is at least 75% less, preferably 90% less, than before the removal and the yield of the target molecule is at least 75%.
Abstract translation: 本发明涉及一种从样品中去除内毒素的方法，包括以下步骤：将包含一种或多种靶分子的样品与包含珠的色谱介质组合，所述珠粒具有由能够结合内毒素的配体功能化的内部多孔核心和 没有官能团的外部多孔层和足够小以从靶芯排出靶分子的孔径; 并从培养基中收集样品，其中样品包含与去除前相比至少75％以上，优选90％以下的内毒素水平，并且目标分子的产率为至少75％。
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