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    Methods of detecting myelin basic protein
    2.
    发明授权
    Methods of detecting myelin basic protein 有权
    检测髓鞘碱性蛋白的方法

    公开(公告)号：US09040019B2

    公开(公告)日：2015-05-26

    申请号：US13689819

    申请日：2012-11-30

    Applicant: General Electric Company

    Inventor： Tiberiu Mircea Siclovan ,  Cristina Abucay Tan Hehir ,  Rong Zhang ,  Victoria Eugenia Cotero ,  Anshika Bajaj

    IPC: A61K49/00 ,  G01N33/68

    CPC classification number: A61K49/0021 ,  A61K49/0002 ,  G01N33/6893 ,  G01N2800/285

    Abstract: A method and a kit for detecting myelin basic protein are provided. The method comprises administering an agent, which binds to myelin basic protein (MBP), to a subject at risk of or diagnosed with a myelin-associated neuropathy, and determining myelination by detecting the agent resided in the subject. The amount of the agent present in the subject is indicative of a myelin-associated neuropathy. A method of quantifying an amount of MBP present in a tissue sample is also provided, wherein the method comprises contacting the tissue sample with the same agent, detecting the agent present in the tissue sample; and quantifying an amount of the agent present in the tissue sample.

    Abstract translation: 提供了一种用于检测髓磷脂碱性蛋白的方法和试剂盒。 该方法包括将与髓磷脂碱性蛋白（MBP）结合的药剂施用于患有髓鞘相关性神经病的风险的受试者，并通过检测存在于受试者中的药物来确定髓鞘形成。 存在于受试者中的药剂的量指示髓鞘相关神经病变。 还提供了定量存在于组织样品中的MBP量的方法，其中所述方法包括使组织样品与相同的试剂接触，检测组织样品中存在的试剂; 并定量存在于组织样品中的试剂的量。

    METHODS OF DETECTING MYELIN BASIC PROTEIN
    3.
    发明申请
    METHODS OF DETECTING MYELIN BASIC PROTEIN 有权
    检测MYELIN基础蛋白的方法

    公开(公告)号：US20140154178A1

    公开(公告)日：2014-06-05

    申请号：US13689819

    申请日：2012-11-30

    Applicant: GENERAL ELECTRIC COMPANY

    Inventor： Tiberiu Mircea Siclovan ,  Cristina Abucay Tan Hehir ,  Rong Zhang ,  Victoria Eugenia Cotero ,  Anshika Bajaj

    IPC: A61K49/00 ,  C12Q1/02

    CPC classification number: A61K49/0021 ,  A61K49/0002 ,  G01N33/6893 ,  G01N2800/285

    Abstract: A method and a kit for detecting myelin basic protein are provided. The method comprises administering an agent, which binds to myelin basic protein (MBP), to a subject at risk of or diagnosed with a myelin-associated neuropathy, and determining myelination by detecting the agent resided in the subject. The amount of the agent present in the subject is indicative of a myelin-associated neuropathy. A method of quantifying an amount of MBP present in a tissue sample is also provided, wherein the method comprises contacting the tissue sample with the same agent, detecting the agent present in the tissue sample; and quantifying an amount of the agent present in the tissue sample.

    Abstract translation: 提供了一种用于检测髓磷脂碱性蛋白的方法和试剂盒。 该方法包括将与髓磷脂碱性蛋白（MBP）结合的药剂施用于患有髓鞘相关性神经病的风险的受试者，并通过检测存在于受试者中的药物来确定髓鞘形成。 存在于受试者中的药剂的量指示髓鞘相关神经病变。 还提供了定量存在于组织样品中的MBP量的方法，其中所述方法包括使组织样品与相同的试剂接触，检测组织样品中存在的试剂; 并定量存在于组织样品中的试剂的量。

    PRODUCTION OF CARBON-11 USING A LIQUID TARGET
    6.
    发明申请
    PRODUCTION OF CARBON-11 USING A LIQUID TARGET 审中-公开
    使用液体目标生产碳-11

    公开(公告)号：US20160035448A1

    公开(公告)日：2016-02-04

    申请号：US14448943

    申请日：2014-07-31

    Applicant: GENERAL ELECTRIC COMPANY

    Inventor： Tiberiu Mircea Siclovan ,  Peter Andras Zavodszky

    IPC: G21G1/00

    CPC classification number: G21G1/001 ,  G21G1/10 ,  G21G2001/0094

    Abstract: The present disclosure relates to the generation of radioisotopes, includes 11-carbon, from liquid targets. In certain embodiments, a liquid hydrazine target is employed which, when irradiated, such as with a charged particle beam, generates 11-carbon in a form that may be recovered and used in downstream processes, such as the generation of radiopharmaceuticals.

    Abstract translation: 本公开涉及从液体靶产生放射性同位素，包括11-碳。 在某些实施方案中，使用液体肼靶，当照射时，例如用带电粒子束，可以以可以回收并用于下游工艺（例如放射性药物的生成）的形式产生11碳。

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