公开(公告)号：US20240104948A1

公开(公告)日：2024-03-28

申请号：US18516417

申请日：2023-11-21

Applicant: Genentech, Inc.

Inventor： Jeffrey Ryan EASTHAM ,  Hartmut Koeppen ,  Xiao Li ,  Darya Yuryevna Orlova

IPC: G06V20/69 ,  G06T7/00 ,  G06T7/11 ,  G06V10/25 ,  G06V10/26 ,  G06V10/77 ,  G06V10/82

CPC classification number: G06V20/698 ,  G06T7/0012 ,  G06T7/11 ,  G06V10/25 ,  G06V10/267 ,  G06V10/77 ,  G06V10/82 ,  G06V20/695 ,  G06T2207/10056 ,  G06T2207/20021 ,  G06T2207/20081 ,  G06T2207/30024 ,  G06T2207/30096 ,  G06V2201/03

Abstract: Systems and methods relate to processing digital pathology images. More specifically, techniques include accessing a digital pathology image that depicts a section of a biological sample, wherein the digital pathology image comprises regions displaying reactivity to a plurality of stains. For each of a plurality of tiles of the digital pathology image, a local-density measurement is calculated for each of a plurality of biological object types. One or more spatial-distribution metrics may be generated for the biological object types based at least in part on the calculated local-density measurements. A tumor immunophenotype may then be generated for the digital pathology image based at least in part on the local-density measurements or the one or more spatial-distribution metrics.

公开(公告)号：US11299544B2

公开(公告)日：2022-04-12

申请号：US14850462

申请日：2015-09-10

Applicant: Genentech, Inc.

Inventor： Daniel Shin-Yu Chen ,  Priti Hegde ,  Hartmut Koeppen ,  Marcin Kowanetz

IPC: G01N33/574 ,  A61K39/00 ,  C07K16/28 ,  C12Q1/6886 ,  G01N33/68 ,  G06Q30/02

Abstract: Provided herein are biomarkers for the treatment of pathological conditions, such as cancer, and method of using PD-1/PD-L1 pathway antagonists. In particular, provided are biomarkers for patient selection and prognosis in cancer, as well as methods of therapeutic treatment, articles of manufacture and methods for making them, diagnostic kits, methods of detection and methods of advertising related thereto.

公开(公告)号：US20130078252A1

公开(公告)日：2013-03-28

申请号：US13622878

申请日：2012-09-19

Applicant: Genentech, Inc.

Inventor： Timothy R. Wilson ,  Hartmut Koeppen ,  Mark Merchant ,  Jeffrey Settleman

IPC: A61K39/00 ,  A61K31/437 ,  A61K39/395 ,  G01N33/74 ,  G01N33/573 ,  A61K31/4545 ,  A61K31/4439 ,  C12Q1/68 ,  G01N33/574

CPC classification number: A61K39/3955 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/4545 ,  A61K45/06 ,  C07K16/2863 ,  C07K16/3053 ,  C07K2317/75 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158 ,  G01N33/5091 ,  G01N33/573 ,  G01N33/5748 ,  G01N33/57488 ,  G01N33/57496 ,  G01N33/6872 ,  G01N33/74 ,  G01N2800/52 ,  A61K2300/00 ,  A61K39/39558

Abstract: The present invention relates generally to the fields of molecular biology and growth factor regulation. More specifically, the invention relates to therapies for the treatment of pathological conditions, such as cancer.

公开(公告)号：US08993249B2

公开(公告)日：2015-03-31

申请号：US13737550

申请日：2013-01-09

Applicant: Genentech, Inc.

Inventor： Maike Schmidt ,  Christopher Adam Callahan ,  Jo-Anne S. Hongo ,  Hartmut Koeppen ,  Ryan J. Watts

IPC: G01N33/53 ,  C07K16/00 ,  C07K16/18 ,  C07K16/28 ,  A61K39/395

CPC classification number: C07K16/2863

Abstract: The invention provides anti-NRP1 antibodies and methods of using the same.

Abstract translation: 本发明提供抗NRP1抗体及其使用方法。

公开(公告)号：US20140038959A1

公开(公告)日：2014-02-06

申请号：US13890411

申请日：2013-05-09

Applicant: Genentech, Inc.

Inventor： Klaus P. Hoeflich ,  Hartmut Koeppen ,  Christy Ong

IPC: A61K31/519 ,  A61K45/06

CPC classification number: A61K31/519 ,  A61K45/06 ,  A61K2300/00

Abstract: The present invention relates to a method of treating tumors wherein PAK1 is over-expressed or amplified by co-administering a PAK1 inhibitor and a second anti-hyper-proliferative agent

Abstract translation: 本发明涉及一种治疗肿瘤的方法，其中PAK1通过共同施用PAK1抑制剂和第二抗超增殖剂过表达或扩增

公开(公告)号：US20250052759A1

公开(公告)日：2025-02-13

申请号：US18933358

申请日：2024-10-31

Applicant: Genentech, Inc.

Inventor： Marcin Kowanetz ,  Daniel Shin-Yu Chen ,  Hartmut Koeppen

IPC: G01N33/574 ,  A61K39/00 ,  A61K39/395 ,  A61K45/06 ,  C07K16/28 ,  C07K16/30 ,  C12Q1/6886 ,  G06Q30/0241 ,  G06Q30/0251

Abstract: Provided herein are biomarkers for the treatment of pathological conditions, such as cancer, and method of using PD-1/PD-L1 pathway antagonists. In particular, provided are biomarkers for patient selection and prognosis in cancer, as well as methods of therapeutic treatment, articles of manufacture and methods for making them, diagnostic kits, methods of detection and methods of advertising related thereto.

公开(公告)号：US20240248092A1

公开(公告)日：2024-07-25

申请号：US18590121

申请日：2024-02-28

Applicant: Genentech, Inc.

Inventor： Marcin Kowantez ,  Daniel Shin-Yu Chen ,  Hartmut Koeppen

IPC: G01N33/574 ,  A61K39/00 ,  A61K39/395 ,  A61K45/06 ,  C07K16/28 ,  C07K16/30 ,  C12Q1/6886 ,  G06Q30/0241 ,  G06Q30/0251

CPC classification number: G01N33/57492 ,  A61K39/39558 ,  A61K45/06 ,  C07K16/2827 ,  C07K16/30 ,  C12Q1/6886 ,  G01N33/574 ,  G06Q30/0241 ,  G06Q30/0251 ,  A61K2039/505 ,  C07K2317/73 ,  C07K2317/76 ,  C12Q2600/106 ,  C12Q2600/158 ,  G01N2333/70532

Abstract: Provided herein are biomarkers for the treatment of pathological conditions, such as cancer, and method of using PD-1/PD-L1 pathway antagonists. In particular, provided are biomarkers for patient selection and prognosis in cancer, as well as methods of therapeutic treatment, articles of manufacture and methods for making them, diagnostic kits, methods of detection and methods of advertising related thereto.

公开(公告)号：US20250046063A1

公开(公告)日：2025-02-06

申请号：US18921918

申请日：2024-10-21

Applicant: Genentech, Inc. ,  Ventana Medical Systems, Inc. ,  Hoffmann-La Roche Inc. ,  Roche Molecular Systems, Inc.

Inventor： Karol Badowski ,  Hartmut Koeppen ,  Konstanty Korski ,  Yao Nie

IPC: G06V10/77 ,  G06V10/80 ,  G06V10/82 ,  G06V20/69

Abstract: Techniques described herein include, for example, generating a feature map for an input image, generating a plurality of concentric crops of the feature map, and generating an output vector that represents a characteristic of a structure depicted in a center region of the input image using the plurality of concentric crops. Generating the output vector may include, for example, aggregating sets of output features generated from the plurality of concentric crops, and several methods of aggregating are described. Applications to classification of a structure depicted in the center region of the input image are also described.

公开(公告)号：US20150125452A1

公开(公告)日：2015-05-07

申请号：US14535071

申请日：2014-11-06

Applicant: GENENTECH, INC.

Inventor： Timothy R. Wilson ,  Hartmut Koeppen ,  Mark Merchant ,  Jeffrey Settleman

IPC: A61K39/395 ,  G01N33/574 ,  C12Q1/68 ,  A61K31/437 ,  A61K31/4545

CPC classification number: A61K39/3955 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/4545 ,  A61K45/06 ,  C07K16/2863 ,  C07K16/3053 ,  C07K2317/75 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158 ,  G01N33/5091 ,  G01N33/573 ,  G01N33/5748 ,  G01N33/57488 ,  G01N33/57496 ,  G01N33/6872 ,  G01N33/74 ,  G01N2800/52 ,  A61K2300/00 ,  A61K39/39558

Abstract: The present invention relates generally to the fields of molecular biology and growth factor regulation. More specifically, the invention relates to therapies for the treatment of pathological conditions, such as cancer.

Abstract translation: 本发明一般涉及分子生物学和生长因子调节领域。 更具体地，本发明涉及用于治疗诸如癌症的病理状况的治疗。

公开(公告)号：US10240207B2

公开(公告)日：2019-03-26

申请号：US15272283

申请日：2016-09-21

Applicant: Genentech, Inc.

Inventor： Wei Yu ,  David Shames ,  Hartmut Koeppen ,  See Phan ,  Sandra Rost

IPC: C12Q1/6886 ,  C07K16/22 ,  C07K16/28 ,  A61K39/00

Abstract: The present invention concerns cancer biomarkers. In particular, the invention concerns HGF as a biomarker for patient selection and patient prognosis in cancer, as well as methods of therapeutic treatment, articles of manufacture and methods for making them, diagnostic kits, methods of detection and methods of advertising related thereto.