公开(公告)号：US20250115618A1

公开(公告)日：2025-04-10

申请号：US18988433

申请日：2024-12-19

Applicant: Genentech, Inc.

Inventor： Christopher MCBRIDE ,  Lynnie Lin TRZOSS ,  Amogh BOLOOR ,  Nadezda V. SOKOLOVA ,  Richard M. PASTOR ,  Steven Thomas STABEN ,  Craig STIVALA ,  Matthew VOLGRAF ,  Sarah M. BRONNER

IPC: C07D498/04 ,  A61P31/04 ,  A61P31/12 ,  A61P31/14 ,  A61P31/16 ,  A61P31/18 ,  C07D231/18 ,  C07D471/04 ,  C07D487/04 ,  C07D513/04

Abstract: The present disclosure relates to novel sulfonimidamide compounds and related compounds and their use in treating a disorder responsive to modulation of cytokines such as IL-1β and IL-18, modulation of NLRP3 or inhibition of the activation of NLRP3 or related components of the inflammatory process.

公开(公告)号：US20190144430A1

公开(公告)日：2019-05-16

申请号：US16247995

申请日：2019-01-15

Applicant: Genentech, Inc.

Inventor： Baihua HU ,  Vishal VERMA ,  Matthew VOLGRAF ,  Anthony ESTRADA ,  Joseph LYSSIKATOS

IPC: C07D403/04 ,  C07D231/12 ,  C07D401/04 ,  C07D231/20 ,  C07D239/26 ,  C07D231/16 ,  C07D213/61

Abstract: The invention is concerned with the compounds of formula I: and pharmaceutically acceptable salts thereof. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.

公开(公告)号：US20240391930A1

公开(公告)日：2024-11-28

申请号：US18670537

申请日：2024-05-21

Applicant: GENENTECH, INC. ,  CONVELO THERAPEUTICS, INC.

Inventor： Marie-Gabrielle BRAUN ,  Georgette CASTANEDO ,  William VERNIER ,  Matthew VOLGRAF ,  Michael SIU ,  James Guy BREITENBUCHER

IPC: C07D495/10 ,  A61K31/4155 ,  A61K31/4196 ,  A61K31/438 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/506

Abstract: The subject matter described herein is directed to myelin-promoting compounds of Formula I and pharmaceutical salts thereof, methods of preparing the compounds, pharmaceutical compositions comprising the compounds, and methods of administering the compounds for the treatment of disorders, such as myelin-related disorders.

公开(公告)号：US20230121700A1

公开(公告)日：2023-04-20

申请号：US17816855

申请日：2022-08-02

Applicant: Genentech, Inc.

Inventor： Jack Alexander TERRETT ,  Huifen CHEN ,  Lea CONSTANTINEAU-FORGET ,  Robin Larouche-Gauthier ,  Luce LÉPISSIER ,  Francis BEAUMIER ,  Martin DÉRY ,  Chantal GRAND-MAÎTRE ,  Claudio STURINO ,  Matthew VOLGRAF ,  Elisia VILLEMURE

IPC: C07D413/14 ,  C07D473/30 ,  C07D471/04 ,  A61P29/00 ,  C07D513/04 ,  C07D487/04 ,  A61P25/00 ,  C07D498/04 ,  A61K31/427 ,  A61P23/00 ,  A61P11/00

Abstract: The invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof wherein A, X, R1, R4 and n are as defined herein. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.

公开(公告)号：US20210253596A1

公开(公告)日：2021-08-19

申请号：US17150349

申请日：2021-01-15

Applicant: Genentech, Inc.

Inventor： Christopher MCBRIDE ,  Lynnie Lin TRZOSS ,  Amogh BOLOOR ,  Nadezda V. SOKOLOVA ,  Richard M. PASTOR ,  Steven Thomas STABEN ,  Craig STIVALA ,  Matthew VOLGRAF ,  Sarah M. BRONNER

IPC: C07D498/04 ,  C07D231/18 ,  C07D471/04 ,  C07D487/04 ,  C07D513/04 ,  A61P31/04 ,  A61P31/12 ,  A61P31/18 ,  A61P31/16 ,  A61P31/14

Abstract: The present disclosure relates to novel sulfonimidamide compounds and related compounds and their use in treating a disorder responsive to modulation of cytokines such as IL-1β and IL-18, modulation of NLRP3 or inhibition of the activation of NLRP3 or related components of the inflammatory process.

公开(公告)号：US20250122184A1

公开(公告)日：2025-04-17

申请号：US18985661

申请日：2024-12-18

Applicant: Genentech, Inc.

Inventor： Jack Alexander TERRETT ,  Huifen CHEN ,  Lea CONSTANTINEAU-FORGET ,  Robin Larouche-Gauthier ,  Luce LÉPISSIER ,  Francis BEAUMIER ,  Martin DÉRY ,  Chantal GRAND-MAÎTRE ,  Claudio STURINO ,  Matthew VOLGRAF ,  Elisia VILLEMURE

IPC: C07D413/14 ,  A61K31/427 ,  A61P11/00 ,  A61P23/00 ,  A61P25/00 ,  A61P29/00 ,  C07D471/04 ,  C07D473/30 ,  C07D487/04 ,  C07D498/04 ,  C07D513/04

Abstract: The invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof wherein A, X, R1, R4 and n are as defined herein. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.

公开(公告)号：US20240400579A1

公开(公告)日：2024-12-05

申请号：US18670520

申请日：2024-05-21

Applicant: GENENTECH, INC. ,  CONVELO THERAPEUTICS, INC.

Inventor： William VERNIER ,  Matthew VOLGRAF ,  Marie-Gabrielle BRAUN ,  Georgette Marie CASTANEDO ,  Paul Anthony GIBBONS ,  James Guy BREITENBUCHER ,  Drew ADAMS ,  Brad LANG

IPC: C07D495/10 ,  A61K31/407 ,  A61K31/4155 ,  A61K31/438 ,  A61K31/4439 ,  A61K31/506

Abstract: The subject matter described herein is directed to myelin-promoting compounds of Formula I and pharmaceutical salts thereof, methods of preparing the compounds, pharmaceutical compositions comprising the compounds, and methods of administering the compounds for the treatment of myelin-related disorders.

公开(公告)号：US20240228463A1

公开(公告)日：2024-07-11

申请号：US18584311

申请日：2024-02-22

Applicant: Genentech, Inc.

Inventor： Marc KSCHONSAK ,  Steven John MCKERRALL ,  Daniel Fred ORTWINE ,  Jian Mehr-Dean PAYANDEH ,  Benjamin Douglas SELLERS ,  John C. TELLIS ,  Matthew VOLGRAF ,  Philippe BERGERON ,  Claudio CIFERRI ,  Peter Scott DRAGOVICH

IPC: C07D401/12 ,  A61K31/18 ,  A61P25/04 ,  C07C311/51 ,  C07D211/96 ,  C07D277/44 ,  C07D277/82 ,  C07D295/26 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04

CPC classification number: C07D401/12 ,  A61K31/18 ,  A61P25/04 ,  C07C311/51 ,  C07D211/96 ,  C07D277/44 ,  C07D277/82 ,  C07D295/26 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04

Abstract: The invention provides compounds of formulae I, II, IIa, and III:




and pharmaceutically acceptable salts thereof, as well as compositions containing such compounds and methods for using such compounds and compositions.

公开(公告)号：US20190284189A1

公开(公告)日：2019-09-19

申请号：US16421114

申请日：2019-05-23

Applicant: Genentech, Inc.

Inventor： Huifen CHEN ,  Daniel SHORE ,  Elisia VILLEMURE ,  Matthew VOLGRAF ,  Baihua HU ,  Aijun LU ,  Andrew CRIDLAND ,  Stuart WARD ,  Francis BEAUMIER ,  Martin DERY ,  Robin LAROUCHE-GAUTHIER

IPC: C07D473/30 ,  C07D471/04 ,  C07D513/04 ,  C07D487/04

Abstract: The invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula (I) as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as respiratory disorders or pain.

公开(公告)号：US20190167681A1

公开(公告)日：2019-06-06

申请号：US16269973

申请日：2019-02-07

Applicant: Genentech, Inc.

Inventor： Vishal VERMA ,  Matthew VOLGRAF ,  Baihua HU

IPC: A61K31/506 ,  A61P11/00

Abstract: The invention provides compounds of formula I: and pharmaceutically acceptable salts thereof where R1 is a substituted or unsubstituted phenyl or a fused bicyclic comprising a substituted or unsubstituted phenyl. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.