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公开(公告)号：US20240182476A1
公开(公告)日：2024-06-06
申请号：US18450646
申请日：2023-08-16
Applicant: GILEAD SCIENCES, INC. , CARNA BIOSCIENCES, INC.
Inventor： Masaaki Sawa , Mai Arai , Ryoko Nakai , Hirokazu Matsumoto , Catherine Pugh , Eric Hu , Juan Guerrero , Jesse Jacobsen , Jonathan William Medley , Jie Xu , Latesh Lad , Leena Patel , Michael Graupe , Qingming Zhu , Stephen Holmbo , Tetsuya Kobayashi , Will Watkins , Yasamin Moazami , Suet C. Yeung , Julian A. Codelli , Heath A. Weaver
IPC: C07D487/04 , A61K31/395 , A61K31/519 , A61K31/5377 , A61K31/538 , A61K31/55 , A61K31/553 , A61K31/695 , A61K31/704 , A61K31/7068 , A61K35/15 , A61K35/17 , A61K39/395 , A61K45/06 , C07D519/00 , C07F7/18
CPC classification number: C07D487/04 , A61K31/519 , A61K31/5377 , A61K31/538 , A61K31/55 , A61K31/553 , A61K31/5545 , A61K31/695 , A61K31/704 , A61K31/7068 , A61K35/15 , A61K35/17 , A61K39/3955 , A61K45/06 , C07D519/00 , C07F7/1804
Abstract: The present disclosure provides diacylglycerol kinase modulating compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.
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公开(公告)号：US20250066328A1
公开(公告)日：2025-02-27
申请号：US18784100
申请日：2024-07-25
Applicant: Gilead Sciences, Inc.
Inventor： Jonah J. Chang , Jayaraman Chandrasekhar , Kevin S. Currie , Stephen D. Holmbo , Jesse M. Jacobsen , David L. Kukla , Seung H. Lee , Yasamin Moazami , Leena B. Patel , Thomas J. Paul , Stephane Perreault , Patrick J. Salvo , Jennifer A. Treiberg , Heath A. Weaver
IPC: C07D401/14 , A61K9/00 , A61K9/02 , A61K9/20 , A61K9/48 , A61K31/501 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/5383 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/26 , A61K47/36 , A61K47/38 , A61K47/44 , C07D403/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D491/048 , C07D498/04
Abstract: Provided herein is a compound of Formula (I): or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, a pharmaceutical composition comprising a compound of the present disclosure, together with a pharmaceutically acceptable excipient thereof, and a method of treating cancer with the same.
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公开(公告)号：US11932634B2
公开(公告)日：2024-03-19
申请号：US17845469
申请日：2022-06-21
Applicant: Gilead Sciences, Inc.
Inventor： Michael Graupe , Juan A. Guerrero , Stephen D. Holmbo , Jesse M. Jacobsen , Tetsuya Kobayashi , Leena B. Patel , Heath A. Weaver , Jie Xu , Suet C. Yeung
IPC: C07D413/14 , C07D239/95 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/04 , C07D417/12 , C07D471/04
CPC classification number: C07D413/14 , C07D239/95 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/04 , C07D417/12 , C07D471/04 , C07B2200/05
Abstract: The present disclosure provides diacylglycerol kinase modulating compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.
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公开(公告)号：US20230060004A1
公开(公告)日：2023-02-23
申请号：US17845469
申请日：2022-06-21
Applicant: Gilead Sciences, Inc.
Inventor： Michael Graupe , Juan A. Guerrero , Stephen D. Holmbo , Jesse M. Jacobsen , Tetsuya Kobayashi , Leena B. Patel , Heath A. Weaver , Jie Xu , Suet C. Yeung
IPC: C07D413/14 , C07D239/95 , C07D401/12 , C07D417/12 , C07D403/12 , C07D401/04 , C07D471/04 , C07D413/04 , C07D401/14
Abstract: The present disclosure provides diacylglycerol kinase modulating compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.
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公开(公告)号：US11845723B2
公开(公告)日：2023-12-19
申请号：US17127297
申请日：2020-12-18
Applicant: GILEAD SCIENCES, INC. , CARNA BIOSCIENCES, INC.
Inventor： Masaaki Sawa , Mai Arai , Ryoko Nakai , Hirokazu Matsumoto , Catherine Pugh , Eric Hu , Juan Guerrero , Jesse Jacobsen , Jonathan William Medley , Jie Xu , Latesh Lad , Leena Patel , Michael Graupe , Qingming Zhu , Stephen Holmbo , Tetsuya Kobayashi , Will Watkins , Yasamin Moazami , Suet C. Yeung , Julian A. Codelli , Heath A. Weaver
IPC: C07D487/04 , A61K31/519 , A61K31/5377 , A61K31/538 , A61K31/55 , A61K31/553 , A61K31/704 , A61K31/7068 , C07D519/00 , A61K31/554 , A61K31/695 , A61K31/395 , A61K35/15 , A61K35/17 , A61K39/395 , A61K45/06 , C07F7/18
CPC classification number: C07D487/04 , A61K31/519 , A61K31/538 , A61K31/5377 , A61K31/55 , A61K31/553 , A61K31/5545 , A61K31/695 , A61K31/704 , A61K31/7068 , A61K35/15 , A61K35/17 , A61K39/3955 , A61K45/06 , C07D519/00 , C07F7/1804
Abstract: The present disclosure provides diacylglycerol kinase modulating compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.
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Patent Agency Ranking
公开(公告)号：US20230365529A1
公开(公告)日：2023-11-16
申请号：US18160082
申请日：2023-01-26
Applicant: Gilead Sciences, Inc.
Inventor： Jayaraman Chandrasekhar , Jonah J. Chang , Kevin S. Currie , Stephen D. Holmbo , Jesse M. Jacobsen , David L. Kukla , Seung H. Lee , Yasamin Moazami , Leena B. Patel , Thomas J. Paul , Stephane Perreault , Patrick J. Salvo , Jennifer A. Treiberg , Heath A. Weaver
IPC: C07D471/04 , C07D405/14 , C07D401/14 , C07D487/04 , C07D498/04 , C07D413/14 , C07D491/107 , C07D495/04 , C07D417/14
CPC classification number: C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/107 , C07D495/04 , C07D498/04
Abstract: Provided herein is a compound of Formula I:
or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, a pharmaceutical composition comprising a compound of the present invention, together with a pharmaceutically acceptable excipient thereof, and a method of treating cancer with the same.-
公开(公告)号：US20230183216A1
公开(公告)日：2023-06-15
申请号：US18050139
申请日：2022-10-27
Applicant: Gilead Sciences, Inc.
Inventor： Gayatri Balan , Jayaraman Chandrasekhar , Jonah J. Chang , Kevin S. Currie , Stephen D. Holmbo , Jesse M. Jacobsen , Jeffrey E. Kropf , Seung H. Lee , Yasamin Moazami , Leena B. Patel , Thomas J. Paul , Stephane Perreault , Patrick J. Salvo , Jennifer A. Treiberg , Heath A. Weaver
IPC: C07D403/14 , C07D487/04 , C07D403/12 , C07D405/14 , C07D493/08
CPC classification number: C07D403/14 , C07D487/04 , C07D403/12 , C07D405/14 , C07D493/08
Abstract: Provided herein is a compound of Formula (I)
wherein the various substituents are described herein.-
公开(公告)号：US20240400568A1
公开(公告)日：2024-12-05
申请号：US18645837
申请日：2024-04-25
Applicant: GILEAD SCIENCES, INC. , CARNA BIOSCIENCES, INC.
Inventor： Masaaki Sawa , Mai Arai , Ryoko Nakai , Hirokazu Matsumoto , Catherine Pugh , Eric Hu , Juan Guerrero , Jesse Jacobsen , Jonathan William Medley , Jie Xu , Latesh Lad , Leena Patel , Michael Graupe , Qingming Zhu , Stephen Holmbo , Tetsuya Kobayashi , Will Watkins , Yasamin Moazami , Suet C. Yeung , Julian A. Codelli , Heath A. Weaver
IPC: C07D487/04 , A61K31/395 , A61K31/519 , A61K31/5377 , A61K31/538 , A61K31/55 , A61K31/553 , A61K31/695 , A61K31/704 , A61K31/7068 , A61K35/15 , A61K35/17 , A61K39/395 , A61K45/06 , C07D519/00 , C07F7/18
Abstract: The present disclosure provides diacylglycerol kinase modulating compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.
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公开(公告)号：US20240199596A1
公开(公告)日：2024-06-20
申请号：US18413767
申请日：2024-01-16
Applicant: Gilead Sciences, Inc.
Inventor： Michael Graupe , Juan A. Guerrero , Stephen D. Holmbo , Jesse M. Jacobsen , Tetsuya Kobayashi , Leena B. Patel , Heath A. Weaver , Jie Xu , Suet C. Yeung
IPC: C07D413/14 , C07D239/95 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/04 , C07D417/12 , C07D471/04
CPC classification number: C07D413/14 , C07D239/95 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/04 , C07D417/12 , C07D471/04 , C07B2200/05
Abstract: The present disclosure provides diacylglycerol kinase modulating compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.
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公开(公告)号：US11976072B2
公开(公告)日：2024-05-07
申请号：US17845534
申请日：2022-06-21
Applicant: Gilead Sciences, Inc.
Inventor： Julian A. Codelli , Michael Graupe , Juan A. Guerrero , Stephen D. Holmbo , Tetsuya Kobayashi , Yasamin Moazami , Leena B. Patel , Heath A. Weaver , Jie Xu , Suet C. Yeung , QingMing Zhu
IPC: C07D487/04 , A61P31/18 , A61P31/20 , A61P35/00 , A61P35/04 , C07D519/00
CPC classification number: C07D487/04 , C07D519/00
Abstract: The present disclosure provides diacylglycerol kinase modulating compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.
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