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    Medical Treatment Using An Ultrasound Phased Array
    3.
    发明申请
    Medical Treatment Using An Ultrasound Phased Array 有权
    使用超声相控阵的医疗

    公开(公告)号：US20080200806A1

    公开(公告)日：2008-08-21

    申请号：US12033370

    申请日：2008-02-19

    申请人： Hao-Li Liu ,  Win-li Lin ,  Hsu Chang

    发明人： Hao-Li Liu ,  Win-li Lin ,  Hsu Chang

    IPC分类号： A61N7/02

    CPC分类号： A61N7/02 ,  A61B34/10 ,  A61B90/37 ,  A61B2090/392

    摘要： A medical system and method for treating a disorder of a subject by thermal ablation, e.g., focused ultrasound thermal ablation, are provided. The method includes obtaining medical images that include at least one image of subject's chest and ribs to reconstruct a three-dimensional chest-rib distribution; and applying ultrasound waves on a target point beyond the subject's ribs by selectively activating one or more elements of an ultrasound phased array to avoid ultrasonic energy absorption or reflection by an intervening rib based on a calculation of a relationship between the three-dimensional chest-rib distribution and an acoustic emission direction.

    摘要翻译： 提供了一种通过热消融治疗受试者病症的医疗系统和方法，例如聚焦超声热消融。 该方法包括获得包括受试者胸部和肋骨的至少一个图像的医学图像，以重建三维胸肋分布; 以及通过选择性地激活超声相控阵列的一个或多个元件，将目标点上的超声波施加到目标点之上，以避免超声能量吸收或由中间肋反射，基于三维胸肋之间的关系的计算 分布和声发射方向。

    Multiple frequency ultrasound apparatus
    5.
    发明授权
    Multiple frequency ultrasound apparatus 有权

    公开(公告)号：US07530272B2

    公开(公告)日：2009-05-12

    申请号：US11889682

    申请日：2007-08-15

    申请人： Hao-Li Liu ,  Chao-Ming Hsieh

    发明人： Hao-Li Liu ,  Chao-Ming Hsieh

    IPC分类号： G01H13/00 ,  H01L41/00

    CPC分类号： B06B1/0276

    摘要： The invention disclosed that the multiple frequency ultrasound apparatus using unique transducer will contain many actuations module, a coupled circuit and a transducer. Each actuation module can separately output the signal of the different frequency, the coupled circuit connecting the actuation module for coupling with the signal of the different frequency. The transducer can receive the signal of the multiple frequencies, then for outputting the multiple ultrasound frequency by the way of transferring from the electrical energy to the mechanical energy.

    TREATMENT OF BRAIN DISEASES VIA ULTRASOUND/MAGNETIC TARGETING DELIVERY AND TRACING OF THERAPEUTIC AGENTS
    7.
    发明申请
    TREATMENT OF BRAIN DISEASES VIA ULTRASOUND/MAGNETIC TARGETING DELIVERY AND TRACING OF THERAPEUTIC AGENTS 审中-公开
    通过超声波/磁性定向递送和治疗药物的治疗来治疗脑疾病

    公开(公告)号：US20120095325A1

    公开(公告)日：2012-04-19

    申请号：US13273368

    申请日：2011-10-14

    申请人： Kuo-Chen Wei ,  Hao-Li Liu ,  Mu-Yi Hua

    发明人： Kuo-Chen Wei ,  Hao-Li Liu ,  Mu-Yi Hua

    IPC分类号： A61B5/055 ,  A61N7/00 ,  B82Y5/00

    CPC分类号： A61B5/0515 ,  A61B5/0042 ,  A61M37/0092 ,  A61M2210/0693 ,  B82Y5/00

    摘要： Disclosed herein is a method for treating a brain disease in which focused ultrasound and magnetic targeting are applied to a subject in need of such treatment, so that therapeutic agent-magnetic nanoparticle composites are directed across the blood-brain barrier to a designated locus inside the brain of the subject. Each of the composites includes a magnetic nanoparticle that is formed of an iron-based core and a shell encapsulating the iron-based core, and a therapeutic agent that is bound to the shell of the magnetic nanoparticle. The magnetic nanoparticle has a size ranging from 5 to 200 nm. The iron-based core has a crystalline structure that imparts the composites with a sufficiently high magnetization, thereby enhancing magnetic targeting of the composites to the designated locus inside the brain of the subject. The magnetic targeting treatment is conducted via a magnet providing a magnetic flux density not less than 0.18 T.

    摘要翻译： 本文公开了一种治疗脑疾病的方法，其中将聚焦超声和磁性靶向应用于需要这种治疗的受试者，使得治疗剂 - 磁性纳米颗粒复合物穿过血脑屏障被引导到内部的指定位点 主题的大脑。 每种复合材料包括由铁基核心和包封铁基核心的壳形成的磁性纳米颗粒，以及结合到磁性纳米颗粒的壳的治疗剂。 磁性纳米粒子的尺寸范围为5〜200nm。 铁基芯具有赋予复合材料足够高的磁化强度的晶体结构，从而增强复合材料对受试者脑内指定位点的磁性靶向。 磁性靶向处理通过提供磁通密度不小于0.18T的磁体进行。

    METHOD FOR DYNAMICALLY ANALYZING DISTRIBUTION VARIATION OF SCATTERERS AND APPLICATION USING THE SAME
    8.
    发明申请
    METHOD FOR DYNAMICALLY ANALYZING DISTRIBUTION VARIATION OF SCATTERERS AND APPLICATION USING THE SAME 有权
    用于动态分析散射体分布变化的方法及其应用

    公开(公告)号：US20110306880A1

    公开(公告)日：2011-12-15

    申请号：US12913481

    申请日：2010-10-27

    申请人： Meng-Lin LI ,  Hao-Li Liu ,  Da-Wei Li

    发明人： Meng-Lin LI ,  Hao-Li Liu ,  Da-Wei Li

    IPC分类号： A61B8/14 ,  A61B18/12

    CPC分类号： A61B8/08 ,  A61B2090/378 ,  A61N7/02

    摘要： A method for dynamically analyzing distribution variation of scatterers is provided and used for dynamically analyzing changes in two or three dimensional scatterer distribution and concentration of ultrasound data by using probability density function along with a moving window technique. The present invention has advantages in low computation load and may be used for real-time analysis. A method for dynamically detecting thermal ablation area and thermal ablation level and a method for dynamically controlling thermal ablation intensity are also provided for non-invasive detection and thermal ablation.

    摘要翻译： 提供动态分析散射体分布变化的方法，用于动态分析二维或三维散射体分布的变化和超声数据的浓度，并利用概率密度函数和移动窗口技术。 本发明具有计算负荷低的优点，可用于实时分析。 还提供了用于动态检测热消融区域和热消融水平的方法以及用于动态控制热消融强度的方法用于非侵入式检测和热消融。

    Artificial sphincter system
    9.
    发明授权
    Artificial sphincter system 有权
    人造括约肌系统

    公开(公告)号：US07955389B2

    公开(公告)日：2011-06-07

    申请号：US12140943

    申请日：2008-06-17

    申请人： Wen-Shiang Chen ,  Hao-Li Liu ,  Yen-Tung Huang ,  Chien-Ching Ma ,  Wei-Bor Tsai ,  Wen-Pin Shih ,  Chi-An Dai

    发明人： Wen-Shiang Chen ,  Hao-Li Liu ,  Yen-Tung Huang ,  Chien-Ching Ma ,  Wei-Bor Tsai ,  Wen-Pin Shih ,  Chi-An Dai

    IPC分类号： A61F2/08

    CPC分类号： A61F2/08 ,  A61F2/14 ,  A61F2210/0014 ,  A61F2210/0057

    摘要： An artificial sphincter system having: (1) a hollow object, which has the ability of contraction and expansion; (2) a shape memory alloy (SMA), which is connected with the hollow object, changes its shape to imitate the motion of human muscle by applying different electric current; (3) an electric power to provide different amounts of electric current to the shape memory alloy and let it contract or expand to control the motion of the hollow object to imitate the motion of human muscle; and (4) a photo resistor added between the electric power and the shape memory alloy, which senses the brightness of surrounding light and controls A/D (analog-to-digital) values of the electric power to cause different conditions of contraction and expansion of each part of the shape memory alloy.

    摘要翻译： 一种人造括约肌系统，具有：（1）具有收缩膨胀能力的中空物体; （2）与中空物体连接的形状记忆合金（SMA），通过施加不同的电流来改变其形状以模仿人体的运动; （3）向形状记忆合金提供不同量的电流并使其收缩或膨胀以控制中空物体的运动以模仿人肌肉的运动的电力; 和（4）在电力和形状记忆合金之间添加的光电阻，其感测周围光的亮度并控制电力的A / D（模数）值，以引起不同的收缩和膨胀条件 形状记忆合金的每一部分。