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    Microscopy system and recording method for visualizing fluorescence
    1.
    发明申请
    Microscopy system and recording method for visualizing fluorescence 有权
    显微镜系统和荧光显像的记录方法

    公开(公告)号：US20070090985A1

    公开(公告)日：2007-04-26

    申请号：US11544269

    申请日：2006-10-06

    申请人： Helge Jess ,  Petra Weinschenk ,  Martin Schneider ,  Christoph Hauger ,  Hans-Joachim Miesner

    发明人： Helge Jess ,  Petra Weinschenk ,  Martin Schneider ,  Christoph Hauger ,  Hans-Joachim Miesner

    IPC分类号： H03M1/12

    CPC分类号： G02B21/0076 ,  G01N21/6428 ,  G01N21/6458

    摘要： An image sensor and a circuitry associated with the image sensor is used for recording a series of fluorescence images. The image sensor comprises a plurality of pixels for accumulating charges generated by incident radiation, and the circuitry converts the charges accumulated in the pixels into binary numbers. A gain of the circuitry is adjustable. The gain is set to a suitable maximum value at the beginning of a recording procedure. The gain is reduced if it is determined during the recording procedure that one or more brightness values of the recorded image exceed a suitably chosen maximum brightness value.

    摘要翻译： 图像传感器和与图像传感器相关联的电路用于记录一系列荧光图像。 图像传感器包括用于累积由入射辐射产生的电荷的多个像素，并且电路将在像素中累积的电荷转换为二进制数。 电路的增益可调。 在记录过程开始时，增益被设置为合适的最大值。 如果在记录过程中确定记录图像的一个或多个亮度值超过适当选择的最大亮度值，则增益减小。

    Microscopy system and recording method for visualizing fluorescence
    2.
    发明授权
    Microscopy system and recording method for visualizing fluorescence 有权
    显微镜系统和荧光显像的记录方法

    公开(公告)号：US07369073B2

    公开(公告)日：2008-05-06

    申请号：US11544269

    申请日：2006-10-06

    申请人： Helge Jess ,  Petra Weinschenk ,  Martin Schneider ,  Christoph Hauger ,  Hans-Joachim Miesner

    发明人： Helge Jess ,  Petra Weinschenk ,  Martin Schneider ,  Christoph Hauger ,  Hans-Joachim Miesner

    IPC分类号： H03M1/00

    CPC分类号： G02B21/0076 ,  G01N21/6428 ,  G01N21/6458

    摘要： An image sensor and a circuitry associated with the image sensor is used for recording a series of fluorescence images. The image sensor comprises a plurality of pixels for accumulating charges generated by incident radiation, and the circuitry converts the charges accumulated in the pixels into binary numbers. A gain of the circuitry is adjustable. The gain is set to a suitable maximum value at the beginning of a recording procedure. The gain is reduced if it is determined during the recording procedure that one or more brightness values of the recorded image exceed a suitably chosen maximum brightness value.

    摘要翻译： 图像传感器和与图像传感器相关联的电路用于记录一系列荧光图像。 图像传感器包括用于累积由入射辐射产生的电荷的多个像素，并且电路将在像素中累积的电荷转换为二进制数。 电路的增益可调。 在记录过程开始时，增益被设置为合适的最大值。 如果在记录过程中确定记录图像的一个或多个亮度值超过适当选择的最大亮度值，则增益减小。

    Coherence microscope using interference of time incoherent light to achieve depth resolution in a measurement specimen
    3.
    发明授权
    Coherence microscope using interference of time incoherent light to achieve depth resolution in a measurement specimen 有权
    相干显微镜使用时间非相干光的干涉来实现测量样本中的深度分辨率

    公开(公告)号：US07400409B2

    公开(公告)日：2008-07-15

    申请号：US10538587

    申请日：2003-12-16

    申请人： Christoph Hauger ,  Hans-Joachim Miesner ,  Ludwin Monz

    发明人： Christoph Hauger ,  Hans-Joachim Miesner ,  Ludwin Monz

    IPC分类号： G01B9/02

    CPC分类号： G02B21/0004 ,  G01B9/02091 ,  G01B2290/65

    摘要： A coherence microscope has a divider (3) that divides light emitted by a light source (1) into measurement light, which is supplied to and reflected by a specimen (13), and reference light. A superimposition device (25, 31) superimposes the measurement light reflected by the specimen (13) with the reference light. A short sensor array (41) detects the light resulting from the superimposition and permits a read-out rate of at least about 60 kHz. The superimposition device has an emission device (25, 31) for emitting the measurement light and the reference light arranged to effect extensive irradiation of the sensor array (41) with superimposed light. The ratio of distances covered by the measurement light and the reference light from the emission device (25, 31) to impingement points on the sensor array (41) varies in the portion of the sensor array (41) that is irradiated with superimposed light.

    摘要翻译： 相干显微镜具有将由光源（1）发射的光分离成被供给到试样（13）并被反射的测量光和参考光的分割器（3）。 叠加装置（25,31）将由试样（13）反射的测量光与参考光重叠。 短传感器阵列（41）检测由叠加产生的光，并允许至少约60kHz的读出速率。 叠加装置具有用于发射测量光的发射装置（25,31）和布置成以叠加的光来广泛照射传感器阵列（41）的参考光。 测量光所覆盖的距离与来自发射装置（25,31）的参考光与传感器阵列（41）上的撞击点的比率在用叠加的光照射的传感器阵列（41）的部分中变化。

    Coherence microscope
    6.
    发明申请
    Coherence microscope 有权
    相干显微镜

    公开(公告)号：US20060056784A1

    公开(公告)日：2006-03-16

    申请号：US10538587

    申请日：2003-12-16

    申请人： Christoph Hauger ,  Hans-Joachim Miesner ,  Ludwin Monz

    发明人： Christoph Hauger ,  Hans-Joachim Miesner ,  Ludwin Monz

    IPC分类号： G02B6/04

    CPC分类号： G02B21/0004 ,  G01B9/02091 ,  G01B2290/65

    摘要： A coherence microscope has a divider (3) that divides light emitted by a light source (1) into measurement light, which is supplied to and reflected by a specimen (13), and reference light. A superimposition device (25, 31) superimposes the measurement light reflected by the specimen (13) with the reference light. A short sensor array (41) detects the light resulting from the superimposition and permits a read-out rate of at least about 60 kHz. The superimposition device has an emission device (25, 31) for emitting the measurement light and the reference light arranged to effect extensive irradiation of the sensor array (41) with superimposed light. The ratio of distances covered by the measurement light and the reference light from the emission device (25, 31) to impingement points on the sensor array (41) varies in the portion of the sensor array (41) that is irradiated with superimposed light.

    摘要翻译： 相干显微镜具有将由光源（1）发射的光分离成被供给到试样（13）并被反射的测量光和参考光的分割器（3）。 叠加装置（25,31）将由试样（13）反射的测量光与参考光重叠。 短传感器阵列（41）检测由叠加产生的光，并允许至少约60kHz的读出速率。 叠加装置具有用于发射测量光的发射装置（25,31）和布置成以叠加的光来广泛照射传感器阵列（41）的参考光。 测量光所覆盖的距离与来自发射装置（25,31）的参考光与传感器阵列（41）上的撞击点的比率在用叠加的光照射的传感器阵列（41）的部分中变化。

    Surgical microscope having an illuminating arrangement
    7.
    发明授权
    Surgical microscope having an illuminating arrangement 有权
    具有照明装置的手术显微镜

    公开(公告)号：US07933066B2

    公开(公告)日：2011-04-26

    申请号：US11892443

    申请日：2007-08-23

    申请人： Joachim Steffen ,  Michael Haisch ,  Frank Rudolph ,  Martin Schneider ,  Hans-Joachim Miesner ,  Nicole Brune

    发明人： Joachim Steffen ,  Michael Haisch ,  Frank Rudolph ,  Martin Schneider ,  Hans-Joachim Miesner ,  Nicole Brune

    IPC分类号： G02B21/06

    CPC分类号： G02B6/4298 ,  G02B21/0012 ,  G02B21/06

    摘要： A surgical microscope (100) is especially suited for use in neurosurgery. The surgical microscope has an illuminating arrangement (101) for making available illuminating light in an operating region (117) to be examined with the surgical microscope (100). The illuminating arrangement (101) contains a high-power light source (102) which includes an intensity adjusting device (112). The intensity adjusting device (112) makes possible to adjust the intensity of the illuminating light (116), which is guided to the object region (117), between a maximum value and a minimum value. The surgical microscope (100) has a control unit (170) for the illuminating arrangement (101) which includes an operator-controlled module (172) via which the illuminating arrangement (101) can be activated and controlled. For adjusting the intensity of the illuminating light (116) guided to the operating region (117), the control unit coacts with the adjustable filter unit (112). A signal generator (175) is provided which outputs a warning signal when an intensity of the illuminating light is adjusted via the operator-controlled module (172) which exceeds the safety limit value stored in a memory (171).

    摘要翻译： 手术显微镜（100）特别适用于神经外科手术。 手术显微镜具有用于在手术显微镜（100）检查的操作区域（117）中提供照明光的照明装置（101）。 照明装置（101）包括包括强度调节装置（112）的高功率光源（102）。 强度调节装置（112）能够将被引导到物体区域（117）的照明光（116）的强度调整在最大值和最小值之间。 所述手术显微镜（100）具有用于所述照明装置（101）的控制单元（170），所述控制单元包括操作者控制模块，通过所述操作者控制模块可以启动和控制所述照明装置。 为了调节被引导到操作区域（117）的照明光（116）的强度，控制单元与可调滤光单元（112）共同作用。 提供信号发生器（175），当通过超过存储在存储器（171）中的安全极限值的操作者控制模块（172）调节照明光的强度时，输出警告信号。

    Surgical microscope having an illuminating arrangement
    8.
    发明申请
    Surgical microscope having an illuminating arrangement 有权
    具有照明装置的手术显微镜

    公开(公告)号：US20080049314A1

    公开(公告)日：2008-02-28

    申请号：US11892443

    申请日：2007-08-23

    申请人： Joachim Steffen ,  Michael Haisch ,  Frank Rudolph ,  Martin Schneider ,  Hans-Joachim Miesner ,  Nicole Brune

    发明人： Joachim Steffen ,  Michael Haisch ,  Frank Rudolph ,  Martin Schneider ,  Hans-Joachim Miesner ,  Nicole Brune

    IPC分类号： G02B21/06 ,  A61B19/00 ,  A61B3/13

    CPC分类号： G02B6/4298 ,  G02B21/0012 ,  G02B21/06

    摘要： A surgical microscope (100) is especially suited for use in neurosurgery. The surgical microscope has an illuminating arrangement (101) for making available illuminating light in an operating region (117) to be examined with the surgical microscope (100). The illuminating arrangement (101) contains a high-power light source (102) which includes an intensity adjusting device (112). The intensity adjusting device (112) makes possible to adjust the intensity of the illuminating light (116), which is guided to the object region (117), between a maximum value and a minimum value. The surgical microscope (100) has a control unit (170) for the illuminating arrangement (101) which includes an operator-controlled module (172) via which the illuminating arrangement (101) can be activated and controlled. For adjusting the intensity of the illuminating light (116) guided to the operating region (117), the control unit coacts with the adjustable filter unit (112). A signal generator (175) is provided which outputs a warning signal when an intensity of the illuminating light is adjusted via the operator-controlled module (172) which exceeds the safety limit value stored in a memory (171).

    摘要翻译： 手术显微镜（100）特别适用于神经外科手术。 手术显微镜具有用于在手术显微镜（100）检查的操作区域（117）中提供照明光的照明装置（101）。 照明装置（101）包括包括强度调节装置（112）的高功率光源（102）。 强度调节装置（112）能够将被引导到物体区域（117）的照明光（116）的强度调整在最大值和最小值之间。 所述手术显微镜（100）具有用于所述照明装置（101）的控制单元（170），所述控制单元包括操作者控制模块，通过所述操作者控制模块可以启动和控制所述照明装置。 为了调节被引导到操作区域（117）的照明光（116）的强度，控制单元与可调滤光单元（112）共同作用。 提供信号发生器（175），当通过超过存储在存储器（171）中的安全极限值的操作者控制模块（172）调节照明光的强度时，输出警告信号。

    Surgical Microscope having an Illuminating Arrangement
    9.
    发明申请
    Surgical Microscope having an Illuminating Arrangement 有权
    具有照明装置的手术显微镜

    公开(公告)号：US20110164315A1

    公开(公告)日：2011-07-07

    申请号：US13051545

    申请日：2011-03-18

    申请人： Joachim Steffen ,  Michael Haisch ,  Frank Rudolph ,  Martin Schneider ,  Hans-Joachim Miesner ,  Nicole Brune

    发明人： Joachim Steffen ,  Michael Haisch ,  Frank Rudolph ,  Martin Schneider ,  Hans-Joachim Miesner ,  Nicole Brune

    IPC分类号： G02B21/06

    CPC分类号： G02B6/4298 ,  G02B21/0012 ,  G02B21/06

    摘要： A surgical microscope (100) is especially suited for use in neurosurgery. The surgical microscope has an illuminating arrangement (101) for making available illuminating light in an operating region (117) to be examined with the surgical microscope (100). The illuminating arrangement (101) contains a high-power light source (102) which includes an intensity adjusting device (112). The intensity adjusting device (112) makes possible to adjust the intensity of the illuminating light (116), which is guided to the object region (117), between a maximum value and a minimum value. The surgical microscope (100) has a control unit (170) for the illuminating arrangement (101) which includes an operator-controlled module (172) via which the illuminating arrangement (101) can be activated and controlled. For adjusting the intensity of the illuminating light (116) guided to the operating region (117), the control unit coacts with the adjustable filter unit (112). A signal generator (175) is provided which outputs a warning signal when an intensity of the illuminating light is adjusted via the operator-controlled module (172) which exceeds the safety limit value stored in a memory (171).

    摘要翻译： 手术显微镜（100）特别适用于神经外科手术。 手术显微镜具有用于在手术显微镜（100）检查的操作区域（117）中提供照明光的照明装置（101）。 照明装置（101）包括包括强度调节装置（112）的高功率光源（102）。 强度调节装置（112）能够将被引导到物体区域（117）的照明光（116）的强度调整在最大值和最小值之间。 所述手术显微镜（100）具有用于所述照明装置（101）的控制单元（170），所述控制单元包括操作者控制模块，通过所述操作者控制模块可以启动和控制所述照明装置。 为了调节被引导到操作区域（117）的照明光（116）的强度，控制单元与可调滤光单元（112）共同作用。 提供信号发生器（175），当通过超过存储在存储器（171）中的安全极限值的操作者控制模块（172）调节照明光的强度时，输出警告信号。

    Surgical microscope for use in surgical procedures including neurosurgery
    10.
    发明授权
    Surgical microscope for use in surgical procedures including neurosurgery 有权
    手术显微镜用于外科手术，包括神经外科手术

    公开(公告)号：US08154797B2

    公开(公告)日：2012-04-10

    申请号：US13051545

    申请日：2011-03-18

    申请人： Joachim Steffen ,  Michael Haisch ,  Frank Rudolph ,  Martin Schneider ,  Hans-Joachim Miesner ,  Nicole Brune

    发明人： Joachim Steffen ,  Michael Haisch ,  Frank Rudolph ,  Martin Schneider ,  Hans-Joachim Miesner ,  Nicole Brune

    IPC分类号： G02B21/06

    CPC分类号： G02B6/4298 ,  G02B21/0012 ,  G02B21/06

    摘要： A surgical microscope has an illuminating arrangement for illuminating light in an operating region to be examined with the surgical microscope. The arrangement contains a high-power light source which includes an intensity adjusting device. The device makes possible an adjustment of the intensity of the illuminating light, which is guided to the object region, between a maximum value and a minimum value. The microscope has a control unit for the illuminating arrangement which includes an operator-controlled module via which the illuminating arrangement can be activated and controlled. For adjusting the intensity of the illuminating light guided to the operating region, the control unit coacts with the adjustable filter unit. A signal generator outputs a warning signal when an intensity of the illuminating light is adjusted via the operator-controlled module which exceeds the safety limit value stored in a memory.

    摘要翻译： 手术显微镜具有用于在手术显微镜下照射要检查的手术区域中的光的照明装置。 该装置包括高功率光源，其包括强度调节装置。 该装置使得能够调整被引导到对象区域的照明光的强度在最大值和最小值之间。 显微镜具有用于照明装置的控制单元，其包括操作者控制的模块，通过该模块可以启动和控制照明装置。 为了调节被引导到操作区域的照明光的强度，控制单元与可调滤光单元共同作用。 当通过操作者控制模块调节照明光的强度时，信号发生器输出警告信号，该操作者控制模块超过存储在存储器中的安全限制值。