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公开(公告)号：US20100286214A1
公开(公告)日：2010-11-11
申请号：US12437704
申请日：2009-05-08
申请人： Hengmiao (Henry) Cheng , Xiao Hu , Kevin D. Jerome , Mark Obukowicz , Lisa Olson , Paul V. Rucker , Ronald Keith Webber
发明人： Hengmiao (Henry) Cheng , Xiao Hu , Kevin D. Jerome , Mark Obukowicz , Lisa Olson , Paul V. Rucker , Ronald Keith Webber
CPC分类号： C07D213/89 , A61K31/44 , C07D213/72 , C07F9/58 , Y10S514/886
摘要： The present invention is directed to compounds of Formula I: or salt thereof, which are modulators of the glucocorticoid receptor. The compounds and salts of the invention are useful in the treatment of conditions mediated by glucocorticoid receptor activity.
摘要翻译： 本发明涉及式I化合物或其盐，它们是糖皮质激素受体的调节剂。 本发明的化合物和盐可用于治疗由糖皮质激素受体活性介导的病症。
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公开(公告)号：US20120088802A9
公开(公告)日：2012-04-12
申请号：US12437704
申请日：2009-05-08
申请人： Hengmiao (Henry) Cheng , Xiao Hu , Kevin D. Jerome , Mark Obukowicz , Lisa Olson , Paul V. Rucker , Ronald Keith Webber
发明人： Hengmiao (Henry) Cheng , Xiao Hu , Kevin D. Jerome , Mark Obukowicz , Lisa Olson , Paul V. Rucker , Ronald Keith Webber
CPC分类号： C07D213/89 , A61K31/44 , C07D213/72 , C07F9/58 , Y10S514/886
摘要： The present invention is directed to compounds of Formula I: or salt thereof, which are modulators of the glucocorticoid receptor. The compounds and salts of the invention are useful in the treatment of conditions mediated by glucocorticoid receptor activity.
摘要翻译： 本发明涉及式I化合物或其盐，它们是糖皮质激素受体的调节剂。 本发明的化合物和盐可用于治疗由糖皮质激素受体活性介导的病症。
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公开(公告)号：US07598231B2
公开(公告)日：2009-10-06
申请号：US12023362
申请日：2008-01-31
申请人： Hengmiao (Henry) Cheng , Rajesh Devraj , Gary A DeCresenzo , Xiao Hu , Kevin D. Jerome , Mark Obukowicz , Lisa Olson , Paul V. Rucker , Ronald Keith Webber
发明人： Hengmiao (Henry) Cheng , Rajesh Devraj , Gary A DeCresenzo , Xiao Hu , Kevin D. Jerome , Mark Obukowicz , Lisa Olson , Paul V. Rucker , Ronald Keith Webber
IPC分类号： A61K31/675 , C07F9/58
CPC分类号： C07D213/89 , A61K31/44 , C07D213/72 , C07F9/58 , Y10S514/886
摘要： The present invention is directed to compounds of Formula I: or salt thereof, which are modulators of the glucocorticoid receptor. The compounds and salts of the invention are useful in the treatment of conditions mediated by glucocorticoid receptor activity.
摘要翻译： 本发明涉及式I化合物或其盐，它们是糖皮质激素受体的调节剂。 本发明的化合物和盐可用于治疗由糖皮质激素受体活性介导的病症。
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公开(公告)号：US07786097B2
公开(公告)日：2010-08-31
申请号：US12506825
申请日：2009-07-21
申请人： Hengmiao (Henry) Cheng , Rajesh Devraj , Gary A Decresenzo , Xiao Hu , Kevin D. Jerome , Mark Obukowicz , Lisa Olson , Paul V. Rucker , Ronald Keith Webber
发明人： Hengmiao (Henry) Cheng , Rajesh Devraj , Gary A Decresenzo , Xiao Hu , Kevin D. Jerome , Mark Obukowicz , Lisa Olson , Paul V. Rucker , Ronald Keith Webber
IPC分类号： A61K31/675 , A61K31/44
CPC分类号： C07D213/89 , A61K31/44 , C07D213/72 , C07F9/58 , Y10S514/886
摘要： The present invention is directed to compounds of Formula I: or salt thereof, which are modulators of the glucocorticoid receptor. The compounds and salts of the invention are useful in the treatment of conditions mediated by glucocorticoid receptor activity.
摘要翻译： 本发明涉及式I化合物或其盐，它们是糖皮质激素受体的调节剂。 本发明的化合物和盐可用于治疗由糖皮质激素受体活性介导的病症。
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公开(公告)号：US20080312294A1
公开(公告)日：2008-12-18
申请号：US12023323
申请日：2008-01-31
申请人： Hengmiao (Henry) Cheng , Xiao Hu , Kevin D. Jerome , Mark Obukowicz , Lisa Olson , Paul V. Rucker , Ronald Keith Webber
发明人： Hengmiao (Henry) Cheng , Xiao Hu , Kevin D. Jerome , Mark Obukowicz , Lisa Olson , Paul V. Rucker , Ronald Keith Webber
IPC分类号： A61K31/44 , C07D213/72 , C07K14/705 , A61P29/00 , A61P25/28
CPC分类号： C07D213/89 , A61K31/44 , C07D213/72 , C07F9/58 , Y10S514/886
摘要： The present invention is directed to compounds of Formula I: or salt thereof, which are modulators of the glucocorticoid receptor. The compounds and salts of the invention are useful in the treatment of conditions mediated by glucocorticoid receptor activity.
摘要翻译： 本发明涉及式I化合物或其盐，它们是糖皮质激素受体的调节剂。 本发明的化合物和盐可用于治疗由糖皮质激素受体活性介导的病症。
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公开(公告)号：US20080188443A1
公开(公告)日：2008-08-07
申请号：US12023362
申请日：2008-01-31
申请人： Hengmiao (Henry) Cheng , Rajesh Devraj , Gary A. DeCresenzo , Xiao Hu , Kevin D. Jerome , Mark Obukowicz , Lisa Olson , Paul V. Rucker , Ronald Keith Webber
发明人： Hengmiao (Henry) Cheng , Rajesh Devraj , Gary A. DeCresenzo , Xiao Hu , Kevin D. Jerome , Mark Obukowicz , Lisa Olson , Paul V. Rucker , Ronald Keith Webber
IPC分类号： A61K31/675 , C07D213/72 , A61K31/44 , A61P1/00 , A61P17/00 , A61P25/00 , A61P25/28 , A61P29/00 , A61P11/06 , C07K14/72 , C07F9/09
CPC分类号： C07D213/89 , A61K31/44 , C07D213/72 , C07F9/58 , Y10S514/886
摘要： The present invention is directed to compounds of Formula I: or salt thereof, which are modulators of the glucocorticoid receptor. The compounds and salts of the invention are useful in the treatment of conditions mediated by glucocorticoid receptor activity.
摘要翻译： 本发明涉及式I化合物或其盐，它们是糖皮质激素受体的调节剂。 本发明的化合物和盐可用于治疗由糖皮质激素受体活性介导的病症。
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公开(公告)号：US20090281148A1
公开(公告)日：2009-11-12
申请号：US12506825
申请日：2009-07-21
申请人： Hengmiao (Henry) Cheng , Rajesh Devraj , Gary A. Decresenzo , Xiao Hu , Kevin D. Jerome , Mark Obukowicz , Lisa Olson , Ronald Keith Webber
发明人： Hengmiao (Henry) Cheng , Rajesh Devraj , Gary A. Decresenzo , Xiao Hu , Kevin D. Jerome , Mark Obukowicz , Lisa Olson , Ronald Keith Webber
IPC分类号： A61K31/44
CPC分类号： C07D213/89 , A61K31/44 , C07D213/72 , C07F9/58 , Y10S514/886
摘要： The present invention is directed to compounds of Formula I: or salt thereof, which are modulators of the glucocorticoid receptor. The compounds and salts of the invention are useful in the treatment of conditions mediated by glucocorticoid receptor activity.
摘要翻译： 本发明涉及式I化合物或其盐，它们是糖皮质激素受体的调节剂。 本发明的化合物和盐可用于治疗由糖皮质激素受体活性介导的病症。
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公开(公告)号：US20050049252A1
公开(公告)日：2005-03-03
申请号：US10922036
申请日：2004-08-19
申请人： Jeffery Carter , Mark Obukowicz , Balekudru Devadas , John Talley , David Brown , Matthew Graneto , Stephen Bertenshaw , Donald Rogier , Srinivasan Nagarajan , Cathleen Hanau , Susan Hartmann , Cindy Ludwig , Suzanne Metz , Donald Korte
发明人： Jeffery Carter , Mark Obukowicz , Balekudru Devadas , John Talley , David Brown , Matthew Graneto , Stephen Bertenshaw , Donald Rogier , Srinivasan Nagarajan , Cathleen Hanau , Susan Hartmann , Cindy Ludwig , Suzanne Metz , Donald Korte
IPC分类号： A61K31/35 , A61K31/352 , A61K31/36 , A61K31/382 , A61K31/4184 , A61K31/436 , A61K31/4375 , A61K31/47 , A61P29/00 , A61P43/00 , C07D215/54 , C07D311/22 , C07D311/58 , C07D311/92 , C07D335/06 , C07D401/12 , C07D405/04 , C07D407/04 , C07D407/12 , C07D409/04 , C07D471/04 , C07D491/04 , C07D491/052 , C07D493/04 , C07D471/02 , A61K31/519 , C07D491/02 , C07D498/02
CPC分类号： C07D335/06 , C07D215/54 , C07D311/22 , C07D311/58 , C07D311/92 , C07D401/12 , C07D405/04 , C07D407/04 , C07D407/12 , C07D409/04 , C07D471/04 , C07D491/04 , C07D493/04
摘要： A class of benzopyran, derivatives is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I′ wherein X, A1, A2, A3, A4, R, R″, R1 and R2 are as described in the specification.
摘要翻译： 描述了一类苯并吡喃衍生物用于治疗环氧合酶-2介导的病症。 特别感兴趣的化合物由式I'定义，其中X，A 1，A 2，A 3，A 4，R，R“，R 1和R 2如 在说明书中描述。
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9.发明授权公开(公告)号：US06340705B1
公开(公告)日：2002-01-22
申请号：US09393790
申请日：1999-09-10
IPC分类号： A61K3120
CPC分类号： A61K31/202 , A23L33/12 , A61K31/557
摘要： Cancer in a mammal can be treated or prevented by administering to a mammal in need thereof a cancer inhibiting amount of metabolite(s) of &agr;-linolenic acid, such as stearidonic acid (18:4 n-3), eicosatetraenoic acid (20:4 n-3), docosaptentaenic acid (22:5 n-3) and mixtures thereof, especially metabolites including stearidonic acid.
摘要翻译： 可以通过向有需要的哺乳动物施用癌症抑制量的α-亚麻酸的代谢物（例如十八碳四烯酸（18：4n-3）），二十碳四烯酸（20： 4 n-3），二十二碳五烯酸（22：5 n-3）及其混合物，特别是包括十碳四烯酸的代谢物。
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10.发明申请Compositions of a cyclooxygenase-2 selective inhibitor and a peroxisome proliferator activated receptor agonist for the treatment of ischemic mediated central nervous system disorders 审中-公开环氧合酶-2选择性抑制剂和过氧化物酶体增殖物激活受体激动剂的组合物用于治疗缺血性介导的中枢神经系统疾病公开(公告)号：US20050107387A1
公开(公告)日：2005-05-19
申请号：US10844269
申请日：2004-05-12
申请人： Philip Needleman , Mark Obukowicz
发明人： Philip Needleman , Mark Obukowicz
IPC分类号： A61K20060101 , A61K31/18 , A61K31/365 , A61K31/415 , A61K31/425 , A61K31/426 , A61K31/4439 , A61K31/50
CPC分类号： A61K31/426 , A61K31/415 , A61K45/06 , A61K2300/00
摘要： The present invention provides compositions and methods for the treatment of ischemic mediated central nervous system disorders. More particularly, the invention provides a combination therapy for the treatment of a central nervous system ischemic mediated disorder comprising the administration to a subject of a peroxisome proliferator activated receptor agonist in combination with a cyclooxygenase-2 selective inhibitor.
摘要翻译： 本发明提供了治疗缺血性介导的中枢神经系统疾病的组合物和方法。 更具体地，本发明提供了用于治疗中枢神经系统缺血性介导病症的组合疗法，其包括与环氧合酶-2选择性抑制剂组合施用过氧化物酶体增殖物激活受体激动剂的受试者。
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