公开(公告)号：US07956060B2

公开(公告)日：2011-06-07

申请号：US10594369

申请日：2005-03-30

申请人： Hitoshi Arai ,  Tsutomu Matsumura ,  Syoichi Isami ,  Hiroshi Ishida ,  Koji Hagihara ,  Hiroshi Umehara ,  Yoshinori Yamashita ,  Nana Oiwa ,  Yukimasa Shiotsu ,  Tomoki Naoe ,  Hitoshi Kiyoi

发明人： Hitoshi Arai ,  Tsutomu Matsumura ,  Syoichi Isami ,  Hiroshi Ishida ,  Koji Hagihara ,  Hiroshi Umehara ,  Yoshinori Yamashita ,  Nana Oiwa ,  Yukimasa Shiotsu ,  Tomoki Naoe ,  Hitoshi Kiyoi

IPC分类号： C07D471/04 ,  C07D471/22 ,  C07D487/04 ,  C07D239/70 ,  C07D471/00 ,  C07D487/00 ,  C07D401/00 ,  C07D403/00 ,  C07D405/00 ,  C07D409/00 ,  C07D411/00 ,  C07D413/00 ,  C07D417/00 ,  C07D419/00 ,  A61K31/505 ,  A01N43/56

CPC分类号： C07D413/04 ,  C07D413/14

摘要： The present invention provides an antitumor agent and the like, which comprises as an active ingredient, a pyrimidine derivative represented by Formula (I): [wherein —X—Y—Z— represents —O—CR3═N— (wherein R3 represents a hydrogen atom, a substituted or unsubstituted aromatic heterocyclic group and the like) and the like, R1 represents —NR10R11 (wherein R10 and R11 may be the same or different, and each represents a hydrogen atom, substituted or unsubstituted lower alkyl and the like) and the like, R2 represents —NR13R14 (wherein R13 and R14 may be the same or different, and each represents a hydrogen atom, substituted or unsubstituted lower alkyl and the like)] or a pharmaceutically acceptable salt thereof.

摘要翻译： 本发明提供了包含作为活性成分的式（I）所示的嘧啶衍生物的抗肿瘤剂等：[其中-X-Y-Z-表示-O-CR 3 = N-（其中R 3表示 氢原子，取代或未取代的芳族杂环基等）等，R 1表示-NR 10 R 11（其中R 10和R 11可以相同或不同，各自表示氢原子，取代或未取代的低级烷基等） 等等，R 2表示-NR 13 R 14（其中R 13和R 14可以相同或不同，各自表示氢原子，取代或未取代的低级烷基等）]或其药学上可接受的盐。

公开(公告)号：US20090012060A1

公开(公告)日：2009-01-08

申请号：US10594369

申请日：2005-03-30

申请人： Hitoshi Arai ,  Tsutomu Matsumura ,  Syoichi Tsami ,  Hiroshi Ishida ,  Koji Hagihara ,  Hiroshi Umehara ,  Yoshinori Yamashita ,  Nana Oiwa ,  Yukimasa Shiotsu ,  Tomoki Naoe ,  Hitoshi Kiyoi

发明人： Hitoshi Arai ,  Tsutomu Matsumura ,  Syoichi Tsami ,  Hiroshi Ishida ,  Koji Hagihara ,  Hiroshi Umehara ,  Yoshinori Yamashita ,  Nana Oiwa ,  Yukimasa Shiotsu ,  Tomoki Naoe ,  Hitoshi Kiyoi

IPC分类号： A61K31/551 ,  C07D413/04 ,  A61K31/506 ,  A61P35/02 ,  C07D413/14 ,  A61K31/5377

CPC分类号： C07D413/04 ,  C07D413/14

摘要： The present invention provides an antitumor agent and the like, which comprises as an active ingredient, a pyrimidine derivative represented by Formula (I): [wherein —X—Y-Z- represents —O—CR3═N— (wherein R3 represents a hydrogen atom, a substituted or unsubstituted aromatic heterocyclic group and the like) and the like, R1 represents —NR10R11 (wherein R10 and R11 may be the same or different, and each represents a hydrogen atom, substituted or unsubstituted lower alkyl and the like) and the like, R2 represents —NR13R14 (wherein R13 and R14 may be the same or different, and each represents a hydrogen atom, substituted or unsubstituted lower alkyl and the like)] or a pharmaceutically acceptable salt thereof.

摘要翻译： 本发明提供了包含作为活性成分的式（I）所示的嘧啶衍生物的抗肿瘤剂等：其中-XYZ-表示-O-CR3-N-（其中R3表示氢原子， 取代或未取代的芳族杂环基等）等，R 1表示-NR 10 R 11（其中R 10和R 11可以相同或不同，各自表示氢原子，取代或未取代的低级烷基等）等， R 2表示-NR 13 R 14（其中R 13和R 14可以相同或不同，各自表示氢原子，取代或未取代的低级烷基等）]或其药学上可接受的盐。

公开(公告)号：US07524852B2

公开(公告)日：2009-04-28

申请号：US10516750

申请日：2003-06-06

申请人： Hitoshi Arai ,  Tsutomu Matsumura ,  Hiroshi Ishida ,  Yosuke Yamaura ,  Seiji Aratake ,  Etsuo Ohshima ,  Koji Yanagawa ,  Motoki Miyama ,  Koji Suzuki ,  Ari Kawabe ,  Satoshi Nakanishi ,  Katsuya Kobayashi ,  Takashi Sato ,  Ichiro Miki ,  Kimihisa Ueno ,  Shinya Fujii ,  Miho Iwase

发明人： Hitoshi Arai ,  Tsutomu Matsumura ,  Hiroshi Ishida ,  Yosuke Yamaura ,  Seiji Aratake ,  Etsuo Ohshima ,  Koji Yanagawa ,  Motoki Miyama ,  Koji Suzuki ,  Ari Kawabe ,  Satoshi Nakanishi ,  Katsuya Kobayashi ,  Takashi Sato ,  Ichiro Miki ,  Kimihisa Ueno ,  Shinya Fujii ,  Miho Iwase

IPC分类号： C07D487/04 ,  A61K31/519 ,  A61P29/00

CPC分类号： C07D263/58 ,  C07D471/04 ,  C07D487/04

摘要： [wherein m and n may be the same or different and each represents an integer of 1 to 3 wherein m+n is 4 or less; R1 represents —NR4R5 (wherein R4 and R5 may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aralkyl or the like); R2 represents the above Formula (II), Formula (IV) or the like; A represents a single bond, —C(═O)—, —SO2—, —OC(═O)— or the like; and R3 represents substituted or unsubstituted lower alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aralkyl or the like] Bicyclic pyrimidine derivatives represented by the above Formula (I), or quaternary ammonium salts thereof, or pharmaceutically acceptable salts thereof, or the like, are provided. These have anti-inflammatory activities or modulation activities on the functions of TARC and/or MDC and are useful for treating and/or preventing a disease which is related to T cells, such as an allergic disease, an autoimmune disease or transplant rejection.

摘要翻译： [其中m和n可以相同或不同，并且各自表示1〜3的整数，其中m + n为4以下; R1表示-NR4R5（其中R4和R5可以相同或不同，各自表示氢原子，取代或未取代的低级烷基，取代或未取代的芳烷基等）; R2表示上述式（II），式（IV）等; A表示单键，-C（-O） - ， - SO 2 - ， - OC（-O） - 等; 并且R 3表示取代或未取代的低级烷基，取代或未取代的环烷基，取代或未取代的芳烷基等〕上式（I）表示的双环嘧啶衍生物或其季铵盐，或其药学上可接受的盐等， 被提供。 它们具有对TARC和/或MDC的功能的抗炎活性或调节活性，并且可用于治疗和/或预防与T细胞相关的疾病，例如过敏性疾病，自身免疫疾病或移植排斥反应。

公开(公告)号：US20070037834A1

公开(公告)日：2007-02-15

申请号：US10516750

申请日：2003-06-06

申请人： Hitoshi Arai ,  Tsutomu Matsumura ,  Hiroshi Ishida ,  Yosuke Yamaura ,  Seiji Aratake ,  Etsuo Ohshima ,  Koji Yanagawa ,  Motoki Miyama ,  Koji Suzuki ,  Ari Kawabe ,  Satoshi Nakanishi ,  Katsuya Kobayashi ,  Takashi Sato ,  Ichiro Miki ,  Kimihisa Ueno ,  Shinya Fujii ,  Miho Iwase

发明人： Hitoshi Arai ,  Tsutomu Matsumura ,  Hiroshi Ishida ,  Yosuke Yamaura ,  Seiji Aratake ,  Etsuo Ohshima ,  Koji Yanagawa ,  Motoki Miyama ,  Koji Suzuki ,  Ari Kawabe ,  Satoshi Nakanishi ,  Katsuya Kobayashi ,  Takashi Sato ,  Ichiro Miki ,  Kimihisa Ueno ,  Shinya Fujii ,  Miho Iwase

IPC分类号： A61K31/519 ,  C07D487/02

CPC分类号： C07D263/58 ,  C07D471/04 ,  C07D487/04

摘要： [wherein m and n may be the same or different and each represents an integer of 1 to 3 wherein m+n is 4 or less; R1 represents —NR4R5 (wherein R4 and R5 may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aralkyl or the like); R2 represents the above Formula (II), Formula (IV) or the like; A represents a single bond, —C(═O)—, —SO2—, —OC(═O)— or the like; and R3 represents substituted or unsubstituted lower alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aralkyl or the like]Bicyclic pyrimidine derivatives represented by the above Formula (I), or quaternary ammonium salts thereof, or pharmaceutically acceptable salts thereof, or the like, are provided. These have anti-inflammatory activities or modulation activities on the functions of TARC and/or MDC and are useful for treating and/or preventing a disease which is related to T cells, such as an allergic disease, an autoimmune disease or transplant rejection.

摘要翻译： [其中m和n可以相同或不同，并且各自表示1〜3的整数，其中m + n为4以下; R 1表示-NR 4 R 5（其中R 4，R 5和R 5） 可以相同或不同，各自表示氢原子，取代或未取代的低级烷基，取代或未取代的芳烷基等）; R 2表示上述式（II），式（IV）等; A表示单键，-C（-O） - ， - SO 2 - ， - OC（-O） - 等; 和R 3表示取代或未取代的低级烷基，取代或未取代的环烷基，取代或未取代的芳烷基等〕由上式（I）表示的双环嘧啶衍生物或其季铵盐或药学上可接受的盐 可接受的盐等。 它们具有对TARC和/或MDC的功能的抗炎活性或调节活性，并且可用于治疗和/或预防与T细胞相关的疾病，例如过敏性疾病，自身免疫疾病或移植排斥反应。

公开(公告)号：US09244298B2

公开(公告)日：2016-01-26

申请号：US12705546

申请日：2010-02-12

申请人： Hiroshi Ishida

发明人： Hiroshi Ishida

IPC分类号： G02F1/1333

CPC分类号： G02F1/133308 ,  G02F2001/133317 ,  G02F2001/133322

摘要： A liquid crystal display device includes a liquid crystal (LC) panel; front and rear frames sandwiching therebetween the LC panel; a latch structure engaging together the LC panel and one of the front and rear frames. The latch structure includes a convex portion formed on one of the LC panel and the one of the front and rear panels and a concave portion formed on the other of the LC panel and the one of the front and rear frames to receive therein the convex portion, whereby the latch structure allows and restricts movement of the LC panel with respect to the one of the front and rear frames in a first direction normal to the LC panel and in a second direction parallel to the LC panel, respectively.

摘要翻译： 液晶显示装置包括液晶（LC）面板; 前后框架夹在它们之间的LC面板; 闩锁结构，其将LC面板与前框架和后框架中的一个接合。 闩锁结构包括形成在LC面板和前面板和后面板中的一个上的凸部和形成在另一个LC面板上的凹部和前框架和后框架中的一个，以在其中容纳凸部 由此闩锁结构允许和限制LC面板相对于前框架和后框架中的一个在垂直于LC面板的第一方向上和在平行于LC面板的第二方向上的移动。

公开(公告)号：US07977846B2

公开(公告)日：2011-07-12

申请号：US11902441

申请日：2007-09-21

申请人： Hiroshi Ishida ,  Mitsuru Kato ,  Craig McKeehan

发明人： Hiroshi Ishida ,  Mitsuru Kato ,  Craig McKeehan

IPC分类号： H02K1/22

CPC分类号： H02K1/28 ,  H02K1/243

摘要： A rotor for a vehicular alternating current generator has a relief space portion formed between axial holes of a pair of pole cores and a shaft for receiving therein a plastically deformed portion produced when the shaft is press-fitted in the axial holes of the pole cores. The relief space portion is located adjacent to a pair of closely contacting inner end faces of the pole cores so that the plastically deformed portion is let to move into a radially outward direction rather than further continuing movement in an axial direction within the relief space portion. The plastically deformed portion is thus prevented from entering between the inner end faces of the pole cores.

摘要翻译： 用于车辆交流发电机的转子具有形成在一对磁极芯的轴向孔之间的释放空间部分和用于在其中插入当轴被压配合在磁极芯的轴向孔中时产生的塑性变形部分的轴。 释放空间部分邻近极芯的一对紧密接触的内端面定位，使得塑性变形部分被允许移动到径向向外的方向，而不是在释放空间部分内沿轴向方向进一步继续移动。 从而防止塑性变形部分进入极芯的内端面之间。

公开(公告)号：US20090052415A1

公开(公告)日：2009-02-26

申请号：US11887833

申请日：2006-03-22

申请人： Hidenori Ishii ,  Satoshi Senga ,  Hiroshi Ishida ,  Takeshi Kanazawa

发明人： Hidenori Ishii ,  Satoshi Senga ,  Hiroshi Ishida ,  Takeshi Kanazawa

IPC分类号： H04W40/00

CPC分类号： H04L65/1083 ,  H04L65/1016 ,  H04L65/1069 ,  H04W40/20 ,  H04W76/12 ,  H04W76/22 ,  H04W80/04 ,  H04W88/06 ,  H04W92/02

摘要： A terminal (101) includes interfaces for communication with a mobile network (102) and a wireless LAN (103). A first IMS server (107) performs IMS call control processing relating to terminals located in the mobile network (102) and a second IMS server (111) relays a signal relating to IMS call control processing concerning terminals located in the wireless LAN (103). These IMS servers search for a mobile network packet gateway (106), a packet data gateway (110), and a gateway to be controlled by a route change request for requesting change of a packet transmission path and relay the route change request. The route change request provided from the terminal (101) is relayed by the IMS servers to provide the change request to all networks specified. The packet transmission path is changed by the gateway in accordance with the request. Thus, the terminal having the interfaces for both of the mobile communication network and the wireless LAN can select a network to use for each communication port.

摘要翻译： 终端（101）包括用于与移动网络（102）和无线LAN（103）通信的接口。 第一IMS服务器（107）执行与位于移动网络（102）中的终端相关的IMS呼叫控制处理，第二IMS服务器（111）中继与涉及位于无线LAN（103）中的终端的IMS呼叫控制处理有关的信号， 。 这些IMS服务器搜索移动网络分组网关（106），分组数据网关（110）以及要由请求改变分组传输路径并中继路由改变请求的路由改变请求来控制的网关。 从终端（101）提供的路由改变请求由IMS服务器中继，以向所指定的所有网络提供改变请求。 分组传输路径由网关根据请求改变。 因此，具有用于移动通信网络和无线LAN两者的接口的终端可以选择用于每个通信端口的网络。

公开(公告)号：US20080117884A1

公开(公告)日：2008-05-22

申请号：US11792370

申请日：2005-12-07

申请人： Hidenori Ishii ,  Satoshi Senga ,  Hiroshi Ishida ,  Takeshi Kanazawa

发明人： Hidenori Ishii ,  Satoshi Senga ,  Hiroshi Ishida ,  Takeshi Kanazawa

IPC分类号： H04Q7/24

CPC分类号： H04W12/06 ,  H04W84/12 ,  H04W92/02

摘要： A radio network controller (104) according to the present invention outputs a context required for a terminal (110a) capable of communicating with a mobile communication network and a wireless local area network to communicate with the wireless local area network to the terminal (110a) among pieces of information input from wireless access gateways (105a, 105b) that control connection with one or more wireless local area networks (103a, 103b) and provide seamless handover of packet communication between the mobile communication network and the wireless LAN.

摘要翻译： 根据本发明的无线电网络控制器（104）输出能够与移动通信网络和无线局域网通信的终端（110a）所需的上下文以与无线局域网通信到终端（110 a）从控制与一个或多个无线局域网（103a，103b）的连接的无线接入网关（105a，105b）输入的信息片段中，并且提供移动通信网络和 无线网络。

公开(公告)号：US07190423B2

公开(公告)日：2007-03-13

申请号：US10463134

申请日：2003-06-17

申请人： Hideaki Sugawara ,  Hiroshi Ishida

发明人： Hideaki Sugawara ,  Hiroshi Ishida

IPC分类号： G02F1/1333

CPC分类号： G02F1/133308 ,  G02F1/133605 ,  G02F2001/133317 ,  G02F2001/13332

摘要： A liquid crystal monitor incorporating therein a liquid crystal module having a direct backlight is configured to have receiving portions in a reflector 8 of the direct backlight that constitutes a liquid crystal module 13, in order to attach together the liquid crystal module 13 and a liquid crystal monitor member 12. The receiving portions are constituted by reflector extensions 111 that are formed by extending a bottom face of the reflector 8 toward a space between an inclined face of the reflector and an upper frame 2 of the liquid crystal module 13. Then, the liquid crystal monitor member 12 is fixed to the reflector extensions 111 by screws 407. Thus, the use of a space near the inclined face of the reflector allows a liquid crystal monitor to be thinned and reduced in its size and the width of monitor frame.

摘要翻译： 其中结合有具有直接背光源的液晶模块的液晶监视器被配置为在构成液晶模块13的直接背光源的反射器8中具有接收部分，以便将液晶模块13和液晶 监视器构件12。 接收部由反射器延伸部111构成，反射器延伸部111通过将反射器8的底面向反射器的倾斜面和液晶模块13的上框架2之间的空间延伸而形成。 然后，液晶监视器构件12通过螺钉407固定到反射器延伸部111。 因此，使用靠近反射镜的倾斜面的空间允许液晶监视器的尺寸和监视器框架的宽度减小。

公开(公告)号：US20070001524A1

公开(公告)日：2007-01-04

申请号：US11475028

申请日：2006-06-27

申请人： Hiroshi Ishida

发明人： Hiroshi Ishida

IPC分类号： H02K9/06 ,  H02K1/22

CPC分类号： H02K9/06 ,  H02K1/243

摘要： An alternator has a rotor having magnetic poles along a circumferential direction and a cooling fan fixed to an end surface of the rotor in an axial direction. The fan has wing portions disposed along the circumferential direction. One wing portion has a fan base extending on or over first and second magnetic poles, first and second fixing members, respectively, fixing first and second fixing portions of the base to the first and second poles, and a fan blade extending from the fan base toward the axial direction. The base or blade has a boundary portion at which a boundary line between the blade and base crosses over a side line of the second pole, and a first distance between the first fixing portion and the boundary portion is substantially equal to a second distance between the second fixing portion and the boundary portion.

摘要翻译： 交流发电机具有沿圆周方向具有磁极的转子和沿轴向固定到转子的端面的冷却风扇。 风扇具有沿圆周方向设置的翼部。 一个翼部具有分别在第一和第二磁极上分别延伸的第一和第二磁极，第一固定部件和第二固定部件的风扇基座，其将第一和第二固定部分固定到第一和第二磁极;以及风扇叶片，其从风扇基座 朝向轴向。 基部或叶片具有边界部分，在该边界部分处，叶片和基部之间的边界线在第二极的侧线上交叉，并且第一固定部分和边界部分之间的第一距离基本上等于第二极点之间的第二距离 第二固定部分和边界部分。