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    Cinnamoylaminoalkyl-substituted benzenesulfonamide derivatives, processes for their preparation, their use, and pharmaceutical preparations comprising them
    1.
    发明授权
    Cinnamoylaminoalkyl-substituted benzenesulfonamide derivatives, processes for their preparation, their use, and pharmaceutical preparations comprising them 有权
    肉桂酰氨基烷基取代的苯磺酰胺衍生物，其制备方法，用途及包含它们的药物制剂

    公开(公告)号：US06350778B1

    公开(公告)日：2002-02-26

    申请号：US09573166

    申请日：2000-05-19

    申请人： Holger Heitsch ,  Heinrich Christian Englert ,  Klaus Wirth ,  Heinz Gögelein

    发明人： Holger Heitsch ,  Heinrich Christian Englert ,  Klaus Wirth ,  Heinz Gögelein

    IPC分类号： A61K3134

    CPC分类号： A61K31/18 ,  C07C311/53 ,  C07C311/58 ,  C07C335/42 ,  C07D307/52

    摘要： The present invention relates to cinnamoylaminoalkyl-substituted benzenesulfonamide derivatives of formula I in which A(1), A(2), A(3), R(1), R(2), R(3), R(4), X, Y, and Z have the meanings indicated in the claims. Compounds of formula I are valuable pharmaceutical active compounds which exhibit, for example, an inhibitory action on ATP-sensitive potassium channels in the cardiac muscle and/or in the cardiac nerve and are suitable, for example, for the treatment of disorders of the cardiovascular system such as coronary heart disease, arrhythmias, cardiac insufficiency or cardiomyopathies, or for the prevention of sudden cardiac death, or for improving decreased contractility of the heart. The invention furthermore relates to processes for the preparation of compounds of formula I, their use, and pharmaceutical preparations comprising them.

    摘要翻译： 本发明涉及式Iin的肉桂酰氨基烷基取代的苯磺酰胺衍生物，其中A（1），A（2），A（3），R（1），R（2），R（3），R（4） ，Y和Z具有权利要求中所示的含义。 式I化合物是有价值的药物活性化合物，其表现出例如对心肌和/或心脏神经中对ATP敏感的钾通道的抑制作用，并且适用于例如治疗心血管疾病 冠状动脉心脏病，心律失常，心功能不全或心肌病等系统，或用于预防心源性猝死或改善心脏收缩力的减轻。 本发明还涉及制备式I化合物，其用途和包含它们的药物制剂的方法。

    Acylaminoalkyl-substituted benzenesulfonamide derivatives, their preparation, their use and pharmaceutical preparations comprising them
    4.
    发明授权
    Acylaminoalkyl-substituted benzenesulfonamide derivatives, their preparation, their use and pharmaceutical preparations comprising them 有权
    酰基氨基烷基取代的苯磺酰胺衍生物，其制备方法，用途和包含它们的药物制剂

    公开(公告)号：US06511989B2

    公开(公告)日：2003-01-28

    申请号：US09985366

    申请日：2001-11-02

    申请人： Holger Heitsch ,  Heinrich Christian Englert

    发明人： Holger Heitsch ,  Heinrich Christian Englert

    IPC分类号： A61K3147

    CPC分类号： C07D407/12 ,  C07C311/58 ,  C07C335/42 ,  C07D215/54

    摘要： One embodiment of the present invention relates to acylaminoalkyl-substituted benzenesulfonamide derivatives of the formula (I), in which A, R(1), R(2), X, Y, and Z have the meanings indicated in the specification, and to pharmaceutically tolerable salts thereof. The compounds of the invention are valuable pharmaceutically active compounds that have, for example, an inhibitory action on ATP-sensitive potassium channels in the cardiac muscle and/or in the vagal cardiac nerve and are suitable, for example, for the treatment of disorders of the cardiovascular system such as coronary heart disease, arrhythmias, cardiac insufficiency, cardiomyopathies, decreased contractility of the heart or vagal dysfunction of the heart, or for the prevention of sudden cardiac death. The invention furthermore relates to processes for the preparation of the compounds of the formula (I) and pharmaceutically tolerable salts thereof, their use, and pharmaceutical preparations comprising them.

    摘要翻译： 本发明的一个实施方案涉及式（I）的酰基氨基烷基取代的苯磺酰胺衍生物，其中A，R（1），R（2），X，Y和Z具有说明书中所示的含义， 其药学上可接受的盐。 本发明的化合物是有价值的药物活性化合物，其具有例如对心肌和/或迷走神经心脏神经中对ATP敏感的钾通道的抑制作用，并且适合于例如治疗 心血管系统如冠心病，心律失常，心功能不全，心肌病，心脏收缩力减退或心脏迷走神经功能障碍，或预防心源性猝死。 本发明还涉及制备式（I）化合物及其药学上可接受的盐，其用途和包含它们的药物制剂的方法。

    Heteroarylacryloylaminoalkyl-substituted benzenesulfonamide derivatives, their preparation, their use and pharmaceutical preparations comprising them
    6.
    发明授权
    Heteroarylacryloylaminoalkyl-substituted benzenesulfonamide derivatives, their preparation, their use and pharmaceutical preparations comprising them 有权
    杂芳基丙烯酰基氨基烷基取代的苯磺酰胺衍生物，其制备方法，用途和包含它们的药物制剂

    公开(公告)号：US06472413B2

    公开(公告)日：2002-10-29

    申请号：US09985359

    申请日：2001-11-02

    申请人： Holger Heitsch ,  Heinrich Christian Englert

    发明人： Holger Heitsch ,  Heinrich Christian Englert

    IPC分类号： C07D21302

    CPC分类号： C07D409/12 ,  C07D213/56 ,  C07D333/24

    摘要： One embodiment of the present invention relates to heteroarylacryloylaminoalkyl-substituted benzenesulfonamide derivatives of the formula (I), in which R(1), R(2), R(3), R(4), Het, X, Y and Z have the meanings indicated in the specification, and to pharmaceutically tolerable salts thereof. The compounds of the invention are valuable pharmaceutically active compounds that have, for example, an at inhibitory action on ATP-sensitive potassium channels in the cardiac muscle and/or in the vagal cardiac nerve and are suitable, for example, for the treatment of disorders of the cardiovascular system such as coronary heart disease, arrhythmias, cardiac insufficiency, cardiomyopathies, decreased contractility of the heart, or vagal dysfunction of the heart, or for the prevention of sudden cardiac death. The invention furthermore relates to processes for the preparation of the compounds of the formula (I) and pharmaceutically tolerable salts thereof, their use, and pharmaceutical preparations comprising them.

    摘要翻译： 本发明的一个实施方案涉及式（I）的杂芳基丙烯酰氨基烷基取代的苯磺酰胺衍生物，其中R（1），R（2），R（3），R（4），Het，X，Y和Z具有 说明书中指出的含义及其药学上可耐受的盐。 本发明的化合物是有价值的药物活性化合物，其具有例如对心肌和/或迷走神经心脏神经中对ATP敏感的钾通道的抑制作用，并且适合于例如治疗疾病 的心血管系统如冠心病，心律不齐，心功能不全，心肌病，心脏收缩力减退或心脏迷走神经功能障碍，或用于预防心源性猝死。 本发明还涉及制备式（I）化合物及其药学上可接受的盐，其用途和包含它们的药物制剂的方法。