公开(公告)号：US20220169808A1

公开(公告)日：2022-06-02

申请号：US17537728

申请日：2021-11-30

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： Wei-Hong CHANG ,  Ching-Mei CHEN ,  Grace H. CHEN ,  Hsin-Hsin SHEN ,  Yuchi WANG ,  Ming-Chia YANG ,  Li-Hsin LIN ,  Sen-Lu CHEN ,  Yi-Hsuan LEE ,  Jian-Wei LIN ,  Liang-Cheng SU

IPC: C08J5/18 ,  C08J7/04

Abstract: An anti-curling film is provided. The anti-curling film includes a first portion and a second portion covering the first portion. The first portion includes polylactic acid (PLA), polycaprolactone (PCL), polyethylene glycol dimethacrylate (PEGDMA) and a photoinitiator. The second portion includes polycaprolactone (PCL), gelatin, hyaluronic acid (HA), alginate (AA), polyvinyl alcohol (PVA) or a combination thereof.

公开(公告)号：US20220204772A1

公开(公告)日：2022-06-30

申请号：US17561133

申请日：2021-12-23

Applicant: Industrial Technology Research Institute

Inventor： Yun-Chung TENG ,  Jen-Huang HUANG ,  Ying-Wen SHEN ,  Yu-Bing LIOU ,  Hsin-Yi HSU ,  Li-Hsin LIN ,  Yuchi WANG ,  Hsin-Hsin SHEN

IPC: C08L89/06 ,  C08J3/24 ,  A61L27/52 ,  A61L27/26 ,  C12N5/00 ,  B33Y80/00

Abstract: A bioprintable material is provided. The bioprintable material includes a hydrogel and microfilaments mixed in the hydrogel. The hydrogel includes a first collagen. The microfilament includes a second collagen. The diameter of the microfilament is ranging from 5 microns to 200 microns. The weight ratio of the microfilaments to the first collagen is ranging from 0.01:1 to 10:1.

公开(公告)号：US20210196648A1

公开(公告)日：2021-07-01

申请号：US16731979

申请日：2019-12-31

Applicant: Industrial Technology Research Institute

Inventor： Hsin-Hsin SHEN ,  Yuchi WANG ,  Li-Hsin LIN ,  Ming-Chia YANG ,  Hsiu-Hua HUANG ,  Liang-Cheng SU ,  Ying-Hsueh CHAO ,  Jing-En HUANG

IPC: A61K9/70

Abstract: A drug-containing multilayer film provided. The drug-containing multilayer film includes: a drug-containing layer; and an anti-adhesion layer on a surface of the drug-containing layer. The drug-containing layer is composed of a first composition including a first polymer material and a drug, and the first polymer material includes at least one selected from the group consisting of: polylactic acid (PLA) and polyethylene glycol (PEG), and the weight ratio of the first polymer material to the drug is about 1:0.01-0.3. The anti-adhesion layer is composed of a second composition, and the second composition includes a second polymer material, and the second polymer material includes at least one selected from the group consisting of polylactic acid and polyethylene glycol.

公开(公告)号：US20250129316A1

公开(公告)日：2025-04-24

申请号：US18542398

申请日：2023-12-15

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： Chao-Hong HSU ,  Teng-Yen WANG ,  Yang-Cheng LIN ,  Hsin-Yi HSU ,  Yu-Bing LIOU ,  Chang-Chou LI ,  Chih-Hung HUANG ,  Tung-Ying LIN ,  Li-Hsin LIN ,  Yuchi WANG ,  Hsin-Hsin SHEN

IPC: C12M3/00 ,  C12M1/00 ,  C12M1/12

Abstract: This disclosure relates to a biological tissue forming method includes the following steps: providing a biological tissue forming package with a base, a membrane, a sliding assembly and a sealing film that seals a chamber of the base used for receiving the membrane and the sliding assembly with one of the base and the sealing film being light-transmitting; passing a biological tissue fluid through the sealing film and the sliding assembly so as to be dispensed on the membrane; moving the sliding assembly away from a covering position used for covering the membrane via at least one passive magnetic element so as to expose the biological tissue fluid on the membrane; and emitting the biological tissue fluid exposed on the membrane by a curing light transmitting through the one of the base and the sealing film so as to cure the biological tissue fluid into a biological tissue.

公开(公告)号：US20210269765A1

公开(公告)日：2021-09-02

申请号：US17126942

申请日：2020-12-18

Applicant: Industrial Technology Research Institute

Inventor： Chia-Jung LU ,  Jing-En HUANG ,  Liang-Cheng SU ,  Hsin-Hsin SHEN ,  Yuchi WANG ,  Ying-Hsueh CHAO ,  Li-Hsin LIN ,  Hsiu-Hua HUANG

IPC: C12N5/00 ,  A61K35/12 ,  A61K9/00 ,  A61K47/38 ,  A61K47/42

Abstract: A temperature-sensitive cell culture composition is provided. The temperature-sensitive cell culture composition includes a hydrogel, a cellulose, a gelatin and a collagen. Based on 1 part by weight of the collagen, a content of the hydrogel is between 0.03 parts by weight and 60 parts by weight, a content of the cellulose is between 150 parts by weight and 360 parts by weight, and a content of the gelatin is between 21 parts by weight and 12 parts by weight. In addition, a method for using the temperature-sensitive cell culture composition, a method for forming the temperature-sensitive cell culture composition, and a use of the temperature-sensitive cell culture composition are also provided.

公开(公告)号：US20210196626A1

公开(公告)日：2021-07-01

申请号：US16731966

申请日：2019-12-31

Applicant: Industrial Technology Research Institute

Inventor： Yu-Bing LIOU ,  Hsin-Yi HSU ,  Ying-Wen SHEN ,  Yun-Chung TENG ,  Yuchi WANG ,  Hsin-Hsin SHEN

IPC: A61K9/00 ,  A61K47/42 ,  A61K47/32 ,  A61K47/34

Abstract: An ophthalmic drug delivery device and a method for fabricating the same are provided. The ophthalmic drug delivery device includes a shield element and a drug release element. The shield element has a light transmittance more than or equal to 80%. The drug release element is an annular body so that the drug release element surrounds the shield element. The drug release element is neutral and includes a cross-linked neutral collagen, a first hydrophilic biodegradable polymer and a drug. The shield element is acidic and includes a cross-linked acidic collagen and a second hydrophilic biodegradable polymer.