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公开(公告)号:US20220379311A1
公开(公告)日:2022-12-01
申请号:US17824929
申请日:2022-05-26
Applicant: Industrial Technology Research Institute
Inventor: Lih-Tao Hsu , Shen-Hua Peng , Cheng-Yi Wu , Jeng-Liang Kuo , Meng-Hsueh Lin , Chih-Chieh Huang , Wei-Lin Yu , Hui-Ting Huang
IPC: B01L3/00
Abstract: A cell purification module, configured to purify multiple cells from a fluid sample is provided. The cell purification module includes a hollow column, multiple hollow fiber membranes, at least one first magnetic component, a fluid sample inlet end, and a fluid sample outlet end. The hollow column has a first opening, a second opening, and an accommodating space connecting the first opening and the second opening. The hollow fiber membranes are disposed in the accommodating space and each hollow fiber membrane has multiple pores. The first magnetic component is disposed at a periphery of the hollow column. The fluid sample inlet end and the fluid sample outlet end are respectively disposed at two ends of the hollow column. The hollow fiber membranes extend in an axial direction of the hollow column, and are arranged in a radial direction of the hollow column. A cell purification system is also provided.
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公开(公告)号:US11242516B2
公开(公告)日:2022-02-08
申请号:US16137925
申请日:2018-09-21
Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
Inventor: Pei-Yi Tsai , Chih-Hung Chen , Yi-Hung Lin , Chih-Chieh Huang , Hsin-Hsin Shen , Liang-Yin Ke , Chu-Huang Chen
Abstract: A method for ex vivo treating blood or plasma is provided. The method includes (a) ex vivo contacting a blood or plasma with an enzyme composition to react the enzyme composition with the blood or plasma, wherein the enzyme composition is capable of eliminating electronegative low-density lipoprotein from the blood or plasma by the activity of the enzyme composition, and the enzyme composition is selected from a group consisting of: a first enzyme for eliminating a glycan residue of an electronegative low-density lipoprotein (LDL); a second enzyme for eliminating ceramide carried by a electronegative low-density lipoprotein (LDL); and a combination thereof; and (b) terminating contact between the blood or plasma and the enzyme composition to terminate the reaction of the enzyme composition with the blood or plasma.
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公开(公告)号:US11141262B2
公开(公告)日:2021-10-12
申请号:US16230666
申请日:2018-12-21
Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
Inventor: Pei-I Tsai , Hsin-Hsin Shen , Kuo-Yi Yang , Chih-Chieh Huang , Shih-Ping Lin , De-Yau Lin
Abstract: A bone implant includes at least one spiral and at least one pillar. The spiral surrounds an accommodating space. The pillar is disposed in the accommodating space and connected to the spiral. The pillar has at least one notch.
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公开(公告)号:US20190388230A1
公开(公告)日:2019-12-26
申请号:US16224809
申请日:2018-12-19
Inventor: Pei-I Tsai , Hsin-Hsin Shen , Kuo-Yi Yang , De-Yau Lin , Yi-Hung Wen , Chih-Chieh Huang , Wei-Luan Fan , Pei-Yu Chen , Ching-Chi Hsu
IPC: A61F2/42
Abstract: An artificial joint includes a first joint assembly and a second joint assembly. The first joint assembly is adapted to be connected to a first bone and has a first contacting surface, wherein the first contacting surface includes a first convex arc surface, a second convex arc surface, and a third convex arc surface. The second joint assembly is adapted to be connected to a second bone and has a second contacting surface, wherein the second contacting surface is in contact with the first contacting surface and includes a first concave arc surface, a second concave arc surface, and a third concave arc surface, and the first concave arc surface, the second concave arc surface, and the third concave arc surface respectively correspond to the first convex arc surface, the second convex arc surface, and the third convex arc surface.
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公开(公告)号:US10973647B2
公开(公告)日:2021-04-13
申请号:US16224809
申请日:2018-12-19
Inventor: Pei-I Tsai , Hsin-Hsin Shen , Kuo-Yi Yang , De-Yau Lin , Yi-Hung Wen , Chih-Chieh Huang , Wei-Luan Fan , Pei-Yu Chen , Ching-Chi Hsu
IPC: A61F2/42
Abstract: An artificial joint includes a first joint assembly and a second joint assembly. The first joint assembly is adapted to be connected to a first bone and has a first contacting surface, wherein the first contacting surface includes a first convex arc surface, a second convex arc surface, and a third convex arc surface. The second joint assembly is adapted to be connected to a second bone and has a second contacting surface, wherein the second contacting surface is in contact with the first contacting surface and includes a first concave arc surface, a second concave arc surface, and a third concave arc surface, and the first concave arc surface, the second concave arc surface, and the third concave arc surface respectively correspond to the first convex arc surface, the second convex arc surface, and the third convex arc surface.
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公开(公告)号:US10064737B2
公开(公告)日:2018-09-04
申请号:US14977234
申请日:2015-12-21
Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
Inventor: Jane S C Tsai , Hsin-Hsin Shen , Fang-Hei Tsau , Ji-Bin Horng , Pei-I Tsai , Chih-Chieh Huang , Yi-Hung Wen , Hong-Jen Lai , Sung-Ho Liu , Ching-Chih Lin , Meng-Huang Wu
Abstract: An implant device for osseous integration includes a plurality of connection bars and at least one frame bar. These connection bars are connected with each other to form a three-dimensional (3D) grid structure. The frame bar is connected with at least two of the connection bars to define at least one edge of the 3D grid structure. Wherein, the frame bar has a diameter substantially greater than that of these connection bars.
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公开(公告)号:US12194192B2
公开(公告)日:2025-01-14
申请号:US17136077
申请日:2020-12-29
Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
Inventor: Hsin-Hsin Shen , Pei-I Tsai , Chih-Chieh Huang , Chien-Cheng Tai , Yi-Hung Wen , Jeng-Liang Kuo , Chun-Hsien Ma , Lih-Tao Hsu , Shin-I Huang , Kuo-Yi Yang , Tsung-Hsien Wu
Abstract: A tissue scaffold for use in a tendon and/or ligament is provided, which includes a weave formed by interlacing warp yarns and weft yarns, wherein the warp yarns include a plurality of fibers with an alternative shaped cross section structure, and the weave includes: a main body area with a bioactive component formed on the fiber surface, and a fixed area comprises the weft yarn having a bioceramic material. The tissue scaffold prepared in the present disclosure has the characteristics of stimulating the growth of tissues and inducing tissue repair, effectively improving the ability of tissue regeneration and bone healing, and is beneficial to the reconstruction of the tendon and/or ligament.
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公开(公告)号:US11596450B2
公开(公告)日:2023-03-07
申请号:US17462722
申请日:2021-08-31
Applicant: Industrial Technology Research Institute
Inventor: Hsin-Hsin Shen , Pei-I Tsai , Chih-Chieh Huang , Kuo-Yi Yang , Yi-Hung Wen , Wei-Lun Fan , Fang-Jie Jang , Shih-Ping Lin
IPC: A61B17/70
Abstract: A low-profile offset-type spinal fusion device includes a first screw, a connection base, a nut and a compression part. The first screw has an external thread and a flange. The connection base includes a penetration part and a connection part disposed no higher than the penetration part, and can sleeve the first screw through a first hole of the penetration part to contact the flange with opposite ends of the first screw protruding out of the first hole. The nut, used to engage the first screw, has a bottom surface to contact against the penetration part. When the first screw is installed by penetrating the first hole, the nut and the flange are located to opposite ends of the first hole. The compression part is to screw into a cavity of the connection part for depressing a connecting bar tightly in the cavity.
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公开(公告)号:US20170156878A1
公开(公告)日:2017-06-08
申请号:US14977234
申请日:2015-12-21
Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
Inventor: Jane SC Tsai , Hsin-Hsin Shen , Fang-Hei Tsau , Ji-Bin Horng , Pei-Yi Tsai , Chih-Chieh Huang , Yi-Hung Wen , Hong-Jen Lai , Sung-Ho Liu , Ching-Chih Lin , Meng-Huang Wu
CPC classification number: A61F2/442 , A61B17/86 , A61F2/4455 , A61F2/447 , A61F2002/30733 , A61F2002/30784 , A61F2002/3092 , A61F2002/3093 , A61F2002/4475 , A61F2002/4495
Abstract: An implant device for osseous integration includes a plurality of connection bars and at least one frame bar. These connection bars are connected with each other to form a three-dimensional (3D) grid structure. The frame bar is connected with at least two of the connection bars to define at least one edge of the 3D grid structure. Wherein, the frame bar has a diameter substantially greater than that of these connection bars.
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公开(公告)号:US11911031B1
公开(公告)日:2024-02-27
申请号:US18089288
申请日:2022-12-27
Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
Inventor: Fang-Chieh Chang , Pei-I Tsai , Shu-Fen Yeh , Kuo-Yi Yang , Chih-Chieh Huang
IPC: A61B17/072 , A61B90/00
CPC classification number: A61B17/072 , A61B2090/0811
Abstract: This disclosure relates to a surgical tool configured for holding an implant includes an inner rod and a sleeve. The inner rod includes a rod portion and a holding portion. The holding portion is located at one end of the rod portion and has a first accommodation space configured for accommodating at least part of the implant. The sleeve includes a sleeving portion and a retaining portion. The sleeving portion is slidably sleeved on the rod portion of the inner rod. The retaining portion is located at one end of the sleeving portion and selectively presses against the holding portion. The inner rod further includes at least one fin portion protruded from the holding portion and located in the first accommodation space for being inserted into at least one slot of the implant.
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