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公开(公告)号：US11369645B2
公开(公告)日：2022-06-28
申请号：US16902732
申请日：2020-06-16
申请人： Institut National de la Sante et de la Recherche Medicale (INSERM) , Centre Hospitalier Universitaire de Rouen , Universite de Rouen , TARGEDYS
发明人： Serguei Fetissov , Pierre Dechelotte , Jonathan Breton , Gregory Lambert , Nicolas Lucas , Romain Legrand
IPC分类号： A61K35/741 , A61P3/04 , A61P3/10 , A23L33/135 , A61P3/06 , A61K35/00
摘要： The present invention relates to method of preventing, treating or attenuating obesity-related manifestations in a human or non-human mammal subject in need thereof, said method comprising orally administering to the subject a composition comprising an effective amount Hafnia alvei probiotics; wherein said obesity-related parameters are selected from the group of hyperphagia, increased fat mass on lean mass ratio, increased waist circumference, postprandial hyperglycemia, fasting hyperglycemia and hypercholesterolemia.
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公开(公告)号：US20180369378A1
公开(公告)日：2018-12-27
申请号：US16032604
申请日：2018-07-11
申请人： Institut National de la Sante et de la Recherche Medicale (INSERM) , Centre Hospitalier Universitaire de Rouen , Universite de Rouen , TARGEDYS
发明人： Serguei Fetissov , Emmanuelle De , Naouel Tennoune , Jonathan Breton , Philippe Chan-Tchi-Song , Pierre Dechelotte , Romain Legrand , Gregory Lambert
CPC分类号： A61K39/40 , A61K2039/545 , A61K2039/55516 , A61P1/14 , C07K14/245 , C07K16/1232 , C07K16/26 , C07K2317/33 , C07K2317/34 , C07K2317/76
摘要： The present invention relates to CIpB expressing bacteria and their impact on obesity. The present invention relates to bacterial CIpB protein and CIpB expressing bacteria and their impact on eating disorders. The invention further relates to compositions comprising antibiotic directed against at least one CIpB expressing bacterium as well as probiotics not expressing CIpB protein and their use in the treatment or prevention of eating disorders. The invention also relates to diagnostic tools for determining whether a subject is likely to respond to a method of treating eating disorders and to methods of immunization against eating disorders.
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公开(公告)号：US20210008125A1
公开(公告)日：2021-01-14
申请号：US16902732
申请日：2020-06-16
申请人： Institut National de la Sante et de la Recherche Medicale (INSERM) , Centre Hospitalier Universitaire de Rouen , Universite de Rouen , TARGEDYS
发明人： Serguei Fetissov , Emmanuelle De , Naouel Tennoune , Jonathan Breton , Philippe Chan-Tchi-Song , Pierre Dechelotte , Romain Legrand , Gregory Lambert
IPC分类号： A61K35/741 , A61P3/04 , A61P3/10 , A61P3/06 , A23L33/135
摘要： The present invention relates to method of preventing, treating or attenuating obesity-related manifestations in a human or non-human mammal subject in need thereof, said method comprising orally administering to the subject a composition comprising an effective amount Hafnia alvei probiotics; wherein said obesity-related parameters are selected from the group of hyperphagia, increased fat mass on lean mass ratio, increased waist circumference, postprandial hyperglycemia, fasting hyperglycemia and hypercholesterolemia.
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公开(公告)号：US10729770B2
公开(公告)日：2020-08-04
申请号：US16032604
申请日：2018-07-11
申请人： Institut National de la Sante et de la Recherche Medicale (INSERM) , Centre Hospitalier Universitaire de Rouen , Universite de Rouen , TARGEDYS
发明人： Serguei Fetissov , Emmanuelle De , Naouel Tennoune , Jonathan Breton , Philippe Chan-Tchi-Song , Pierre Dechelotte , Romain Legrand , Gregory Lambert
摘要： The present invention relates to ClpB expressing bacteria and their impact on obesity. The present invention relates to bacterial ClpB protein and ClpB expressing bacteria and their impact on eating disorders. The invention further relates to compositions comprising antibiotic directed against at least one ClpB expressing bacterium as well as probiotics not expressing ClpB protein and their use in the treatment or prevention of eating disorders. The invention also relates to diagnostic tools for determining whether a subject is likely to respond to a method of treating eating disorders and to methods of immunization against eating disorders.
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5.发明申请BACTERIAL INFLUENCE ON REGULATION OF APPETITE VIA CLPB PROTEIN MIMICRY OF ALPHA-MSH 审中-公开对通过ALPHA-MSH的CLPB蛋白质微粒调节的细菌影响公开(公告)号：US20160313348A1
公开(公告)日：2016-10-27
申请号：US15101452
申请日：2014-12-04
申请人： Institut National de la Sante et de la Recherche Medicale (INSERM) , Centre Hospitalier Universitaire de Rouen , Universite de Rouen
发明人： Serguei Fetissov , Emmanuelle De , Naouel Tennoune , Jonathan Breton , Philippe Chan-Tchi-Song , Pierre Dechelotte , Romain Legrand
IPC分类号： G01N33/68 , A61K39/108 , C12Q1/68 , A61K35/741
CPC分类号： G01N33/6893 , A61K31/00 , A61K31/11 , A61K35/741 , A61K39/0258 , A61K2039/58 , C12Q1/6883 , C12Q2600/158 , G01N2800/02 , G01N2800/52 , Y02A50/474
摘要： The present invention relates to bacterial Clp B protein and Clp B expressing bacteria and their impact on eating disorders. The invention further relates to compositions comprising antibiotic directed against at least one Clp B expressing bacterium as well as probiotics not expressing Clp B protein and their use in the treatment or prevention of eating disorders. The invention also relates to diagnostic tools for determining whether a subject is likely to respond to a method of treating eating disorders and to methods of immunization against eating disorders.
摘要翻译： 本发明涉及细菌Clp B蛋白和Clp B表达细菌及其对进食障碍的影响。 本发明还涉及包含针对至少一种ClP B表达细菌的抗生素以及不表达Clp B蛋白的益生菌及其在治疗或预防进食障碍中的用途的组合物。 本发明还涉及用于确定受试者是否可能对治疗进食障碍的方法作出反应的诊断工具以及针对进食障碍的免疫方法。
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6.发明申请公开(公告)号：US20180153959A1
公开(公告)日：2018-06-07
申请号：US15579459
申请日：2016-04-05
申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , CENTRE HOSPITALIER UNIVERSITAIRE DE ROUEN , UNIVERSITÉ DE ROUEN , TARGEDYS
IPC分类号： A61K38/16 , A61K35/741 , A23L33/135 , A23L33/00 , A61P3/04
CPC分类号： A61K38/164 , A23L33/135 , A23L33/30 , A23V2002/00 , A23V2200/3204 , A61K35/74 , A61K35/741 , A61P3/04
摘要： The present invention relates to pharmaceutical and food compositions for inducing satiation and prolonging satiety in subjects in need thereof. In particular, the present invention relates to a method of inducing satiation in a subject in need thereof comprising administering to the subject an effective amount of a ClpB protein or an effective amount of a bacterium that expresses the ClpB protein.
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公开(公告)号：US10682389B2
公开(公告)日：2020-06-16
申请号：US15579459
申请日：2016-04-05
申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , CENTRE HOSPITALIER UNIVERSITAIRE DE ROUEN , UNIVERSITÉ DE ROUEN , TARGEDYS
IPC分类号： A61K39/00 , A61K39/38 , A61K39/02 , A61K39/385 , A61K39/08 , A61K45/00 , A61K38/16 , A61K35/74 , A23L33/00 , A23L33/135 , A61P3/04 , A61K35/741
摘要： The present invention relates to pharmaceutical and food compositions for inducing satiation and prolonging satiety in subjects in need thereof. In particular, the present invention relates to a method of inducing satiation in a subject in need thereof comprising administering to the subject an effective amount of a ClpB protein or an effective amount of a bacterium that expresses the ClpB protein.
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公开(公告)号：US10888592B2
公开(公告)日：2021-01-12
申请号：US16091678
申请日：2017-04-05
申请人： INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) , CENTRE HOSPITALIER UNIVERSITAIRE DE ROUEN , TARGEDYS , UNIVERSITE DE ROUEN
发明人： Serguei Fetissov , Pierre Dechelotte , Jonathan Breton , Gregory Lambert , Romain Legrand , Nicolas Lucas
IPC分类号： A61K35/741 , A61K35/74 , A61K38/16 , A23L33/00 , A23L33/135 , A61K9/00 , A61P3/04
摘要： The present invention relates to pharmaceutical and food compositions for inducing satiation and prolonging satiety in subjects in need thereof. In particular, the present invention relates to a method of inducing satiation in a subject in need thereof comprising administering to the subject an effective amount of Hafnia alvei.
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