中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

35 records (took 0.029 seconds)

    Compounds and methods for the treatment of pain and other diseases
    1.
    发明授权
    Compounds and methods for the treatment of pain and other diseases 有权
    用于治疗疼痛和其他疾病的化合物和方法

    公开(公告)号：US08765953B2

    公开(公告)日：2014-07-01

    申请号：US13141384

    申请日：2009-12-21

    Applicant: Irving Sucholeiki

    Inventor： Irving Sucholeiki

    IPC: C07D221/02 ,  C07D209/04 ,  C07D209/20

    CPC classification number: C07D409/12 ,  A61K31/381 ,  A61K31/404 ,  Y02A50/465

    Abstract: The present invention relates generally to alkyne containing pharmaceutical agents, and in particular, to phenylethynyl-thiophene based metalloprotease inhibitor compounds. More particularly, the present invention provides a new class of MMP inhibiting compounds that exhibit increased potency, metabolic stability and/or reduced toxicity in relation to currently known MMP inhibitors for the treatment of pain and other diseases such as cancer. Additionally, the present invention relates to methods for treating pain in a patient comprising administering to the patient a pain-reducing effective amount of a present compound.

    Abstract translation: 本发明一般涉及含有炔烃的药剂，特别是苯基乙炔基 - 噻吩基金属蛋白酶抑制剂化合物。 更具体地，本发明提供了一类新的MMP抑制化合物，其相对于目前已知的用于治疗疼痛和其它疾病如癌症的MMP抑制剂表现出增加的效力，代谢稳定性和/或降低的毒性。 另外，本发明涉及用于治疗患者疼痛的方法，包括向患者施用减少疼痛的有效量的本发明化合物。

    Paramagnetic scintillation particles and assay
    5.
    发明授权
    Paramagnetic scintillation particles and assay 失效
    顺磁闪烁颗粒和测定

    公开(公告)号：US5750412A

    公开(公告)日：1998-05-12

    申请号：US699796

    申请日：1996-08-19

    Applicant: Irving Sucholeiki

    Inventor： Irving Sucholeiki

    IPC: G01N33/543 ,  G01N33/58 ,  G01N33/60 ,  G01N33/553 ,  G01N33/542 ,  G01N33/546

    CPC classification number: G01N33/58 ,  G01N33/54333 ,  G01N33/60 ,  Y10S436/808

    Abstract: An immunoscintillating composition and method of radioimmunoassay is disclosed whereby polymer coated paramagnetic particles and binding agent such as an antibody are associated by chemical or physical means to provide solid scintillating immunoadsorbent particles which are paramagnetic. These particles are capable of selectively binding or retaining radioactive or labeled antigens or ligands and transmitting radioactive energy to a phosphor or photon emitting substance that is bound by chemical or physical means to the particles. Upon binding of the antigens or ligands to the surface of the particles the particles are separated from the unbound components in solution by application of a magnetic field. The luminescence emitted by the phosphor which is attached to the magnetically separated particles is measured by a scintillator counter and is directly proportional to the radioactive energy released by the labeled antigen bound to the antibody. Upon completion of the measurement the paramagnetic particles can be magnetically separated and the labeled antigens or ligands removed for further analysis and the particles recycled for use in other assays.

    Abstract translation: 公开了免疫组织化学和放射免疫测定方法，其中聚合物涂覆的顺磁性颗粒和结合剂如抗体通过化学或物理手段相关联，以提供顺磁性的固体闪烁免疫吸附剂颗粒。 这些颗粒能够选择性地结合或保留放射性或标记的抗原或配体，并将放射能量传输到通过化学或物理手段结合到颗粒的磷光体或光子发射物质。 当抗原或配体与颗粒的表面结合时，颗粒通过施加磁场与溶液中未结合的组分分离。 通过闪烁计数器测量由附着在磁分离的颗粒上的荧光体发射的发光，并与与抗体结合的标记抗原释放的放射性能量成正比。 测量完成后，顺磁性颗粒可被磁性分离，标记的抗原或配体被去除用于进一步分析，再循环使用的颗粒用于其他测定。

Patent Agency Ranking